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A Functional Variant, rs967591G>A, in the 19q13.3 and Survival of Early-Stage Lung Cancer
박재용,( Hyo Sung Jeon ),( Seung Soo Yoo ),( Shin Yup Lee ),( Jaehee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Eung Bae Lee ),( Young Tae Kim ),( Sang Hoon Jheon ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Purpose: This study was conducted to investigate the associations between single nucleotide polymorphisms (SNPs) in 19q13.3 and survival of early-stage non-small cell lung cancer (NSCLC) patients, and to define the causative functional SNP of the association. Methods: A two-stage study design was used to evaluate five SNPs in relation to survival outcomes in 328 patients and then to validate the results in an independent patient population (n=565). Luciferase assay and real-time PCR was performed to examine functional relevance of a potentially functional SNP. Results: Of the five SNPs, three SNPs (rs105165C>T, rs967591G>A and rs735482A>C) were significantly associated with survival outcomes in a stage 1 study. The rs967591A allele had significantly higher promoter activity of CD3EAP compared with the rs967591G allele (P=0.002), but the SNP did not have an effect on the promoter activity of PPP1R13L. The rs967591G>A was associated with the level of CD3EAP mRNA expression in lung tissues (P=0.01). The rs967591G>A exhibited consistent associations in a stage 2 study. In combined analysis, the rs967591 AA genotype exhibited a worse overall survival (adjusted hazard ratio=1.69, 95% confidence interval=1.29-2.20, P=0.0001). Conclusion: The rs967591G>A affects CD3EAP expression and thus influences survival in early-stage NSCLC. The analysis of the rs967591G>A polymorphism can help identify patients at high risk of a poor disease outcome.
Lee, Seulki,Cha, Eui-Joon,Park, Kyeongsoon,Lee, Seung-Young,Hong, Jin-Ki,Sun, In-Cheol,Kim, Sang Yoon,Choi, Kuiwon,Kwon, Ick Chan,Kim, Kwangmeyung,Ahn, Cheol-Hee WILEY-VCH Verlag 2008 Angewandte Chemie Vol.47 No.15
<B>Graphic Abstract</B> <P>Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected—both in vitro and in vivo. Experiments disclose an apparent positive contrast in MMPs-positive tumor-bearing mice (right). <img src='wiley_img/14337851-2008-47-15-ANIE200705240-content.gif' alt='wiley_img/14337851-2008-47-15-ANIE200705240-content'> </P>
오세림,( Hyo Sung Jeon ),( Yong Hoon Lee ),( Seung Soo Yoo ),( Shin Yup Lee ),( Jaehee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Ji Woong Son ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Introduction: MicroRNAs play important roles in the development and progression of human cancers. It has been reported that miR-146a down-regulates EGFR and the NF-κB regulatory kinase interleukin-1 receptor-associated kinase 1 genes that plays important roles in lung carcinogenesis. This study was conducted to evaluate the association between a functional poly-morphism, rs2910164C>G, in the pre-miR-146a and lung cancer risk. Material and Methods: The rs2910164C>G genotypes were determined in 1,094 lung cancer patients and 1,100 healthy con-trols who were frequency-matched for age and gender. Results: The rs2910164 CG or GG genotype was associated with a significantly decreased risk of lung cancer compared to the CC genotype (adjusted odds ratio [aOR]=0.80, 95% confidence interval [CI]=0.66-0.96, P=0.02). When the cases were cate-gorized by tumor histology, the effect of the rs2910164C>G genotype on the risk of lung cancer was significant in ad-enocarcinoma (aOR=0.74, 95% CI=0.58-0.93, P=0.01) and small cell lung cancer (aOR=0.68, 95% CI=0.46-0.99, P=0.04) but not in squamous cell carcinoma. Conclusions: This finding suggests that the pre-miR-146a rs1910164C>G might be a useful marker for determining the sus-ceptibility to lung cancer and that miR-146a might be involved in the development of lung cancer.
Identification of polymorphisms in the Caspase-3 gene and their association with lung cancer risk
Jang, Jin Sung,Kim, Kyung Mee,Choi, Jin Eun,Cha, Sung Ick,Kim, Chang Ho,Lee, Won Kee,Kam, Sin,Jung, Tae Hoon,Park, Jae Yong Wiley Subscription Services, Inc., A Wiley Company 2008 Molecular carcinogenesis Vol.47 No.5
<P>Caspase-3 (CASP-3) is a primary effector CASP that executes programmed cell death, and it plays an important role in the development and progression of cancer. Polymorphisms in the CASP-3 gene may influence CASP-3 production and/or activity, thereby modulating the susceptibility to lung cancer. To test this hypothesis, we first screened for polymorphisms in the CASP-3 gene by direct sequencing of genomic DNA samples from 27 healthy Koreans, and then evaluated their associations with lung cancer in a case–control study that consisted of 582 lung cancer patients and 582 healthy controls. Individuals with at least one variant allele of the −928A > G, 77G > A, and 17532A > C polymorphisms were at a significantly decreased risk for lung cancer in comparison to the carriers with each homozygous wild-type allele [adjusted odds ratio (OR) = 0.79, 95% confidence interval (CI) = 0.62–1.00, P = 0.05; adjusted OR = 0.78, 95% CI = 0.61–0.99, P = 0.04; and adjusted OR = 0.74, 95% CI = 0.58–0.95, P = 0.02, respectively]. Consistent with the results of genotyping analysis, the GAGC haplotype carrying the variant allele at all of the −928A > G, 77G > A, and 17532A > C loci was associated with a significantly decreased risk of lung cancer compared to the AGGA haplotype carrying no variant alleles at the three loci (adjusted OR = 0.66, 95% CI = 0.51–0.86, P = 0.002 and Bonferroni corrected P = 0.008). These results suggest that the CASP-3 polymorphisms and their haplotypes contribute to the genetic susceptibility to lung cancer. © 2007 Wiley-Liss, Inc.</P>