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GO Guide : 생물학 온톨로지를 위한 브라우저 및 질의 변환
정준원(Jun-Won Jung),박형우(Hyoung-Woo Park),임동혁(Dong-Hhyuk Im),이강표(Kang-Pyo Lee),김형주(Hyoung-Joo Kim) 한국정보과학회 2006 정보과학회 컴퓨팅의 실제 논문지 Vol.12 No.3
생물학 분야에서 유전자에 대한 연구가 활발하게 이루어지면서 유전자에 대한 정보 구축 및 통합에 대한 필요성이 대두 되었다. 그 결과 Gene Ontology Consortium은 W3C에서 제정한 온톨로지 기술언어인 OWL로 유전자에 대한 정보와 분류를 담고 있는 Gene Ontology를 구축하였다. 하지만 Gene Ontology를 위한 기존의 브라우저들은 키워드, 트리, 그래프 기반의 단순 검색만을 지원할 뿐 다양한 관계를 고려한 고급 정보 검색이 불가능하다. 본 논문은 실제 생물학 연구를 수행하는 사용자들이 Gene Ontology를 효과적이고 편리하게 사용할 수 있도록 하기 위해 다양한 온톨로지 검색 기법을 통합적으로 지원하는 방법을 제안하였다. 또한 질의어 입력대신 검색 중에 손쉽게 질의를 생성하는 기법과 생성된 질의를 SeRQL 질의로 변환하는 기법을 제안함으로써 온톨로지에서 지원하는 질의어에 독립적으로 손쉽게 질의를 생성하고 고급정보를 얻을 수 있도록 하였다. 그리고 이렇게 구축한 GO Guide 브라우저를 통해 Gene Ontology의 방대한 정보를 효과적으로 이용할 수 있음을 확인하였다. As genetic research is getting more active, data construction of genes are needed in the field of biology. Therefore, Gene Ontology Consortium has constructed genetic information by OWL, which is Ontology description language published by W3C. However, previous browsers for Gene Ontology only support simple searching mechanisms based on keyword, tree, and graph, but it is not able to search high quality information considering various relationships. In this paper, we suggest browsing technique which integratesvarious searching methods to support researchers who are doing actually experiment in biology field. Also, instead of typing a query, we propose query generation technique which constructs query while browsing and query translation technique which translate generated query into SeRQL query. It is convenient for user and enables user to obtain high quality information. And by this GO Guide browser, it has been shown that the information of Gene Ontology could be used efficiently.
서정건(Jung Kun Seo),정준표(Jun Pyo Chung),조현근(Hyeon Geun Cho),이귀순(Kwi Soon Lee),이관식(Kwan Sik Lee),전재윤(Chae Yoon Chon),강진경(Jin Kyung Kang),박인서(In Suh Park),김기황(Ki Whang Kim),김호근(Ho Geun Kim),이상인(Sang In Lee 대한내과학회 1997 대한내과학회지 Vol.53 No.1
N/A We experienced a case of primary sclerosing cholangitis(PSC) in a 40-year-old female who complained of jaundice and pruritus. Marked elevation of serum alkaline phophatase level, typical beaded appearance and pruned-tree appearance on endoscopic retrograde cholangiography, together with a finding of chronic obliterative fibrosing cholangitis on sono-guided gun biopsy specimen of the liver led to a confirmative diagnosis of PSC. The patient responded to ursodeoxycholic acid (UDCA), but was reluctant to treatment and died of hepatic failure 7 months later. PSC is a very rare disease in Korea. So far, only 5 cases including our present case have been reported in the Korean literature. Male-to-female ratio was 2:3 and the median age was 40(27-80 years old). Ulcerative colitis was associated in one case. Four cases involved both intra, and extrahepatic bile ducts and one case was reported to be confined in the intrahepatic bile ducts. Fatality was in 3 cases, 20 days, 36 days, and 7 months after the initial presentaion, respectively. The causes of death were acute cholangitis and sepsis in two, and hepatic failure in one. We herein report a case of PSC and clinical charateristics of the reported cases in Korea, and review the literature with an emphasis on UDCA treatment in PSC.
