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Anti-Platelet Effect of the Constituents Isolated from the Barks and Fruits of Magnolia obovata
표미경,이용욱,최숙연 대한약학회 2002 Archives of Pharmacal Research Vol.25 No.3
.In the course of our work on anti-platelet constituents from plants, five phenolic compounds, magnolol, honokiol, obovatol, methyl caffeate, and syringin, were isolated from the methanol extracts of the barks and fruits of Magnolia obovata. The compounds were identified based on the spectroscopic data. Methyl caffeate was isolated for the first time from the genus Magnolia and it showed 3∼4-folds higher potency than ASA. The activities of obovatol and honokiol were comparable to ASA. Magnolol and syringin showed only very mild inhibitory effects to all the stimulators.
인삼잎으로부터 분리된 진세노사이드 F1의 Elastase 및 Tyrosinase 억제 효과
표미경,홍세철,유남희,유지현,이건희,김보람,이호주,김종민,성낙술 한국생약학회 2013 생약학회지 Vol.44 No.1
This study was carried to establish a simple isolation and purification method of ginsenoside F1 from leaves of Panax ginseng and was to evaluate the inhibitory effect of purified ginsenoside F1 on the activities of elastase and tyrosinase. The content of ginsenoside F1 was 90-fold higher in leaves than in root of ginseng. Ginsenoside F1 was isolated from EtOAc fraction between EtOAc and alkalized water of 80% EtOH extract after remove of hydrophobic components. The 50% inhibitory concentration (IC50) of ginsenoside F1 on elastase activity and tyrosinase activity was 1.07 mM and 1.81 mM, respectively. Especially, inhibitory effect of ginsenoside F1 on tyrosinase activity was higher than that of arbutin (IC50; 2.20 mM). These results indicate that ginsenoside F1 have a potential for industrial cosmetic materials.
홍삼가수분해추출물(GS-E3D)의 항산화 및 양모 효과
표미경,홍세철,정종태,조윤호,이기무 한국생약학회 2017 생약학회지 Vol.48 No.3
To develop new therapy for prevention and treatment of hair loss is very important according to increase of the number of hair loss people. The aim of this study was to investigate the hair growth promoting effects of pectin lyase-modified red ginseng extract (GS-E3D). We examined antioxidant and anti-inflammatory effects, human hair dermal papilla cells (HHDPC) proliferation, and testoterone-induced 5a-reductase inhibitory effects. GS-E3D show not only 1,1-diphenyl-2-picryhydrazyl (DPPH) radical scavenging activity and xanthine oxidase inhibitory effects as an anti-oxidant property, but also lipoxygenase and hyaluronidase inhibitory effects as an anti-inflammatory property. Human hair dermal papilla cells proliferation by GS-E3D was higher than those of minoxidil or finasteride, using the positive controls. Moreover, GS-E3D exhibited 5a-reductase inhibitory activities after stimulating by testoterone. The present results indicate that GS-E3D has a potential to be as an hair growth promoting agent for cosmetic materials.
표미경,이경희,차선우,박기용,이기무 한국생약학회 2018 생약학회지 Vol.49 No.3
Pectin lyase-modified red ginseng extract (GS-E3D) is a newly developed ginsenoside Rd-enriched ginseng extract. This study was designed to investigate the skin safety of GS-E3D. Single oral toxicity, single dermal toxicity, bovine corneal opacity and permeability (BCOP) assay, skin irritation test with SkinEthicTM human epidermis model, skin sensitization local lymph node assay, and human patch test, were examined. The oral and dermal LD50 value of GS-E3D was over 2,000 mg/kg in rats. GS-E3D was identified as a non-irritant to skin in BCOP assay, human epidermis models, and patch test from the 32 human subjects. The skin sensitization potential of GS-E3D was less than 25% in local lymph node assay. These results indicate that GS-E3D can be used as a safe ingredient without adverse effects in various skin care products.
Isolation of n-Butyl-b-D-fructopyranoside from Gastrodia elata Blume
표미경,윤혜숙,Yong Kwon Kim 한국생약학회 2006 Natural Product Sciences Vol.12 No.2
Gastrodia elata, a fructoside constituent wasisolated from the n-butanol soluble fraction prepared from the methanol extract. The structure of this compoundwas identified as n-butyl-β-D-fructopyranoside from various spectroscopic data including 1H- and 13C-NMR,HMQC, HMBC, and FABMS.KeywordsGastrodia elata, n-butyl-β-D-fructopyranoside
홍삼가수분해농축액 (GS-E3D)의 피부 안전성 평가를 위한 인체첩포시험
표미경,이경희,김진성,조윤호,이유진,정다유,유대석,김원용,차선우,박기용,이기무 한국약용작물학회 2018 한국약용작물학술대회 발표집 Vol.2018 No.10
Background : The human patch test is a method used to evaluate potential skin irritation after contact with a cosmetic materials. Pectin lyase-modified red ginseng extract (GS-E3D) is a newly developed ginsenoside Rd-enriched ginseng extract. This study was designed to investigate the skin safety of GS-E3D in human patch test. Methods and Results : Thirty two female volunteers were tested with GS-E3D. GS-E3D (20 ㎕) was applied to occlusive patch test devices and was then applied onto the back of subject with normal skin for 24 hours. Cutaneous irritation responses were evaluated and graded according to criterion of International Contact Dermatitis Research Group (ICDRG) at 30 min, 24 hours, and 48 hours after removing of GS-E3D patch. The average age of subjects was 47.3 ± 9.3 years. Skin reactivity calculated from irritation score in GS-E3D treated group was 0.51 and skin irritation score of no application group was 0, respectively. Skin irritancy was no response in both GS-E3D treated group and no application group. From above data, GS-E3D was identified as a non-irritant according to ICDRG guideline that skin irritation score of ‘0.00 - 0.75’ is a non-irritant. Conclusion : These results indicate that GS-E3D can be useful as a safe cometic ingredient.