제습위령탕가감이 집 먼지 진드기 추출물로 유도된 NC/Nga mouse의 아토피 피부염에 미치는 영향

나동규,한재경,김윤희,Na, Dong-Gyu,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.2

Objectives : The purpose of this study is to investigate the effect of Jeseupwiryeongtang-gagam(JWTG) on atopic dermatitis by in vivo experiment using NC/Nga atopic dermatitis mouse, which has histological and clinical similarities to the atopic dermatitis of human. Methods : To investigate the effect of JWTG on AD, we evaluated atopic dermatitis-like skin lesions by clinical skin index and analyzed immunological parameters in peripheral blood mononuclear cells(PBMCs), splenocytes, draining lymph node(DLN) and performed skin histology in ears and dorsal skin of atopic dermatitis-like skin NC/Nga mouse in vivo. Results and Conclusions : In vivo, clinical skin severity score were significantly lower in JWTG group than control group. IgE, IL-6, $TNF-{\alpha}$, IgM, IgG2a and IgG2b levels in serum were decreased remarkably in JWTG group than control group and $IFN-{\gamma}$ production, secreted in Th1 cell were increased by JWTG. After experiment ended, we analyzed immunological cells ($CD3^+$, $CD19^+$, $CD4^+$, $CD8^+$, $CD3^+$$CD69^+$, $CD4^+$$CD25^+$ and $CD49b^+$) by flow cytometry. It resulted that total absolute number of $CD3^+$, $CD19^+$, $CD4^+$ and $CD8^+$ cells were recovered as normal and $CD3^+$$CD69^+$ were decreased significantly compared with control group in isolated DLN and PBMCs from NC/Nga mouse and total absolute number of $Gr-1^+$, $CD11b^+$ and $CD3^+$ in dorsal skin of NC/Nga mouse were decreased by JWTG. We analyzed ear, DLN, and neck-back skin after biopsy and dyeing by hematoxyline/eosin(H&E) and toluidine staining (mast cells marker) and obtained results that JWTG were effective to histological symptoms (dermal and epidermal thickening, hyperkeratosis and inflammatory cell infiltration). Ear thickness was decreased significantly than the control group and the size of inflammatory lymphocytes cells(ILC) and plasma cells(PC) in DLN were also decreased.

폐옹(肺癰)에 대(對)한 문헌적(文獻的) 고찰(考察)

나동규,김병탁,Na, Dong-Gyu,Kim, Byeong-Tak 대전대학교 한의학연구소 1998 혜화의학회지 Vol.7 No.1

두개 내 종양 절제술 후 확산강조영상

나동규,유재욱,변홍식,Na, Dong-Gyu,Yu, Jae-Uk,Byeon, Hong-Sik 대한영상의학회 2001 대한영상의학회지 Vol.45 No.6

