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RISS 인기검색어
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- 저자 : 고창순(Chang Soon Ko) (검색결과 29 건)
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주사용(走査用) $^{113m}In$ 교질(膠質)의 조제(調製) 및 흰쥐에서의 장기분포(臟器分布)에 관(關)한 연구(硏究)
고창순,이종헌,장고창,홍창기,Koh, Chang-Soon,Rhee, Chong-Heon,Chang, Ko-Chang,Hong, Chang-Gi D. 대한핵의학회 1969 핵의학 분자영상 Vol.3 No.1
The newly developed diagnostic method with application of $^{113}Sn-^{113m}In$ cow system ($^{113}Sn:\;T\frac{1}{2}$ 118 days, $^{113m}In:\;T\frac{1}{2}$ 1.7 hrs, 390 Kev, Single ${\gamma}$) has the remarkable advantages such as increased diagnostic ability by single large dose administration of $^{113m}In$ with no subsequent radiation hazard and shortened examining time. We reformed the research of following scope with the use of developed $^{113}Sn-^{113m}In$ cow (25 mCi) generator: The sizes of particles produced under various conditions were investigated, and possibility for application to the scannings of various organs such as brain, liver, lung, bone marrow and blood pool etc. were studied. Results: $^{113m}InCl_3$ solution eluted from diluted HCl solution (pH 1.5) passed through $^{113}Sn-^{113m}In$ generator, and there can be produced various sized particles of colloidal indium. And there observed the state of distribution of $^{113m}In$ in each organ which showed many differences according to the particle sizes of colloidal indium. The results are stated as follows: 1. The adjustment of pH is the most important factor in making the desirable particle size of colloidal indium. The colloid for blood pool showed the highest level as 7.1%/gm blood, at pH 1.7, the colloid of pH 3.5 for liver scanning showed the highest level, 88.4%, in the liver, the colloid pH 6 showed the highest level, 3.1%, in the spleen, and the colloid of pH 11.0 showed the highest level, 85.3%/gm, in the lung. 2. The colloid for liver scanning made with NaCl-NaOH system showed the highest liver uptake at pH 7.2, and at either higher or lower pH than 7.2 showed decrease of liver uptake more or less. 3. The activity of $^{113m}In$ eluted through $^{113}Sn-^{113m}In$ generator indicated over 90% in the initial 4 ml, and particularly 88.1%-86.0% in the initial 2 ml. 4. The incubation time, tempertaure and mechanical irritation related to colloid formation and coating of colloid were not the definite condition of influence.
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수온과 광주기에 의한 볼락 ( Sebastes inermis ) 의 번식주기 조절
고창순(Chang Soon Ko),장영진(Young Jin Chang),임한규(Han Kyu Lim),김종현(Jong Hyun Kim),조기채(Kee Chae Cho) 한국수산과학회 1998 한국수산과학회지 Vol.31 No.5
Experiments on the control of rockfish, Sebastes inermis reproduction were performed by artificially changed water temperature (WT) and photoperiod (PP). The experiments were divided into three conditions; artificial changes of both WT and PP delayed two months against their natural variations (Exp.I), natural WT and PP replaced with artificial light (Exp.II) and natural WT and PP (Exp.III) from September to April (220 days). Initial gonadosomatic index (GSI) in female groups of experiments was 0.2. Female GSI of responded group in Exp.I began to increase from December and reached the highest value in February with 15.0, while the unresponded group kept the lower value during the experimental period. Female GSI of Exp.II and Exp.III reached the highest values in January with 13.0 and 14.7, respectively. Male GSI of Exp.I reached the maximum in October, and that of Exp.II and III reached the maximum in November and then rapidly decreased. Among the experimental groups, male GSI did not show the different tendency. Monthly changes of hepatosomatic index in both sexes showed the reciprocal tendency with those of GSI. The control of WT and PP did not affect on the changes of HSI and condition factor of rockfish. From the histological observations, maturation of ovary was delayed by the changes of WT and PP, but that of testis was not influenced. Judging from the above results, the maturation and parturition of female rockfish could be delayed one or two months by artificial changes of WT and PP.
