Graves 병과 혈청 면역글로불린-E의 연관성

김현영,박기룡,김성훈,김지연,송수근,최영식,박요한 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.5

연구배경: Graves 병은 미만성 갑상선종, 갑상선기능한진, 안구침법 등을 특징으로 하는 자가면역성 질환으로, 갑상선자극호르몬 수용체에 대한 자가항체(TRAb)가 갑상선을 자극하여 발생된다. TRAb는 Graves병 환자의 약 85%이상에서 검출되며 활성화된 TRAb는 대부분 IgE로 알려져 있다. 그러나 최근 Graves병 환자의 갑상선조직과 안구조직에 IgE의 침착과 꽃가루 등에 의한 알레르기성 비염으로 인해 Graves병이 발생하거나 재발된 견우가 보고되어 Graves병의 병인에 IgE의 연관성이 제기 되고 있으나, 국내에서는 이에 대한 연구가 드물다. 본 연구에서는 Graves병에서의 혈청 IgE농도와 Graves병의 병기와의 관계 및 TRAb와 IgE 농도와의 연관성을 살펴보고자 하였다. 대상 및 방법 : 2000년 4월 1일부터 7월 1일까지 고신의료원 내분비내과를 방문한 환자 중 Graves병 46예, 만성갑상선염 6예 및 고신의료원 건강증진센터를 방문한 환자 중 갑상선질환의 병력이나 가족력 및 알레르기성 비염의 병력이 없는 35예의 정상대조군을 대상으로 연구를 시행하였다. TRAb는 갑상선자극호르몬 결합 억제 면역글로불린(TBII)으로 측정하였으며, IgE는 효소면역분석법으로 측정하였다. 결과: IgG인 TBII는 Graves병에서 만성갑상선염과 대조군에 비해 높았으며, IgE 평균농도는 Graves병에서 598.1±1112.9U/mL로 만성갑상선염 환자의 98350±79.7U/mL, 대조군 161.72±194.4U/mL에 비해 높았다(p<0.05). Graves병에서 알레르기성 비염의 발병율은 10.9%(5/46)였으며, Graves 병에서의 혈청 IgE 농도는 알레르기성 비염의 병력이 있는 경우 903.1±1152.2U/mL로 없는 경우 560.8±1117.0U/mL보다 높은 경향을 보였다. Graves병의 병기에 따른 TBII와 IgE 농도의 변화를 항갑상선제로 치료하지 않은 군(비치료군)과 치료한 군(치료군) 및 재발군으로 나누어 비교하였을 때, TBII는 치료군(7.4±18.6%)에 비해 비치료군(49.9±23.9%)과 재발군(21.1±3.1%)에서 높았으며(p<0.05), 혈청 IgE치도 치료군(233.8±432.7U/mL)에 비해 비치료군(758.6±1250.0U/mL)과 재발군(1198.5±1952.1U/mL)에서 높은 경향을 보였다. 항갑상선제로 치료한 치료기간에 따른 TBII와 IgE 농도 변화에서, TBII는 비치료군(49.9±23.9%)과 1년 미만 치료군(24.8±3.8%)에서 1년 이상 치료군(2.22±1.97%)에 비해 높았으며(p<0.05), 혈청 IgE 농도는 비치료군(758.6±1250.2U/mL)에서 1년 미만 치료한 군(158.3±91.5U/mL)과 1년 이상 치료군(252.7±483.4U/mL)에 비해 높았으나 유의하지는 않았다. 결론: Graves 병에서 IgE 농도는 증가되어 있었으며, Graves 병의 각각 다른 병기에서의 혈청 IgE 농도의 변화는 Graves qudd의 경과에 영향을 미치는 IgG인 TBII치의 변화와 유사한 경향을 보였다. 그러나 혈청 IgE와 Graves 병과의 연관성을 알아보기 위해서 IgE와 더불어 CD23항원 등의 다른 검사도 병행하는 전향적 연구가 필요할 것으로 생각된다. Background: It is widely believed that Graves' disease is and autoimmune disorder characterized by the presence of the circulation TSH receptor antibody (TRAb). The majority of the activity of TRAb is of the immunoglobulin G(IgG) class. However, other immunoglobulin such as immunoglobulin E(IgE), may play a rloe in the activity. IgE accumulation has been reported to occur in the thyroid gland and ocular muscles of subjects with Graves' disease. Furthermore, it has been noted that recurrence of Graves' disease can be induced by and allergy to pollen. Because an allergy to pollen is commonly associated with IgE, IgE might play a role in the induction of Graves' disease. Therefore, investigated whether IgE was elevated in Graves' disease, and evaluated the potential relationship between the