PURPOSE: To evaluate the usefulness of diffusion-weighted imaging after intracranial surgery in patients with intracranial tumors. MATERIALS AND METHODS: Within ten days of intracranial surgery, diffusion-weighted MR images were obtained in 68 patients with intracranial tumors which included meningioma (n=31), glioma (n=21), neurogenic tumor(n=4), hemangiopericytoma (n=3), and in three cases involved metastasis. The signal intensity of the resected margin and adjacent parenchyma was visually assessed on diffusion-weighted images, and the signal intensities on seen T1-and T2-weighted images were also analyzed. In patients with newly developed hyperintense lesions in parenchyma adjacent to the resection sites seen on postoperative T2-weighted images, apparent diffusion coefficients (ADC) were calculated and analyzed on follow-up MR images. RESULTS: Immediate postoperative diffusion-weighted images showed various signal intensities at the resected margins visible on conventional and diffusion-weighted MR images. In 15 patients, newly developed hyperintense lesions adjacent to resected sites were seen on postoperative T2-weighted images. On diffusion-weighted images, nine of these lesions were hyperinteuse and and were shown by follow-up MR imaging to be subject to focal tissue loss and atrophy, and six were isointense but with no sign of tissue loss or atrophy. Among the 15 patients with postoperative lesions near the site of tumorectomy, diffusion-weighted imaging showed that the ADC values of hyperintense lesions were significantly lower than those of isointense lesions (independent sample t-test: p<0.05). CONCLUSION: In patients with intracranial tumors, immediate postoperative diffusion-weighted imaging is useful for differentiating between ischemic tissue damage and vasogenic edema. 목적:두개 내 종양 환자에서 수술 후 시행한 확산강조영상의 유용성을 평가하고자 하였다. 대상과 방법:두개 내 종양절제 후 10일 이내에 확산강조영상을 시행한 68명 (수막종 31예, 교종 21예, 신경초종 4예, 전이 암 3예, 혈관주위세포종 3예 등)을 대상으로 확산강조영상, T2 및 T1강조영상에서 종양 절제 부위 및 인접한 뇌실질의 신호강도를 육안적으로 분석하였다. 종양절제 주변조직에 수술 후 T2강조영상에서 새로 발생한 고신호강도 병변의 경우 병변의 현성확산계수를 측정하였고, 추적검사에서 변화 소견을 비교 분석하였다. 결과:종양절제술 후 초기에 시행한 통상적 자기공명영상과 확산강조영상에서 종양절제 경계에 다양한 신호강도를 보였다. 종양절제술 후 초기에 종양절제 주변에 T2강조영상에서 새로운 고신호강도를 보인 경우는 15예 (22%)였고, 그 중 9예 (60%)에서는 확산강조영상에서 고신호강도, 6예 (40%)에서는 등신호강도를 나타냈다. 추적검사에서 확산강조영상과 T2강조영상에서 모두 고신호강도를 나타낸 병변은 모든 예에서 뇌연화 소견을 나타냈고, 확산강조영상에서 등신호강도를 나타낸 6예 (40%)에서는 뇌연화 소견이 없었다. 종양절제 주변에 병변이 발생한 15예 중 확산강조영상에서 고신호강도를 보인 병변은 등신호강도를 보인 병변보다 통계적으로 유의하게 현성확산계수가 낮게 측정되었다 (independent sample t-test, p <.05). 결론:수술 직후 시행한 확산강조 영상에서 수술절제 경계부위는 다양한 신호강도를 나타냈으며, 확산강조영상은 수술 후 주변조직에서 발생한 혈관성 부종과 허혈성 조직 손상을 구분하는데 유용할 것으로 생각된다.

갑상선암 환자에서 전이 림프절 진단의 최신지견: 영상의학적 진단

나동규 ( Dong Gyu Na ) 대한갑상선학회 2009 International Journal of Thyroidology Vol.2 No.1

The preoperative accurate diagnosis of metastatic lymph nodes is important for the optimal surgical management in patients with thyroid carcniomas. Ultrasonography (US) is an imaging modality of choice for the diagnosis of metastatic lymph nodes. Ultrasound-guided fine needle aspiration cytology (FNAC) is a very useful technique with a high specificity for metastatic nodes. Combination of FNAC and thyroglobulin assessment in needle washout fluid provides higher sensitivity and accuracy for detection of metastatic lymph nodes from differentiated thyroid carcinomas compared to FNAC alone. Routine preoperative use of contrast enhanced CT or MRI is not recommend and the role of CT is controversial. CT may provide additional benefit for detecting metastatic nodes in some patients, and may has a complementary role for the diagnosis of metastatic nodes in patients with thyroid carcinomas.

대한갑상선영상의학회 역사

나동규 ( Dong Gyu Na ),백정환 ( Jung Hwan Baek ) 대한갑상선학회 2018 International Journal of Thyroidology Vol.11 No.1

