원발성 폐암 환자의 생존율에 관한 보고

김현태,이상무,어수택,박춘식,정성환,허승재,남충희,강창희,김용훈 순천향대학교 1994 논문집 Vol.17 No.4

We analysed 404 patients with primary lung carcinoma who were treated at Soonchunhyang University Hospital from July, 1985 to september, 1993 in order to investigate the survival rate and epidemiolgical properties of primary lung cancer. They were 330 males and 74 females. The most prevalent decade was seventh. In terms of cell type, the squamous cell was 225 patients (55%), and adenocarcinoma, small cell, mixed type was 21%, 19%, 4%, respectively. Among non-small cell lung carcinoma, stage Ⅲa was the most prevalent one(92%). In case of small cell carcinoma, the limited stage was 64%. The 12-, 24-, 36- month survival rate of total patients was 57%, 31%, 22%, respectivley and median sruvival time was 15 months. The 36-month survival rate tended to be longer in non-small cell lung carcinoma than that of small cell lung cancer, but there was no difference between two groups, statistically. In non-small cell carcinoma, The 36-month survival rate and meidan survival time were longer in the stage Ⅰ and Ⅱ than those of Ⅲa, Ⅲb, Ⅳ (80% versus 38%, 22%, 0%, p<0.05). According to involvement of lymph node, the 36-month survival rate was longer in NO and N1 than those of N2, N3 (61.9%, 48.7% versus 17.7%, 17.3%, p<0.05). In small cell carcinoma, The 36-month survival rate and median survival rate were higher and longer in limited stage than those of extensive stage(16.1% and 13 month vs 10% and 8 month, p<0.05). In conclusion, we report here the incidence of primary lung carcinoma and the survival rate of paients with primary lung carcinoma who were treated in Soonchunhyang University Hospital.

Ni-Cr-Mo鋼의 熱處理에 따른 機械的 性質과 衝擊靭性에 關한 硏究

秋現植,梁權承,崔秉起 조선대학교 기초과학연구소 1987 自然科學硏究 Vol.10 No.1

The influence of heat treatment on the mechanical properties and the charpy impact toughness of Ni-Cr-Mo Steel in austenitizing temperature range between 750℃~1100℃ and tempering temperature range between 250℃~500℃ was studied. The results obtained from this study are summarized as follows; 1) The most impact energy is obtained at about 900℃ of austenitizing temperature, and at the temperature of more than 900℃, impact energy decreased. That was seen to be caused from coarse of martensite structure. 2) As the austenitizing temperature increased, strength and elongation decreased. As tempering temperature increased, strength and hardness decreased, but elongation increased. 3) When the tempering temperature was 350℃, the impact energy was lowest and as the temperature was high, the impact energy increased. 4) As the austenitizing time under constant austenitizing temperature was long, hardness and impact toughness decreased.

