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A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130
Hong, Soon-Sun,Choi, Jung Ho,Lee, Sung Yoon,Park, Yeon-Hwa,Park, Kyung-Yeon,Lee, Joo Young,Kim, Juyoung,Gajulapati, Veeraswamy,Goo, Ja-Il,Singh, Sarbjit,Lee, Kyeong,Kim, Young-Kook,Im, So Hee,Ahn, Sun The American Association of Immunologists, Inc. 2015 JOURNAL OF IMMUNOLOGY Vol.195 No.1
<P>IL-6 is a major causative factor of inflammatory disease. Although IL-6 and its signaling pathways are promising targets, orally available small-molecule drugs specific for IL-6 have not been developed. To discover IL-6 antagonists, we screened our in-house chemical library and identified-LMT-28, a novel synthetic compound, as a candidate IL-6 blocker. The activity, mechanism of action, and direct molecular target of LMT-28 were investigated. A reporter gene assay showed that LMT-28 suppressed activation of STAT3 induced by IL-6, but not activation induced by leukemia inhibitory factor. In addition, LMT-28 downregulated IL-6-stimulated phosphorylation of STAT3, gp130, and JAK2 protein and substantially inhibited IL-6-dependent TF-1 cell proliferation. LMT-28 antagonized IL-6-induced TNF-alpha production in vivo. In pathologic models, oral administration of LMT-28 alleviated collagen-induced arthritis and acute pancreatitis in mice. Based on the observation of upstream IL-6 signal inhibition by LMT-28, we hypothesized IL-6, IL-6R alpha, or gp130 to be putative molecular targets. We subsequently demonstrated direct interaction of LMT-28 with gp130 and specific reduction of IL-6/IL-6R alpha complex binding to gp130 in the presence of LMT-28, which was measured by surface plasmon resonance analysis. Taken together, our data suggest that LMT-28 is a novel synthetic IL-6 inhibitor that functions through direct binding to gp130.</P>
Physical Nature of Biodegradable Polydioxanone Filaments upon Synthetic Conditions
Sang Sun Choi(최상선),Joon Hyuk Lee(이준혁),Soon Hong Lee(이순홍) 한국고분자학회 2020 폴리머 Vol.44 No.4
의학분야에서 polydioxanone(PDO)는 생체 안전성, 생분해도 및 기계적 강성의 이점으로 인해 기초적 및 실용적 연구 분야에서 큰 관심을 받고 있다. 선행연구 결과에서 PDO의 생화학적 구조는 증명되었으나, 단계별 제조조건 중 촉매와 세척 간 상관관계가 PDO의 물리적 특성에 미치는 영향에 대한 연구는 미미한 실정이다. 따라서 본 연구에서는 PDO의 촉매와 세척의 변화에 따른 물리적 강성 및 생분해도의 변화를 추적하였다. 샘플 중 가장 많은 ppm의 촉매(30 ppm)와 진공세척시간(3시간)을 도입한 PDO-3-30 샘플은 물리적 특성에서 가장 우수한 결과를 도출하였으나, 열역학 및 생분해도에서는 타 샘플대비 상대적으로 낮은 결과를 드러냈다. 모든 샘플의 특성을 비교하였을 때, 촉매의 양은 중합에서 가장 중요한 역할을 한다. 여기에서, 세척등급 또한 보다 세밀한 PDO 필라멘트의 물리적 특성을 제어할 수 있는 보조조건이 될 수 있다. In the medical field, polydioxanone (PDO) has increasingly attracted scientific interests in both fundamental research and applications for synthesizing sutures due to its safety, biodegradability, and mechanical strength. Chemical pathways of the aforementioned architecture have already been proven via a plethora of multidisciplinary researches, however, the physical nature of PDO filaments by each stage of the synthetic condition has yet been solely observed in detail. The scope of the present study tracks a couple of pre- and post-fiberation to tailor the success in tunable physical strength with the variance of purification time and the dosage of a catalyst. We first fabricated PDO filaments using lauryl alcohol (C12H26O) and stannous octoate (C16H30O₄Sn) as an initiator and a catalyst, respectively. PDO-3-30 with 3 h of vacuum purification and 30 ppm dosage of a catalyst led to unfavorable thermal properties and degradability but an increase in physical properties including tensile, flexural, and Izod impact strengths. From thermal and physical profiles, it was confirmed that the amount of a catalyst is a major driving factor of polymerization while the degree of purification could be an additive aid for more sensitive control of the physical nature of PDO filaments.
Comparative Study on Efficiencies of Naturally-Ventilated Multi-Span Greenhouses in Korea
Soon-Hong Kwon(권순홍),Sung-Won Jung(정성원),Soon-Gu Kwon(권순구),Jong-Min Park(박종민),Won-Sik Choi(최원식),Jong-Soon Kim(김종순) 한국산업융합학회 2017 한국산업융합학회 논문집 Vol.20 No.1
This research analyzed the ventilation effect of the multi-span greenhouse based on the types of greenhouse structure, weather conditions, and locations inside the greenhouse. To compare and analyze the ventilation effects with different types of greenhouse, the uniform environmental conditions should be selected in advance. But these factors are not controlled and require tense many precision facilities and labor forces. Thus, the CFD simulation was used for the air stream to be analyzed qualitatively and quantitatively. In addition, for the ventilation effect analysis, the TGD (Tracer Gas Decay) was used to overcome the shortcomings of the current ventilation measurement method. The calculation error of ventilation rate using TGD was low (10.5%). Thus, the TGD is very effective in calculating the ventilation efficiency. The wind direction of 90 degrees showed the best ventilation effect. The ventilation rate also decreased along the air circulation path, and the rate was the lowest around the outlet. The computed fluid method (CFD) turned out to be a power tool for simulating flow behavior in greenhouse.