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이홍준,손일진,정은경,문경래,박상기,박영봉 조선대학교 1993 The Medical Journal of Chosun University Vol.18 No.2
The pimapty sella syndrome results from and extension of the subarachnoid space into and intrasellar position with subsequent remodeling of the sella turcica and flattening of the pituitary gland. We experienced a case of primary emty sella syndrome in a 14-year-old male patient who was hospitalized because of short stature and micropenis. The endocrinologic studies revealed growth hormone and gonadotropin hormone deficiencies. The magnetic resonance imaging showed sella turica filled with CSF and flattened pituitary glad. The patient was followed-up with growth hormone therapy and the result was favorable.
( Gyeoung Jin Kang ),( Sang Chul Han ),( Young Sang Koh ),( Hee Kyoung Kang ),( You Jin Jeon ),( Eun Sook Yoo ) 한국응용약물학회 2012 Biomolecules & Therapeutics(구 응용약물학회지) Vol.20 No.6
Prostaglandin (PG) E2, the most abundant prostaglandin in the human body, is synthesized from arachidonic acid via the actions of cyclooxygenase (COX) enzymes. PGE2 exerts homeostatic, cytoprotective, inflammatory, and in some cases anti-inflammatory effects. Also, it has been reported that PGE2 is involved in hair growth. Diphlorethohydroxycarmalol (DPHC) is a phlorotannin compound isolated from the brown algae Ishige okamurae, with various biological activities in vitro and in vivo. In this study, the biological effect and mechanism of action of DPHC on prostaglandin synthesis in HaCaT human keratinocytes was examined. The results showed that, in these cells, DPHC significantly and dose-dependently induced PGE2 synthesis by increasing the protein and mRNA levels of COX-1 and COX-2. Interestingly, DPHC-induced COX-1 expression preceded that of COX-2. Also, while both rofecoxib and indomethacin inhibited PGE2 production, the latter was seems to be the more potent. From above results, we can expect that DPHC has some beneficial effects via increasing of PGE2 production.
Genetic relationship of Phellinus linteus complex isolates collected in Korea
Gyeoung-Jin Min,A-Yeong Jo,Han-Ul Kim,Hee-Wan Kang 한국버섯학회 2018 버섯 Vol.22 No.1
This study aimed to analyse genetic relationship of Phellinus linteus complex isolates collected in Korea. P. linteus have reported a variety of medical efficacies, including immunomodulator, anti-inflammatory, antioxidant and anticancer. P. linteus is called Sanghwang, Sanghaung, Meshimakobu mushrooms in Korea, China, and Japan. Numerous medicinal and biochemical studies of Sanghwang mushroom were mostly focused on P. linteus. However, P. linteus is morphologically similar to P. baumii, P. lonicericola, P. vaninii, and P. weigelae and thus it was suggested the Phellinus spp. should be classically included in P. linteus complex. The wild type collections of Phellinus spp. in Korea were identified in the basis of Internal transcribed spacer (ITS) rDNA sequences and further the P. linteus complex isolates are classified by URP-PCR profiles at inter and intra-species levels.
( Gyeoung Jin Kang ),( Jung Ho Park ),( Hyun Ji Kim ),( Eun Ji Kim ),( Boram Kim ),( Hyun Jung Byun ),( Lu Yu ),( Tuan Minh Nguyen ),( Thi Ha Nguyen ),( Kyung Sung Kim ),( Hiệu Phùng Huy ),( Mostafizu 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.4
Advanced or metastatic breast cancer affects multiple organs and is a leading cause of cancer-related death. Cancer metastasis is associated with epithelial-mesenchymal metastasis (EMT). However, the specific signals that induce and regulate EMT in carcinoma cells remain unclear. PRR16/Largen is a cell size regulator that is independent of mTOR and Hippo signalling pathways. However, little is known about the role PRR16 plays in the EMT process. We found that the expression of PRR16 was increased in mesenchymal breast cancer cell lines. PRR16 overexpression induced EMT in MCF7 breast cancer cells and enhances migration and invasion. To determine how PRR16 induces EMT, the binding proteins for PRR16 were screened, revealing that PRR16 binds to Abl interactor 2 (ABI2). We then investigated whether ABI2 is involved in EMT. Gene silencing of ABI2 induces EMT, leading to enhanced migration and invasion. ABI2 is a gene that codes for a protein that interacts with ABL proto-oncogene 1 (ABL1) kinase. Therefore, we investigated whether the change in ABI2 expression affected the activation of ABL1 kinase. The knockdown of ABI2 and PRR16 overexpression increased the phosphorylation of Y412 in ABL1 kinase. Our results suggest that PRR16 may be involved in EMT by binding to ABI2 and interfering with its inhibition of ABL1 kinase. This indicates that ABL1 kinase inhibitors may be potential therapeutic agents for the treatment of PRR16-related breast cancer.