안면비대칭자의 3차원 전산단층사진 분석에서 경·연조직간 비대칭 정도 차이

김왕식,이기헌,황현식 대한치과교정학회 2005 대한치과교정학회지 Vol.35 No.3

본 연구는 안면비대칭 환자에서 경조직의 비대칭 정도와 연조직 비대칭 정도의 차이를 3차원적으로 밝히고자 시행되었다. 안면비대칭으로 보이는 성인 남녀 34명을 대상으로 두경부 전산단층사진을 촬영하고 3차원 입체영상으로 재구성한 후 기준평면에 대해 비대칭을 나타내는 6개의 계측항목을 경조직에 설정하고, 이에 대응하는 연조직계측항목을 각각 설정한 후 3차원 계측을 시행하고 경조직과 연조직의 계측항목간 차이를 비교하였다. 이부편위측과 반대측간의 계측치 차이를 비교한 결과, 경조직과 연조직 모두에서 좌우측 계측치관에 통계적으로 유의한 차이가 관찰되었으며 경조직과 연조직의 비대칭 계측항목을 비교한 결과. 0개의 계측항목 모두에서 통계적으로 유의한 차이를 나타내었다. 이부편위를 나타내는 chin deviation, 하악지와 하악골체를 나타내는 frontal ramal inclination difference. frontal corpus inclination difference 항목은 경조직의 비대칭 정도에 비하여 연조직 비대칭정도가 작게 나타난 반면, 입술경사를 나타내는 lip cheilion height difference. lip canting은 maxillary height difference, occlusal plane canting보다 크게 나타나 입술부위의 비대칭 정도는 하부 경조직의 비대칭정도보다 큰 것으로 나타났다. 안면비대칭자에서 경조직과 연조직간 비대칭 정도 차이를 규명한 본 연구 결과는안면비대칭 평가 시 경조직 외에 연조직 계측항목을 이용한 비대칭 분석도 필요함을 시사하였다. The purpose of this study was to compare the asymmetric degree between maxillofacial hard and soft tissues in individuals with facial asymmetry. Computerized tomographies (CT) of 34 adults (17 male, 17 female) who had facial asymmetry were taken. The CT images were transmitted to personal computers and then reconstructed into three-dimensional (3D) images through the use of computer software. In order to evaluate the degree of facial asymmetry, 6 measurements were constructed as the hard tissue measurements while 6 counterpart measurements were taken as the soft tissue measurements. The means and standard deviations were obtained for each measurement using 3D measure, then t-test was used to investigate the differences between each hard tissue measurement and the corresponding soft tissue measurement. All measurements used in the present study showed statistically significant differences between the hard and soft tissues. The degree of soft tissue asymmetry was smaller than that of corresponding hard tissue asymmetry in case of chin deviation, frontal ramal inclination difference, and frontal corpus inclination difference. On the other hand, the degree of soft tissue asymmetry was greater than that of underlying hard tissue asymmetry in the measurement of lip canting and lip cheilion height difference. The present study suggests that asymmetric differences of hard and soft tissue is observed in facial asymmetric subjects, and thus soft tissue analysis is needed in addition to hard tissue analysis when making an evaluation of facial asymmetry.

응급의료정보 체계를 위한 전지 의료 카드의 활용방안

박흥식,남승곤,안재억,김현의,김주한,정철규,김태진,이기한 대한의료정보학회 1998 Healthcare Informatics Research Vol.4 No.2

무증상적 현미경적 혈뇨의 진단

김현주,김광식,허정식 제주대학교 생명과학연구소 2002 제주생명과학연구 Vol.5 No.6

Hematuria is one of the most common problems to medical service. Blood in the urine (hematuria) may originate from any site along the urinary tract. Serious urologic lesions have been reported in 4.8% to 16.5% of patients referred for asymptomatic microscopic hematuria. The purpose of evaluating any patient with asymptomatic microscopic hematuria is significant urologic disease at an early stage when it is amenable to curative treatment and prior to it causing significant morbidity. The commonly accepted diagnostic algorithm for hematuria includes intravenous urograpy and cystoscopy. Full Urologic evaluation (IVP< or renal sonography>, urine cytology and cystoscopy) is warranted in the majority of patients referred to a urologist with asymptomatic microscopic hematuria. The most commonly recommended surveillance protocol includes urinalysis and urine cytology every 6 months with cystoscopy and intravenous urography either yearly or alternating biannually.

