http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
송우정,Mira Choi,Dong Hun Lee,Jae-Woo Kwon,Gun-Woo Kim,Myung Hwa Kim,Mi-Ae Kim,Min-Hye Kim,Byung-Keun Kim,Sujeong Kim,Joung Soo Kim,Jung Eun Kim,Ju Young Kim,Joo Hee Kim,Hyun Jung Kim,Hye One Kim,Hyo-Bin 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.4
Chronic spontaneous urticaria (CSU) is defined as the occurrence of spontaneous wheals, angioedema, or both for >6 weeks in the absence of specific causes. It is a common condition associated with substantial disease burden both for affected individuals and societies in many countries, including Korea. CSU frequently persists for several years and requires high-intensity treatment; therefore, patients experience deteriorations in quality of life and medication-associated complications. During the last decade, there have been major advances in the pharmacological treatment of CSU and there is an outstanding need for evidence-based guidelines that reflect clinical practice in Korea. The guidelines reported here represent a joint initiative of the Korean Academy of Asthma, Allergy and Clinical Immunology and the Korean Dermatological Association, and aim to provide evidence-based guidance for the management of CSU in Korean adults and children. In Part 1, disease definition, guideline scope and development methodology as well as evidence-based recommendations on the use of antihistamines and corticosteroids are summarized.
Kim Mi-Yeong,조은정,Kim Sujeong,Kim Min-Hye,Jung Jae-Woo,Kim Joo-Hee,Moon Ji-Yong,Kwon Jae-Woo,Lee Jae-Hyun,Park Chan Sun,Jin Hyun Jung,Shin Yoo Seob,Kim Sae-Hoon,Cho Young-Joo,Park Jung-Won,Cho Sang-Heo 대한의학회 2022 Journal of Korean medical science Vol.37 No.7
Background: Some reports have suggested that the clinical and economic burdens of asthma are associated with blood eosinophil levels. The association between clinical burden and blood eosinophil counts were evaluated in a Korean adult asthma cohort. Methods: Clinical information including blood eosinophil counts that were not affected by systemic corticosteroids were extracted from the Cohort for Reality and Evolution of Adult Asthma in Korea database. Clinical burden was defined as 1) asthma control status, 2) medication demand and 3) acute exacerbation (AE) events during 1 consecutive year after enrollment. All patients were divided into atopic and non-atopic asthmatics. The associations between asthma outcomes and the blood eosinophil count were evaluated. Results: In total, 302 patients (124 atopic and 178 non-atopic asthmatics) were enrolled. In all asthmatics, the risk of severe AE was higher in patients with blood eosinophil levels < 100 cells/µL than in patients with levels ≥ 100 cells/µL (odds ratio [OR], 5.406; 95% confidence interval [CI], 1.266–23.078; adjusted P = 0.023). Among atopic asthmatics, the risk of moderate AE was higher in patients with blood eosinophil levels ≥ 300 cells/µL than in patients with levels < 300 cells/µL (OR, 3.558; 95% CI, 1.083–11.686; adjusted P = 0.036). Among non-atopic asthmatics, the risk of medication of Global Initiative for Asthma (GINA) steps 4 or 5 was higher in patients with high blood eosinophil levels than in patients with low blood eosinophil levels at cutoffs of 100, 200, 300, 400, and 500 cells/µL. Conclusion: The baseline blood eosinophil count may predict the future clinical burden of asthma.
Disparate roles of zinc in chemical hypoxia-induced neuronal death
Kim, Sujeong,Seo, Jung-Woo,Oh, Shin Bi,Kim, So Hee,Kim, Inki,Suh, Nayoung,Lee, Joo-Yong Frontiers Media S.A. 2015 Frontiers in cellular neuroscience Vol.9 No.-
<P>Accumulating evidence has provided a causative role of zinc (Zn<SUP>2+</SUP>) in neuronal death following ischemic brain injury. Using a hypoxia model of primary cultured cortical neurons with hypoxia-inducing chemicals, cobalt chloride (1 mM CoCl<SUB>2</SUB>), deferoxamine (3 mM DFX), and sodium azide (2 mM NaN<SUB>3</SUB>), we evaluated whether Zn<SUP>2+</SUP> is involved in hypoxic neuronal death. The hypoxic chemicals rapidly elicited intracellular Zn<SUP>2+</SUP> release/accumulation in viable neurons. The immediate addition of the Zn<SUP>2+</SUP> chelator, CaEDTA or N,N,N’N’-tetrakis-(2-pyridylmethyl) ethylenediamine (TPEN), prevented the intracellular Zn<SUP>2+</SUP> load and CoCl<SUB>2</SUB>-induced neuronal death, but neither 3 hour later Zn<SUP>2+</SUP> chelation nor a non-Zn<SUP>2+</SUP> chelator ZnEDTA (1 mM) demonstrated any effects. However, neither CaEDTA nor TPEN rescued neurons from cell death following DFX- or NaN<SUB>3</SUB>-induced hypoxia, whereas ZnEDTA rendered them resistant to the hypoxic injury. Instead, the immediate supplementation of Zn<SUP>2+</SUP> rescued DFX- and NaN<SUB>3</SUB>-induced neuronal death. The iron supplementation also afforded neuroprotection against DFX-induced hypoxic injury. Thus, although intracellular Zn<SUP>2+</SUP> release/accumulation is common during chemical hypoxia, Zn<SUP>2+</SUP> might differently influence the subsequent fate of neurons; it appears to play a neurotoxic or neuroprotective role depending on the hypoxic chemical used. These results also suggest that different hypoxic chemicals may induce neuronal death via distinct mechanisms.</P>
Tribological Behavior of Whiteware with Different Transparent Glazes
Heo, Sujeong,Kim, Soomin,Kim, Ungsoo,Pee, Jaehwan,Han, Yoonsoo,Kim, Seongwon,Lee, Sungmin,Kim, Hyungtae,Oh, Yoonsuk The Korean Ceramic Society 2015 한국세라믹학회지 Vol.52 No.3
Tribological properties of whiteware with various transparent glazes, which have different composition and microstructure, were investigated. The wear resistance and friction behavior of the glazed whiteware are a very important aspect if the whiteware is used as tableware and for sanitation purposes. Generally, the wear property is influenced by the microstructure and surface morphology of the material. The whiteware specimens with two kinds of transparent glazes were fabricated by using the commercially available porcelain body. Furthermore, the commercial tableware, such as bone china, and traditional tableware were also examined as reference materials. All of the specimens showed that different pore structures might affect the mechanical and tribological properties. It seems that the wear resistance of whiteware is substantially related to the pore size and distribution of glaze rather than the hardness value of the specimen.