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      • KCI등재

        Risk factors for early death among ovarian cancer patients: a nationwide cohort study

        Berit Jul Mosgaard,Amani Meaidi,Claus Høgdall,Mette Calundann Noer 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.3

        Objective: To characterize ovarian cancer patients who die within 6 months of diagnosis and to identify prognostic factors for these early deaths. Methods: A nationwide cohort study covering ovarian cancer in Denmark in 2005–2016. Tumor and patient characteristics including comorbidity and socioeconomic factors were obtained from the comprehensive Danish national registers. Results: A total of 5,570 patients were included in the study. Three months after ovarian cancer diagnosis 456 (8.2%) had died and 664 (11.9%) died within 6 months of diagnosis. Adjusted for age and comorbidity, patients who died early were admitted to hospital significantly more often in a 6-month period before the diagnosis (odds ratio [OR]=1.61 [1.29–2.00], and OR=1.47 [1.21–1.78]), for patients who died within 3 and 6 months respectively). Low educational level (OR=2.11), low income (OR=2.50) and singlehood (OR=1.90) were factors significantly associated with higher risk of early death. The discriminative ability of risk factors in identifying early death was assessed by cross-validated area under the receiver operating characteristic curve (AUC). The AUC was found to be 0.91 (0.88–0.93) and 0.90 (0.87–0.92) for death within 3 and 6 months, respectively. Conclusions: Despite several admissions to hospital, the ovarian cancer diagnosis is delayed for a subgroup of patients, who end up dying early, probably due to physical deterioration in the ineffective waiting time. Up to 90% of high-risk patients might be identified significantly earlier to improve the prognosis. The admittance of the patients having risk symptoms should include fast track investigation for ovarian cancer.

      • The Terminology of Silks in Texts of the Roman Empire: Qualities, Origins, Products, and Uses

        ( Berit Hildebrandt ) 계명대학교 실크로드중앙아시아연구원 2021 Acta Via Serica Vol.6 No.2

        At the beginning of the Roman imperial period, moralizing authors criticized a material from the East that quickly gained popularity among the elites: silk. During Late Antiquity, the trade, production, and use of purple-dyed silks increasingly became the privilege of the emperors. While literature, court poetry, and laws give insights into the discourses surrounding silk, they are rather unspecific concerning silk qualities. This contribution analyzes the scattered descriptions of silks in Greek and Latin texts in a diachronic perspective, with a focus on the 1st cent. BCE to the 4th cent. CE, paying particular attention to the terminology, products, origins, and qualities of silk. The aim is to build a framework for comparisons with archaeological silk finds and other textile terminologies along the Silk Roads. Here, the silk finds from the oasis city of Palmyra/Tadmor in modern-day Syria, dating from the 1st cent. BCE to the 2nd cent. CE, will be used as a case study for the early imperial period. Taking these silk finds as a comparison, it will be shown that Greek and Latin terminology does not match the variety of silks known in the Mediterranean. Rather, linguistic differentiations focus on the forms in which silk reached the Mediterranean, as skeins, yarns, and fabrics, as well as on the different kinds of silks that were produced in the West, namely pure silk and half-silken fabrics, checkered “scutlata” damasks, purple-dyed, and gold-embellished silks. In contrast, silks from the East were subsumed under the term for “silks from the silk people” or simply “silks”. Moreover, ancient authors do not use the terms in the same way. These findings show the limitations of Western silk terminology and the importance of combining archaeological and written sources.

      • SCOPUSKCI등재

        Changes in the Thebaine Content of Papaver bracteatum Lindl. after Colchicine Treatment of the Seeds

        Berit Smestad Paulsen,Jens K. Wold,Morten M. Laane Tuva Haugli,Arnold Nordal 한국생약학회 1989 생약학회지 Vol.20 No.2

        Of the Papaveraceae, Papaver somniferum is the most important from a medical and pharmaceutical point of view, since it produces morphine and other alkaloids. 90-95% of the legally produced morphine is used for production of codeine. As P. somniferum and morphine are responsible for a great proportion of the world`s drug problem, a great effort has been made to find other sources for the production of codeine. The Iranian mountain-poppy, P. bracteatum, is producing thebaine as the main alkaloid. Since thebaine also can be converted into codeine, it was of interest to study the production of thebaine in P. bracteatum and try to develop a plant giving a higher yield of thebaine than normally obtained. Seeds of P. bracteatum were treated either with γ-radiation or colchicine in order to create a change in the genetic material in such a way that the production of thebaine is increased. This treatment resulted in several plants giving higher yields of thebaine, and by cultivating plants after vegetative cloning, we obtained plants producing up to 17% thebaine in the capsula. A method for quantitative determination of thebaine has also been developed.

      • Why do registered nurses choose to offer complementary and alternative medicine?