The Inhibitory Effect of Premature Citrus unshiu Extract on Atopic Dermatitis In Vitro and In Vivo
Gyeoung-Jin Kang,Sang-Chul Han,Eun-Jou Yi,Hee-Kyoung Kang,Eun-Sook Yoo 한국독성학회 2011 Toxicological Research Vol.27 No.3
Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disease that is associated with Th2 cell-mediated allergy. The process that leads to infiltration of inflammatory cells into an AD lesion is remarkably dependent on various chemokines, especially TARC (thymus and activation-regulated chemokine/CCL17) and MDC (macrophage-derived chemokine/CCL22). Serum levels of these chemokines are over-expressed in AD patients. Citrus unshiu, which is known as Satsuma mandarin, has anti-oxidative, anti-inflammation, and anti-microviral activity. Therefore, we investigated the effect of EtOH extract of premature C. unshiu on AD. We did this using a DNCB-induced AD mouse model. We also tried to confirm an inhibitory effect for premature C. unshiu on the expression of inflammatory chemokines in IFN-γ and TNF-α stimulated HaCaT human keratinocytes. We found that extract of premature C. unshiu reduced DNCB-induced symptoms such as hyperkeratosis, increased skin thickness, and infiltrated mast cells, in our AD-like animal model. The extract decreased levels of IFN-γ and IL-4 in ConA-stimulated splenocytes isolated from DNCB-treated mice. Also, extract of premature C. unshiu inhibited mRNA expression and protein production of TARC and MDC through the inhibition of STAT1 phosphorylation. These results suggest that C. unshiu has anti-atopic activity by regulating inflammatory chemokines such as TARC and MDC.
Gyeoung-Jin Kang,Na-Jin Kang,Sang-Chul Han,Dong-Hwan Koo,Hee-Kyoung Kang,Byoung-Sam Yoo,Eun-Sook Yoo 한국독성학회 2012 Toxicological Research Vol.28 No.4
Inflammation is the immune system’s response to infection and injury-related disorders, and is related to pro-inflammatory factors (NO, PGE<sub>2</sub>, cytokines, etc.) produced by inflammatory cells. Atopic dermatitis (AD) is a representative inflammatory skin disease that is characterized by increasing serum levels of inflammatory chemokines, including macrophage-derived chemokine (MDC). Carpinus tschonoskii is a member of the genus Carpinus. We investigated the anti-inflammatory activity of C. tschonoskii by studying the effects of various solvent fractions prepared from its leaves on inflammatory mediators in HaCaT and RAW264.7 cells. We found that the chloroform fraction of C. tschonoskii inhibited MDC at both the protein and mRNA levels in HaCaT cells, acting via the inhibition of STAT1 in the IFN-γ signaling pathway. In addition, the chloroform fraction significantly suppressed the expression of inflammatory factors induced by lipopolysaccharide stimulation, except COX-2 and TNF-α. These results suggest that the chloroform fraction of C. tschonoskii leaves may include a component with potential anti-inflammatory activity.
Eun-Jin Yang,Hye-Ja Lee,Gyeoung-Jin Kang,Sun-Soon Park,Weon-Jong Yoon,Hee-Kyoung Kang,Somi Kim Cho,Eun-Sook Yoo 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.5
Dangyuja (Citrus grandis Osbeck) is a native plant growing only on Jeju Island in Korea. In this study, antiinflammatory effect of dangyuja leaves on a murine macrophage cell line was investigated. RAW 264.7 murine macrophage cells were stimulated with lipopolysaccharide (LPS, 1 ㎍/㎖) to induce expression of pro-inflammatory markers [interleukin (IL)-6 and inducible nitric oxide synthase (iNOS)]. The crude extract (80% MeOH Ex.) and solvent fractions (hexane, CHCl3, EtOAc, BuOH, and H₂O Ex.) were obtained from dangyuja leaves. The CHCl3 fraction inhibited the nitric oxide (NO) and IL-6 production in a dose-dependent manner. Also, the CHCl₃ fraction inhibited mRNA expression and protein levels of iNOS in a dose-dependent manner. Furthermore, the CHCl₃ fraction inhibited LPS-induced nuclear factor (NF)-κB activation and phosphorylation of mitogen-activated protein kinases (MAPKs: ERK, JNK, and p38). These results suggest that dangyuja leaves may inhibit LPS-induced production of inflammatory markers by blocking NF-κB and MAPKs signaling in RAW 264.7 cells.
The Inhibitory Effect of Premature Citrus unshiu Extract on Atopic Dermatitis In Vitro and In Vivo
Kang, Gyeoung-Jin,Han, Sang-Chul,Yi, Eun-Jou,Kang, Hee-Kyoung,Yoo, Eun-Sook Korean Society of ToxicologyKorea Environmental Mu 2011 Toxicological Research Vol.28 No.3
Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disease that is associated with Th2 cell-mediated allergy. The process that leads to infiltration of inflammatory cells into an AD lesion is remarkably dependent on various chemokines, especially TARC (thymus and activation-regulated chemokine/CCL17) and MDC (macrophage-derived chemokine/CCL22). Serum levels of these chemokines are over-expressed in AD patients. Citrus unshiu, which is known as Satsuma mandarin, has anti-oxidative, anti-inflammation, and anti-microviral activity. Therefore, we investigated the effect of EtOH extract of premature C. unshiu on AD. We did this using a DNCB-induced AD mouse model. We also tried to confirm an inhibitory effect for premature C. unshiu on the expression of inflammatory chemokines in IFN-${\gamma}$ and TNF-${\alpha}$ stimulated HaCaT human keratinocytes. We found that extract of premature C. unshiu reduced DNCB-induced symptoms such as hyperkeratosis, increased skin thickness, and infiltrated mast cells, in our AD-like animal model. The extract decreased levels of IFN-${\gamma}$ and IL-4 in ConA-stimulated splenocytes isolated from DNCB-treated mice. Also, extract of premature C. unshiu inhibited mRNA expression and protein production of TARC and MDC through the inhibition of STAT1 phosphorylation. These results suggest that C. unshiu has anti-atopic activity by regulating inflammatory chemokines such as TARC and MDC.