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Sim, Se-Hoon,Yeom, Ji-Hyun,Shin, Choy,Song, Woo-Seok,Shin, Eunkyoung,Kim, Hong-Man,Cha, Chang-Jun,Han, Seung Hyun,Ha, Nam-Chul,Kim, Si Wouk,Hahn, Yoonsoo,Bae, Jeehyeon,Lee, Kangseok Blackwell Publishing Ltd 2010 Molecular microbiology Vol.75 No.2
<P>Summary</P><P>During the course of experiments aimed at identifying genes with ribonuclease III (RNase III)-dependent expression in <I>Escherichia coli</I>, we found that steady state levels of <I>bdm</I> mRNA were dependent on cellular concentrations of RNase III. The half-lives of adventitiously overexpressed <I>bdm</I> mRNA and the activities of a transcriptional <I>bdm‘–’cat</I> fusion were observed to be dependent on cellular concentrations of RNase III, indicating the existence of <I>cis</I>-acting elements in <I>bdm</I> mRNA responsive to RNase III. <I>In vitro</I> and <I>in vivo</I> cleavage analyses of <I>bdm</I> mRNA identified two RNase III cleavage motifs, one in the 5′-untranslated region and the other in the coding region of <I>bdm</I> mRNA, and indicated that RNase III cleavages in the coding region constitute a rate-determining step for <I>bdm</I> mRNA degradation. We also discovered that downregulation of the ribonucleolytic activity of RNase III is required for the sustained elevation of RcsB-induced <I>bdm</I> mRNA levels during osmotic stress and that cells overexpressing <I>bdm</I> form biofilms more efficiently. These findings indicate that the Rcs signalling system has an additional regulatory pathway that functions to modulate <I>bdm</I> expression and consequently, adapt <I>E. coli</I> cells to osmotic stress.</P>
Sim, Sung Hoon,Beom, Seung‐,Hoon,Ahn, Yong‐,Oon,Keam, Bhumsuk,Kim, Tae Min,Lee, Se‐,Hoon,Kim, Dong‐,Wan,Heo, Dae Seog Wiley-Blackwells 2016 Thoracic cancer Vol.7 No.2
<P><B>Abstract</B></P><P><B>Background</B></P><P>The neutrophil‐lymphocyte ratio (NLR) is a marker of poor prognosis in lung cancer patients. However, previous data have been based on an heterogeneous population of lung cancer patients and various treatments. In this study, we evaluate the prognostic value of NLR in an homogeneous population of epidermal growth factor receptor (EGFR)‐mutant non‐small cell lung cancer (NSCLC) patients.</P><P><B>Methods</B></P><P>We restrospectively evaluated the data of 250 NSCLC patients with EGFR mutations. All data are based on first‐line treatment.</P><P><B>Results</B></P><P>All tumors harbored in‐frame deletions in exon 19 or an L858R point mutation. Eighty‐five patients were treated with tyrosine kinase inhibitors (TKIs), while 165 received cytotoxic chemotherapy as first‐line treatment. Multivariate survival analysis revealed that the NLR was a significant prognostic factor for first‐line progression‐free survival (PFS) in the chemotherapy group (hazard ratio [HR] 1.882, 95% confidence interval [CI] 1.319–2.686, <I>P</I> = 0.001), but was not significant in the TKI group (HR 1.239, 95% CI 0.693–2.215, <I>P</I> = 0.469). The response rate (RR) to first‐line treatment was 76.5% in the TKI group and 29.5% in the chemotherapy group; however, the RR, according to the NLR (≤3 vs. > 3), was the same for both groups.</P><P><B>Conclusions</B></P><P>The NLR was a significant prognostic factor in the chemotherapy group, but it did not affect either RR or PFS in EGFR‐mutant NSCLC patients treated with TKIs.</P>
Application of Cancer Genomics to Solve Unmet Clinical Needs
Lee, Se-Hoon,Sim, Sung Hoon,Kim, Ji-Yeon,Cha, SooJin,Song, Ahnah Korea Genome Organization 2013 Genomics & informatics Vol.11 No.4
The large amount of data on cancer genome research has contributed to our understanding of cancer biology. Indeed, the genomics approach has a strong advantage for analyzing multi-factorial and complicated problems, such as cancer. It is time to think about the actual usage of cancer genomics in the clinical field. The clinical cancer field has lots of unmet needs in the management of cancer patients, which has been defined in the pre-genomic era. Unmet clinical needs are not well known to bioinformaticians and even non-clinician cancer scientists. A personalized approach in the clinical field will bring potential additional challenges to cancer genomics, because most data to now have been population-based rather than individualbased. We can maximize the use of cancer genomics in the clinical field if cancer scientists, bioinformaticians, and clinicians think and work together in solving unmet clinical needs. In this review, we present one imaginary case of a cancer patient, with which we can think about unmet clinical needs to solve with cancer genomics in the diagnosis, prediction of prognosis, monitoring the status of cancer, and personalized treatment decision.
