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Isolation of Triterpene Glycosides from the Fruit of Cornus kousa
Lakoon-Jung,이대영,Jin-Gyeong Cho,안은미,김세영,백남인 한국응용생명화학회 2009 Journal of Applied Biological Chemistry (J. Appl. Vol.52 No.1
Dried, unripe fruits of Cornus kousa Burg. were extracted with 80% aqueous MeOH and the concentrated extracts were partitioned using EtOAc, n-BuOH and H2O, successively. From the EtOAc fraction, three triterpene glycosides were isolated through repeated SiO2 and ODS column chromatography. Based on NMR, MS and IR spectroscopic data, the chemical structures of the compounds were determined to be tormentoside (1), niga-ichigoside F2 (2), and arjunglucoside (3).This is the first report of these compounds being isolated from this plant.
Isolation of Triterpene Glycosides from the Fruit of Cornus kousa
Jung, Lakoon,Lee, Dae-Young,Cho, Jin-Gyeong,Ahn, Eun-Mi,Kim, Se-Young,Baek, Nam-In The Korean Society for Applied Biological Chemistr 2009 Journal of Applied Biological Chemistry (J. Appl. Vol.52 No.1
Dried, unripe fruits of Cornus kousa Burg. were extracted with 80% aqueous MeOH and the concentrated extracts were partitioned using EtOAc, n-BuOH and ${H_2}O$, successively. From the EtOAc fraction, three triterpene glycosides were isolated through repeated $SiO_2$ and ODS column chromatography. Based on NMR, MS and IR spectroscopic data, the chemical structures of the compounds were determined to be tormentoside (1), niga-ichigoside $F_2$ (2), and arjunglucoside (3). This is the first report of these compounds being isolated from this plant.
α-Tocopherol from the Fruits of Cornus kousa Burg.
Lee, Dae-Young,Lakoon Jung,Song, Myoung-Chong,Ahn, Eun-Mi,Kim- Dae-Keun,Baek, Nam-In 慶熙大學校 食糧資源開發硏究所 2007 硏究論文集 Vol.26 No.2
The fruits of Cornus kousa Burg. were extracted with 80% aqueous methanol, and the concentrated extract was partitioned with ethyl acetate, n-butanol and water, successively. From the ethyl acetate fraction, a compound was isolated through the repeated silica gel and ODS column chromatographies. According to the results of physico-chemical data including NMR, MS and IR, the chemical structure of the compound was determined as a-tocopherol (1). It was the first to be isolated from C. kousa.
Triterpenoids from the Fruits of Cornus kousa Burg. as Human Acyl-CoA
Dae-Young Lee,Lakoon Jung,Ha-Na Lyu,Tae-Sook Jeong,Youn-Hyung Lee,Nam-In Baek 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.1
The fruits of Cornus kousa Burg. were extracted with 80% aqueous methanol (MeOH) and the concentrated extract was partitioned with ethyl acetate (EtOAc), n-butanol (n-BuOH), and H₂O. From the EtOAc fraction, 5 triterpenoids were isolated through repeated silica gel (SiO₂), octadecyl silica gel (ODS), and Sephadex LH-20 column chromatography (c.c.). These compounds were determined to be ursolic acid (1), corosolic acid (2), taraxasterol (3), betulinic acid (4), and betulinic aldehyde (5) on the basis of their spectroscopic data including electronic ionization mass spectrometry, ultraviolet spectroscopy, infrared spectroscopy, and nuclear magnetic resonance. This is the first reported isolation of these compounds from this plant. Also, compounds 1, 3, 4, and 5 show a relatively high inhibitory activity against human acyl-CoA: cholesterol acyltransferase-1 (hACAT-1) with inhibition values of 52.8±0.7, 91.1±0.4, 93.0±0.7, and 96.2±0.2% at a concentration of 100 μM, respectively.
산딸나무 열매로부터 저밀도 지질 단백질(LDL) 산화 역제물질의 분리
이대영,송명종,김민정,정낙훈,정태숙,이윤형,백남인 경희대학교식량자원개발연구소 2007 硏究論文集 Vol.26 No.1
산딸나무 열매를 100% MeOH로 추출하고, 얻어진 추출물을 EtOAc, n-BuOH 및 물로 용매 분획 하였다. 이 중 EtOAc 분획으로부터 silica gel과 octadecyl silica gel(ODS) column chromatography를 반복하여 1종의 lignan 화합물을 분리, 정제하였다. 화합물의 화학구조는 NMR, Ms 및 IR 등의 스펙트럼 데이터를 해석하여, (+)-pinoresinol (1) 로 동정하였다. 이 화합물은 산딸나무에서 처음 분리되었다. LDL-항산화활성 억제활성이 20㎍/mL 처리농도에서 85.1±1.3%로 나타났다. (+)-Pinoresinol was isolated from the EtOAc fraction of methanol extracts of the fruits of Cornus kousa Burg. The chemical structures of (+)-pinoresinol was determined by spectroscopy method, as well as 1D- and 2D-NMR (^(1)H-^(1)H COSY, HSQC and HMBC) spectroscopy. This compound was the first to be isolated from C. kousa Burg. Also, (+)-pinoresinol inhibited LDL-oxidation with the inhibitory activity of 85.1±1.3% at a concentration of 20 ㎍/mL.