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이홍준,손일진,정은경,문경래,박상기,박영봉 조선대학교 1993 The Medical Journal of Chosun University Vol.18 No.2
The pimapty sella syndrome results from and extension of the subarachnoid space into and intrasellar position with subsequent remodeling of the sella turcica and flattening of the pituitary gland. We experienced a case of primary emty sella syndrome in a 14-year-old male patient who was hospitalized because of short stature and micropenis. The endocrinologic studies revealed growth hormone and gonadotropin hormone deficiencies. The magnetic resonance imaging showed sella turica filled with CSF and flattened pituitary glad. The patient was followed-up with growth hormone therapy and the result was favorable.
교수학습지도안의 효과적 활용을 위한 기초 연구 : 교수 설계 측면을 중심으로 Focus on the instructional systematic design
이경희 대진대학교 교육대학원 교육연구소 2002 교육연구 Vol.4 No.1
In the knowledge based society, various, creative, and systematic lessons are more required, together with the change of educational system. The teachers should analyse the characteristics and contents of curriculum, and develope the learners-centered lessons which provide them with attractive and efficient educational experience. For this purpose, the teacher could develope, practice, evaluate, revise and complement the lesson plans which connect various elements and procedures of teaching-learning process with the educational field in the systematic approach. This essay researches the needs and methods of lessons plans through the current instructional systematic design(ISD)models. And, it tries to find how to develope the subject-oriented lessons plans, and how to apply them into the educational field.
윤용칠,이경희 대진대학교 교육대학원 교육연구소 1999 교육연구 Vol.1 No.1
This study aims to find that the mathematics education in the seventh curriculum is more positive than the sixth curriculum about the effect of the ability to solve the questions in relation to real life problems and interest measures. The seventh curriculum based on structurism helps the students who live at the global and information world to create them through their ye-experience and media. First this study tells it's aims through literature methods: interest, accomplishment of Math, mathematical curriculum and the sixth and seventh comparism of mathematical curriculum. had experimental research for this study; I took 175 students in four classes of the first grade in a middle school in Ujungbu city as objects : two group for experiment, others for comparison. The experimental groups used the materials: a line ruler, a microchronometer, sugar, and weight scale which they could use directly and learn with using the computer. These can help students to solve the questions in relation to real life. On the other hand, the classes for comparison with experimental classes were taught by the traditional teaching. The test materials are test of interest measures and the ability to solve the questions in relation to real life test. The materials of real life lest are the calculation problems of equation of the first degree and those of real life problems. The ability to solve the questions in real life were experimented: each has ten questions. The results of this study are following, 1. Experimental groups answered that mathematics effects of the questions in relation to real life and the learning method were interested. 2. Experimental groups achieved much higher achievement measures of simple equations used to solve the questions related to real life than other group 3. When the students solved the questions related to real life, there weren't the differences between the experimental groups and that the comparism groups. But I could guess that the former would have good effects than the later in that case through the long term. As the result, mathematics learning by the seventh curriculum affected improvement of interest measures, learning method and achievement measure positively and effectively when the students tried to solve the questions in relation to real life.
박홍수,조경규,오석조,편무실 明知大學校 産業技術硏究所 1993 産業技術硏究所論文集 Vol.12 No.-
To prepare a durable softening water repellent, quaternized stearyl methacrylate-2-diethylami-noethyl methacrylate as a mother resin and quaternized 1-behenoylaminoethyl-2-docosyl imidazo-line which increase the softening effect and the hydrostatic pressure blended with waxes and their emulsifier in various proportions to give water repellent PPSBC. As the results of the measurement of water repellency. washable, tear strength and crease recovery to polyester-cotton(P/C) blended fabrics treated with PPSBC only or addition of textile finishing resin, the physical properties were increased. there was no significant lowering effect in water repellency when PPSBC was treated the antistatic agent by the one-bath method. and the effect of water repellency by the adding the catalyst was studied. PPSBC was confirmed as durable water repellent with the results of making little difference of water repellency as±5 point after and before washing. And, the water repellency mechanism of P/C blended fabrics treated with PPSBC was also discussed in detail.
( Gyeoung Hee Lee ),( Eui Kil Lee ) 한국교육공학회 2001 Educational Technology International Vol.3 No.1
The purpose of this study was to investigate the effect of cognitive and metacognitive Self-Regulated Learning(SRL) strategies. instructional effectiveness, and gender on the collaborative learning in an asynchronous distance class. The three main questions are as follows: 1 ) How do students use SRI. strategies in an online class? 2) What is the relation among gender. SRL strategy uses, and perceived instructional effectiveness? 3) What is the relative strength of the three independent variables as predictors of collaborative learning? The subjects of this study were a group of graduate students enrolled in a graduate course offered in the spring of 2001 at a State University of New York, AIOOny, U.S.A .. They responded to the Web-based online questionnaire in the end of tht semester. The questionnaire included a demographic inf ormalion and an open- cnded question plus three different inventories: Self-Regulated Learning Strategies Inventory (SRLSl). Instructional Effectiveness Invemory (lEt), and Collaborative Lea rning Inventory (eLl). The data collected from the subjects were coded and analyzed using the SPSS statistical package. The results showed that all the three independent variables, gender. SRL, and instructional effectiveness together contributed to the dependent variable significantly. There. however. was only one predictor explained the criterion variable significantly: perceived instructional effectiveness. The SRL strategy almost failed to explain the dependent variable. The reasons for these results and the direction of the further studies were discussed.
