우리나라 일부 석면사업장의 석면폐 유병률

백도명,백남원,최정근,손미아,임정기,이원진,문영한,박정선,최병순 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

Asbestos industry has been in operation over 60 years in Korea. However, the prevalence of asbestosis has not been yet reported. With rapid turn-over of workers, previous cross-sectional studies of current workers on the job could not find cases with exposures long enough for the development of asbestosis. This study was done to evaluate asbestosis prevalence of those worksites with operation history of more than 20 years. In total, 139 workers from 5 worksites were examined. Asbestos industries covered in the study include 2 asbestos textile, 1 brake lining, and 2 ship repairing worksites. Chest x-ray was taken from all workers and read by two experts familiar with pneumoconiosis classification according to 1980 ILO guidelines. Those with findings compatible with asbestosis were further ckecked with high resolution computerized tomography (HRCT). Pulmonary function tests were done according to ATS guidelines, and occupational and previous medical history was taken through a standardized interview. Air-borne asbestos was measured according to NIOSH method 7400. The air-borne asbestos concentrations ranged from 0.2-1.3 f/cc for asbestos textile, from 0.7-1.0 f/cc for brake lining, and from 6.3-7.8 f/cc during asbestos removal at ship repairing worksite. Of the 139 workers 25 had abnormal chest radiographic findings, and 10 of them had findings compatible with pneumoconiosis. When work history and current asbestos measurements were accounted, 9 workers who had more than 10 years of asbestos exposure history showed chest radiographic findings of pneumoconiosis with Finally, 4 workers showed finding of pulmonary fibrosis and/or pleural thickening at HRCT, and 2 of them had restrictive lung function changes. The study results showed that, among 139 subjects, there were 4(3%) definite asbestosis cases confirmed with HRCT. The prevalence of probable asbestosis was 7% for 10-14 years of exposure, 13% for 15-19 years of exposure, and 23% for 20 or more years of exposure. The prevalence of compensable asbestosis with abnormal lung function was 4-6% for those with 15 or more years of exposure.

남성복 잡지광고의 표현양식에 관한 연구

김미정,김수연,백은영,전혜신,정미희,조영옥,최일경,한은주,설호정 연세대학교 생활과학대학 1991 婦學 Vol.24 No.-

Prevalence and Associated Factors of Anxiety and Depressive Symptoms Among Bereaved Family Members of Cancer Patients in Korea : A Nation-Wide Cross-Sectional Study

Jho, Hyun Jung,Choi, Jin Young,Kwak, Kiu Sang,Chang, Yoon Jung,Ahn, Eun Mi,Park, Eun Jung,Paek, Soo Jin,Kim, Kyoung Mee,Kim, Soo Hyun Williams & Wilkins Co 2016 Medicine Vol.95 No.22

<P><B>Abstract</B></P><P>Bereaved family members of cancer patient are at risk of having psychological problems such as anxiety and depression. However, prevalence and associated factors of anxiety and depressive symptoms among this population have not been explored in Korea.</P><P>We conducted a nation-wide cross-sectional questionnaire survey of 3522 bereaved family members of cancer patients who died at 44 hospice palliative care unit (HPCU) in Korea in 2012. The questionnaire comprised the Hospital Anxiety and Depression Scale (HADS) and Good Death Inventory (GDI). Deceased patient's age, sex, primary site of cancer, duration of stay at HPCU, awareness of terminal status, bereaved family member's age, sex, and relation to the deceased were collected from Korean Terminal Cancer Patients Information System.</P><P>1121 returned questionnaires were analyzed (response rate, 31.8%). Using a cut-off value of 8 for HADS subscale, the prevalence of anxiety and depressive symptoms was 48.0% and 57.6%, respectively. Mean scores for HADS-A and HADS-D were 7.88 ± 4.87 and 8.91 ± 4.82, respectively. Among the bereaved, older age, being a spouse to the deceased, family members of younger patient, and negative score for a few GDI items were significantly associated with an increased risk of having anxiety or depressive symptoms in the multivariate logistic analysis.</P><P>In conclusion, we noted the high prevalence of anxiety and depressive symptoms among the bereaved of cancer patients and identified associated factors for these psychological morbidities. Systematic efforts are needed to improve the mental health of the bereaved family members of cancer patients.</P>

