Effect of Modified High-heels on Metatarsal Stress in Female Workers

김관태,Hsien-Te Peng 한국운동역학회 2019 한국운동역학회지 Vol.29 No.3

Objective: The purpose of this study was to identify the effect of high-heels (HH) modification on metatarsal stress in female workers. Method: Seven females who work in clothing stores (heights = 160.4±3.9 cm; weights = 47.4± 4.1 kg; age = 31.3±11.1 yrs; HH wear career = 8±6.5 yrs) wore two types of HH (original and modified). The modified HH had been grooved with 1.5 cm radius and 0.2 cm depth around the first metatarsal area inside of the shoes using the modified shoe-last. Participants were asked to walk for 15 minutes on a treadmill and to stand for 10 minutes with original and modified HH, respectively. Kinetics data were collected by the F-scan in-shoe system. After each test, participants were asked to rate their perceived exertion using the Borg's 15-grade RPE scale and interviewed about their feeling of HH. Nonparametric Wilcoxon signed-rank test and effect size (Cohen's d) were used to determine the difference of the variables of interest between the original and modified HH. Results: In the present study, modified HH of the peak contact pressure of 1st metatarsal (PCP) left, PCP right, pressure time integral (PTI) left, peak pressure gradient (PPG) left during standing and PPG right during walking are greater than original HH. And even it didn't show statistically significant, the average in all pressure values of modified HH showed bigger than original HH. It surmised to be related to awkward with modified HH. Even though they said to feel the comfortable cause of big space inside of HH in the interview, they seemed to be not enough time to adapt with new HH. So their walking and standing postures were unstable. Conclusion: Modified the fore-medial part of HH can reduce the stress in the first metatarsal head and big toe area during standing and walking.

Rosmarinus officinalis Extract Suppresses Propionibacterium acnes–Induced Inflammatory Responses

Tsung-Hsien Tsai,Lu-Te Chuang,Tsung-Jung Lien,Yau-Rong Liing,Wei-Yu Chen,Po-Jung Tsai 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.4

Propionibacterium acnes is a key pathogen involved in the progression of acne inflammation. The development of a new agent possessing antimicrobial and anti-inflammatory activity against P. acnes is therefore of interest. In this study, we investigated the inhibitory effect of rosemary (Rosmarinus officinalis) extract on P. acnes–induced inflammation in vitro and in vivo. The results showed that ethanolic rosemary extract (ERE) significantly suppressed the secretion and mRNA expression of proinflammatory cytokines, including interleukin (IL)-8, IL-1β, and tumor necrosis factor-α in P. acnes–stimulated monocytic THP-1 cells. In an in vivo mouse model, concomitant intradermal injection of ERE attenuated the P. acnes–induced ear swelling and granulomatous inflammation. Since ERE suppressed the P. acnes–induced nuclear factor kappa-B (NF-κB) activation and mRNA expression of Toll-like receptor (TLR) 2, the suppressive effect of ERE might be due, at least partially, to diminished NF-κB activation and TLR2-mediated signaling pathways. Furthermore, three major constituents of ERE, carnosol, carnosic acid, and rosmarinic acid, exerted different immumodulatory activities in vitro. In brief, rosmarinic acid significantly suppressed IL-8 production, while the other two compounds inhibited IL-1β production. Further study is needed to explore the role of bioactive compounds of rosemary in mitigation of P. acnes–induced inflammation.

