Simulation Testing in Mobile Networks Protocols and Applications Perspective

Anurag Jain,Saurabh Tyagi 한국정보통신설비학회 2004 정보통신설비학회논문지 Vol.3 No.1

Band Selection Using Forward Feature Selection Algorithm for Citrus Huanglongbing Disease Detection

( Anurag R. Katti ),( W. S. Lee ),( R. Ehsani ),( C. Yang ) 한국농업기계학회 2015 바이오시스템공학 Vol.40 No.4

Purpose: This study investigated different band selection methods to classify spectrally similar data - obtained from aerial images of healthy citrus canopies and citrus greening disease (Huanglongbing or HLB) infected canopies - using small differences without unmixing endmember components and therefore without the need for an endmember library. However, large number of hyperspectral bands has high redundancy which had to be reduced through band selection. The objective, therefore, was to first select the best set of bands and then detect citrus Huanglongbing infected canopies using these bands in aerial hyperspectral images. Methods: The forward feature selection algorithm (FFSA) was chosen for band selection. The selected bands were used for identifying HLB infected pixels using various classifiers such as K nearest neighbor (KNN), support vector machine (SVM), naive Bayesian classifier (NBC), and generalized local discriminant bases (LDB). All bands were also utilized to compare results. Results: It was determined that a few well-chosen bands yielded much better results than when all bands were chosen, and brought the classification results on par with standard hyperspectral classification techniques such as spectral angle mapper (SAM) and mixture tuned matched filtering (MTMF). Median detection accuracies ranged from 66-80%, which showed great potential toward rapid detection of the disease. Conclusions: Among the methods investigated, a support vector machine classifier combined with the forward feature selection algorithm yielded the best results.

Poster Session : PS 0314 ; Hematology : Acute Psychosis: A Presentation of Cyanocobalamin Defi ciency Megaloblastic Anemia

( Anurag Bahekar ),( Girish Bhageshwar Ramteke ),( Sanjay Dubey ),( Amith R ),( Ankit Meshram ),( Amit Agarwal ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Mental disturbances due to vitamin B12 deficiency have been reported previously as chief or sole symptoms, occasionally even preceding decrease of cobalamin in serum. Frank psychosis related to vitamin B12 defi ciency is considered very rare and has received little attention. We report a 28 yrs young female presenting with acute psychosis due to cyanocobalamine deficiency which reversed with treatment. Presentation was irrelevant talking, picking of clothes, inability to recognize people for 3 days. No fever, headache, vomiting, weakness, head trauma, drug intake, stressor or addiction. No past major illness, psychiatric illness or memory loss. Pt. had weaknes easy fatigability since 2 years was on vegetarian diet. Bladder bowel habits were regular. Hb 2. 9 gm/dl, thrombocytopenia 1 lakh/cumm, normal leucocytes, MCV-142. 7 fi , smear showed dimorphic picture, pencil cells, tear drop cells, anisopoikilocytosis, hypersegmented neutrophils. Diagnosis of megaloblastic anemia was made. CSF, CT head, electrolytes were normal. B12 level 77. 12 pmol/l (N200-800 pmol/l). Endoscopy- atrophic gastritis. Histology-atrophic gastriris. Antiparietal cell antibody-negative. Patient recovered fully within 3 days therapy with Inj. cyanacobalamin 1000 microgm i. m. with no need of antipsychotics at discharge. Biermer`s disease, also called acquired pernicious anemia, disorder of vitamin B12 absorption characterized by megaloblastic anemia, gastrointestinal symptoms, can lead to neurological abnormalities. Frequent in elderly, less in adults(15%), extremely rare inchildren, adolescents. It is asymptomatic for years, non-specifi c symptoms of anemia, atrophic gastritis. Possible mechanism for psychotic behaviour suggested by Hutto, reported cobalamin and folate participate in synthesis of monoamine neurotransmitters in brain by increasing BH4(tetrahydrobiopterin) synthesis. Treatment:Oral administration of high-dose vitamin B(12) (1-2 mg daily) as effective as intramuscular administration in correcting defi ciency. We recommend consideration be given to B-12 defi ciency as an etiological possibility in some cases of depression, organic psychosis, certain childhood-disorders and dementia.