The Korean Society of Thyroid Radiology (KSThR) was founded as an affiliated subspecialty society of Korean Society of Radiology in 2010. The KSThR was originated from the thyroid radiology research committee which had started within the Korean Society of Neuroradiology in 2005. In the beginning, the research committee was organized to make a clinical guideline for ultrasonography (US) diagnosis and US-guided biopsy of thyroid nodules to cope with the rapidly increasing role of US imaging and the increasing burden of US-guided biopsy for thyroid nodules in the early 2000s. The KSThR proposed a subspecialty of thyroid radiology which is a medical subspecialty dealing with the imaging-based diagnosis and interventional treatment of thyroid disease. The KSThR has made an effort to make an advance in the research of thyroid imaging and intervention, which could provide scientific evidences for imaging-based management of nodular thyroid disease and thyroid cancers. The KSThR has published clinical guidelines of diagnostic imaging and interventional management of thyroid nodules, which included the US diagnosis and imaging-based management, fine-needle aspiration, core needle biopsy, and radiofrequency ablation therapy in thyroid nodules. The KSThR has a mission to play a leading role in the research and clinical practice of imaging-based management of thyroid disease, and the KSThR will make an advance in collaboration with Korean Thyroid Association.

터어키안 및 그 주위 종양에서 이중시기 나선식CT를 이용한 조영 증강 양상의 분석

우지영,유재욱,나동규,노홍기,변홍식,Woo, Ji-Young,Ryoo, Jae-Wook,Na, Dong-Gyu,Roh, Hong-Gee,Byun, Hong-Sik 대한영상의학회 2002 대한영상의학회지 Vol.46 No.1

목적: 이중시기 나선식 CT에서 나타나는 터어키안 및 그 주위 종양의 조영 증강 양상을 알아보고자 하였다. 대상과 방법: 수술로 진단된32명의 터어키안 및 그 주위 종양을 가진 환자를 대상으로 하였다. 수막종이 17예, 뇌하수체 거대선종 6예, 신경성 종양 5예, 해면 혈관종, 연골육종, 골육종, 접형동 종양이 각 1예였다. 이중시기 나선식 CT는 초당 3 ml로 90 ml의 조영제를 주입한 후 30초와 120초 후에 조기 및 지연 횡단 영상을 얻었고,횡단면 영상을 얻은 후 관상면 영상을 얻었다. 종양의 감쇠 변화와 조영 증강 양상을 육안적으로 평가하였고,조기 횡단 영상에 대한 지연 횡단 및 지연 관상면 영상의 CT수치의 비율을 정량적으로 분석하였다. 결과: 육안적 평가에서 조기 횡단 영상에 대한 지연 횡단 영상의 감쇠 변화는 수막종17예 모두(100%)에서 감소하였고, 뇌하수체 거대선종6예 모두(100%)에서는 뚜렷한 차이를 보이지 않았으며, 신경성 종양 5예 모두(100%)에서 증가하였다.조기 횡단 영상에 대한 지연 관상면 영상의 감쇠 변화는 수막종 17예 모두(100%)에서 감소하였고, 신경성 종양 5예 모두(100%)에서 증가하였으며, 뇌하수체 거대선종 6예중 4예(66.7%)에서는 뚜렷한 차이를 보이지 않았다. 수막종, 신경성 종양, 뇌하수체 거대선종에서 계산한 CT 수치의 비율은 통계적으로 유의한 차이를 보였다 (p<0.05). 결론: 이중시기 나선식 CT에서 터어키안 과 그 주위 종양은 병리에 따라 특징적인 조영 증강양상을 나타냈다. 이중시기 나선식 CT를 이용한 조영 증강 양상의 분석은 이들 종양의 감별진단에 도움이 될 것으로 생각된다. Purpose: To assess the enhancement patterns of sellar and parasellar tumors at two-phase helical CT. Materials and Methods: Thirty-two patients with pathologically proven sellar and parasellar tumors [meningioma (n=17), pituitary mocroadenoma (n=6), neurogenic tumor (n=5), cavernous angioma (n=1), chondrosarcoma (n=1), osteosarcoma (n=1), sphenoid carcinoma (n=1)] were included in this study. Two-phase helical CT was performed after the injection of 90 mL of contrast material at a rate of 3 mL/sec. Transverse helical CT scans were obtained during the early and late phases, with scanning delays of 30 and 120 seconds, respectively. Delayed coronal images were obtained after delayed axial images. Attenuation change and the enhancement patterns of the tumors were visually assessed; the former was also assessed quantitatively as the ratio of the CT number at late-phase axial and coronal scanning to that at early-phase scanning. Results: Visual assessment of two-phase helical CT images revealed decreased attenuation in all 17 meningiomas, no change in all six pituitary macroadenomas and increased attenuation in 5 all five neurogenic tumors on late-phase axial scans as compared with early phase scans. Coronal images showed decreased attenuation in all 17 meningiomas, increased attenuation in all five neurogenic tumors and no change in four pituitary macroadenomas (66.7%). The ratio of CT numbers was significantly different between meningiomas, neurogenic tumors and pituitary macroadenomas(p<0.05). Conclusion: According to their histopathology, sellar and parasellar tumors showed characteristic enhancement patterns at two-phase helical CT. An analysis of the observed enhancement patterns can be useful in the differential diagnosis of juxtasellar tumors.

