Rolandic Cortical Dysplasia : 증례보고 Case Report

김형일,정채경,최하영,Palmini, Andre,이민철,이정청 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.6

The advent of MRI enables us to make an in-vivo diagnosis of cortical dysplastic lesions which are highly epiletogenic and show the variety of seizure patterns. Authors report a case of rolandic cortical dysplasia who had highly intractable focal motor clonic seizures. Invasive recording with subdural grid was very helpful in delinating the epileptogenic area as well as in functional mapping of eloquent areas. Total removal of dysplastic lesion could treat this highly intractable epilepsy successfully.

덤프 소각기에서 CCI_4/C_3H_8 분해 특성에 관한 연구

전영남,채종성,송형운,김미환 조선대학교 환경연구소 2001 環境硏究 Vol.17 No.1

A major source of the hazardous waste generated is from chemical industries producing plastics, herbicides, pesticides and chlorinated solvents. All of these process produce a class of hazardous waste termed the chlorinated hydrocarbons(CHCs), either directly or from undesirable side reactions. Generally, hazardous waste is physical characteristics of difficult destruction at high temperature. We investigated the destruction characteristics of hazardous waste through incineration. A nonequilibrium combustion model was used to describe the effect of the chemical kinetics due to the flame inhibition characteristics of CCl_4 which was used as the surrogate of hazardous waste. In this study, the numerical simulation data for 3-dimensional dump combustor shows a quantitative good agreement with experimental data. Also dump incinerator shows high destruction efficience of CCl_4. And parametric screening studies was carried out through numerical simulation with changed CCl_4/C_3H_8 ratio, waste injection velocity and waste equilibrium ratio.

덤프 소각기에서 CCI₄/C₃H_(8)분해 특성에 관한 연구

전영남,채종성,송형운,김미환 조선대학교 환경공해연구소 2001 環境公害硏究 Vol.17 No.1

A major source of the hazardous waste generated is from chemical industries producing plastics, herbicides, pesticides and chlorinated solvents. All of these processes produce a class of hazardous waste termed the chlorinated hydrocarbons(CHCs), either directly or from undesirable side reactions. Generally, hazardous waste is physical characteristics of difficult destruction at high temperature. We investigated the destruction characteristics of hazardous waste through incineration. A nonequilibrium combustion model was used to describe the effect of the chemical kinetics due to the flame inhibition characteristics of CCU which was used as the surrogate of hazardous waste. In this study, the numerical simulation data for 3-dimensional dump combustor shows a quantitative good agreement with experimental data. Also dump incinerator shows high destruction efficience of CCl_(4). And parametric screening studies was carried out through numerical simulation with changed CCl_(4)/C_(3)H_(8) ratio, waste injection velocity and waste equilibrium ratio.