Effect of Modified High-heels on Metatarsal Stress in Female Workers

( Kwantae Kim ),( Hsien-te Peng ) 한국운동역학회 2019 한국운동역학회지 Vol.29 No.3

Objective: The purpose of this study was to identify the effect of high-heels (HH) modification on metatarsal stress in female workers. Method: Seven females who work in clothing stores (heights = 160.4±3.9 cm; weights = 47.4±4.1 kg; age = 31.3±11.1 yrs; HH wear career = 8±6.5 yrs) wore two types of HH (original and modified). The modified HH had been grooved with 1.5 cm radius and 0.2 cm depth around the first metatarsal area inside of the shoes using the modified shoe-last. Participants were asked to walk for 15 minutes on a treadmill and to stand for 10 minutes with original and modified HH, respectively. Kinetics data were collected by the F-scan in-shoe system. After each test, participants were asked to rate their perceived exertion using the Borg's 15-grade RPE scale and interviewed about their feeling of HH. Nonparametric Wilcoxon signed-rank test and effect size (Cohen's d) were used to determine the difference of the variables of interest between the original and modified HH. Results: In the present study, modified HH of the peak contact pressure of 1st metatarsal (PCP) left, PCP right, pressure time integral (PTI) left, peak pressure gradient (PPG) left during standing and PPG right during walking are greater than original HH. And even it didn't show statistically significant, the average in all pressure values of modified HH showed bigger than original HH. It surmised to be related to awkward with modified HH. Even though they said to feel the comfortable cause of big space inside of HH in the interview, they seemed to be not enough time to adapt with new HH. So their walking and standing postures were unstable. Conclusion: Modified the fore-medial part of HH can reduce the stress in the first metatarsal head and big toe area during standing and walking.

Effect of Modified High-heels on Metatarsal Stress in Female Workers

Kim, Kwantae,Peng, Hsien-Te Korean Society of Sport Biomechanics 2019 한국운동역학회지 Vol.29 No.3

Objective: The purpose of this study was to identify the effect of high-heels (HH) modification on metatarsal stress in female workers. Method: Seven females who work in clothing stores ($heights=160.4{\pm}3.9cm$; $weights=47.4{\pm}4.1kg$; $age=31.3{\pm}11.1yrs$; $HH\;wear\;career=8{\pm}6.5yrs$) wore two types of HH (original and modified). The modified HH had been grooved with 1.5 cm radius and 0.2 cm depth around the first metatarsal area inside of the shoes using the modified shoe-last. Participants were asked to walk for 15 minutes on a treadmill and to stand for 10 minutes with original and modified HH, respectively. Kinetics data were collected by the F-scan in-shoe system. After each test, participants were asked to rate their perceived exertion using the Borg's 15-grade RPE scale and interviewed about their feeling of HH. Nonparametric Wilcoxon signed-rank test and effect size (Cohen's d) were used to determine the difference of the variables of interest between the original and modified HH. Results: In the present study, modified HH of the peak contact pressure of 1st metatarsal (PCP) left, PCP right, pressure time integral (PTI) left, peak pressure gradient (PPG) left during standing and PPG right during walking are greater than original HH. And even it didn't show statistically significant, the average in all pressure values of modified HH showed bigger than original HH. It surmised to be related to awkward with modified HH. Even though they said to feel the comfortable cause of big space inside of HH in the interview, they seemed to be not enough time to adapt with new HH. So their walking and standing postures were unstable. Conclusion: Modified the fore-medial part of HH can reduce the stress in the first metatarsal head and big toe area during standing and walking.

The correlation between upper body angles and performance on elite pole vault athletes in Taiwan

Kwan-Tae Kim,Ki-Hong Kim,Ji-Hwan Kang,Hsien-Te Peng 한국운동재활학회 2013 한국운동재활학회 학술대회 Vol.2013 No.1

SOPC Based Weight Lifting Control Design for Small-Sized Humanoid Robot

Tzuu-Hseng S. Li,Chia-Ling Hsu,Chun-Yang Hu,Yu-Te Su,Ming-Feng Lu,Shao-Hsien Liu 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10

An SOPC based small-sized humanoid robot for weight lifting is introduced in this paper. All performances will be implemented using the SOPC chip, Altera EP1C12F324C8. The contribution of this paper is mainly the design of the self-balanced control of a small sized humanoid robot. According to the concept of sensory reflex, we combine the signals of the accelerometers and force sensors with a fuzzy controller to design a dynamic balanced controller for the humanoid robot. Through the implementation of the controller, we can strengthen the activity stability and the robustness of adapting to lift the weight. Finally, the experiment results show that the robot can successfully execute weight lifting function.

