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안성환 ( Seong Hwan Ahn ),이재진 ( Jae Jin Lee ),김진호 ( Jin Ho Kim ),정원영 ( Won Young Jung ),노준 ( Joon Roh ),김동규 ( Dong Gyu Kim ),고희관 ( Hee Kwan Koh ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.4
Pseudotumor cerebri syndrome is characterized clinically by raised intracranial pressure without ventriculomegaly. Several conditions known to interfere with CSF absorption pathways at the level of the arachnoid villi can produce the pseudotumor cerebri syndrome. Systemic lupus erythematosus (SLE) is an autoimmune, inflammatory and chronic disorder characterized by multi-organ involvement including the nervous system. Clinical evidence of central nervous system involvement includes headache, seizure, psychosis and altered mental status. However, pseudotumor cerebri syndrome has been reported infrequently as a primary feature of central nervous system involvement or a complication of SLE. A 19 year-old female was admitted with seizure preceded by headache and blurred vision. Ophthalmoscopic examination showed papilledema. The diagnosis of pseudotumor cerebri syndrome was confirmed by increased intracranial pres-sure (>550mmH20) in the absence of any abnormal radiological findings of the brain. We described a 19-year old girl whose first clinical manifestation was pseudotumor cerebri syndrome, which was diagnosed as SUE later. Therefore pseudotumor cerebri syndrome may be the part of the spectrum of clinical manifestation of SLE.
사과주스의 품질에 미치는 pulsed electric field 연속 처리효과
안성환 ( Seong Hwan Ahn ),임정호 ( Jeong Ho Lim ),김영호 ( Young Ho Kim ),정석진 ( Suk Jin Chung ),박기재 ( Kee Jai Park ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2013 한국식품저장유통학회지 Vol.20 No.5
Apple juices were sterilized by continuous pulsed electric field (PEF) treatments of pulse width of 25 μs at electric field intensity of 20.0 kV/cm, and with the varied pulse frequencies of 35 Hz (40 kJ/L), 55 Hz (70 kJ/L), 72 Hz (100 kJ/L) and 85 Hz (130 kJ/L). The PEF treatments of apple juice reduced the microbial counts from 5.3 log CFU/mL of initial state to 3.0 log CFU/mL after PEF treatment at energy density of 130 kJ/L. Also yeast and fungi after PEF treatments were reduced from 5.3 log CFU/mL to 3.0 log CFU/mL and Escherichia coli were from 5.3 log CFU/mL of initial state to 4.7 log CFU/mL to <101 CFU/mL. The soluble solids and free sugars did not significantly differ (p<0.05) depending on conditions of PEF treatment. The total phenolic contents and antioxidant activity such as the DPPH and ferric reducing antioxidant power (FRAP) by PEF treatments were significantly partly reduced, but the PEF-reduced value came in smaller quantities than the heat treatment at 65℃. The iterative PEF treatments with pulse width of 25 μs and pulse frequency of 85 Hz at electric field intensity of 20.0 kV/cm showed limited in microbial reduction. Also, total phenolic contents and antioxidant activity such as DPPH and FRAP, significantly decreased depending on treatment numbers of PEF (p<0.05).
고전압 펄스 전기장 처리가 사과의 착즙 특성에 미치는 영향
임정호 ( Jeong Ho Lim ),안성환 ( Seong Hwan Ahn ),이동언 ( Dong Un Lee ),김영호 ( Young Ho Kim ),박기재 ( Kee Jai Park ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2012 한국식품저장유통학회지 Vol.19 No.5
The effects of pretreatment by pulsed electric fields (PEFs) on the juice expression characteristics of the Malus pumila fruit were investigated. Fresh fruits were divided into quarters, were produced on a laboratory scale (100 g apples per lot) by pretreatment with electric fields at two different field intensities (1, 2 kV/cm; n=50, 100, 200, and 400 pulses), and were then pressed at room temperature. Relative to the control samples, the juice yield increased with increasing field intensities. The total phenolics and antioxidant activity were higher in the juice from the PEF-treated fruit than in the juice from the untreated fruit. There was no significant difference in soluble-solid and reducing sugar contents between the PEF-treated and untreated fruits. These results suggest that PEF pretreatment may be useful for increasing the juice yield, total phenolics, and antioxidant activity of the Malus pumila fruit.