levels of TRAb and IgE Graves' disease. Methods: Forty-six patients with Graves' disease, and 6 with chronic thyroiditis, diagnosed at the Kosin Medical Center between April, 2000 and July, 2000 were included in this study. Thirty-five persons without thyroid disease or a history of allergic rhinitis were used as normal controls. The level or TRAb was measured using thyrotropin binding inhibitory immunoglobulin (TBII). Serum total IgE was measured using as enzymeimmunoassay method. Test for thyroid function, TBII and total IgE were performed in all cases, and the results statistically analyzed. Results: TBII, as IgG, and the serum IgE level were higher in the patients with Graves' disease, and the levels of the latter were 598.1±1112.9U/mL, 98.5±79.7U/mL and controls 161.7±194.4U/mL in the Graves' patients, those with thyroiditis and the controls, respectively (p<0.05). The prevalence of allergic rhinitis in Graves' disease was 10.9%. The serum IgE level in Graves' disease with, and without, allergic rhinitis were 903.1±1152.2U/mL and 560.8±1117.0U/mL, respectively, although there was no significancant difference between the two groups. According to the clinical stage, the serum TBII level was higher in the untreated Graves', and relapsed patients 49.9±23.9% and 21.1±3.1%, respectively, than in the treated group, 7.4±18.6% (p<0.05). The serum IgE level was higher in the untreated Graves' and relapsed patients 758.6±1250.2U/mL and 1198.5±1952.1U/mL, respectively, than in the treated group 233.8±432.7U/mL, although this was not significant. According to the duration of treatment, the serum TBII levels were higher in the untreated Graves' patients, and those treated for less than 1 year, than in those treated for more than 1 year, with values of 49.9±23.9, 24.8±3.8 and 2.22±1.97%, respectively (p<.05). The serum IgE level was higher in the untreated Graves' disease (758.6±1250.2U/mL) than in the groups treated for less than 12 months (158.3±91.5U/mL) and more than 12 months (252.7±483.4U/mL), but the differences were not significant. Conclusions: The concentration of IgE was high in Graves' patients, and although not statistically significant, the serum igE level in Graves' patients with allergic rhinitis was higher than those without. With regard to the clinical stage of Grave's disease, the change in the IgE level tended to follow that of the TBII. Further study will be required to define the possible role of IgE in the pathogenesis in Graves' disease (J Kor Soc Endocrinol 17:640∼648, 2002).