3차원 수치모델링을 통한 스토커식 도시페기물 소각로의 연소특성 및 운전성능 최적화

전영남,송형운,김미환,채종성 조선대학교 환경공해연구소 2001 環境公害硏究 Vol.17 No.2

사람 Ferritin 유전자를 이용한 담배의 형질전환

이주안,김형석,임채완,김해영,박영두 경희대학교 생명자원과학연구원 2002 硏究論文集 Vol.22 No.-

사람 H-chain ferritin 유전자를 Agrobcterium-mediated transformation 방법으로 담배(Nicotiana tabaccum L)에 전이시켰다. 이를 위하여 사람 H-chain ferritin 유전자를 C_(S)VMV promotor와 NOS terminator를 운반하는 plant binary vector, pILTAB 357에 도입하였다. pILTAB 357를 포함하는 Agrobcterium tumefaciens LBA4404로 담배 잎 절편체를 감염시킨 후 형질전환 신초는 MS배지에 1 5 ㎎/L BA, 50 ㎎/L kanamycin 그리고 200 ㎎/L cefotaxim이 첨가된 1차 선발배지에서 유도하였다. 유도된 신초는 MS배지에 100 ㎎/L kanamycin과 200 ㎎/L cefotaxim이 포함된 2차 선발배지에서 뿌리를 유기하였다. 뿌리가 형성된 재분화 개체는 온실에서 재배하였으며 자가수분하여 종자를 수확하였다. 사람 H-chain ferritin유전자의 담배 genome내로의 전이여부를 H-chain ferritin 유전자내의 primer를 이용하여 PCR 방법으로 확인한 바 형질전환 개체에서 예상했던 560bp 단편을 볼 수 있었으나 형질전환을 시키지 않은 식물체에서는 PCR 산물을 확인할 수 없었다. Kanamycin 저항성 분석은 전이유전자의 후대로의 안정적인 유전을 보여 주었으며 저항성 종자들은 homozygous개체를 확보하기 위해 온실에서 재배 중에 있다. A human H-chain ferritin gene was introduced into tobacco (Nicotiana tabaccum L.) plants by Agrobcterium-mediated transformation. To introduce this gene, human ferritin gene was cloned into plant binary vector, pILTAB 357, horboring CsVMV promotor and nopalin synthase terminator (3' NOS). After infection with Agrobacterium tumefaciens LBA4404 containing pILTAB 357, transformed shoots were induced from first selection media (MS media + 1.5 ㎎/L BA + 50 ㎎/L kanamycin + 200 ㎎/L^(1) cefotaxim). Induced shoots were rooted in second selection media (MS media + 100 ㎎/L kanamycin + 200 ㎎/L cefotaxim). Rooted shoots were cultivated, selfed, and seeds were harvested in the green house. To confirm the transfer of the human H-chain ferritin gene in the genome of tobacco plants, PCR was conducted using specific primers of the H-chain femritin gene. A PCR fragment of 560 bp was obtained from each transformed plants, which is the predicted size of the H-cham ferritin gene but not from nontransformed plants. Kanamycin resistance assay showed that transgenes were stably inherited to next generation in all lines. These resistance seeds from each line were cultivated in the green house to obtain homozygous lines for further study.

정신분열병 환자에서 Apolipoprotein E 유전자 다형성

최영숙,임채기,류철형 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

연구목적 : 본 연구에서는 Apolipoprotein E와 정신분열병의 관련성을 알아보기 위하여 정신분열병 환자와 정상인을 대상으로 apolipoprotein E 유전자형과 대립유전자 빈도를 조사하였고 정신분열병 환자군에서는 여러 임상변인에 따른 유전자형의 빈도를 알아보았다. 방 법 ; 정신분열병 환자 101명과 정상대조군 96명을 대상으로 중합효소 연쇄반응을 이용하여 apolipoprotein E 유전자 다형성을 분리하였다. 결 과 : 환자군과 대조군 사이에 유전자형과 대립유전자 빈도는 유의한 차이가 없었다. PANSS에 의한 양성 및 음성군, DSM-IV에 의한 아형, 가족력 유무 등의 임상변인에 따라 각 유전자형의 빈도는 차이를 보이지 않았다. 결 론 : 정신분열병 및 특정 임상양상과 apolipoprotein E 유전자 다형성은 관련성이 없었으며 이 결과는 apolipoprotein E가 정신분열병의 표현에 있어 주요 유전적 요인으로 작용하지 않음을 시사하였다. Objectives : To explore the role of apolipoprotein E in schizophrenia, we investigated apolipoprotein E polymorphism in groups of patients with schizophrenia and normal controls. We also examined the reationship of clinical characteristics of schizophrenia to apolipoprotein E genotypes. Methods : Sample were obtained from 101 schizpohrenic patients and 96 controls in Korea and apolipoprotein E polymorphisms were analysed using polymerase chain reaction. Results : The genotype and allele frequencies did not differ from those of controls. The clinical variables of schizophrenia, such as positive and negative groups by PANSS, subtypes by DSM-IV, family history were not associated with each genotypes. Conclustion : We could not find the association of apolipoprotein E in Korean schizophrenic patients and it could be suggested that apolipoprotein E isoforms might not play a main role in expression of schizophrenia.

3차원 수치모델링을 통한 스토커식 도시폐기물 소각로의 연소특성 및 운전성능 최적화

전영남,송형운,김미환,채종성 조선대학교 환경연구소 2001 環境硏究 Vol.17 No.2

This study has developed the 3-dimensional numerical model, and applied for the investigation of combustion characteristics and optimized operating conditions in MSW incinerator, in Gwangju. The model developed in this study has verified through the correspondence between the predicted and the measured temperature in combustion chamber which is operating as reference condition. By predictive results. The Sangmoo incinerator has a good characteristics of combustion and low emission, even though after burning zone produces incomplete products by which primary air is introduced not enough. Parametric screening studies have been achieved for the suggestion of optimal operating conditions. For the optimum of combustion characteristics, operating conditions should be changed with varying the property of wastes.