전립선암의 소분할 방사선치료 시에 위치표지자 삽입의 유용성
최영민(Youngmin Choi),안성환(Sung-Hwan Ahn),이형식(Hyung-Sik Lee),허원주(Won-Joo Hur),윤진한(Jin-Han Yoon),김태효(Tae-Hyo Kim),김수동(Soo-Dong Kim),윤성국(Seong-Guk Yun) 대한방사선종양학회 2011 Radiation Oncology Journal Vol.29 No.2
목적: 전립선암의 소분할 방사선치료에서 골반뼈를 기준으로 한 준비자세(setup)와 전립선에 삽입된 위치표지자(fiducial marker)를 이용한 준비자세를 비교하였다. 대상 및 방법: 2009년 9월부터 2010년 8월까지 전립선암으로 근치적 소분할 방사선치료를 받은 4명의 환자를 대상으로 하였다. 방사선치료 1주일 전경에 경직장초음파 검사 하에 3개의 위치표지자를 직장을 통하여 전립선에 삽입하였다. 방사선치료계획용 컴퓨터단층촬영과 매 방사선치료 전에 직장 관장을 하였다. 소분할 방사선치료는 노발리스 장치를 이용하여, 매일 3.5 Gy씩 총 59.5 Gy를 계획하였다. 분할조사 전에 서로 수직인 두 방향의 kV X-선을 촬영하여 얻은 영상의 위치표지자와 방사선치료계획의 디지털재구성사진에서 관찰되는 위치표지자를 융합하여, 환자의 자세를 조정하고 준비자세를 하였다. 위치표지자 기준 준비자세에서 방사선치료계획의 디지털재구성사진과 kV X-선 영상의 골반뼈를 가상적으로 융합하여, 골반뼈 기준 준비자세를 구하였다. 결과: 67회의 분할조사를 분석하였다. 위치표지자 기준 준비자세에서 방사선치료 중심점과의 3차원적 위치 차이의 평균은 0.94±0.62 ㎜ (범위, 0.09~3.01 ㎜; 중앙값, 0.81 ㎜)였고, 좌우, 상하, 전후 방향으로 위치 차이의 평균은 각각 0.39±0.34 ㎜, 0.46±0.34 ㎜, 0.57±0.59 ㎜였다. 골반뼈 기준 준비자세에서 방사선치료 중심점과의 3차원적 위치 차이의 평균은 3.15±2.03 ㎜ (범위, 0.25~8.23; 중앙값, 2.95 ㎜)였고, 상하 방향의 위치 차이(평균, 2.29±1.95 ㎜)가 전후(평균, 1.73±1.31 ㎜), 좌우(평균, 0.45±0.37 ㎜) 방향보다 유의하게 컸다(p<0.05). 위치표지자 기준 준비자세와 골반뼈 기준 준비자세들에서 방사선치료 중심점과의 3차원적 위치 차이가 3㎜ 이상이었던 경우는 전체 분할방사선조사 횟수의 1.5%와 49.3%였고, 5㎜ 이상이었던 경우가 각각 0%, 17.9%였다. 결론: 위치표지자를 이용하여 보다 정확하게 준비자세를 함으로써 계획용표적체적의 여유를 줄일 수 있고, 따라서 전립선 주변의 정상조직에 대한 방사선량을 감소시켜 보다 안전하게 소분할 방사선치료를 할 수 있을 것으로 예상된다. Purpose: To assess the usefulness of implanted fiducial markers in the setup of hypofractionated radiotherapy for prostate cancer patients by comparing a fiducial marker matched setup with a pelvic bone match. Materials and Methods: Four prostate cancer patients treated with definitive hypofractionated radiotherapy between September 2009 and August 2010 were enrolled in this study. Three gold fiducial markers were implanted into the prostate and through the rectum under ultrasound guidance around a week before radiotherapy. Glycerin enemas were given prior to each radiotherapy planning CT and every radiotherapy session. Hypofractionated radiotherapy was planned for a total dose of 59.5 Gy in daily 3.5 Gy with using the Novalis system. Orthogonal kV X-rays were taken before radiotherapy. Treatment positions were adjusted according to the results from the fusion of the fiducial markers on digitally reconstructed radiographs of a radiotherapy plan with those on orthogonal kV X-rays. When the difference in the coordinates from the fiducial marker fusion was less than 1㎜, the patient position was approved for radiotherapy. A virtual bone matching was carried out at the fiducial marker matched position, and then a setup difference between the fiducial marker matching and bone matching was evaluated. Results: Three patients received a planned 17-fractionated radiotherapy and the rest underwent 16 fractionations. The setup error of the fiducial marker matching was 0.94±0.62㎜ (range, 0.09 to 3.01㎜; median, 0.81㎜), and the means of the lateral, craniocaudal, and anteroposterior errors were 0.39±0.34㎜, 0.46±0.34㎜, and 0.57±0.59㎜, respectively. The setup error of the pelvic bony matching was 3.15±2.03㎜ (range, 0.25 to 8.23㎜; median, 2.95㎜), and the error of craniocaudal direction (2.29±1.95㎜) was significantly larger than those of anteroposterior (1.73±1.31㎜) and lateral directions (0.45±0.37㎜), respectively (p<0.05). Incidences of over 3㎜ and 5㎜ in setup difference among the fractionations were 1.5% and 0% in the fiducial marker matching, respectively, and 49.3% and 17.9% in the pelvic bone matching, respectively. Conclusion: The more precise setup of hypofractionated radiotherapy for prostate cancer patients is feasible with the implanted fiducial marker matching compared with the pelvic bony matching. Therefore, a less marginal expansion of planning target volume produces less radiation exposure to adjacent normal tissues, which could ultimately make hypofractionated radiotherapy safer.