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홍창기 ( Chang Ki Hong ),고창순 ( Chang Soon Koh ),이종헌 ( Chong Heon Rhee ),장고창 ( Ko Chang Chang ) 대한핵의학회 1969 핵의학 분자영상 Vol.3 No.1
간 scan용 113mIn 교질을 만들어 이의 간섭취율 및 혈중 clearance을 측정하고 간 scan을 시행하여 198Au 교질의 성적과 비교관찰하여 다음과 같은 결론을 얻었다. 1) 정상인에 있어서 113mIn 교질의 간섭취율 반감시간은 1.40±0.24분 및 혈중 clearance의 반감시간은 1.47±0.27분으로 198Au 교질의 경우보다는 유의한 단축을 보였다. 그러나 이로서 간기능을 추정하는 것은 반드시 정확한 index가 되는 것 같지 않았다. 2) Space occupying lesion의 해상능은 113mIn 교질을 사용하면 198Au 교질보다 우수함을 알 수 있었다. 3) 113mIn 교질의 간섭취율은 간기능의 변화에 따르는 198Au 교질의 간섭취율의 변동과 반드시 일치하는 것은 아님을 알 수 있었으며 따라서 이는 RES의 탐식능의 다양성에 기인한 듯 하였다. 4) 113mIn 교질에 의한 간 scan에 있어서는 정상인에 있어서도 비장의 출현이 있었다. 5) 간기능장애가 있을때는 간의 교질 섭취성이 113mIn 교질에 있어서 198Au 교질보다 더욱 장애를 받으며 비장의 교질 섭취능은 상반되는 관계에 있음을 알 수 있었다. 6) 113mIn 교질을 만든 다음 인체에 사용하기 전에 coarse filter에 걸려서 사용하는 경우 더욱 좋은 간 scan상을 볼 수 있었다. 7) 간 scan에 113mIn 교질을 사용함으로서 scan시간을 더욱 단축시킬 수 있었다. There have been reported numberous cases of liver scanning in use of 198Au colloid by many investigators, however, one in use of 113mIn colloid has not been reported as yet in this country. The dose of 113mIn for high diagnostic value in examination of each organ was determined and the diagnostic interpretability of liver scanning with the use of 113mIn was carefully evaluated in comparison with the results of the liver scanning by the conventionally applied radioisotope. The comparative study of both figures of liver scanning with the use of 113mIn colloid and 198Au colloid delivered following results:1) The liver uptake rate and clearance into peripheral blood were accentuated more in case of 113mIn colloid than in case of 198Au colloid. 2) The interpretability of space occupying lesion in liver scanning with 113mIn was also superior to one with 198Au. 3) The figure of liver scanning with 113mIn colloid corresponds not always to the figure with 198Au. This difference can be explained by difference of phagocytic ability of reticuloendotherial system within liver. 4) In the liver scanning with 113mIn colloid, the spleen is also visualized even in normal examine. 5) In the cases of disturbed liver function, uptake is more decreased in use of 113mIn colloid than in 198Au, in the spleen, however, the way is contrary. 6) With use of 113mIn colloid, the time required for scanning could be shortened in comparison with 198Au. 7) The filtration of 113mIn colloid for scanning prior to human administration gives an expectation for better scanning figure.
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실험 배합사료 및 미역 공급시 참전복 치패의 적정 사육밀도
김병학(Byung Hak Kim),이상민(Sang Min Lee),고창순(Chang Soon Ko),김재우(Jae Woo Kim),명정인(Jeong In Myeong) 한국수산과학회 1998 한국수산과학회지 Vol.31 No.6
A feeding trial was carried out to investigate the optimum density of juvenile abalone (Haliotis discus hannai) fed the formulated diet or macroalgae (Undaria). Abalone with initial average shell length of 8.41 ㎜ were stocked into three replicate tanks at four different densities of 1430, 2860, 4290, and 5720 individual/㎡ for 15 weeks. The formulated diet produced higher body weight and shell growth, soft body weight and survival rate than Undaria in abalone. Abalone fed the formulated diet have significantly (P<0.05) higher lipid and ash, and lower moisture and protein in soft body. Higher density resulted in lower growth and survival (P<0.05). Whereas shell growth, survival rate and weight gain were not significantly (P>0.05) different within the abalone stocked at stocking densities of 1430 and 2860 individual/㎡ in each diet group. Body composition of abalone was not affected by increasing density. These study indicate that the number of abalone (shell length ranges of between 8 ㎜ and 17 ㎜) below 2860 individual/㎡ were predicted to effective density in the indoor tank culture system.