부유식 구조물의 동위치제어에 관한 연구(Ⅰ)

김성근(Kim Seoung-Gun),유휘룡(Yoo Hui-Ryong),김상봉(Kim Sang-Bong) 한국해양공학회 1993 韓國海洋工學會誌 Vol.7 No.2

A design method of DPS control algorithm for adopting rotable thruster is introduced by applying a servo system design method and the control algorithm is evaluated on the basis of the results of computer simulations performed for a semi-submersible 2-lower hull 8-column type platform. It is observed from the simulation results that position error due to the irregular drifting forces becomes zero after very short regulating time and dynamic positioning system is robust in spite of random disturbance.

Protective effects of sodium para-amino salicylate on manganese-induced neuronal death: the involvement of reactive oxygen species.

Yoon, Hyonok,Kim, Do-Sung,Lee, Geum-Hwa,Kim, Ji Ye,Kim, Diana H,Kim, Kee-Won,Chae, Soo-Wan,You, Wan-Hee,Lee, Yong Chul,Park, Seoung Ju,Kim, Hyung-Ryong,Chae, Han-Jung Pharmaceutical Society of Great Britain 2009 Journal of pharmacy and pharmacology Vol.61 No.11

<P>OBJECTIVES: This study tested whether sodium para-amino salicylic dihydrate, an antibacterial drug for tuberculosis, could block manganese-induced apoptosis in SK-N-MC neurons. METHODS: Cell viability, Hoechst staining, dichlorofluorescin diacetate analysis for reactive oxygen species measurement, and immunoblotting were performed. KEY FINDINGS: In vitro, manganese chloride significantly decreased the viability of SK-N-MC cells, accompanied by apoptotic features such as changes in nuclear morphology. Sodium para-amino salicylic dihydrate inhibited these apoptotic characteristics through reducing intracellular reactive oxygen species generation, protecting mitochondrial membrane potential and caspase-3 activation. CONCLUSIONS: Sodium para-amino salicylic dihydrate inhibits manganese-induced apoptosis in neurons and may reduce manganese-mediated neurodegeneration.</P>

Development of the Caliper System for a Geometry PIG Based on Magnetic Field Analysis

Kim, Dong-Kyu,Cho, Sung-Ho,Park, Seoung-Soo,Yoo, Hui-Ryong,Park, Yong-Woo,Kho, Young-Tai,Park, Gwan-Soo,Park, Sang-Ho The Korean Society of Mechanical Engineers 2003 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.17 No.12

This paper introduces the development of the caliper system for a geometry PIG (Pipeline Inspection Gauge). The objective of the caliper system is to detect and measure dents, wrinkles, and ovalities affect the pipe structural integrity. The developed caliper system consists of a finger arm, an anisotropic permanent magnet, a back yoke, pins, pinholes and a linear hall effect sensor. The angle displacement of the finger arm is measured by the change of the magnetic field in sensing module. Therefore the sensitivity of the caliper system mainly depends on the magnitude of the magnetic field inside the sensing module. In this research, the ring shaped anisotropic permanent magnet and linear hall effect sensors were used to produce and measure the magnetic field. The structure of the permanent magnet, the back yoke and pinhole positions were optimized that the magnitude of the magnetic field range between a high of 0.1020 Tesla and a low of zero by using three dimensional nonlinear finite element methods. A simulator was fabricated to prove the effectiveness of the developed caliper system and the computational scheme using the finite element method. The experimental results show that the developed caliper system is quite efficient for the geometry PIG with good performance.

Design and Implementation of 30" Geometry PIG

Kim, Dong-Kyu,Cho, Sung-Ho,Park, Seoung-Soo,Yoo, Hui-Ryong,Park, Yong-Woo The Korean Society of Mechanical Engineers 2003 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.17 No.5

This paper introduces the developed geometry PIG (Pipeline Inspection Gauge), one of several ILI (In-Line Inspection) tools, which provide a full picture of the pipeline from only single pass, and has compact size of the electronic device with not only low power consumption but also rapid response of sensors such as calipers, IMU and odometer. This tool is equipped with the several sensor systems. Caliper sensors measure the pipeline internal diameter, ovality and dent size and shape with high accuracy. The IMU (Inertial Measurement Unit) measures the precise trajectory of the PIG during its traverse of the pipeline. The IMU also provide three-dimensional coordination in space from measurement of inertial acceleration and angular rate. Three odometers mounted on the PIG body provide the distance moved along the line and instantaneous velocity during the PIG run. The datum measured by the sensor systems are stored in on-board solid state memory and magnetic tape devices. There is an electromagnetic transmitter at the back end of the tool, the transmitter enables the inspection operators to keep tracking the tool while it travels through the pipeline. An experiment was fulfilled in pull-rig facility and was adopted from Incheon LT (LNG Terminal) to Namdong GS (Governor Station) line, 13 km length.

