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Parthasarathy Thirumala,Daniel Lai,Jonathan Engh,Miguel Habeych,Donald Crammond,Jeffrey Balzer 대한신경과학회 2013 Journal of Clinical Neurology Vol.9 No.4
Background and Purpose Intraoperative neurophysiological monitoring (IONM) using upper and lower somatosensory evoked potentials (SSEPs) is an established technique used to predict and prevent neurologic injury during intracranial tumor resections. Endoscopic port surgery (EPS) is a minimally-invasive approach to deep intraparenchymal and intraventricular brain tumors. The authors intended to evaluate the predictive value of SSEP monitoring during resection of intracranial brain tumors using a parallel endoscopic technique. Methods A retrospective review was conducted of patients operated on from 2007-2010 utilizing IONM in whom endoscopic ports were used to remove either intraparenchymal or intraventricular tumors. Cases were eligible for review if an endoscopic port was used to resect an intracranial tumor and the electronic chart included all intraoperative monitoring data as well as pre- and post-operative neurologic exams. Results 139 EPS cases met criteria for inclusion. Eighty five patients (61%) had intraparenchymal and fifty four (39%) had intraventricular tumors or colloid cysts. SSEP changes were seen in eleven cases (7.9%), being irreversible in three (2.2%) and reversible in eight cases (5.8%). Seven patients (5.0%) with intraparenchymal tumors had SSEP changes which met our criterea for significant changes while there were four (2.9%) with intraventricular (p-value=0.25). Five patients suffered post operative deficits, two reversible and two irreversible SSEP changes. Only one case exhibited post operative hemiparesis with no SSEP changes. The positive predictive value of SSEP was 45.4% and the negative predictive value was 99.2%. Conclusions Based on the high negative and low positive predictive values, the utility of SSEP monitoring for cylindrical port resections may be limited. However, the use of SSEP monitoring can be helpful in reducing the impact of endoscopic port manipulation when the tumor is closer to the somatosensory pathway.
Parthasarathy Thirumala,Felix D. Nguyen,Amol Mehta,John Schindler,Suresh Mulukutla,Vinodh Jeevanantham,Lawrence Wechsler,Thomas Gleason 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.4
Background and Purpose Perioperative stroke is a significant complication of transcatheter aortic valve implantation (TAVI). This study aimed to quantify perioperative stroke as an independent risk factor for in-hospital mortality and postoperative morbidity in patients receiving TAVI. Methods A retrospective cohort study was conducted using the National Inpatient Sample. Patients undergoing TAVI during 2012 and 2013 were identified using diagnostic codes of International Classification of Diseases, ninth revision. Univariate and multivariate analyses were performed using patient demographics and comorbidities to identify predictors of mortality and morbidity, defined by a length of stay of >14 days and/or discharge to a place other than home. Results Data were obtained from 7,556 patients undergoing TAVI during 2012 and 2013. The incidence rates of mortality and morbidity were 4.57 and 71.12%, respectively. Perioperative stroke was an independent risk factor for mortality [odds ratio (OR)=3.182, 95% confidence interval (CI)=1.530–6.618, p=0.002], as were infection (OR=17.899, 95% CI=9.876–32.440, p< 0.001) and pericardial tamponade (OR=7.272, 95% CI=2.874–18.402, p<0.001). Stroke also predicted morbidity (OR=5.223, 95% CI=2.005–13.608, p=0.001), which was also associated with age, being female, being Asian, moderate and high Van Walraven scores (VWR), and infection. Conclusions In conclusion, perioperative stroke was found to be independently associated with in-hospital mortality and postoperative morbidity, as are age and high VWR. Our findings support the use of further preoperative, intraoperative, and postoperative management strategies during TAVI.
Vegetarian ethnic foods of South India: review on the influence of traditional knowledge
Parthasarathi Srinidhi K.,Hebbani Ananda Vardhan,Dharmavaram Desai Padma Priya 한국식품연구원 2022 Journal of Ethnic Foods Vol.9 No.-
South Indian cultures are diverse and unique amongst Indian traditions. In spite of many changes in Indian traditions over generations, South Indian states seem to have maintained a great extent of similarity with reference to vegetarian ethnic food habits and the reason behind is not convincingly known. Hindu traditional texts have extensive mention of the ethnic origins of many cultural practices prevailing in India and the present review aims to explore the different vegetarian ethnic foods of South India and also look into the influential role of food related ideologies mentioned in the traditional texts. Ethnographic study data about the prevailing vegetarian foods of the states were generated using multiple tools and presented. It is observed that there is a great extent of similarity amongst the varieties of vegetarian foods being prepared in Hindu communities of South India. Our study also highlights the strong influential role of tradition in evolution of vegetarian foods prevailing even today in South India.