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당뇨유발 백서에서 △6 탈포화효소의 활성도 및 지방산 구성
신찬수(Chan Soo Shin),이문규(Moon Kyu Lee),한은경(Eun Kyung Han),고경수(Kyung Soo Ko),김철희(Chul Hee Kim),김성연(Seong Yeon Kim),조보연(Bo Youn Cho),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min) 대한내과학회 1992 대한내과학회지 Vol.43 No.2
N/A Microsomal △6 desaturase is a key enzyme in the metabolism of polyunsaturated fatty acids, the activity of which is regulated by insulin. To determine if changes in d △6 desaturase activity in experimental diabetes correspond to changes in fatty acid compoistion of microsome and RBC membrane, 18 Sprague-Dawley rats were studied for 6 weeks. The animals were divided into 3 groups with 6 rats in each group. The first group was the contrals, the 2nd 3rd groups were streptozotocin diabetic rats but insulin was injected to the 3rd group. The △ 6 desaturase activities of diabetic rats were 68pg of those of controls (p<0.05) and increased to 119% of controls (p<0.05) with insulin treatment. Linolic (LA), palmitic (PA) and docosahexaenoic acids (DHA) were increased and arachidonic (AA) & oleic acids (OA) decreased in liver microsome of diabetic rats, which were reversed with insulin treatment, respectively. In erythrocyte membrane LA & stearic acids (SA) were increased, and PA, AA, and palmitoleic acids were decreased which were not reversed with insulin treatment, however. To summarize, insulin controls the △ 6 desaturase activities, which in turn affect fatty acid compositions of microsome and RBC membranes. Theee findings suggest that adequate insulin therapy is required for the correction of the polyunsaturated fatty acid metabolism as well as blood glucose control in the insulin dependent diabetics.
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99m - Tc DISIDA Scan 을 이용한 정상인과 담석증 환자에서의 담낭역학에 관한 연구
윤용범(Yong Bum Yoon),박용현(Yong Hyun Park),이영철(Young Cheol Lee),정준기(Joon Ki Jung),고창순(Chang Soon Ko) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A Gallbladder stasis has been implicated as one of factors in gallstone formation. To evaluate the gallbladder dynamics, gallbladder filling and emptying were quantitated by the computer assisted 99m-Tc DISIDA scan in 8 normal subjects and 23 patients with gallstones. Gallstone patients exhibited normal gallbladder filling rate, and there seemed to be three periods (Lag period, Rapid contraction period, Slow contraction period) in gallbladder contraction induced by a fatty meal. In patients with gallstones, ejection fraction in whole contraction period, ejection fraction and ejection rate in rapid contraction period of gallbladder were reduced (p<0.05) when compared with controls. On closer inspection, the gallstone patients fell into two subgroups, separated by ejection fraction 72%(x-2S.D. of control). There were no significant differences in opacity, number, size of gallstones and biliary colic episodes between these two subgroups. When we divided 3 contraction parameter which were significant differences between control and gallstone group into two subgroups by E.F. 72%, E.F.a 38.9%, E.R.a 2.9%/min (x-2S.D. of control) and compared them with gallbladder wall thickness by ultrasonography, the thicker gallbladder wall brought about the decreased ejection fraction and ejection rate in rapid contraction period, but the ejection fraction in whole emtying period was not influenced by gallbladder wall thickness. To elucidate the relationship between gallbladder inflammation and contraction, Spearmans rank correlation analysis between inflammatory scorings of chronic cholecystitis and several parameters of gallbladder contraction was used; the linear relationships between two groups were not found (p> 0,05), but owing to small number of cases the result was hard to be accepted. Thus defective gallbladder emptying is evident in a subgroup of gallstone patients and is indepen- dent of clinical features, stone size, number and opacity. The gallbladder wall thickness influenced to ejection fraction and ejection rate in rapid contraction period, but not to whole ejection fraction. Relationship between gallbladder inflammation and gallbladder contractions was not elucidated.
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