안와를 제외한 두경부의 염증성 가성종양: CT 및 MR 소견

노은진,유재욱,나동규,김삼수,한헌,한춘환,이시경,No, Eun-Jin,Yu, Jae-Uk,Na, Dong-Gyu,Kim, Sam-Su,Han, Heon,Han, Chun-Hwan,Lee, Si-Gyeong 대한영상의학회 2002 대한영상의학회지 Vol.46 No.5

목적: 안와를 제외한 두경부에서 발생한 염증성 가성종양의 MR 및 CT소견을 알아보고자 하였다. 대상과 방법: 조직학적으로 증명된 11명의 안와를 제외한 염증성 가성종양 환자를 대상으로 MR(n=10)와 CT (n=9)을 후향적으로 분석하였다. 9명의 환자에서 추적 검사를 시행했고 스테로이드에 대한 반응을 알아보았다. 결과: 병변은 저작공간 (n=8),협공간 (n=6),인두 (n=5),부비동 (n=4),인두주위간극 (n=3), 추전공간 (n=2), 안와 (n=2),경동맥공간 (n=2), 척추주위공간 (n=1), 이하선아 (n=1), 비 강및구강(n=1)을 침범하였다. 11명의 환자중 10명에서 주변 골 변화가 있었으며, 6명의 환 자에서 두개강내로 침범이 있었다. MR을 시행한 10명의 환자중 9명에서 T2-강조영상에서 병변이 저신호강도를 보였고, 이 중 4명에서는 현저한 저신호강도를 포함하고 있었다.종괴 전체에 고신호강도를 보이는 경우는 없었다.5명의 환자에서 스테로이드 투여후 종괴 크기가 감소하였다. 결론: 염증성 가성종양은 주변의 여러 공간을 침범하며 T2-강조영상에서 동등신호 강도부터 저신호강도까지 보였으며 림프절 종대를 보이지 않았다. Purpose: To determine the MR and CT imaging findings of inflammatory pseudotumor of the extraorbital head and neck. Materials and Methods: We reviewed the MR (n=10) and CT (n=9) imaging studies of 11 patients with this condition (M:F=5:6, age range: 35-75 years), analysing each case in terms of location, occupying space, signal intensity, intracranial involvement, degree of contrast enhancement and adjacent bone change. Follow-up images were obtained in nine cases, and the response of each patient to steroid treatment was reviewed. Results: Lesions involved the masticator space (n=8), the buccal space (n=6), the nasopharynx (n=5), the paranasal sinus (n=4), the parapharyngeal space (n=3), the prevertebral space (n=2), the orbit (n=2), the carotid space (n=2), the paravertebral space (n=1), parotid space (n=1), and the oral cavity (n=1). In ten of eleven cases, there was adjacent bone change. In three cases, the cavernous sinus was involved, and in two, the dura. One case involved both of them. At T2-weighted imaging, the lesions showed hypointensity in nine of ten cases; in four of nine, signal intensity was markedly low, and in no case was it diffusely high. In five of nine cases, the mass decreased in size after steroid therapy. Conclusion: Inflammatory pseudotumor showed iso-to hypointensity at T2-weighted imaging. Lymphadenopathy was not apparent.