Detection and Classification of Barley Yellow Dwarf Virus Strains Using RT-PCR

Paek, Nam-Chon,Woo, Mi-Ok,Kim, Yul-Ho,Kim, Ok-Sun,Nam, Jung-Hyun The Korean Society of Crop Science 2001 Korean journal of crop science Vol.46 No.1

Barley Yellow Dwarf Virus (BYDV), an aphid-borne luteovirus, is a major plant pathogenic disease causing a huge economic loss in the grain production of a wide range of Gramineae species throughout the world. It has been recently reported that BYDV also occurred frequently in wheat field of Korea. Here, we performed to develop the detection and classification methods of BYDV strains that were accomplished by reverse transcription-polymerase chain reaction (RT-PCR). Since there are high variations among BYDV strains, three pairs of primers were designed to detect BYDV strains such as PAV (Vic-PAV and CN-PAV) and MAV (primer A) simultaneously, specifically Vic-PAV(primer B), and MAV (primer C) based on the genomic RNA sequences of BYDV strains previously published. The validity of the primers was confirmed using several BYDV strains obtained from CIMMYT. Though three BYDV strains were able to be detected using primer A, PCR products were not distinguished between two PAV strains. It was possible to separate them with a restriction enzyme, EcoRI, whose restriction site was present in the amplified DNA fragment from Vic-PAV, but not from CN-PAV.

Regional Distribution of Barley Yellow Dwarf Virus Strains in Korea and Identification of Resistant Wheat

Mi-Ok Woo,Hyung-Ho Park,Jung-Hyun Nam,Nam-Chon Paek 韓國作物學會 2001 Korean journal of crop science Vol.46 No.1

Barley Yellow Dwarf Virus (BYDV) has been a major disease causing a severe loss of yield in winter cereals worldwide. It has been recently reported that BYDV occurs frequently in wheat field and also causes serious yield reduction in Korea. This study was performed to investigate the regional distributions of BYDV strains in Korea and to identify the resistant cultivars or lines of wheat to the predominant BYDV strains, providing basic information for the breeding of BYDV-resistant wheat varieties. Using RT-PCR and EcoRI digestion methods, the regional distribution of BYDV strains in Korea from 1999 to 2000 showed that PAV strain was mainly detected about 65% (Vic-PAV 52.6% ; CN-PAV 47.4%) and MAV strain about 3%. Using ELISA test for the examination of BYDV resistance with 17 cultivars and 4 lines among Korean wheat, three cultivars, Gurumil, Topdongmil, and Olgurumil, were susceptible to BYDV and the others were resistant. In plant growth and yield component responses to BYDV infection, Gurumil showed significant difference between the uninfected and the infected, suggesting the most susceptible to BYDV among Korean wheat, but Eun-pamil and Seohae118 did no difference, an indication that they have the highest resistance.

Detection and Classification of Barley Yellow Dwarf Virus Strains Using RT-PCR

Mi-Ok Woo,Yul-Ho Kim,Ok-Sun Kim,Jung-Hyun Nam,Nam-Chon Paek 韓國作物學會 2001 Korean journal of crop science Vol.46 No.1

Barley Yellow Dwarf Virus (BYDV), an aphid-borne luteovirus, is a major plant pathogenic disease causing a huge economic loss in the grain production of a wide range of Gramineae species throughout the world. It has been recently reported that BYDV also occurred frequently in wheat field of Korea. Here, we performed to develop the detection and classification methods of BYDV strains that were accomplished by reverse transcription-polymerase chain reaction (RT-PCR). Since there are high variations among BYDV strains, three pairs of primers were designed to detect BYDV strains such as PAV (Vic-PAV and CN-PAV) and MAV (primer A) simultaneously, specifically Vic-PAV(primer B), and MAV (primer C) based on the genomic RNA sequences of BYDV strains previously published. The validity of the primers was confirmed using several BYDV strains obtained from CIMMYT. Though three BYDV strains were able to be detected using primer A, PCR products were not distinguished between two PAV strains. It was possible to separate them with a restriction enzyme, EcoRI, whose restriction site was present in the amplified DNA fragment from Vic-PAV, but not from CN-PAV.

