사람 적혈구 막에 있어서 Carnitine acyltransferase 효소에 관한 연구

박중근,김응렬,조기승 漢陽大學校敎養學部 1976 硏究論文集 Vol.- No.1

사람 적혈구막에서 palmitoyl carnitine을 생성하는 효소계의 존재를 확인하였는데 이 효소계에 의해 palmitoyl coenzyme A와 DL-Carnitine(methyl-14C)으로부터 palmitoyl carnitine-14C이 생합성됨을 고찰하였고, 한편 이 효소계에 의해 화학적으로 합성한 palmitoyl-14C-carnitine이 palmitic acid-14C과 carnitine으로 가수분해됨을 확인하였다. 이 효소계에 의해서나 또는 화학적 방법에 의해 만들어진 palmitoyl carnitine은 적혈구막을 용해하며 이때 막에 부착된 효소계인 Adenosine Triphosphatase나 Glucose-6-phosphatase등이 활성화됨을 발견하였다. An enzyme system in human erythrocyte membrane was found to catalyze the formation of palmitoyl carnitine-14C from palmitoyl coenzyme A and carnitine-(methyl-14C). It was also confirmed that the same enzyme acts on the hydrolysis of palmitoyl-14C-carnitine into palmitic acid-14C and carnitine. Palmitoyl carnitine formed from this enzyme system or other chemical method solubilized the erythrocyte membrane and stimulated significantly the membrane bound enzymes, such as Adeno-sine Triphosphatase (ATPase) and Glucose-6-phosphatase (G-6-Pase) tried.

광대역 이동통신 시스템에 적합한 채널추정 기법

박정근,박중후 漢陽大學校 工學技術硏究所 2002 工學技術論文集 Vol.11 No.-

파일럿 심볼을 이용하여 채널추정을 하는 통신시스템에서는 파일럿 심볼이 데이터 심볼과 시간적으로 다중화 되기 때문에 사용할 수 있는 파일럿 심볼의 수가 제한된다. 이러한 상황에서 파일럿 심볼만을 이용한 채널 추정은 일반적으로 좋은 성능을 보장할 수 없다. 최근에 연구되는 PADD(pilot-aided decision-directed) 알고리즘은 채널 추정을 위하여 파일럿 심볼과 데이터 심볼을 모두 사용하기 때문에 페이딩 채널 환경에서 파일럿 심볼만을 이용하여 채널을 추정하는 PA(pilot-aided) 알고리즘보다 우수한 성능을 보여준다. 본 논문에서는 기존의 PADD 알고리즘들을 분석하여 보다 개선된 구조의 PADD 알고리즘 구조를 제안하고 레일레이 다중 경로 페이딩 환경에서 모의실험을 실시하였다. 컴퓨터를 이용한 모의실험 결과를 통해 제안된 알고리즘이 기존의 알고리즘에 비해 성능이 향상됨을 확인할 수 있었다. In the communication systems that employ pilot-acid channel estimation techniques, pilot symbols are time-multiplexed with data symbols, and the number of pilot symbol is usually limited. It is known that PADD(pilot-aided decision-directed) approches exhibit better bit-error ratio (BER) performance than PA (pilot-aided) estimation algorithm over fading channels, because they use both pilot and data symbols for channel estimation. In this paper, conventional PADD algorithm are analyzed and an improved PADD algorithm for pilot symbol-acided channel estimations is proposed. The performance of this algorithm is evaluated in Rayleigh fading environments. Simulation results show that the proposed algorithm has better performance than conventional PADD algorithms.

다형성 교모세포종에서 광범위 전적출술후 단기 재발된 치험 1예

박호권,강중식,조준,문창택,장상근,임정애 건국대학교 의과학연구소 2003 건국의과학학술지 Vol.13 No.-

Glioblasty/ma Multiforme(GBM) is the one of the most common malignant tumors in central nervous system(CNS). The incidence of the tumor is about 12% of all CNS tumors and about 50% of all intracranial tumors. Though the development of the microsurgical technique, radiosurgical technique, and chemotherapy works effectively, complete cure of the GBM has not been achieved. It has been known that the prognosis of GBM depends on the extent of surgical tumor removal, remained tumor volume, radiation dose, and chemotherapy. Not only patient's age but also tumor characteristics such as MRI enhancement, angiogenesis and necrosis are also very important prognostic factors. Authors experienced very aggressive GBM in aged woman, who received gross total tumor removal, but refused other therapeutic motalities postoperatively. Very rapid recurrence of GBM and global cerebral edema in aged woman should be considered fatal. This case demonstrates the effectiveness of aggressive removal and the limited usefulness of neurosurgical tools in GBM recurrence. Authors would suggest that the early diagnostic effort and the verified neurosurgical therapy for malignant tumor are still strongly requested to make better prognosis.