Enterococcus faecalis 추출물이 임파구의 IL-2, IL-4, TGF-β1분비에 미치는 영향에 관한 연구

김현식,이우철,손원준,이상탁,김철호,임성삼 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.1

In order to examine the immunoresponse of host cells to Enterococcus faecalis, this in vitro study monitored the production of Interleukin-2 (IL-2), Interleukin-4 (IL-4) and Transforming growth factor-β1 (TGF-β1) in human lymphocytes. Lymphocytes were activated with PHA in the presence or abscence of sonicated extracts of E. Faecalis (SEF) and further incubated for 72 hours. The level of each cytokine was measured by ELISA. Data were analyzed with Kruskal-Wallis test and Mann-Whitney U test (P < 0.05). PHA-activated group did exhibit higher level of IL-2 and IL-4 than untreated control group. The levels of expression of both cytokines were significantly decreased following the treatment of high (25㎍/㎖) and medium concentration (12.5㎍/㎖) of SEF (P > 0.05) than those of PHA activated group. But low concentration (5㎍/㎖) of SEF showed th similar level of IL-2 and IL-4 production as those of PHA activated group. TGF-β1 was unaffected by SEF treatment. These results suggested that E. faecalis may suppress IL-2 and IL-4 production by lymphocytes and this could be one of possible factors why E. faecalis are found frequently in the teeth with failed endodontic treatment. 근관치료의 실패원인 중 중요한 세균으로 알려진 Enterococcus faecalis는 최근에 중요성이 더해지며 많은 연구들이 진행중이다. 여러가지 기전들이 보고되고 있으나 면역반응에 관한 연구는 거의 알려져 있지 않은 상태이다. 본 연구에서는 Enterococcus faecalis의 초음파 분쇄 추출물을 성인의 말초혈액으로부터 얻은 임파구에 적용시켜서 여기서 분비되는 interleukin-2, interleukin-4, transforming growth fater-β1의 농도를 Enzyme linked immunosorbent assay (ELISA)로 측정하여 비교, 평가하는 것을 목적으로 한다. E. faecalis를 적절한 조건에서 배양한 뒤 초음파 분쇄를 하여 추출물을 얻어냈다. 임파구는 건강한 성인의 말초혈액에서 추출하여 분리하였다. 임파구를 적절한 농도의 mitogen (Phytohemagglutinin: PHA)으로 자극시킨 뒤에 다양한 농도의 E. faecalis 초음파 추출물을 적용시키고 72시간 동안 배양하였다 ELISA를 이용하여 IL-2, IL-4,TGF-β1 의 농도를 측정하였다. 실험결과는 Kruskal-Wallis test, Man-Whitney rank sum test (p < 0.05)를 사용하여 통계처리 하였다. 실험결과 PHA로 처리한 군은 아무것도 처리하지 않은 군에 비해서 IL-2, IL-4의 수치가 유의성 있게 높았다 (p < 0.05). PHA로 처리한 군중에서 고농도와 중농도의 sonic extract of E. faecalis (SEF)로 처리한 군은 그렇지 않은 군에 비해서 IL-2 IL-4의 농도가 유의성 있게 낮았다 (p < 0.05). PHA로 처리한 군중에서 저농도의 SEF로 처리한 군은 그렇지 않은 군과 비교하여 유의할 만한 차이를 보이지 않았다.TGF-β1의 농도는 모든 군에서 유의할 만한 차이를 보이지 않았다 (p > 0.05). 따라서, E. faecalis의 추출물은 임파구의 IL-2, IL-4의 분비능력을 저하시킨다고 할 수 있다.

작도법에 따른 연조직 분석에 관한 비교연구

김왕식,황현식 전남대학교 치과대학 1999 전남치대논문집 Vol.11 No.1

The construction of angles is needed for soft tissue analysis and the angles can be made by drawing lines connecting anatomic points or tangent lines. The purpose of the present study is to compare the two drawing methods and show the difference between them. Soft tissue outlines were traced in the lateral cephalograms of 40 normal occlusion individuals, 20 males and 20 females. On the traced cephalograms, angles were constructed by means of both drawing methods. The procedure was repeated twice in a two-week period by the same investigator, and then performed once more by another. In each procedure, angular forms of profile was digitized and 10 angular measurements were computed. The two sets of measurement by the first investigator was compared to study differences due to the interval between drawings, while the two sets of measurement by the two investigators were compared to show any differences resulting from the drawers. The obtained results were as follows: 1. The comparison of the measurements between the anatomic point and tangent line group showed a statistically significant difference in nine of ten measurements. 2. The comparison for the reproducibility through correlation analysis showed a high reproducibility in both the anatomic point group and tangent line group. 3. In the analysis of the measurement difference according to the drawing time, two measurements showed significant difference in the anatomic point group and four measurements represented significant difference in the tangent line group. 4. In the analysis of the measurement difference according to the drawers, five measurements showed significant difference in the anatomic point group and six measurements represented significant difference in the tangent line group.

