조직기생 선충류 유충에서 분리한 단백 분해 효소의 특성 및 항원성 검토

임한종,주경환,최성아,이혜정,주종윤,정명숙 한국농촌보건회 1997 농촌의학·지역보건 Vol.22 No.1

저용량 Cyclosporine-A와 Diltiazem 병합요법에 의한 신증후군의 관해

김성은,정연순,임학 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Background : Cyclosporine-A (CsA) has been widely used as a treatment of nephrotic syndrome especially in patients with steroid-resistance or steroid-dependence. However, it can be nephrotoxic and its cost might also be a point to be considered. Diltiazem (DZ), one of calcium channel blockers, may have a potential benefit of renoprotection, which decreases acute tubular necrosis of renal transplants. DZ can also be used for reducing CsA dose because it slows down the metabolism of CsA by inhibition of cytochrome P-450 hepatic enzyme. In these points of view, low-dose CsA with DZ combination could be considered as an alternative to nephrotic syndrome treatment. However, such a kind of trial was hardly found so far. The purpose of this study was to evaluate the therapeutic effect of low-dose CsA with DZ in patients with steroid-resistant or steroid-dependent nephrotic syndrome. Methods : Low-dose of CsA (mean 1.7±0.5 mg/kg) and 90 mg of DZ were administered simultaneously to 15 patients of steroid-resistant or steroid-dependent nephrotic syndrome for 6 months with no alteration of dose. Blood pressure, body weight and random urine protein, 24-hour urine protein, serum creatinine, albumin, total cholesterol, and trough level of CsA were analyzed. Results : The random urine protein tended to decrease by CsA treatment. Twenty-four hour urine protein excretion decreased significantly at 6th months of treatment (from 7,211±5,374 mg to 1,094±1,688 mg, n=7, p=0.018). Complete remission was achieved in 10 patients and partial remission in 5 patients. Changes in serum albumin, total cholesterol, hemoglobin, body weight and blood pressure were statistically not significant. Conclusion : Low-dose CsA combined with DZ may be an effective in patients with steroid-resistant or steroid-dependent nephrotic syndrome.

인체기생 열두조충류의 형태비교 및 진단적 소견

임신영,강성구,양용상,백승한,류장근 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1998 Journal of biomedical laboratory sciences Vol.4 No.1