ZnO 바리스터의 미세구조에 미치는 Al₂O₃의 영향

소진중,박근호,김종화,김형식 國立 昌原大學校 産業技術硏究所 1996 産技硏論文集 Vol.10 No.-

The electrical properties of ZnO varistor depend on characteristics of ZnO grain and grain boundary. Here we investigated how additive compositions and processing variables affected the electrical and the physical properties of these ZnO varistors. Non-ohmic characteristic and other properties of ZnO varistor are related to their microstructure. Therefore, understanding and controlling the microstructure are essential for the improvement of the properties of ZnO varistor. ZnO varistors examined in this study had ZnO-Bi₂O₃-Sb₂O₃-Co₂O₃-NiO-MnO₂-Cr₂O₃basic composition and Al₂O₃addition varying from 0.005wt% to 5.0wt%. Microstructure development, phase changes and electrical properties of the sintered specimens were investigated using scanning electron microscopy (SEM) with an energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) and V-I meter. The average size of ZnO grain was decreased from about 7μm to 2.4μm with increasing Al₂O₃addition. The Al₂O₃reacted with the ZnO to from ZnAl₂O₄spinel, which seemed to reduce the rate of ZnO grain growth. The spinel particles, were formed both along the grain boundaries and within the ZnO grain. The Bi-rich phase was located at the triple (or multiple) point of the ZnO grains. In the distribution of the dopant oxides (Sb₂O₃, Co₂O₃, MnO₂, Cr₂O₃, NiO, Al₂O₃), Co, Mn and Ni were distributed uniformly throughout the specimen. The distribution of Sb and Cr coincided with small spinel particles located at the grain boundaries, which showed significant dissolution of Cr in the spinel phase. Al was mainly located at the intergranular phase and triple point. Highest nonlinear exponent was obtained for ZnO varistor specimens containing 0.005wt% Al₂O₃.

교통사고 발생 추이에 관한 연구

양혁준,최봉근,윤태영,최중명,박순영,유동준 慶熙大學校 醫科大學 1997 慶熙 醫大 論文集 Vol.22 No.1

건축물의 LCC Database 구축에 관한 연구

전찬민,우경헌,김중현,김경업,박태근 목원대학교 건축도시연구센터 2003 建築·都市環境硏究 Vol.11 No.-

The importance of LCC analysis has been enlarged. Also, it would be necessary to computerize LCC analysis for accurate and logical analysis of LCC. In other papers, they showed LCC analysis model but the study of database development which could be applied in LCC analysis have been undeveloped. This study showing the development of common database for the LCC analysis computerization inquires into cost breakdown structure by previous researches. Also, it makes cost breakdown structure for deriving LCC cost item. As a result, the standard of LCC analysis computerization by developing LCC DB of cost breakdown structure would be shown.

김치유래 젖산균의 균체지방산 분석을 이용한 분류학적 연구

이정숙,정민철,김우식,이근철,김홍중,박찬선,이헌주,주윤정,이근종,안종석,박완,박용하,민태익 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

표준균주를 포함한 230여개의 김치유래 젖산균에 대한 균체지방산(FAMEs)을 분석하였다. FAMEs profiles는 Euclidian Distance 17.5에 의해 7개의 Major Cluster와 1개의 Single Cluster로 나뉘어졌다. 이중 A, B, C 및 Cluster는 Leuconostoc속으로 분석되어졌고, F는 Lactobacillus속으로 분석되어졌다. 그리고 E와 G cluster는 두개의 Genus가 혼재되어 나타났으며 보충적인 연구가 필요하다. 앞으로 김치유래 젖산균의 균체지방산 분석결과를 기반으로 한 데이타베이스에 95가지 탄소원을 이용하는 수치분류학적 접근방법 및 Pyrolysis Mass Spectrometry 등의 화학적 분석 방법과 분자친화적 연구를 통한 종합적 분류정보 체계가 갖추어지면 젖산균의 신속, 정확한 동정 및 연구에 활발히 이용되어질 것이다. Two hundreds and thirty lactic acid bacteria, mostly isolated from Kimchi, including type strains were sued for analysis of cellular fatty acids. The 230 test strains were recoverd in 7 major and 1 single clusters defined a Euclidian distance of 17.5. These aggregate taxa were equivalent to the genus Leuconostoc (aggregate group A, B, C and D), and the genera Leuconostoc and Lactobacillus (aggregate group G). It is concluded as evident that FAMEs (Fatty Acid Methyl Esters) profile of cell can be used as a criterion in classification of lactic acid bacterial from kimchi. Additional comparative taxonomic studies need to be carried out on well chosen representative strains to determine the most appropriate methods of value.