서정건(Jung Kun Seo),정준근(Jun Keun Jung),정준표(Jun Pyo Chung),박효진(Hyo Jin Park),전재윤(Chae Yoon Chon),지훈(Hoon Ji),김기황(Ki Hwang Kim),지훈상(Hoon Sang Chi),정우희(Woo Hee Jung) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.3
Castlemans disease is a rare, benign disorder of the lymphoid tissue, and refers ta a distinctive type of giant lymphoid hyperplasia that forms tumor-like masses in lymph nodes and, occasionally, in extranodal sites. Although the mediastinum is its the most common location, it also occurs, albeit rare, in other areas of the body, where lymph nodes are normally found. It is difficult to differentiate between Castlernans disease and other malignant lesions preoperatively. We report a case of a hyaline-vascular variant of Castlemans disease presenting as a solitary retroperitoneal mass in a 39 year old female patient. We also present the MR features, together with conventional radiologic imagings, which made it possible to diagnose Castlemans disease preoperatively, although the mass of the patient was in an unusual location, This report may provide information on differentiation between primary retroperitoneal malignancies and Castlemans disease. (Korean J Gastroenterol 1996; 28:462-468)
윤희정(Hee Jung Yoon),지상원(Sang Won Chi),정준표(Jun Pyo Chung),박효진(Hyo Jin Park),김준우(Jun Uh Kim),송기섭(Kee Sup Song),이관식(Kwan Sik Lee),이상인(Sang In Lee),박미숙(Mi Suk Park),윤상욱(Sang Wook Yoon),유정식(Jeong Sik Yu),김기 대한소화기학회 2001 대한소화기학회지 Vol.38 No.2
Primary epiploic appendagitis, an acutely torsed and ischemic colonic epiploic appendages, is a benign condition that may present with peritoneal findings. Until recently, the accurate diagnosis could not be made preoperatively. However, since the advent of more refined imaging modalities, primary epiploic appendagitis may be distinguished preoperatively. This entity is a self limiting disease and thus, the awareness of this entity may help avoid an unnecessary laparotomy. Herein we present 3 cases of primary epiploic appendagitis. The first case of 40-year-old man has not been correctly diagnosed for 6 years even after a laparoscopic examination. The other 2 cases of 29-year-old and 40-year-old men, were diagnosed by CT examinations and managed conservatively. (Korean J Gastroenterol 2001;38:136-140)
윤희정 ( Hee Jung Yoon ),정준표 ( Jun Pyo Chung ),최승호 ( Seung Ho Choi ),김철식 ( Chul Sik Kim ),강병승 ( Byung Seung Kang ),이태희 ( Tae Hee Lee ),지상원 ( Sang Won Chi ),조준식 ( Jun Sik Cho ),문범수 ( Byoung Soo Moon ),이관식 대한소화기학회 2003 대한소화기학회지 Vol.41 No.2
Background/Aims: The purpose of this study was to evaluate the prognosis of gastric proper muscle (pm) cancer and its prognostic factors to identify a high risk group of patients with recurrence. Methods: Consecutive 154 patients (mean age, 57.6 years; M;
방광암 환자에서 방광내 BCG 점적술 시행 후 발생한 육아종성 간염 1 예
손주익(Ju Ik Son),정준표(Jun Pyo Chung),백승석(Seung Suk Paek),이정일(Jung Il Lee),김정환(Jung Hwan Kim),문병수(Byung Soo Moon),이관식(Kwan Sik Lee),이상인(Sang In Lee),문영명(Young Myoung Moon),박찬일(Chan Il Park),김혜령(Hae Ryoung 대한소화기학회 2002 대한소화기학회지 Vol.39 No.5
Granulomatous hepatitis is a rare but serious systemic complication of intravesical Bacillus Calmette- Guerin (BCG) therapy, which has been proved more effective than most chemotherapeutic agents in the treatment of superficial bladder tumors and carcinoma in situ. Recently, we experienced a 64 year-old male with granulomatous hepatitis which had occurred following an intravesical BCG immunotherapy for an adjuvant treatment of superficial bladder cancer. The patient took isoniazid (300 mg) due to fever that had developed soon after an intravesical BCG immunotherapy. When he presented with clinical features of hepatic failure and sepsis, it was difficult to differentiate granulomatous hepatitis from isoniazid- induced hepatotoxicity. The patient died 20 days after the intravesical BCG immunotherapy (2 days after liver biopsy). This case indicates that granulomatous hepatitis is a fatal complication of the intravesical BCG therapy. Thus, a close follow- up and prompt diagnostic effort with optimal treatment should be instituted. (Korean J Gastroenterol 2002 ; 39: 375-378)
손주익(Ju Ik Son),이준희(Jun Hee Lee),이상인(Sang In Lee),정준표(Jun Pyo Lee),송기섭(Kee Sup Song),박진아(Jin A Park),최성우(Sung Woo Choi),이정일(Jung Il Lee),이관식(Kwan Sik Lee),유정식(Jeong Sik Yoo),최승호(Seung Ho Choi),박찬일(Chan 대한소화기학회 2001 대한소화기학회지 Vol.38 No.4
Gastroduodenal intussusception is a rare condition caused by the prolapse of a gastric tumor and subsequent invagination of the gastric wall into the duodenum. The lead point of the intussusception is usually a benign gastric tumor such as adenoma, lipoma, and leiomyoma. Only a small number was attributed to gastric carcinoma, giant solitary gastric heterotopia, Menetrier's disease, and Peutz-Jeghers syndrome. In Korea, only two cases of gastroduodenal intussusception caused by adenoma and by leiomyoma have been reported. We experienced a case of gastroduodenal intussusception caused by gastric carcinoid tumor in a 76-year-old woman. Interestingly, she had been diagnosed as having gastric carcinoid tumor metastasized to the liver 5 years and 3 months before this gastroduodenal intussusception occurred. This rare clinical setting of gastroduodenal intussusception by a rare cause is reported with a review of the literature. (Korean J Gastroenterol 2001;38:288-291)
김인재(In Jai Kim),박효진(Hyo Jin Park),정준근(Jun Keun Jung),정준표(Jun Pyo Chung),전재윤(Chae Yoon Chon),박인서(In Suh Park) 대한소화기학회 1998 대한소화기학회지 Vol.30 No.2
Oropharyngeal dysphagia is characterized by difficulty in transfer of food frorn the mouth through the upper esophageal sphincter into the upper esophagus. Idiopathic pharyngeal <iyskinesia, such as pharyngeal paresis is a rare moiility disorder in oropharyngeal dysphagia. The most comrnon abnormality of pharynx is decreased amplitude of pharyngeal contraction, which result in misdirection of bolus into the nasal, oral, or laryngeal cavity, and finally lead to aspiration pneumonia. Treatment consists of maneuver to reduce pharyngeal stasis and enhance airway protection under the direction of a trained swallow therapist, We experienced a case of idiopathic pharyngeal dyskinesia of 75 years old male who was treated with physiologic technique. (Korean J Gastroenterol 1997; 30:257-261)