Detection of transgene in early developmental stage by GFP monitoring enhances the efficiency of genetic transformation of pepper

Jung, Min,Shin, Sun-Hee,Park, Jeong-Mi,Lee, Sung-Nam,Lee, Mi-Yeon,Ryu, Ki-Hyun,Paek, Kee-Yoeup,Harn, Chee-Hark The Korean Society of Plant Biotechnology 2011 Plant biotechnology reports Vol.5 No.2

In order to establish a reliable and highly efficient method for genetic transformation of pepper, a monitoring system featuring GFP (green fluorescent protein) as a report marker was applied to Agrobacteriummediated transformation. A callus-induced transformation (CIT) system was used to transform the GFP gene. GFP expression was observed in all tissues of $T_0$, $T_1$ and $T_2$ peppers, constituting the first instance in which the whole pepper plant has exhibited GFP fluorescence. A total of 38 T0 peppers were obtained from 4,200 explants. The transformation rate ranged from 0.47 to 1.83% depending on the genotype, which was higher than that obtained by CIT without the GFP monitoring system. This technique could enhance selection power by monitoring GFP expression at the early stage of callus in vitro. The detection of GFP expression in the callus led to successful identification of the shoot that contained the transgene. Thus, this technique saved lots of time and money for conducting the genetic transformation process of pepper. In addition, a co-transformation technique was applied to the target transgene, CaCS (encoding capsaicinoid synthetase of Capsicum) along with GFP. Paprika varieties were transformed by the CaCS::GFP construct, and GFP expression in callus tissues of paprika was monitored to select the right transformant.

Statistical analyses in an occupational health study

Jung Keun Choi(최정근),Mi A Son(손미아),Do Myung Paek(백도명) 한국통계학회 1993 응용통계연구 Vol.6 No.2