최근 우리 나라는 열두조충과 (Diphyllobothridae)에 속하는 조충류의 인체 감염예가 빈번하게 보고되고 있다. 이는 본 조충류의 감염매체인 어류를 날 것으로 생식할 기회가 많으며, 또한 본 조충류의 제1중간숙주인 물벼룩이 음료수를 통한 인체 감염이 원인일 것으로 추정되고 있다. 조충류의 진단은 충체에 있어 두적과 편절의 형태학적 특징을 감별하여 種의 분류와 진단을 하는 것이 기본적 순서가 될 것이나, 1차적으로 가능한 진단은 환자의 증상 참작과 분변으로부터 충란을 발견 감별하게 된다. 특히 광절열두조충류의 충란에 의한 種鑑別은 환자로부터 편절이나 충체의 확실한 감별을 위한 사전 정보를 가늠하는 뜻에서도 중요성이 있다. 이에 저자들은 환자의 치료와 함께 수집된 Diphyllobothrium latum, D. latum parvum 그리고 Spirometra erinacei의 편절과 충란을 재료로 형태 및 진단적 결과를 분석한 바 그 성적은 다음과 같다. 1. 환자의 분변에서 수집된 충란 50개씩을 각각 선택하여 형태와 크기에 대한 계측을 실시하였다. D. latum의 충란은 난개가 있고 난원형 또는 타원형의 모양으로 관찰되었으며 D. latum parvum은 D. latum에 비하여 더 난원형이면서 작게 관찰되었다. S. erinacei의 충란은 폭이 비대칭적이며 길쭉한 모양으로 관찰되었다. 2. D. latum, D. latum parvum 그리고 S. erinacei의 충란의 크기에서 충란의 평균 길이와 폭은 각각 61.4X41.7㎛, 55.9X41.4㎛ 그리고 66.7X36.4㎛이었다. 3. 각 조충의 편절을 고정한 다음, 첫째 포매하고 microtome으로 절편을 만들어 hematoxylin-eosin 염색을 실시하였고, 둘째 고정과 함께 semicon's aceto-carmine 염색표본을 작성하여 현미경 관찰을 한 결과 D. latum과 D. latum parvum은 생식선이 편절의 중앙선상에 위치하고 개구된 자궁구가 관찰되었다. 그리고 편절의 양측에 난황이 follicle로 관찰되었으며 전형적인 rosette모양을 형성하고 있었다. 그러나 D. latum parvum은 D. latum에 비하여 아주 작은 크기로 관찰되었다. S. erinacei의 편절은 자궁이 나선형으로 5∼7회 이상으로 말려서 관찰되었고 음경낭안에서 저정낭이 이어져 연결되고 있었다. 이로써 본 연구에서는 편절의 형태특징과 함께 충란 크기에 대한 계측과 분석을 하고자 하였으며, 공학현미경에 의한 계측치로 세 종류의 조충 감별에 유의한 참고치를 제기하는 바이다. Recently there have been frequent reports on human infection caused by the Diphyllobothridae in Korea. The adequate opportunities for Koreans to eat raw fish, the primary infection medium of cestodes and the human infection through drinking water by cyclops, the first intermediate host are believed to be main reasons for the infection. The first task of this study was to classify and diagnose the species by differentiating morphological characteristic between scolex and proglottids of cestodes. However, the initially available diagnosis was done with the patient's symptoms and the eggs obtained from his stool. It is important to differentiate the species by the eggs of Diphyllobothrium latum especially in that it can help get advance information for a more reliable analysis in the near future. The morphological and diagnostic results from proglottids and eggs of Diphyllobothrium latum, Diphyllobothrium latum parvum and Spirometra erinacei are as follows; In each kind of cestodes from the patient's stool, the shape and size of 50 eggs were measured. Eggs of Diphyllobothrium latum had an operculum and were ovoidal or ellipsoid to elliptical in shape. Eggs of Diphyllobothrium latum parvum were more ovoidal in shape and smaller in size than Diphyllobothrium latum. And eggs of Spirometra erinacei were asymmetrical in width and long and slender in shape. The average lengths and widths of Diphyllobothrium latum, Diphyllobothrium latum parvum and Spirometra erinacei were 61.4X41.7㎛, 55.9X41.4㎛ and 66.7X36.4㎛, respectively. After the segments of each cestode were fixed, embedding and hematoxylin-eosin dyeing on a microtome-made specimen were done. The micrographs of the semicon's aceto-carmine dyed specimen showed that Diphyllobothrium latum and Diphyllobothrium latum parvum had a centrally-located genital gland and an opened uterine pore. The yolks were observed on both sides of proglottids and had a typical rosette pattern. Yet, Diphyllobothrium latum parvum was shown smaller than Diphyllobothrium latum in the micrograph. Proglottids of Spirometra erinacei displayed that the uterus was rolled spirally more than five to seven times, and connected successively to the seminal vesicle in the cirrus sac. Shown above, this study was performed to measure the size of eggs and analyze the morphological characteristics of proglottids and provided the measurements of three types of cestodes obtained by a light microscope.

수정된 토양트렌치 공정을 이용한 소규모 오수처리

임재명,김병욱,강성환 江原大學校 附設 環境硏究所 1998 環境硏究 Vol.15 No.-

This research aims to improve the previous trench process. The modified process is consist of 3 processes; first setting tank, 3-staged second contact-filter, and last trench system. The experiments was operated by varying the HRT 8, 6 and 4 hours in trench. The results of laboratory experiments showed removal rate of 97~98% of TKN 91~98% do T-P. From the results of this research, organic materials were removed in settling setting tank and nutrients in the trench stage. Therefore it is recommended to replace the previous 3-staged contact-filter to 1-staged one, and to increase contact-time in trench system.

인천시관내 고1 건강검진 결과분석

임순철,안상용,김기성,황옥분,고봉순,박대정 한국건강관리협회 2000 건협 Report Vol.3 No.-

Anoxic-Oxic 공법에 의한 豚舍廢水處理

林裁明,李相台,權在赫 江原大學校 附設 環境硏究所 1993 環境硏究 Vol.10 No.-

The treatability of piggery wastewater was studied by using the anoxic~oxic process(four stage Bardenpho process). The influent average COD concentration ranged from 2,475 to 2,807mg/L. The influent average TKN concentration was betwen 692 and 725 mg/L. The influent wastewater had NH₃-N concentrations of 482 to 546 mg/L, but NO₃-N contents were found to be negligible. The experiment was operated by decreasing the aeration tank HRT from 6 to 3 days. The inner and the outer recysle ratio was 400% and 50%, respectively. The organic loading rate 0.205-0.474 KgBOD/㎡/day and F/M ratio was 0.13-0.23 KgBOD/KgMv/day. Total kjeldahl nitrogen concentration and pH of the piggery wastewater were higher than those typically found in domestic wstewater. Considering the relatively high pH of the sample, it was estimated that about 60% of free ammonia existed in a from of TKN. The primary process for nitrogen removal appeared in air stripping. At the operating conditions in this experiment, phosphorus removal was in the range of 57-67% and the BOD removal was in the range of 77-91% at organic loading rate of 0.205-0.474 KgBOD/㎡/day (0.395-0.953 KgCOD/㎡/day).