부비동내시경수술 후 후각기능의 변화

김진국,남태욱,임채형,장현종 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

Background and Objectives: Rhinosinusitis is the most common cause of olfactory impairment and endoscopic sinus surgery is considered as a surgical procedure of choice for treating chronic sinusitis. CC-SIT (Cross-Cultural Smell Identification Test) consists of 12 items well known in most non-English-speaking cultures. Authors evaluated the therapeutic effects of endoscopic sinus surgery on olfactory dysfuction using CC-SIT. Materials and Methods: The subjects of this study were seventeen sinusitis patient who had undergone ESS from November 2001 through April 2002. All patients were divided into two groups according to nasal polyp and CT findings. CC-SIT was used for the evaluation of olfactory function. Results: Forty seven percents of patients had improvement in olfactory function postoperatively. No correlation was found between changes in CC-SIT score and nasal polyp and preoperative CT findings. Conclusion: It is concluded that nasal polyp and CT findings have no effect on olfaction.

비·부비동 양성 종양의 임상적 고찰

김진국,신향애,임채형,장현종,심대보 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.13 No.-

Background and Objectives: Benign tumors of the nose and paranasal sinues are rare in comparison with malignant growths. Authors aimed to investigate the incidence and characteristics of benign sino-nasal tumors. Materials and Methods: From 1994 through 2004, 25 cases of benign sino-nasal tumors (17 men and 8 women) were diagnosed and cared at the Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Konkuk University. We reviewed medical records of patients to find out clinical features, radiologic findings, operative findings, therapeutic options, and outcomes. Postoperative observation was given for fifteen months on the average. Results: The most common symptom was nasal obstruction, followed by nasal mass, frequent nasal bleeding, headache, and rhinorrhea, and the mass mainly placed in the lateral nasal wall. There were 12 cases (48%) of inverted papilloma, 4 (16%) cases of squamous papilloma, 4 (16%) cases of hemangioma, 1 (4%) case of pleomorphic adenoma, 1 (4%) case of leiomyoma, 1 (4%) case of lipoma. All the tumors were surgically removed. For the treatment of inverted papilloma, medial maxillectomy had been performed before 1997(2 cases); however, most cases have been managed with endonasal endoscopic technique since 1997. Recurrence was observed in two patients with inverted papilloma and one patients with squamous papilloma. Conclusion: Inverted papilloma is the most common benign tumor in the nose and paranasal sinuses, followed by squamous papilloma and hemangioma. The optimal management of benign tumors is complete excision of tumor and endonasal endoscopic surgery is an effective treatment for an inverted papilloma.

한국인에서 CC-SIT와 비교한 KVSS Test의 임상적 유용성 평가 : 예비연구 Pilot study

김진국,장현종,임채형,남태욱,심대보 건국대학교 의과학연구소 2003 건국의과학학술지 Vol.13 No.-

Background and Objectives: Sniffin' Sticks test is the test of nasal chemosensory performance based on pen-like odor dispensing devices. KVSS(Korean Version of Sniffin' Sticks) Test was developed as the "Korean olfactory test" using the odorants which are familiar to Korean. Authors evaluated the clinical validity of KVSS Test compared with CC-SIT (Cross-Cultural Smell Identification Test) in Korean. Materials and Methods: The subjects of this study were 25 normosmic volunteers who were divided into five groups according to age. Each group was 5 normosmic volunteers. And they consisted of 12 men and 13 women. KVSS Test and CC-SIT were used for the evaluation of olfactory function. Results: Our study showed the negative correlation between age and olfactory function test (CC-SIT score, KVSS Test I score and KVSS Test II score). Normosmia rate of KVSS Test was more higher than that of CC-SIT. Also KVSS Test had more familiar items for Koreans compared with that of CC-SIT. CC-SIT score and KVSS Test score showed showed the positive corrclation. And each test revealed high reliability in test-retest evaluation. Conclusion: The KVSS Test can be used as an olfactory function test for Koreans.