알렉시딘과 차아염소산나트륨의 화학적 상호반응 후 mass spectrometry를 이용한 파라클로로아닐린의검출 분석

김현식,한승현,오소람,임상민,구유,금기연 大韓齒科保存學會 2010 Restorative Dentistry & Endodontics Vol.35 No.4

근관세척제인 NaOCl과 CHX를 병행 사용하는 경우 적갈색의 발암물질로 알려진 PCA가 생성된다. 본 연구의 목적은 CHX와 유사한 buigunide 계통의 소독제 인 ALX을 NaOCl 과 흔합 반응 시 PCA가 생성되 는지 여부를 mass spectrometry를 이용하여 평가하고자 하였다. 대조군으로는 4% NaOCl 용액과 2% CHX의 혼합용액, 0.5%PCA 용액, 및 1%ALX 용액을 사용하였고 실험군으로는 5가지 농도(1%, 0.5%, 0.25%, 0.125%, 0.0625%)의 ALX 용액과 4% NaOCl의 흔합용액을 질량분석기를 이용하여 mole-cular peak를 분석한 결과 ALX과 NaOCl의 혼합물에서는 PCA(m/w=128)로 보이는 128 피크가 관찰되지 않았다. 또한 용액의 색 변화에서도 ALX이 농도가 높을수록 열은 노랑색을 띄었으나 농도가 낮아질수록 흰색으로 관찰되었으며 어떠한 침전물의 형성도 보이지 않았다. Recent studies demonstrated that the combination of chlorhexidine (CHX) and sodium hypochlorite (NaOCl) resulted in the formation of a precipitate, para-chloroaniline (PCA). Alexdidine (ALX) is a kind of biguanides like CHX, and has stronger detoxification effect against the bacterial virulence factors such as lipoteichoic acid and lipopolysacchardide compared with CHX. The purpose of this study was to determine whether PCA was formed after chemical interaction between ALX and NaOCl using mass spectrometry. Mass spectrometry was performed for the mixture of five different concentrations of ALX (1, 0.5, 0.25, 0.125, 0.0625%) and 4% NaOCl. Results showed that the peak of PCA was not detected in mixed solu tions of ALX and NaOCl in mass spectrometry analysis. The color of mixed solution of ALX and NaOCl after chemical interaction was light yellow to white, but there wasn't any precipitate found.

전자 의료 카드를 위한 보건의료 정보 표준화 연구

박흥식,남승곤,안재억,김현의,김주한,정철규,김태진,이기한 대한의료정보학회 1998 Healthcare Informatics Research Vol.4 No.2

방사선상 enhancement 정도에 따른 측모두부방사선규격사진 계측점 설정의 재현도

유황석,황현식,김왕식,김경근 전남대학교 치의학연구소 2001 구강과학 Vol.13 No.4

The purpose of this study was to evaluate the reproducibility of lateral cephalometric landmarks according to radiographic image enhancement, and to contribute to the identification of cephalometric landmarks. Lateral cephalograms of ten individuals were taken and stored into computer. The images were then enhanced up to four grades by Quick Ceph Image Pro^TM on condition that the gray-scale equalization number was 50 and the detail enhancement number was 50. After thirty two landmarks were identified on monitor images by five observers, the deviations from the mean, the distances estimated between identified points and the mean point of five identified points, were evaluated for each landmark at each enhancement grade. Through the statistical analysis, following results were obtained. 1. In case of unenhanced radiographic images, the inter-observer reproducibility of the landmarks showed a large variation. 2. The comparison of deviation from the mean according to the degree of radiographic image enhancement for each landmark showed that the inter-observer reproducibility was significantly different at 5 landmarks. 3. The landmark of pterygomaxillary fissure showed higher reproducibility at enhancement grade 1 and 2 images that at unenhanced images. So did the landmark of posterior nasal spine at enhancement grade 1 images, and the landmark of menton at enhancement grade 2, 3 and 4 images respectively. The above results suggest that the reproducibility of some landmarks can be increased by radiographic image enhancement during the identification of the lateral cephalometric landmarks on the monitor.