Robust home brew fragment sizing assay for detection of MET exon 14 skipping mutation in non–small cell lung cancer patients in resource constrained community hospitals

Anurag Mehta,Shrinidhi Nathany,Aanchal Chopra,Sakshi Mattoo,Dushyant Kumar,Manoj Kumar Panigrahi 대한병리학회 2021 Journal of Pathology and Translational Medicine Vol.55 No.5

Background: A mutation/deletion involving donor or acceptor sites for exon 14 results in splicing out of exon 14 of the mesenchymal epithelial transition (MET) gene and is known as “MET exon 14 skipping” (ΔMET14). The two recent approvals with substantial objective responses and improved progression-free survival to MET inhibitors namely capmatinib and tepotinib necessitate the identification of this alteration upfront. We herein describe our experience of ΔMET14 detection by an mRNA-based assay using polymerase chain reaction followed by fragment sizing. Methods: This is a home brew assay which was developed with the concept that the transcripts from true ΔMET14 will be shorter by ~140 bases than their wild type counterparts. The cases which were called MET exon 14 skipping positive on next-generation sequencing (NGS) were subjected to this assay, along with 13 healthy controls in order to establish the validity for true negatives. Results: Thirteen cases of ΔMET14 mutation were detected on NGS using RNA-based sequencing. Considering NGS as a gold standard, the sizing assay using both gel and capillary electrophoresis that showed 100% specificity for both with concordance rates of 84.6% and 88.2% with NGS, respectively, were obtained. Conclusions: Owing to the cost-effective nature and easy to use procedures, this assay will prove beneficial for small- and medium-sized laboratories where skilled technical personnel and NGS platforms are unavailable.

Efficacy of hepatitis B vaccination in patients with ulcerative colitis: a prospective cohort study

Anurag Mishra,Amarender Singh Puri,Sanjeev Sachdeva,Ashok Dalal 대한장연구학회 2022 Intestinal Research Vol.20 No.4

Background/Aims: Response to vaccine in patients with inflammatory bowel disease is lower than in the general population. We aimed to evaluate the efficacy of hepatitis B virus (HBV) vaccination in patients with ulcerative colitis (UC) versus controls.Methods: We prospectively compared antibody response to HBV vaccination in 100 patients with UC versus controls. HBV vaccination was given to all the cases and controls at 0, 1 and 6 months. Anti-hepatitis B surface (anti-HBs) titers were then measured 4 weeks after the first and the third dose. Adequate immune response (AIR) was considered if the anti-HBs titer was >10 IU/L and effective immune response (EIR) if the anti-HBs titer was >100 IU/L.Results: Median anti-HBs titer was lower in patients with UC than controls (67 IU/L vs. 105 IU/L, P<0.01). AIR and EIR were significantly lower in patients than in controls (82% vs. 96%, P=0.001; 41% vs. 66%, P<0.001, respectively). Univariate analysis showed that age <30 years, mild to moderate severity of disease, disease duration <5 years, male sex, post first dose anti-HBs titer >2 IU/L and non-exposure to corticosteroids, azathioprine and biologicals were predictors of AIR in patients with UC (P<0.05). Multivariate analysis revealed that only non-exposure to corticosteroids, azathioprine and biologicals, male sex, and disease duration <5 years were independent predictors of AIR.Conclusions: Response rate to the HBV vaccination in patients with UC was significantly lower as compared to the controls. Male sex, shorter disease duration, and non-exposure to immunomodulators were independent predictors of AIR.

