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조강희,유재욱,김봉옥,윤승호 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2
Fall-related accidents account for more than 800,000 injuries and 13,000 fatalities a year in North Americain. And also it is estimated that one-third of all persons 60 years old and older suffer falls each year. The Balance and posture are affected by vision, vestibular system and somatosensory system(proprioception). Three influences related to the older population's risk of falling are normal aging progress, pathology that increases with age and environmental conditions. In this study, to understand the effect of various environmental conditions on kinetic characteristics of initiation of gait and standing posture, vertical ground reaction forces(VGRF), center of pressurc(COP), postural analysis and psychologic index were evaluated in 20 men with no history of neuromusculoskeletal abnormality. The results are 1) VGRF according to various environmental conditions are not significant change. 2) Temporal analysis of IOG according to carpet and wood floor are significantly slowed in wooden floor. 3) Temporal analysis of IOG with or without shoes are not significnat change. 4) The effects of illumination to balance increased maximal oscillation by decreased of illumination
Ryu, Seung-Wook,Choi, Kyungsun,Park, Jong-Hwan,Park, Yeong-Min,Kim, Sunchang,Choi, Chulhee Elsevier 2012 Cancer letters Vol.323 No.1
<P><B>Abstract</B></P> <P>Mitochondrial fusion and fission are dynamically regulated during apoptotic cell death, and mitofusin (Mfn) and related proteins have been shown to be involved in apoptosis-associated changes in mitochondrial morphology and function. Here, we investigated the involvement of Mfn proteins in the conformational activation and mitochondrial translocation of Bax, a key molecule responsible for apoptosis-associated mitochondrial changes. When ectopically expressed, Mfn1 inhibited the amino-terminal activation, but not the mitochondrial translocation, of Bax during staurosporine-induced apoptosis; overexpression of Mfn2 had no effect. Overexpression of Mfn1 mutants carrying point mutations in the GTPase domain (Mfn1-K88T and Mfn1-T109A) did not inhibit the amino-terminal activation of Bax. Furthermore, staurosporine-induced amino-terminal activation of Bax was significantly delayed in Mfn1-shRNA transfected (Mfn1-depleted) HeLa cells compared to cells transfected with control shRNA. These results collectively suggest a role for Mfn1 in regulating the activation of Bax on the outer mitochondrial membrane in a GTPase-dependent manner.</P>
Thermal Stability of SiO_2 Doped Ge_2Sb_2Te5 for Application in Phase Change Random Access Memory
Seung Wook Ryu,Young Bae Ahn,Jong Ho Lee,김형준 대한전자공학회 2011 Journal of semiconductor technology and science Vol.11 No.3
Thermal stability of Ge2Sb2Te5 (GST) and SiO2 doped GST (SGST) films for phase change random access memory applications was investigated by observing the change of surface roughness, layer density and composition of both films after isothermal annealing. After both GST and SGST films were annealed at 325 oC for 20 min, root mean square (RMS) surface roughness of GST was increased from 1.9 to 35.9 nm but that of SGST was almost unchanged. Layer density of GST also steeply decreased from 72.48 to 68.98 g/cm^2 and composition was largely varied from Ge : Sb : Te = 22.3 : 22.1 :55.6 to 24.2 : 22.7 : 53.1, while those of SGST were almost unchanged. It was confirmed that the addition of a small amount of SiO_2 into GST film restricted the deterioration of physical and chemical properties of GST film, resulting in the better thermal stability after isothermal annealing.
Ryu, Seung-Wook,Han, Eun Chun,Yoon, Jonghee,Choi, Chulhee Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.1
The shape and activity of mitochondria are tightly regulated by fusion and fission processes that are essential for maintaining normal cellular function. However, little is known about the involvement of mitochondrial dynamics in the development of the immune system. In this study, we demonstrate that mitochondrial dynamics play a role in the differentiation and migration of immature dendritic cells (imDCs). We show that mitochondrial elongation is induced during GM-CSF-stimulated differentiation of bone marrow progenitors to imDCs accompanied by upregulation of mitochondrial fusion proteins. These processes precede the changes in mitochondrial morphology and connectivity that occur during differentiation. Mfn2 and OPA1, but not Mfn1, are transcriptionally upregulated during differentiation; however, knockdown of Mfn2 and OPA1 does not induce any change in expression of CD11c, CDC80, or CD86. Notably, knockdown of Mfn2 or OPA1 by siRNA in imDCs significantly reduces CCR7 expression and CCL19-mediated migration. These results suggest that the mitochondrial fusion-related proteins Mfn2 and OPA1 are upregulated during bone marrow progenitor differentiation and promote the migration of imDCs by regulating the expression of CCR7.
Ryu, Seung-Wook,Ahn, Young-Bae,Lee, Jong-Ho,Kim, Hyeong-Joon The Institute of Electronics and Information Engin 2011 Journal of semiconductor technology and science Vol.11 No.3
Thermal stability of $Ge_2Sb_2Te_5$ (GST) and $SiO_2$ doped GST (SGST) films for phase change random access memory applications was investigated by observing the change of surface roughness, layer density and composition of both films after isothermal annealing. After both GST and SGST films were annealed at $325^{\circ}C$ for 20 min, root mean square (RMS) surface roughness of GST was increased from 1.9 to 35.9 nm but that of SGST was almost unchanged. Layer density of GST also steeply decreased from 72.48 to 68.98 $g/cm^2$ and composition was largely varied from Ge : Sb : Te = 22.3 : 22.1 : 55.6 to 24.2 : 22.7 : 53.1, while those of SGST were almost unchanged. It was confirmed that the addition of a small amount of $SiO_2$ into GST film restricted the deterioration of physical and chemical properties of GST film, resulting in the better thermal stability after isothermal annealing.
Ryu, Seung Wook,Lyeo, Ho-Ki,Lee, Jong Ho,Ahn, Young Bae,Kim, Gun Hwan,Kim, Choon Hwan,Kim, Soo Gil,Lee, Se-Ho,Kim, Ka Young,Kim, Jong Hyeop,Kim, Won,Hwang, Cheol Seong,Kim, Hyeong Joon IOP Pub 2011 Nanotechnology Vol.22 No.25
<P>This study examined the various physical, structural and electrical properties of SiO<SUB>2</SUB> doped Ge<SUB>2</SUB>Sb<SUB>2</SUB>Te<SUB>5</SUB> (SGST) films for phase change random access memory applications. Interestingly, SGST had a layered structure (LS) resulting from the inhomogeneous distribution of SiO<SUB>2</SUB> after annealing. The physical parameters able to affect the reset current of phase change memory (<I>I</I><SUB>res</SUB>) were predicted from the Joule heating and heat conservation equations. When SiO<SUB>2</SUB> was doped into GST, thermal conductivity largely decreased by ∼ 55%. The influence of SiO<SUB>2</SUB>-doping on <I>I</I><SUB>res</SUB> was examined using the test phase change memory cell. <I>I</I><SUB>res</SUB> was reduced by ∼ 45%. An electro-thermal simulation showed that the reduced thermal conductivity contributes to the improvement of cell efficiency as well as the reduction of <I>I</I><SUB>res</SUB>, while the increased dynamic resistance contributes only to the latter. The formation and presence of the LS thermal conductivity in the set state test cell after repeated switching was confirmed. </P>