Verification of the Theoretical Model for Analyzing Dynamic Behavior of the PIG from Actual Pigging

Kim, Dong-Kyu,Cho, Sung-Ho,Park, Seoung-Soo,Park, Yong-Woo,Yoo, Hui-Ryong,Nguyen, Tan-Tien,Kim, Sang-Bong The Korean Society of Mechanical Engineers 2003 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.17 No.9

This paper deals with verification of the theoretical model for dynamic behavior of Pipeline Inspection Gauge (PIG) traveling through high pressure natural gas pipeline. The dynamic behavior of the PIG depends on the differential pressure across its body. This differential pressure is generated by injected gas flow behind the tail of the PIG and expelled gas flow in front of its nose. To analyze the dynamic behavior characteristics such as gas flow in pipeline, and the PIG position and velocity, not only the mathematical models are derived, but also the theoretical models must be certified by actual pigging experiment. But there is not any found results of research on the experimental certification for dynamic behavior of the PIG. The reason is why the fabrication of the PIG as well as, a field application are very difficult. In this research, the effectiveness of the introduced solution using the method of characteristics (MOC) was certified through field application. In-line inspection tool, 30" geometry PIG, was fabricated and actual pigging was carried out at the pipeline segment in Korea Gas Corporation (KOGAS) high pressure system, Incheon LT (LNG Terminal) -Namdong GS (Governor Station) line. Pigging is fulfilled successfully. Comparison of simulation results with experimental results show that the derived mathematical models and the proposed computational schemes are effective for predicting the position and velocity of the PIG with a given operational conditions of pipeline.

AUV의 궤적제어에 관한 연구

유휘룡(Hui-ryong Yoo),김성근(Seoung-gun Kim),김상봉(Sang-bong Kim) 한국해양공학회 1994 韓國海洋工學會誌 Vol.8 No.2

This paper presents a design method of multivariable robust servo system for tracking control system for AUV(Autonomous Underwater Vehicle). In order to obtain the basic data for the design of the tracking control system, the control algorithm is evaluated in the view of computer simulation results. The tracking control is carried out for an AUV with 2 main thrusters, 2 side thrusters and 2 thrusters for the movement to up-down direction.<br/> The results of computer simulation show that the proposed multivariable servo system design method is an efficient method for the control performance of tracking control system of AUV under severe underwater environment.

Sy-8 Photo Resist를 이용한 100 ㎛ 두께의 인덕터 제조

류성룡(Sung-Ryong Ryu),배석(Seok Bae),남승의(Seoung-Eui Nam),김형준(Hyoung-June Kim),김현식(Hyun-Sik Kim),송재성(Jae-Sung Song) 한국자기학회 2001 한국자기학회 학술연구발표회 논문개요집 Vol.11 No.1

Verification of the Theoretical Model for Analyzing Dynamic Behavior of the PIG from Actual Pigging

Dong Kyu Kim,Sung Ho Cho,Seoung Soo Park,Yong Woo Rho,Hui Ryong Yoo,Tan Tien Nguyen,Sang Bong Kim 대한기계학회 2003 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.17 No.9

This paper deals with verification of the theoretical model for dynamic behavior of Pipeline Inspection Gauge (PIG) traveling through high pressure natural gas pipeline. The dynamic behavior of the PIG depends on the differential pressure across its body. This differential pressure is generated by injected gas flow behind the tail of the PIG and expelled gas flow in front of its nose. To analyze the dynamic behavior characteristics such as gas flow in pipeline, and the PIG position and velocity. not only the mathematical models are derived, but also the theoretical models must be certified by actual pigging experiment. But there is not any found results of research on the experimental certification for dynamic behavior of the PIG. The reason is why the fabrication of the PIG as well as, a field application are very difficult. In this research, the effectiveness of the introduced solution using the method of characteristics (MOC) was certified through field application. In-line inspection tool, 30" geometry PIG. was fabricated and actual pigging was carried out at the pipeline segment in Korea Gas Corporation (KOGAS) high pressure system. Incheon LT (LNG Terminal)-Namdong GS(Governor Sta­tion) line. Pigging is fulfilled successfully. Comparison of simulation results with experimental results show that the derived mathematical models and the proposed computational schemes are effective for predicting the position and velocity of the PIG with a given operational conditions of pipeline.

Development of a Geometry PIG for the Inspection of Natural Gas Pipeline and It’s application

Dong-Kyu Kim,Sung-Ho Cho,Seoung-Soo Park,Dae-Jin Park,Sung-Ja Koo,Hui-Ryong Yoo,Yong-Woo Rho,Young-Tai Kho 제어로봇시스템학회 2001 제어로봇시스템학회 국제학술대회 논문집 Vol.2001 No.10