Founder <i>BRCA1</i> mutations in Nepalese population

Anurag Mehta,Himanshi Diwan,Garima Gupta,Shrinidhi Nathany,Shalini Agnihotri,Surender Dhanda 대한병리학회 2022 Journal of Pathology and Translational Medicine Vol.56 No.4

Background: Founder mutation is a heritable genetic alteration observed with high frequency in a geographically and culturally isolated population where one or more ancestors becomes the forebearer of the altered gene. The current study reports two founder mutations in the <i>BRCA1</i> gene in the Nepalese people.Methods: Germline <i>BRCA</i> testing in all surface epithelial ovarian cancers and the selected case of breast, prostate, and pancreatic cancers has been the standard practice from 2016 to 2021. One thousand one hundred thirtythree probands were screened for germline <i>BRCA</i> variants by next generation sequencing. The variants were classified as per the American Society of Medical Genetics and Genomics recommendations. Pathogenic (class V) and likely pathogenic (class IV) were considered clinically relevant and utilized for cascade screening.Results: Nepalese population made up a subcohort of 5.12% (58/1,133) of probands tested for germline <i>BRCA1/2</i> variants. Twenty-seven of these 58 tested harbored pathogenic genetic alterations in <i>BRCA1/2</i> genes, with 23 being <i>BRCA1</i> mutant. Sixteen of 23 <i>BRCA1</i> mutant cases shared one common pathogenic mutation c.2214_2215insT (p.Lys739Ter) (NM_007294.4). Additionally, a second highly recurrent mutation in <i>BRCA1</i> gene c.5068A>T (p.Lys1690Ter) (NM_007294.4) was noted in six patients from this population.Conclusions: The overwhelming abundance of the above two variants in a geographically confined population confers these two genetic alterations a status of founder mutations amongst the people of Nepal. A more extensive population-based study to reaffirm these findings will help establish a dual site-specific germline testing similar to the “Multisite-3-assay” in Ashkenazi Jews as the primary screening tool, especially in a resource-constrained environment.

End-effector Position Analysis of SCORBOT-ER Vplus Robot

Anurag Verma,Vivek A. Deshpande 보안공학연구지원센터 2011 International Journal of Smart Home Vol.5 No.1

TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma

Anurag Mehta,Himanshi Diwan,Divya Bansal,Manoj Gupta 대한병리학회 2022 Journal of Pathology and Translational Medicine Vol.56 No.1

SMARCA4/BRG1-deficient lung adenocarcinoma (SD-LUAD) is being recognized as a distinct subtype based on subtle differences in its clinical, morphological, and immunophenotypic attributes compared to other non–small cell lung carcinomas. We present here a case of SD-LUAD with curious thyroid transcription factor 1 (TTF1) expression in a morphologically heterogenous lung adenocarcinoma. The better differentiated area showed preservation of TTF1 expression, and a poorly differentiated tumor had loss of TTF1 expression with universal BRG1 loss.

DUALITY IN MULTIOBJECTIVE FRACTIONAL PROGRAMMING PROBLEMS INVOLVING (Hρ, r)-INVEX FUNCTIONS

Anurag Jayswal,I. Ahmad,Ashish Kumar Prasad 한국전산응용수학회 2014 Journal of applied mathematics & informatics Vol.32 No.1

In this paper, we have taken step in the direction to establish weak, strong and strict converse duality theorems for three types of dual models related to multiojective fractional programming problems involving (Hp,r)-invex functions.

ON SUFFICIENCY AND DUALITY IN MULTIOBJECTIVE SUBSET PROGRAMMING PROBLEMS INVOLVING GENERALIZED d-TYPE I UNIVEX FUNCTIONS

Anurag Jayswal,I.M. Stancu-Minasian 한국전산응용수학회 2012 Journal of applied mathematics & informatics Vol.30 No.1

In this paper, we introduce new classes of generalized convex n-set functions called d-weak strictly pseudo-quasi type-I univex, d-strong pseudo-quasi type-I univex and d-weak strictly pseudo type-I univex functions and focus our study on multiobjective subset programming problem. Sufficient optimality conditions are obtained under the assumptions of aforesaid functions. Duality results are also established for Mond-Weir and general Mond-Weir type dual problems in which the involved functions satisfy appropriate generalized d-type-I univexity conditions.