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Utilization of Sunitinib for Renal Cell Cancer: an Egyptian University hospital experience
Ezz El Din, M Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
Background: Metastatic renal cell carcinoma (mRCC) status as poor prognosis improved with the introduction of tyrosine-kinase inhibitors, especially sunitinib. There is sparse data reporting from our region on use of sunitinib in metastatic RCC. Thus the present study explores sunitinib usage at our institute. Materials and Methods: An unselected population of patients with metastatic RCC receiving sunitinib was analyzed with respect to patient characteristics, response, toxicity, and outcomes. Results: Fourty-nine patients with a median age of 50.5 years (range 21-71 years) were included. Most were male (61.2%). Twenty‑one (42.9%) had metastatic disease at presentation. Sunitinib was first line therapy in 45. Conventional clear cell carcinoma was the most common pathology present (39 patients; 79.59 %). The most common site of metastasis was the lung (75.5%). Most patients (30) were started at a dose of 50 mg once a day for 4 weeks and then 2 weeks rest. Clinical benefit rate was 73.5% (n= 36), and 22.5% (n= 11) demonstrated progressive disease at first imaging evaluation within the first 3-6 months. The following objective response performed for patients was 48.9% (n=24) and progression at 24.5 % (n=12). The median follow‑up was 16 months (range, 4-34 months), the overall estimated median PFS was 9 months and the estimated median OS was 15 months. Conclusions: This study demonstrated sunitinib is tolerable and effective in advanced/metastatic RCC Egyptian patients and indicates we should further seek second and third lines to increase survival equivalence as reported in the worldwide literature.
Abu-Gharib, Ezz A.,EL-Khatib, Rafat M.,Nassr, Lobna A.E.,Abu-Dief, Ahmed M. Korean Chemical Society 2011 대한화학회지 Vol.55 No.3
7-hydroxy-2H-chromen-2-one(HC)와 7-hydroxy-2H-chromen-2-one-4-acetic acid(HCA)의 염기성 가수분해반응을 aqueous-methanol과 aqueous-acetone 혼합물에서 283 K에서 313 K의 온도 범위에서 속도론적으로 연구하였다. 반응의 활성화 파라미터를 구하고 토의하였다. 게다가, 물, 물-에탄올, 물-아세톤 혼합물 내에서 화합물들에 대한 활성화 에너지 장벽의 변화를 속도론적 데이터로부터 추정하였다. 활성화 장벽의 변화는 HC and HCA의 가수분해 반응과 거의 같았다. HC와 HCA의 염기성 가수분해는 $k_{obs}=k_2[OH^-]$와 같은 속도법칙을 따른다. 메탄올 또는 아세톤의 비가 증가함에 따라 HC 와 HCA의 속도 상수들이 감소하는 것은 $OH^-$ 이온이 불안정해지기 때문이다. 활성화 엔트로피가 큰 음의 값을 갖는 다는 것은 반응이 중간 착물의 형성을 경유하며 진행된다는 것을 의미하며, 또한 중간 착물이 경직성과 안정도를 갖는다는 것을 의미한다. 그러므로, 중간 착물의 고리 열림이 속도 조절 단계가 될 것이다. Base hydrolysis of 7-hydroxy-2H-chromen-2-one (HC) and 7-hydroxy-2H-chromen-2-one-4-acetic acid (HCA) in aqueous-methanol and aqueous-acetone mixtures were studied kinetically at temperature range from 283 to 313 K. The activation parameters of the reactions were evaluated and discussed. Moreover, the change in the activation energy barrier of the investigated compounds from water to water-methanol and water-acetone mixtures was estimated from the kinetic data. It is observed that the change in activation barriers is more or less the same for the hydrolysis of HC and HCA. Base hydrolysis of HC and HCA follows a rate law with $k_{obs}=k_2[OH^-]$. The decrease in the rate constants of HC and HCA as the proportion of methanol or acetone increases is due to the destabilization of $OH^-$ ion. The high negative values of entropy of activation support the proposal mechanism, i.e. the investigated reaction takes place via the formation of an intermediate complex. Moreover, these values refer to the rigidity and stability of the intermediate complex. Thus, the ring opening of the intermediate complex would be the rate controlling step.