        Berit Johannessen 셀메드 세포교정의약학회 2012 TANG Vol.2 No.1

        The use of Complementary and Alternative Medicine (CAM) is increasing in Norway. A growing number of nurses choose to offer CAM, and the purpose of the study presented in this article was to examine the reasons for their choices. Fieldwork including interviews with 20 nurses offering CAM was conducted. The results showed that the nurses in general are not satisfied with the public health service. They had four main reasons for their choice to offer CAM: 1. A desire to perform holistic nursing. 2. A tendency to value self-realization. 3. A wish to experience meaning in their work and develop a stronger professional identity. 4. A freedom to mix care and cure. The results of this study are also discussed in view of medicalization.

      • Q 방법론을 적용한 일상적인 부양과 관련한 연구

        Susan Ramlo,Kari Berit 한국주관성연구학회 2013 Journal of Human Subjectivity Vol.11 No.1

        As the population ages, the international demand for care of aging adults increases and many will find themselves, possibly unexpectedly, in a caregiver situation. According to the National Family Caregivers Association, 59% of the U.S. population will become informal caregivers to aging friends and/or family. Our social wellbeing is affected when family members and friends age and require our care, creating an increasingly complex relationship. Most models of successful caregiving are limited to what researchers perceive to be successful caregiving rather than connecting to caregivers and determining their views (Hilton, Kopera-Freye, & Krave, 2009). We will describe three studies of informal caregivers that used Q methodology, find common themes, and demonstrate how these studies provide descriptive models that are not tied to researcher pre-conceived views and allow the caregivers to provide their own perspectives such that government policies and programming can better serve this population. 고령화 사회로 접어들면서, 전 세계적으로 노인 복지를 위한 수요가 늘고 있고 많은 사람들이 예상치 못하게 간병을 해야 하는 상황에 처하고 있다. 국가 가족 부양자협회(National Family Caregiver Association)에 따르면 59%의 미국 인구가 그들의 나이든 친구 또는 가족의 비공식적인 간병인이 된다고 한다. 가족이나 친구가 늙어 우리의 도움이 필요로 할 때 우리의 사회적 안녕감은 영향을 받게 되고, 복잡한 관계가 형성되게 된다. 대부분의 성공적인 모델의 간병은 연구자가 느낌에 의존한 것이지, 간병인과 간병인의 의견에 따른 것이 아니다(Hilton, Kopera-Freye, & Krave, 2009). 우리는 비공식적 간병인에 대한 세 가지 연구를 기술한다. Q 방법론을 사용하였고 공통 주제를 발견하였으며 어떻게 본 연구가 연구자의 편견에 의한 모델이 아니라 간병인 본인의 견해를 반영하였는지 증명하여 정부 정책과 프로그램이 이간병 인구에게 보다 적합하도록 할 것이다.

      • KCI등재후보

        A Challenge to Multiculturalism

        Anders S. Wigerfelt,Berit Wigerfelt 숙명여자대학교 아시아여성연구원 2014 OMNES: The Journal of Multicultural Society Vol.5 No.1

        At times of economic decline, such as the deep economic crisis experienced in many European countries today, vulnerable groups can clash with other vulnerable groups. These clashes can be exploited by different political movements and individuals, who point to the Other and the multicultural society as the cause of society’s problems. This can result in intensified everyday racial violations, and an increase in violent hate crimes. A case study, from a small Swedish town in which an asylum seeker from The Ivory Coast was stabbed to death by extreme right-wing youths, illustrates how racist hate crime relates to discrimination and everyday harassment. The murder became a test case for what in Sweden later became known as hate crime.

      • KCI등재

        The Polar High Molecular Weight Fraction of the Agaricus blazei Murill Extract, AndoSan™, Reduces the Activity of the Tumor-Associated Protease, Legumain, in RAW 264.7 Cells

        Lise Berven,Pernille Karppinen,Geir Hetland,Anne Berit C. Samuelsen 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.4

        AndoSan™ is an extract of Agaricus blazei Murill (AbM; 82.4%), Hericium erinaceum (14.7%), and Grifola frondosa (2.9%). The main ingredient of AndoSan, AbM, is rich in different forms of β-glucans. Since these exhibit potent antitumor activity and have immunomodulatory effects, the stimulatory effect of AndoSan on the production of different cytokines, chemokines, and leukocyte growth factors has predominantly been attributed to β-glucans. AndoSan has been claimed to consist of 90% carbohydrate, of which 2.8% is β-glucans, but in this study, we show that the carbohydrate content is only 2% of the dry weight, corresponding to 0.09% β-glucan per mL of AndoSan. Fractionation of AndoSan, followed by carbohydrate analysis and HPLC analysis revealed that most of the glucose was concentrated in the polar high molecularweight fraction of AndoSan (ethanol insoluble water extract [EIWE]-A) and that this extract was able to significantly inhibit the activity of the tumor-associated protease, legumain, in RAW 264.7 cells. Legumain is synthesized as a zymogen and undergoes pH-dependent autoactivation of the proform to reach an enzymatically active form. In this study, we demonstrate that both the polar and nonpolar AndoSan fractions are able to inhibit the autoactivation of prolegumain, and that the polar fractions of AndoSan are the most potent inhibitors of the active form of the enzyme.

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