Genetic relationship of Phellinus linteus complex isolates collected in Korea
Gyeoung-Jin Min,A-Yeong Jo,Han-Ul Kim,Hee-Wan Kang 한국버섯학회 2018 버섯 Vol.22 No.1
This study aimed to analyse genetic relationship of Phellinus linteus complex isolates collected in Korea. P. linteus have reported a variety of medical efficacies, including immunomodulator, anti-inflammatory, antioxidant and anticancer. P. linteus is called Sanghwang, Sanghaung, Meshimakobu mushrooms in Korea, China, and Japan. Numerous medicinal and biochemical studies of Sanghwang mushroom were mostly focused on P. linteus. However, P. linteus is morphologically similar to P. baumii, P. lonicericola, P. vaninii, and P. weigelae and thus it was suggested the Phellinus spp. should be classically included in P. linteus complex. The wild type collections of Phellinus spp. in Korea were identified in the basis of Internal transcribed spacer (ITS) rDNA sequences and further the P. linteus complex isolates are classified by URP-PCR profiles at inter and intra-species levels.
( Gyeoung Jin Kang ),( Jung Ho Park ),( Hyun Ji Kim ),( Eun Ji Kim ),( Boram Kim ),( Hyun Jung Byun ),( Lu Yu ),( Tuan Minh Nguyen ),( Thi Ha Nguyen ),( Kyung Sung Kim ),( Hiệu Phùng Huy ),( Mostafizu 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.4
Advanced or metastatic breast cancer affects multiple organs and is a leading cause of cancer-related death. Cancer metastasis is associated with epithelial-mesenchymal metastasis (EMT). However, the specific signals that induce and regulate EMT in carcinoma cells remain unclear. PRR16/Largen is a cell size regulator that is independent of mTOR and Hippo signalling pathways. However, little is known about the role PRR16 plays in the EMT process. We found that the expression of PRR16 was increased in mesenchymal breast cancer cell lines. PRR16 overexpression induced EMT in MCF7 breast cancer cells and enhances migration and invasion. To determine how PRR16 induces EMT, the binding proteins for PRR16 were screened, revealing that PRR16 binds to Abl interactor 2 (ABI2). We then investigated whether ABI2 is involved in EMT. Gene silencing of ABI2 induces EMT, leading to enhanced migration and invasion. ABI2 is a gene that codes for a protein that interacts with ABL proto-oncogene 1 (ABL1) kinase. Therefore, we investigated whether the change in ABI2 expression affected the activation of ABL1 kinase. The knockdown of ABI2 and PRR16 overexpression increased the phosphorylation of Y412 in ABL1 kinase. Our results suggest that PRR16 may be involved in EMT by binding to ABI2 and interfering with its inhibition of ABL1 kinase. This indicates that ABL1 kinase inhibitors may be potential therapeutic agents for the treatment of PRR16-related breast cancer.
The Inhibitory Effect of Premature Citrus unshiu Extract on Atopic Dermatitis In Vitro and In Vivo
Gyeoung-Jin Kang,Sang-Chul Han,Eun-Jou Yi,Hee-Kyoung Kang,Eun-Sook Yoo 한국독성학회 2011 Toxicological Research Vol.27 No.3
Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disease that is associated with Th2 cell-mediated allergy. The process that leads to infiltration of inflammatory cells into an AD lesion is remarkably dependent on various chemokines, especially TARC (thymus and activation-regulated chemokine/CCL17) and MDC (macrophage-derived chemokine/CCL22). Serum levels of these chemokines are over-expressed in AD patients. Citrus unshiu, which is known as Satsuma mandarin, has anti-oxidative, anti-inflammation, and anti-microviral activity. Therefore, we investigated the effect of EtOH extract of premature C. unshiu on AD. We did this using a DNCB-induced AD mouse model. We also tried to confirm an inhibitory effect for premature C. unshiu on the expression of inflammatory chemokines in IFN-γ and TNF-α stimulated HaCaT human keratinocytes. We found that extract of premature C. unshiu reduced DNCB-induced symptoms such as hyperkeratosis, increased skin thickness, and infiltrated mast cells, in our AD-like animal model. The extract decreased levels of IFN-γ and IL-4 in ConA-stimulated splenocytes isolated from DNCB-treated mice. Also, extract of premature C. unshiu inhibited mRNA expression and protein production of TARC and MDC through the inhibition of STAT1 phosphorylation. These results suggest that C. unshiu has anti-atopic activity by regulating inflammatory chemokines such as TARC and MDC.