Gayathri, Parthasarathy,Hariharan, Palamarneri Sivaraman,Moon, Dohyun,Anthony, Savarimuthu Philip Elsevier 2019 Journal of luminescence Vol.211 No.-
<P><B>Abstract</B></P> <P>Aggregation enhanced emissive (AEE) triphenylamine-phenylacetonitrile based donor-accepter compounds showed alkoxy chain length dependent solid state fluorescence efficiency and stimuli induced off-on fluorescence switching. Molecular conformational and packing differences lead to fluorescence tuning between 480 and 530 nm. The compounds exhibited off-on mechanofluorochromism upon crushing and heating. Interestingly, all compounds produced stable non-fluorescent melt that was converted to strongly fluorescent solids upon crystallization. The high-contrast off-on crystallization induced fluorescence switching has been used to demonstrate rewritable fluorescence platform. Single crystal structural analysis, powder X-ray diffraction and differential scanning calorimetry have been performed to understand the mechanism of fluorescence switching.</P> <P><B>Graphical abstract</B></P> <P>Crystallization induced fluorescence switching of alkoxy chain substituted triphenylamine smart fluorophores have been used to demonstrate rewritable fluorescent platform.</P> <P>[DISPLAY OMISSION]</P>
Novel Antioxidants and Atherosclerosis
Sampath Parthasarathy,Nalini Santanam 한국식품영양과학회 2004 한국식품영양과학회 학술대회발표집 Vol.55 No.-
Coronary heart disease (CHD) has been the number one killer in western society for a long time, and CHD in most instances is due to atherosclerosis. One of the earliest events in atherogenesis is the intracellular accumulation of lipids, particularly cholesterol esters, in the aortic intima. The lipids presumably came from the uptake of plasma lipoproteins, particularly from LDL. These foam cells were identified as being predominantly as macrophages. Currently, it is believed that oxidation of low density lipoprotein (LDL) might contribute to the generation of foam cells. An outcome of the oxidation hypothesis is that the consumption of antioxidants would be beneficial. In this study, Boldine, an alkaloid of Peumus boldus was tested for their antioxidant potency both in, in vitro oxidation system and in mouse models. Boldine decreased the ex-vivo oxidation of Low-density lipoprotein (LDL). In vivo studies were performed to study the effect of these compounds on the atherosclerotic lesion formation in LDL r-/- mice. Three groups of LDL r-/- mice (N=12 each) were fed an atherogenic diet. Group 1 was given vehicle and group 2 and 3 were given 1 and 5 mg of Boldine/day in addition to the atherogenic diet. The results indicated that there was a decrease in lesion formation reaching a 40% reduction due to Boldine compared to controls. The in vivo tolerance of Boldine in humans (has been used as an herbal medicine in other diseases) should make it an attractive alternative to vitamin E.
Prabha Parthasarathy,Bugewa Apampa,Andrea Manfrin 한국보건의료인국가시험원 2019 보건의료교육평가 Vol.16 No.-
PurposeThis study aimed to evaluate students’ perception of team-based learning (TBL) amongst a cohort exposed to this methodology for the first time at a university in the United Kingdom. MethodsBetween November and December 2018, 26 first-year Master of Pharmacy and 90 second-year Biomedical Science students of the School of Life Sciences, University of Sussex, United Kingdom were invited to participate and requested to complete a questionnaire that contained quantitative and qualitative questions. The quantitative component was based on the Team-Based Learning Student Assessment Instrument (TBL-SAI). It additionally contained questions about key student characteristics. ResultsThe response rate was 60% (70 of 116); of the participants, 74% (n=52) were females and 26% (n=18) males. The percentage of agreement in the TBL-SAI suggested a favourable response to TBL. The overall mean score for the TBL-SAI was 115.6 (standard deviation, 5.6; maximum score, 140), which was above the threshold of 102, thus suggesting a preference for TBL. Statistically significant differences were not found according to demographic characteristics. Students who predicted a final grade of ≥70% strongly agreed that TBL helped improve their grades. Some students highlighted issues with working in teams, and only 56% of students agreed that they could learn better in a team setting. ConclusionThis study shows that students exposed to TBL for the first time favoured several aspects of TBL. However, more focused strategies including team-building activities and expert facilitation skills could potentially tackle resistance to working in teams.
The Review of Upgrading Coal Techniques in South Korea
Prakash Parthasarathy,Hang Seok Choi,Hoon Chae Park,Jae Gyu Hwang,Ho Seong Yoo,Byeong-Kyu Lee 한국폐기물자원순환학회 2016 한국폐기물자원순환학회지 Vol.33 No.5
High-rank coals are limited, while low-rank coals are abundant. However, the low-rank coals needs upgradation so as to improve their quality. If not, the utilization of low-rank coals will lead to many operational difficulties. As this study was made in South Korea, this article discusses the energy and coal scenario of South Korea. The critique discusses the concerns of utilizing low-grade coal and the need for upgrading low-grade coal. The article also briefly discusses the currently practiced low-rank coal upgradation techniques. Also, the review paper suggests some best upgradation techniques.