안성환 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S
Stroke is a leading cause of death in Korea. Although the most cost-effective treatment is primary prevention, appropriate managements are influenced on mortality or disability during acute period after onset. Stroke is a vascular event secondary to real disease of blood vessels of the brain. Also, stroke is not one illness but rather it includes several diseases that lead to occlusion of a vessel and progression of neurologic symptoms. Neurologist or physicians must decide treatment options according to medical problems of individual patient. In this review, the process of diagnosis and the principles of evidence based management of patients with acute stroke were described.
정상인에서 전기 및 자기 자극을 이용한 설 근육의 전기생리학적 평가
조은미,류종현,안성환,조경원,임건한,김진호,김후원 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.1
Background: Abnormality of lingual muscles is clinically common. But its exact clinical assessment is quite difficult. Evaluation of motor power of the lingual muscles and their neural pathway is limited because of anatomical inaccessibility and individual variation of subjective symptoms. Transcranial magnetic stimulation (TMS) of the human motor cortex is a non-invasive tool to assess the functional integrity of the fast conducting central motor pathways and electrical stimulation of lingual nerve is a conventional method of peripheral nerve conduction. Therefore both study will be helpful to understanding of pathophysiology of lingual abnormality. Until now there is no such report in Korea. This study was conducted to acquire the easier method and normal control values of Korean subjects. Method: We recorded the motor responses from the lingual muscles of 32 healthy subjects (22 men, 10 women) by focal cortical TMS with a circular coil. Motor potentials were recorded by means of surface electrodes applied on the both side of the tongue, following TMS several centimeters lateral from the vertex and parietooccipital cortex and peripheral electrical stimulation of the 12th cranial nerve at the lateral 1/3 point of the line between the midline and angle of mandible. Results: During moderate motor activation, majority of maximal motor response were obtained 4-6cm lateral to the vertex with similar latencies. And the responses from magnetic stimulation of the intracranial segment of hypoglossal nerve were discarded because of difficulty to obtain and unsatisfactory reproducibility. The latency of motor evoked potentials in right cortical stimulation was 10.08 ± 1.17 msec and in left stimulation 10.04 ± 1.32 msec. The amplitudes in right 2.15 ± 1.02, left 2.09 ± 1.11 mV. The latencies electric hypoglossal nerve stimulation were 2.42 ± 0.34 in right, 2.49 ± 0.35 msec in left side. The amplitudes were 2.90 ± 2.37 in right, 2.43 ± 1.86 mV in left side. Central conduction times as calculated by subtracting the response latencies obtained by magnetic and electric stimulation are right 7.65 ± 1.19, left 7.55 ± 1.35 msec. There was no significant difference between man and woman, Conclusion: The method may be efficient, noninvasive, painless, and easy reproduced. With more extensive application to various neurological disorders, it comes close to being an ideal clinical conduction study technique for this cranial nerve.