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甘桔湯 및 甘桔湯 加味方의 解熱 , 消炎 , 祛痰 작용에 대한 연구
박만석,손영종,이영종 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1
Objects : Gamgiltant, which is in common use of laryngopharyngeal disease, consists of Glycyrrhizae Radix and Placotycodi Radix. Author intended to find out the efficacy of Kami-gamgiltant(added Houttuyniae Herba, Schizandrae Fructus and Sterculliae lychnophorae Semen, which are good for respiratory disease, to Gamgiltant) for the purpose of developing a recipe effective for sphagitis or bronchitis. Methods : After oral administration of Gamgiltang or Kami-gamgiltant to rats, the efficacies of antipyretics, antiinflammation and discharge of phlegm are figured. After inducing the rats to be feverish by injecting LPS(10㎍ LPS/㎏ body weight) of Serratia marcescens into caudal vein of them, rectal temperatures were taken to prove antipyretic effect. After inducing the rats to be edematous by injecting 0.1% of carrageenin into hind paw, the volumes of hind paw were measured to prove antiinflammatory effect. To testify the effect on discharge of phlegm, after administrating the decoctions to rats, quantity of mucous in their throat are measured. Also by aspirating 250ppm of sulfur dioxide 2 and half hours a day during 12 days, rats were induced laryngopharyngeal infections. Then adminstrating the decoction since 5th day of aspiration, the numbers of leukocyte were figured with the object to identify microbial infections. Results : 1) Gamgiltang and Kami-gamgiltant have antipyretic effects on pyrexia induced by LPS injection. Also the latter recovered quickly than the former. 2) Gamgiltant and Kami-gamgiltang have antiedematous effects on edema induced by carrageenin injection. Also the latter shows a quick recovery than the former. 3) Gamgiltant and Kami-gamgiltang have no effect on normal mucous tissue in their throat. 4) The decoction of Gamgiltang has an effect on inflammation induced by exposure to sulfur dioxide, but the Kami-gamgiltant doesn't. Conclusion : Gamgiltang and Kami-gamgiltant could be effective for laryngopharyngeal disease.
정성주,김성범,박대원,정혜원,기세윤,권정아,박만석,박미연,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3
브루셀라증은 전 세계적으로 발생하는 인수공통 전염병중에 하나로서, 본 증례는 국내에서 감염된 가축에 대한 노출력이 없는 집단에서 현증 브루셀라증이 발생한 첫 증례이기에 문헌 고찰과 함께 보고한다. 또한 환자가 근무하였던 축산물 부산물 시장에서 역학 조사를 실시하여, 현증환자 및 기감염자를 발견하여 축산물 부산물 시장 근무자에서 현증 브루셀라증이 발생할 위험성을 평가하였다. 역학 조사 결과 축산물 부산물을 다루는 일을 하는 사람들에서 감염된 가축과의 직접 접촉이 없이도 브루셀라증이 발생할 수 있음을 알 수 있었다. Brucellosis is a world-wide zoonotic disease. We report the first case of brucellosis in South Korea that is not related to direct contract with intected cattles. The patient had been working in the market of by-product, stock raising for twenty years and complained of 1-month history of fever, chill, and intermittent epistaxis. We confirmed brucellosis by anti-brucella antibody test and PCR. After 6 weeks' treatment with rifampicin and doxycycline, fever and chilling subsided, and, generalized weakness and oral intake improved. We performed seroepidemiology study against workers who were working in the same market as the patient. However, we couldn't find out other cases with seropositivity. We concluded that although the workers of by-product market have a risk of getting brucellosis, the risk is low.