산업보건연구의 통계학적 분석은 작업환경측정에 대한 평가방법과 산업보건에 특유한 혼란변수의 통제 등 건강상태와의 연관성을 분석하는 평가방법에 있어 아른 보건통계분야와 구별되는 특성을 지니고 있다. 본 논문에서는 주물공장 근로자들의 호흡기 건강상태와 작업환경에서 폭로되는 유해물질에 대한 조사를 통하여 산업보건연구에 사용되는 통계학적 분석에 대한 기술을 하였다. 조사된 환경측정결과의 일부는 허용폭로기준을 초과하고 있었는 바, 폭로기준의 준수여부를 판정하기 위하여 작업환경측정결과와 그들의 대수변환치들로 부터 얻은 산술평균과 대수평균들이 폭로기준과 다른지에 대한 t-검정을 실시하였다.환경측정을 비롯한 위험요인들과 그들로 인한 건강상태와의 관계 분석을 위해, 범주적 건강측정 변수인 경우에는 χ-square 검정과 다변량 logistic분석을 시행하였고, 연속적 변수인 경우에는 다변량 회귀분석을 시행하였다. 작업환경내의 오염물질의 농도는 그 측정장소와 측정시점에 따라 매우 가변적이다. 이러한 작업환경의 측정결과를 평가하는데 있어 사용될 수 있는 서로 다른 여러 지수들의 장단점과 가변적 측정결과들로 인한 오차를 보정할 수 있는 통계학적 분석 방법에 대한 논의를 하였다. 본 조사의 폐기능검사 결과는 직업에서 폭로되는 정도와 아무 연관성을 보이고 있지 않은 바, 이는 건강한 근로자 효과에 기인한 것으로 추정되고 있다. 이러한 건강한 근로자 효과를 비롯한 측정시점에 따라 변화하는 혼란변수를 보정하기 위한 통계적 분석 방법이 논의 되었다. 산업보건 연구에서 기본적으로 사용될 수 있는 전국적 생정통계와 같이 광범위하며 쉽게 비교되는 외부 대조군 내지는 질병의 예측기대치에 대한 통계가 한국의 경우에는 아직 없다. 이러한 경우, 그 분석의 범위가 매우 제한되어 있으나, 문제되는 질병 내지는 임상검사결과가 다른 일반적 질환과 비교하여 차지하는 비율을 서로 다른 집단간에 비교함으로써 서로 다른 작업환경에 폭로되는 집단들에 대한 통계학적 분석을 시도할 수 있다. 현재 한국에서는 일반검진과 특수검진이 정규적으로 실시되고 있으며, 이러한 검진결과에 대한 체계적 통계학적 분석이 앞으로 필요할 것으로 기대된다. The health status of workers in a foundry was analyzed in a study which consisted of evaluations of respiratory health together with environmental measurements. The results from environmental measurements showed values exceeding permissible exposure limits. A t-test was done with log transformed and untransformed data to examine the statistical significance for the noncompliance with exposure standards. For the analysis of categorical health outcomes, χ-square test with 2×2 tables and logistic regression analysis were employed. For continuous variables, multiple linear regression was done against assessed risk factors. Pros and cons of different parameters in the compliance (or noncompliance) testing were presented. Respiratory function did not show any relation with occupational exposures, which may be due to the healthy worker effects. Strategies for controlling time dependent covariates were discussed in relation to the healthy worker effect. The scope of statistical analysis in occupational health studies is still limited in Korea without a suitable external comparison group such as credible vital statistics for the whole nation. Internal comparisons between different exposure status often result in unstable estimates of effect, and proportional morbidity study is discussed as an alternative potential research tool.

Regional Distribution of Barley Yellow Dwarf Virus Strains in Korea and Identification of Resistant Wheat

Woo, Mi-Ok,Park, Hyung-Ho,Nam, Jung-Hyun,Paek, Nam-Chon The Korean Society of Crop Science 2001 Korean journal of crop science Vol.46 No.1

Barley Yellow Dwarf Virus (BYDV) has been a major disease causing a severe loss of yield in winter cereals worldwide. It has been recently reported that BYDV occurs frequently in wheat field and also causes serious yield reduction in Korea. This study was performed to investigate the regional distributions of BYDV strains in Korea and to identify the resistant cultivars or lines of wheat to the predominant BYDV strains, providing basic information for the breeding of BYDV-resistant wheat varieties. Using RT-PCR and EcoRI digestion methods, the regional distribution of BYDV strains in Korea from 1999 to 2000 showed that PAV strain was mainly detected about 65% (Vic-PAV 52.6% ; CN-PAV 47.4%) and MAV strain about 3%. Using ELISA test for the examination of BYDV resistance with 17 cultivars and 4 lines among Korean wheat, three cultivars, Gurumil, Topdongmil, and Olgurumil, were susceptible to BYDV and the others were resistant. In plant growth and yield component responses to BYDV infection, Gurumil showed significant difference between the uninfected and the infected, suggesting the most susceptible to BYDV among Korean wheat, but Eun-pamil and Seohae118 did no difference, an indication that they have the highest resistance.

Development of Transgenic Peppers Tolerant to PepMoV

Min Jung,Ji Hee Lee,Sun Hee Shin,Soon Ho Choi,Ki Hyun Ryu,Jang Ha Lee,Chee Hark Harn,Dong Bo Shim,Nam Han Her,Joung Mi Park,Kee Yoeop Paek 한국육종학회 2009 한국육종학회 학술발표회 발표요지 Vol.41 No.1