Effects of Modified Insole on Lower Extremities Biomechanics in College Male Basketball Players

( Kwantae Kim ),( Mi-sun Kim ),( Ki-kwang Lee ),( Hsien-te Peng ) 한국체육학회 2020 International journal of human movement science Vol.14 No.1

The purpose of this study was to investigate the effect of fore-medial-side thin insole on lower extremities kinematics and kinetics in college male basketball players. Seven male college basketball players voluntarily participated in the study (heights= 173.1 ± 3.1 cm; weights= 68.6 ± 5.7 kg; age= 21.1 ± 2.0 yrs.). They wore the same basketball shoes with 2 types of insoles: one type was original insole (OI); another one was fore-medial-side gradually thin insole (TI). Participants were asked to perform L-cut, V-cut, Backdoor-cut, walk, shuttle run of basketball movement in a 5-meter running way with their maximum speed. They were instructed to step with their right leg when they changed direction. The kinematic and kinetic data were collected during support phase. Non-parametric Wilcoxon signed rank test and the effect size were used to determine the difference of the variables of interest between the original and fore-medial-side thin insoles. The fore-medial-side thin insole showed less foot inversion angle at contact, peak ankle lateral shear force and ankle dorsiflexion moment than the original insole in L-cut (p<.05). In V-cut, the fore-medial-side thin insole showed less hip internal rotation at contact than the original insole (p<.05). In the shuttle run, the fore-medial-side thin insole showed less hip abduction at contact than the original insole (p<.05). In case of foot pressure, it showed no statistically significant but had large effect size on left foot’s pressure time integral (PTI), in L-cut (≥0.8), large effect size on left foot’s PCP, PTI, right foot’s PTI in V-cut (≥0.8), large effect size on left foot’s peak contact pressure of 1st metatarsal (PCP), PTI, peak pressure gradient (PPG), right foot’s PTI in BD-cut (≥0.8), large effect size on left foot’s PTI, medium effect size on left foot’s PPG (≥0.5), and medium effect size on left foot’s the distance from the point of peak contact pressure to the medial edge of 1st metatarsal (PCPd) (≥0.5). In conclusion, the fore-medial-side thin insole can help to push our body to the medial side and decrease the risk of injuries of the lower extremity during cutting movements.

Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity

Lin Chih-Hsin,Hsieh Yu-Shao,Sun Ying-Chieh,Huang Wun-Han,Chen Shu-Ling,Weng Zheng-Kui,Lin Te-Hsien,Wu Yih-Ru,Chang Kuo-Hsuan,Huang Hei-Jen,Lee Guan-Chiun,Hsieh-Li Hsiu Mei,Lee-Chen Guey-Jen 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.1

Glycogen synthase kinase-3β (GSK-3β) is an important serine/threonine kinase that implicates in multiple cellular processes and links with the neurodegenerative diseases including Alzheimer’s disease (AD). In this study, structure-based virtual screening was performed to search database for compounds targeting GSK-3β from Enamine’s screening collection. Of the top-ranked compounds, 7 primary hits underwent a luminescent kinase assay and a cell assay using human neuroblastoma SH-SY5Y cells expressing Tau repeat domain (TauRD) with pro-aggregant mutation ΔK280. In the kinase assay for these 7 compounds, residual GSK-3β activities ranged from 36.1% to 90.0% were detected at the IC50 of SB-216763. In the cell assay, only compounds VB-030 and VB-037 reduced Tau aggregation in SH-SY5Y cells expressing ΔK280 TauRD-DsRed folding reporter. In SH-SY5Y cells expressing ΔK280 TauRD, neither VB-030 nor VB-037 increased expression of GSK-3α Ser21 or GSK-3β Ser9. Among extracellular signal-regulated kinase (ERK), AKT serine/threonine kinase 1 (AKT), mitogen-activated protein kinase 14 (P38) and mitogenactivated protein kinase 8 (JNK) which modulate Tau phosphorylation, VB-037 attenuated active phosphorylation of P38 Thr180/ Tyr182, whereas VB-030 had no effect on the phosphorylation status of ERK, AKT, P38 or JNK. However, both VB-030 and VB-037 reduced endogenous Tau phosphorylation at Ser202, Thr231, Ser396 and Ser404 in neuronally differentiated SH-SY5Y expressing ΔK280 TauRD. In addition, VB-030 and VB-037 further improved neuronal survival and/or neurite length and branch in mouse hippocampal primary culture under Tau cytotoxicity. Overall, through inhibiting GSK-3β kinase activity and/or p-P38 (Thr180/Tyr182), both compounds may serve as promising candidates to reduce Tau aggregation/cytotoxicity for AD treatment.