Leading Depression N (LDN) Wave 조파기법에 기초한 Hybrid Breaker의 지진해일 처오름 저감효과 수치해석

조용준(Yong Jun Cho),나동규(Dong Gyu Na) 한국해안해양공학회 2015 한국해안해양공학회 논문집 Vol.27 No.1

지진해일에 대한 기존의 연구는 이차원 Boussinesq 모형과 Solitary wave에 기초한 수치해석이 그 주류를 이룬다. 최근 Solitary wave에 의한 처오름 높이가 관측치를 하회한다는 인식에 기초하여 지진해일 내습전 해안선이 전진하는 현상의 모의가 가능한 Leading Depression N (LDN) Wave가 제시되었으며 이에 기초하는 경우 보다 정확한 모의가 가능한 것으로 보고된 바 있다. 이러한 성과에도 불구하고 수리모형 실험의 경우 안정적인 Leading Depression N (LDN) Wave의 구현에 상당한 어려움을 겪어왔다. 이러한 이차원 Boussinesq 모형과 삼차원 수리모형 실험에서의 상충된 결과는 이차원 Boussinesq 계열 파랑 모형 유도과정에서 수행되는 파랑의 비선형성과 분산성이 균형을 이룬다는 가정과 이로 인해 다소 과소하게 평가된 분산성에 기인하는 것으로 판단된다. 이러한 인식에 기초하여 본고에서는 삼차원 수치수조에서 비교적 안정적인 LDN 파형의 조파가 가능한 수정 조파기법과 Navier Stoke 파랑모형에 기초하여 Hybrid Breaker의 지진해일에 의한 처오름 저감효과를 수치 해석하였다. 파랑모형의 검증은 불규칙 파랑을 대상으로 기 수행된 수리모형 실험결과를 토대로 진행되었으며, 그 결과 비교적 근접한 처오름 높이를 얻을 수 있었다. 세 개의 유수실과 전면 경사면으로 구성된 Hybrid Breaker의 경우 일반 경사제에 비해 H = 5m의 경우 약 13%, H = 6 m의 경우 10%정도의 처오름 저감 효과를 지니는 것으로 모의되었다. Past study of tsunami heavily relied on the numerical modelling using 2D Boussinesq Eq. and Solitary wave. Lately, based on the fact that numerically simulated run up heights based on solitary wave are somewhat smaller than the measured one, Leading Depression N (LDN) Wave has been elaborated, which can account the advancement of a shore line before tsunami strikes a shore. Thereafter it is reported that more accurate simulation can be possible once LDN is deployed. On the other hand, there were numerous reports indicating that stable LDN wave can’t be sustained in the hydraulic model test. These conflicts between the hydraulic model tests and numerical results have their roots on the assumption made in the derivation of Boussinesq type wave model such as that wave nonlinearity is equally balanced with wave dispersiveness. Hence, in the numerical simulation based on the Boussinesq type wave model, wave dispersiveness is inevitably underestimated, especially in deep water. Based on this rationale, we developed the modified methodology for the generation of stable LDN wave in the 3D numerical wave flume, and proceeded to numerically analyze the depression effect of Hybrid Breaker on the run up height due to tsunami using the Navier Stoke Equation. The verification of newly proposed wave model in this study was carried out using the run up height from the hydraulic model test. It was shown that Hybrid Breaker consisting of three water chamber and slope at its front can reduce 13% of run up height for H = 5m, and 10% of run up height for H = 6m.

지진해일방재 시스템 개발

조용준(Yong Jun Cho),나동규(Dong Gyu Na) 대한조선학회 2012 대한조선학회 학술대회자료집 Vol.2012 No.5

대한갑상선학회 갑상선결절 및 암 진료 권고안 개정안

이가희 ( Ka Hee Yi ),박영주 ( Young Joo Park ),궁성수 ( Sung-soo Koong ),김정한 ( Jung-han Kim ),나동규 ( Dong Gyu Na ),류진숙 ( Jin-sook Ryu ),박소연 ( So Yeon Park ),박인애 ( In Ae Park ),백정환 ( Chung-hwan Baek ),송영기 ( Youn 대한갑상선학회 2010 International Journal of Thyroidology Vol.3 No.2