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여대원,김진성,윤상협,류봉하,류기원 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
This study was performed to investigate the effect of Bunsimgieum on antitumor effect after sarcoma-180 cells transplantation into peritoneal cavity or left groin and immune responses on the depressed immunity induced by methotrexate in mice. The Bunsimgieum extract of 10㎎/㎏ was orally administered 14 days for antitumor effects and 21 days for immune responses. 50% inhibitory concentration(IC_(50)) of SUN-1, SUN-C4. and SUN-396 cancer cell, mean sunvival days and body weight of tumor bearing mice, and growth of tumor mass for antitumor effect; delayed type hypersentivity, hemagglutinin titer, hemolysis titer, rosette forming cells, natured killer cell activity, lymphocyte transformation. productivity of interleukin-2 and phagocytic activity for their immune responses were measured in ICR mice. Significance in antitumor effect is noted in the enlongation of mean life days and inhibition of tumor growth(p<0.01 respectively). Significance of immune responses is also noted in hemolysis titer, lymphocyte transfumotion IL-2 productivity, phagocytic activity, and natural killer cell activity at E/T ratio 100 : 1(p<0.01, respectively). Significant in rosette cell formation was seen dosage of 20㎎/㎏(p<0.01) However, Difference of body weight as antitumor effect, delayed type hypersensitivity, and hemagglutinin titer were not shown significantly. According to the above results, it could be suggested that Bunsimgieum has prominent antitumor and immunity enhancing effect.
유리의 조성에서 MgO, Li_2O의 함량변화가 유리침투 알루미나 세라믹 재료의 강도와 색조의 변화에 미치는 영향
배태성,원대희,원상용,윤여은 大韓齒科器材學會 2002 대한치과재료학회지 Vol.29 No.3
This study was performed to investigate the effect of composition changes in glasses on the strength and shade of glass-infiltrated alumina ceramics. Six different borosilicate glasses containing MgO, Li₂O and ZrO₂ in the glass composition were prepared, porous alumina compacts were prepared by slip casting and sintered at 1100℃ for 2 hours. Dense composites were made by infiltration of molten glass into partially sintered alumina at 1110℃ for 6 hours. Specimens were polished sequentially form #800 to #2000 diamond wheel, and the final surface finishing on the tensile side was received an additional polishing sequence through 0.3 ㎛ diamond paste. To evaluate the effect of composition change in glass on the shade changes of glass-infiltrated alumina core ceramics, the color was measured by the CIE L^*, a^*, b^* color scale relative to standard source C. The biaxial flexure strength was measured using the ball-on-three-ball method at a crosshead speed if 0.5mm/min. The color change of composites infiltrated with experimental glasses to In-Ceram Glass AL1 showed that L^* values increased but a^* and b^* values decreased with addition of MgO, Li₂O and ZrO₂ in the glass composition. Maximum color difference of experimental glass-infiltrated alumina core ceramics was obtained in the Group B containing 2.4 mol% MgO in the glass composition. The maximum biaxial flexure strength values 47.41 MPa was obtained in the Group E containing 0.3 mol% Li₂O in the glass composition. The observation of fracture surfaces indicated the microstructurally rough surface with a tendency of toughening by crack deflection and crack bridging.
Yeo Dae Yoon,이은숙,박종필,김미리,Jun Won Lee,Tae Hoon Kim,나민균,김진희 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.6
Hizikia fusiforme is a commonly used food that possesses potent anti-bacterial, anti-fungal, and antiinflammatory activities. The immunostimulatory activities of aqueous extract of Hizikia fusiforme (HFAE) in RAW 264.7 macrophages and whole spleen cells were investigated. HFAE activated RAW 264.7 macrophages to produce cytokines such as nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in a dose-dependent manner. In addition, HFAE induced the mRNA expression of TNF-α, IL-1β, and IL-6in RAW 264.7 macrophages. Moreover, HFAE stimulated proliferation of whole spleen cells and reference mitogen. Taken together, the results demonstrate that HFAE potently activates the immune function by regulating NO, TNF-α,IL-1β, and IL-6 in RAW 264.7 macrophage and promoting spleen cell proliferation.