Striatopallidodentate 석회화증과 의도 진전이 동반된 원발성 부갑상선 기능 저하증 1례

강성진,김민정,임학 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

We present a 65-year-old man with ataxic gait and both hands tremor. Laboratory findings were consistent with idiopathic hypoparathyroidism, and brain magnetic resonance images showed extensive bilateral calcification of the basal ganglia, dentate nuclei of cerebellum. These results suggested that striopallidodentate calcification developed by hypoparathyroidism. Administration of calcium and calcitriol returned serum calcium and phosphorus level to normal, with considerable clinical benefit.

산업대학 건축공학과 교육과정 개발에 관한 연구

임응찬,한인웅,이승준,박재호,조방현,서형수,정구용,한기원,김진원,임상규,이재윤 三陟大學校 1996 論文集 Vol.29 No.2

By impproving the educational program of the Department of Architectural Engineering and studying the theory of learning and the applied method necessary for the development of nation and society, we should develop a satisfying course of education to meet the demand and skill in the industralized society for the purpose of cultivating men of baility with great personalities and creative minds. Therefore, this study focused on classifying several kinds of occupations in the prart of architectured related to what graduates from the department of Architectural Engineering go with into the society. Accordingly after choosing some works adequate to each occupation by the proposed curricula, we tried to establish the scope of education and courses corresponding to the jobs and thus and develop a satisfying curriculum.

高興郡 浦頭面에 있어서의 肺吸蟲症의 疫學的 推移

林漢鍾,李駿商,金東彦,鄭城守 고려대학교 의과대학 1980 고려대 의대 잡지 Vol.17 No.1

It is recognized that Ko Heung Gun is the most well known endemic foci of paragonimiasis in Korea. Authors carried out the survey for human paragonimiasis in Po Du Myun, Ko Heung Gun (from 1968 to 1979) by the use of intradermal screening test with Veronal buffered saline antigens. In 1968 and 1979, inhabitants, of all age groups in these areas were examined. In 1979, 1,484 middle school students in Po Du Myun and 1,247 high school students in Ko Heung Eup were examined. The infestation rate of crabs with Paragonimus metacercaria was also examined. The following results were obtained in this survey. 1. In 1968, 353 inhabitants were showed 56.9% positive reaction, with sexual difference of 60.2% in male and 50.8% in female. The positive rate was shown over 50% in the age groups of over 10 years old. 2. In 1979, 387 inhabitants were showed 48.8% positive reaction, with sexual difference of 61.0% in male and 38.6% in female. The positive rate was shown over 50% in the age groups over 40 years old. 3. In 1979, middle school students in Po Du Myun were showed 16.4% positive reaction and high school students in Ko Heung Eup were showed 5.7% positive reaction. 4. The positive rate of Paragonimus metacercariae was 25.0% in crabs (Eriocheir japonicus) and the mean number of metacercaria per crab was 0.6.

Barium Titanate의 濕式合成의 그 誘電特性에 關한 硏究

林炳五,金丞鎬 弘益大學校 1981 弘大論叢 Vol.13 No.-

The industrial synthesis of BaTiO₃, used widely in ferroelectric materials, has generally been manufactured by solid state reactions between TiO₂and BaCO₃. But it is very difficult to get an uniformity of component. Another difficulty is that this process needs very high temperature. In this synthesis BaTiO(C₂O₄)₂·4H₂O has been synthesized with BaCl₂, TiCl₄, and H₂C₂O₄through an aqueous synthesis and BaTiO₃, having the structure of perovskitetype, has been prepared by the calcining to 900℃. I have experimented with several conditions of synthesis so that the mole ratio of BaO to TiO₂in the component of BaTiO₃is one to one. While BaTiO₃ is synthesized, the solution of TiCl₄and BaCl₂is maintained in an ice bath to prevent the hydrolysis of TiCl₄·H₂C₂O₄added to the mixed solution. BaCl₂is added to 1% more than the theoretical quantity and H₂C₂O₄is added in excess of 10%. The properties of temp-dielectric constants have been studied in order to evaluate the dielectric properties of samples. The result is that the dielectric constant, at ordinary temperature, increases slowly from 1450, very quickly from around 120℃, and when curie-point is 125℃, the dielectric constant is 8100. Therefore BaTiO₃, by aqueous synthesis, can be used as the dielectric because the components are homogeneous. Ⅰ. 緖 論 Ⅱ. 實驗方法 1. 試 藥 2. 試料의 合成 3. 測 定 1) 化學分析 2) X-線 回折分析 3) 密度測定 4) 誘電率 測定 Ⅲ. 結果 및 考察 1. 試料의 合成과 確認 2. 最適 ????燒溫度 3. 溫度-誘電率 特性 Ⅳ. 結 論