Mohamed Adel Deniwar,Saima Ahmad,Ashraf Ezz Eldin 대한신경외과학회 2022 Journal of Korean neurosurgical society Vol.65 No.1
Objective : There are different types of cerebral vascular malformations. Pial arteriovenous fistulas (PAVFs) and dural arteriovenous fistulas (DAVFs) are two entities; they consist of one or more arterial connections to a single venous outlet without a true intervening nidus. The high turbulent flow of PAVFs and aggressive DAVFs with cortical venous reflux can result in venous outflow varix and aneurysmal dilatation. They pose a significant challenge to transvenous embolization (TVE), stereotactic radiosurgery, and surgical treatment. We aim to share our centers’ experience with the transarterial embolization (TAE) for arteriovenous fistulas (AVFs) with large venous pouches and to report the outcome. Methods : The authors’ two institutions’ databases were retrospectively reviewed from February 2017 to February 2021. All patients with intracranial high flow PAVFs and aggressive DAVFs with venous outlet ectasia and large venous varix and were treated by TAE were included. Results : Fifteen patients harboring 11 DAVFs and four PAVFs met our inclusion criteria. All patients underwent TAE in 17 sessions. Complete angiographic obliteration was achieved after 14 sessions in 12 patients (80%). Four patients (25%) had residual after one TAE session. Technical failure was documented in one patient (6.7%). Fourteen patients (93.3%) had favorable functional outcome (modified Rankin score 0–2). Conclusions : TAE for high flow or aggressive intracranial AVFs is a safe and considerable treatment option, especially for those associated with large venous pouches that are challenging and relatively high-risk for TVE.
Synthesis and Biological Investigations of New Thiazolidinone and Oxadiazoline Coumarin Derivatives
Abd Elhafez, Omaima Mohamed,El Khrisy, Ezz El Din Ahmed Mohamed,Badria, Farid,Fathy, Alaa El Din Mohamed The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.9
Ethyl (coumarin-4-oxy)acetate 1 was prepared through the reaction of 4-hydroxycoumarin with ethyl bromoacetate. Compound 1 was allowed to react with hydrazine hydrate to produce coumarin-4-oxyacetic hydrazide 2. The synthesis of N-(arylidene and alkylidene)-coumarin-4-oxyacetic hydrazones 3-20 was performed. The preparation of 2-substituted-3-[(coumarin-4-oxy) acetamido]thiazolidinones 21-26 and 2-[(coumarin-4-oxy )methyl]-4-acetyl-5-substituted-$\Delta^2$-1,3,4-oxadiazolines 27-33 was performed by the reaction of the hydrazones 3, 4, 7, 9, 12, 14 with mercaptoacetic acid and the hydrazones 3, 4, 5, 7, 12, 15, 16 with acetic anhydride, respectively. The antiviral activities, cytotoxicities and structure-activity relationship (SAR) towards different microorganisms of the prepared compounds were studied.
Impact of Social Networks in Educational Media
Al-Said, Khaleel M.,Al Said, Nidal,Hattab, Ezz The Korea Institute of Information and Commucation 2020 Journal of information and communication convergen Vol.18 No.4
This study aims to determine whether student participation on Twitter affects academic performance. The key goals of the training course were to acquire social networking knowledge and skills and to learn how to share information, be productive in discussions, and create an interest-based community. The initial sample comprised 286 students from Jordan universities, 68.4% of whom agreed to participate in the study. Undergraduate students accounted for 73.9%, and graduate students accounted for 26.1%. Only 14.3% of the students chose the Twitter-based learning model. This is a mixed-methods study that integrates quantitative and qualitative approaches. The undergraduate students were found to tweet more and have more likes, while graduate students had more followers and were following more accounts. Moreover, 21% of the participants were the most active. Spearman's correlation analysis revealed a connection between participation in social media and student performance. Therefore, the results of this study may help educational professionals and education managers.
Ahmed H. Eid,Noha F. Abdelkader,Ola M. Abd El-Raouf,Hala M. Fawzy,Ezz-El-Din S. El-Denshary 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.12
The clinical application of the anticancer drugcisplatin is limited by its deleterious side effects, includingmale reproductive toxicity. In this context, the potentialprotective effect of carvedilol on testicular and spermatologicaldamage induced by cisplatin in male Sprague–Dawley rats was investigated. Carvedilol was orallyadministered at a dose of 10 mg/kg for 2 weeks, and cisplatinwas given as a single intraperitoneal injection of10 mg/kg on the 12th day to induce toxicity. Cisplatinsignificantly reduced reproductive organ weight, spermcount and sperm motility, and increased sperm abnormalitiesand histopathological damage of testicular tissue. Inaddition, it resulted in a significant decline in serumtestosterone as well as levels of testicular enzymatic andnon-enzymatic antioxidants (superoxide dismutase, catalase,glutathione peroxides, and reduced glutathione). Moreover, cisplatin remarkably augmented malondialdehyde,nitric oxide, tumor necrosis factor-a, and nuclearfactor-kappa B contents in testicular tissue. Conversely,carvedilol administration markedly mitigated cisplatin-inducedtesticular and spermatological injury as demonstratedby suppression of oxidative/nitrosative andinflammatory burden, amendment of antioxidant defenses,enhancement of steroidogenesis and spermatogenesis, andmitigation of testicular histopathological damage. Thecurrent study reveals a promising protective action ofcarvedilol against cisplatin-induced reproductive toxicityby virtue of its anti-inflammatory and antioxidantproperties.