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- 저자 : Anurag Verma (검색결과 5 건)
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Preparation of Activated Carbon Fibers from Cost Effective Commercial Textile Grade Acrylic Fibers
Mekala Bikshapathi,Nishith Verma,Rohitashaw Kumar Singh,Harish Chandra Joshi,Anurag Srivastava 한국탄소학회 2011 Carbon Letters Vol.12 No.1
Activated carbon fibers (ACFs) were prepared from cost effective commercial textiles through stabilization, carbonization, and subsequently activation by carbon dioxide. ACFs were characterized for surface area and pore size distribution by physical adsorption of nitrogen at 77 K. ACFs were also examined for various surface characteristics by scanning electron microscopy, Fourier transform infrared spectroscopy, and CHNO elemental analyzer. The prepared ACFs exhibited good surface textural properties with well developed micro porous structure. With improvement in physical strength, the commercial textile grade acrylic precursor based ACFs developed in this study may have great utility as cost effective adsorbents in environmental remediation applications.
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Vaibhav Rastogi,Pragya Yadav,Navneet Verma,Anurag Verma 한국약제학회 2018 Journal of Pharmaceutical Investigation Vol.48 No.3
The objective of this study was to design a novel microemulsion system for transdermal delivery of natural antimicrobial agent, i.e. bacteriophage (T4) specifically lysing E. coli bacteria. Pseudoternary phase diagrams were constructed and various formulations were prepared using a combination of ethyl oleate (oil), Tween 80:Span 20 (surfactant mixture) and water (aqueous phase). Developed formulations were subjected to physicochemical characterization, ex vivo and thermodynamic stability studies, skin irritation and histology studies. All the formulations had small droplet size (150–320nm), uniform size distribution (PI < 0.4), adequate viscosity and surface tension. 4 × 105, 6.02 × 106 and 6.7 × 106 PFU/mL was the cumulative amount of bacteriophage permeated from ME1-3, respectively. Results from permeation studies suggested the synergistic effect of oil and surfactant mixture on the permeation profile (p < 0.05), on increasing surfactant concentration with respect to oil, the bacteriophage permeation was increasing and so, the flux was increases too. ME2 was found to be thermodynamically stable, nonirritant and followed zero order kinetics. The bacteriophage viability to lyse E. coli was significantly affected at various temperatures, pH and dilution. Histological findings revealed the effect of formulation variables on the skin, necessary for permeation. These results indicate that microemulsion-based transdermal delivery of bacteriophage can be a promising approach to treat the infections caused by antibiotic-resistant bacteria but needs thorough clinical investigations.
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Pragya Yadav,Vaibhav Rastogi,Mayur Porwal,Prashant Upadhyay,Anurag Verma 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.6
3(2) factorial design and response surface methodology in the fabrication of matrix transdermal films of aceclofenac (ACL) was utilized in this study to investigate the effects of polymers (hydrophilic and hydrophobic) and penetration enhancer (PE) on ex vivo and in vivo drug performance. FTIR and DSC showed no interaction of drug with polymers. The physicochemical characterization showed uniformity among the formulations. Results from the permeation study suggested the effect of polyvinyl pyrrolidone (PVP K-30) and PE, on increasing concentration of PVP K-30 with respect to ethyl cellulose as well as increased concentration of PE resulted in enhanced permeation through the matrix. Significant effect of PE on the lipid and protein framework of the skin was also observed which is responsible for increased permeation. From response surface curve and contour plots, an optimized formulation was selected and evaluated for their ex vivo permeation, skin irritation, in vivo efficacy and stability studies. The optimized formulation showed Higuchi controlled diffusion and was found to be non-irritant and efficacious in reducing carrageenan induced paw edema in rats over a prolonged duration of time as compared to oral delivery. Thus, results indicated that the prepared transdermal system can be a promising non-oral approach to deliver effective amount of ACL to treat various inflammatory conditions.
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( Amith Ram ),( Bhageshwar Girish Ramteke ),( Anjali Matani ),( Apoorva Paurank ),( Archana Verma ),( Anurag Bahekar ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Subacute Sclerosing Pan-Encephalitis is a prototype neurodegenerative disease of childhood characterised by onset of neurological symptoms between 5 and 15 years of age with a progressive downhill course and death within 2-4 years. Incidence of adult onset SSPE has been reported between 1-1.75% and 2.6%. To-date less than 140 cases of adult onset SSPE have been published, the majority being case reports. A 24 year old male presented with progressive neurological syndrome characterised by very frequent myoclonic jerks associated with brief dystonic posturing of upper limbs for 8 months. No history of seizures, cognitive decline or personality changes, no history-of measles in childhood but immunized. Routine blood investigations normal. EEG-periodic complexes, CSF- mild increase in proteins, normal sugar, cell count. Measles antibody titre elevated, serum as well as CSF levels, CSF/serum antibody quotient 2.62 which was strongly suggestive of SSPE. Other antibody titres were unremarkable. MRI-bilateral & near symmetrical T2 hyperintense signal in posterior putamen, slightly larger on right, restriction of diffusion & are hypo on T1. No cortical or white matter changes seen. Our patient is not classical case of SSPE. Atypical for age, late-onset, qualifi es as adult-onset of SSPE (defi ned onset after 18 years), well preserved cognition. He did not have seizures, spasticity or visual complaints which are common. Imaging fi ndings are also atypical as common fi ndings early in disease are white matter changes and cortical atrophy mainly in the posterior region of brain and the hyperintense signals seen in late course of the disease are seen early in this patient. EEG Stereotyped periodic complexes with normal background and is strongly suggestive SSPE. MRI reveals T2 hyperintense lesions in bilateral putaminal region slightly larger on right side. Treatment: No curative-therapy is available, few disease-modifying agents have been tried which may delay progression.
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