심성훈 ( Sung Hoon Sim ),김희준 ( Hee Jun Kim ),김미정 ( Mi Jung Kim ),차용준 ( Yong Jun Cha ),이윤수 ( Yoon Su Lee ),임규형 ( Kyu Hyoung Lim ),이세훈 ( Se Hoon Lee ) 대한내과학회 2009 대한내과학회지 Vol.77 No.2
저자들은 갑상선에서 발생한 소세포암의 증례 2예를 경험하여 문헌과 함께 고찰하는 바이다. Historically, small cell carcinoma in the thyroid has been regarded as a kind of lymphoma and small cell carcinoma in the thyroid as a distinct disease entity is still controversial. Here, we present two cases of thyroid small cell carcinoma that were differentiated from lymphoma, based on immunohistochemical staining. One case was misdiagnosed as anaplastic carcinoma that occurred during the treatment of follicular carcinoma. Both cases responded well to chemotherapy. These cases support the hypothesis that thyroid small cell carcinoma is a distinct disease entity. One should consider small cell carcinoma when there is a rapidly growing mass in the thyroid. (Korean J 77:241-245, 2009)
A Study of Diary Management System for Mushroom Cultivation Data Analysis
Se-Hoon Jung,Kyung-Jong Kim,Jong-Chan Kim,Chun-Bo Sim 한국정보통신학회 2017 2016 INTERNATIONAL CONFERENCE Vol.9 No.1
A new mushroom cultivation diary system based on objective environment IoT with analysis data is suggested to improve the previous system based on subjective data of cultivators. The proposed system is designed by applying object oriented modeling called mini-architecture to enhance reliability of software as well as promote stability of overall system design. The temperature and humidity sensor for the environment sensor data are used to develop the new reliable diary. Also, an active interface based on Web and Android as the user GUI are used to maximize the convenience when recording the cultivation diary.
Se-Hoon Jung,Jong Chan Kim,Hong Joon Park,Won Ho So,Chun-Bo Sim 한국정보통신학회 2015 2016 INTERNATIONAL CONFERENCE Vol.7 No.1
Today the world is flooded by the exponential growth of data, and active research efforts are made on predictive analysis processes to categorize and analyze data. Sample variables under certain situations to predict data, however, have huge influences on prediction performance according to the selection methods and sample numbers. This study thus set out to propose a high-order data classification and analysis process to test extracted sample data to enhance the consistency and reliability of sample data and designed a prediction process for risk classification areas with R based on risk area information.
In Vitro Selection of Hammerhead Ribozymes with Optimized Stems I and III
Sim, So-Yeong,Kim, Se-Mi,Kim, Ha-Dong,Ahn, Jeong-Keun,Lee, Young-Hoon,Cho, Bong-Rae,Park, In-Won Korean Society for Biochemistry and Molecular Biol 1998 Journal of biochemistry and molecular biology Vol.31 No.2
A pool of cis-acting hammerhead ribozymes randomized in their substrate recognition sequences was constructed. A variety of active cis-acting ribozymes which had various structures of stems I and III was selected from the pool by in vitro selection. The selected ribozymes were cloned and sequenced. The relationship between the cleavage efficiency and base-pairing in stems I and III of the selected ribozymes was investigated. The ribozymes with the smaller difference in folding energies between the active conformation and the stable but inactive conformation showed a tendency to have the better cleavage efficiency. The optimum length of stem I was 5 or 6 bases while the longer stem III, in general, appeared to be required for efficient cleavage. The specificity of the ribozyme reaction is discussed in terms of the length of stems I and III.