Photo-induced hybrid nanopatterning of titanium dioxide <i>via</i> direct imprint lithography

Park, Hyeong-Ho,Choi, Dae-Geun,Zhang, Xin,Jeon, Sohee,Park, Seong-Je,Lee, Soon-Won,Kim, Sarah,Kim, Ki-don,Choi, Jun-Hyuk,Lee, Jihye,Yun, Dae Keun,Lee, Ki Joong,Park, Hyung-Ho,Hill, Ross Henry,Jeong, J Royal Society of Chemistry 2010 Journal of materials chemistry Vol.20 No.10

<P>A novel ultraviolet (UV)-assisted imprinting procedure that employs photosensitive titanium(<SMALL>IV</SMALL>) di-n-butoxide bis(2-ethylhexanoate) is presented for the fabrication of well-ordered titanium dioxide (TiO<SUB>2</SUB>) nanostructures at room temperature. The main novelty of this technique is the use of the photosensitive titanium organic compound, rather than a commonly used UV-curable resin, for direct UV-assisted nanoimprint lithography. Fourier transform infrared and X-ray photoelectron spectroscopy studies suggest that exposure to UV light resulted in the gradual removal of organic groups from films prepared from titanium(<SMALL>IV</SMALL>) di-n-butoxide bis(2-ethylhexanoate) photochemically and successively converted the films to TiO<SUB>2</SUB> at room temperature. This approach allows direct fabrication of TiO<SUB>2</SUB> nanopatterns with lines down to 35 nm in width, hole arrays of 265 nm in diameter, and three-dimensional TiO<SUB>2</SUB> hybrid micro/nano-patterns without observable defects for use in applications where ordered surface nanostructures are required, such as photovoltaics, photonics, and optical waveguides.</P> <P>Graphic Abstract</P><P>A novel UV-assisted imprinting procedure that employs photosensitive Ti(<SMALL>IV</SMALL>) di-n-butoxide bis(2-ethylhexanoate) is presented for the fabrication of well-ordered TiO<SUB>2</SUB> and 3-D TiO<SUB>2</SUB> hybrid micro/nano-patterns at room temperature. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b921343k'> </P>

Virus-Like Particle Vaccine Confers Protection against a Lethal Newcastle Disease Virus Challenge in Chickens and Allows a Strategy of Differentiating Infected from Vaccinated Animals

Park, Jae-Keun,Lee, Dong-Hun,Yuk, Seong-Su,Tseren-Ochir, Erdene-Ochir,Kwon, Jung-Hoon,Noh, Jin-Yong,Kim, Byoung-Yoon,Choi, Soo-Won,Kang, Sang-Moo,Lee, Joong-Bok,Park, Seung-Yong,Choi, In-Soo,Song, Cha American Society for Microbiology 2014 CLINICAL AND VACCINE IMMUNOLOGY Vol.21 No.3

<P>In this study, we developed Newcastle disease virus (NDV) virus-like particles (VLPs) expressing NDV fusion (F) protein along with influenza virus matrix 1 (M1) protein using the insect cell expression system. Specific-pathogen-free chickens were immunized with oil emulsion NDV VLP vaccines containing increasing dosages of VLPs (0.4, 2, 10, or 50 μg of VLPs/0.5-ml dose). Three weeks after immunization, the immunogenicity of the NDV VLP vaccines was determined using a commercial enzyme-linked immunosorbent assay (ELISA) kit, and a lethal challenge using a highly virulent NDV strain was performed to evaluate the protective efficacy of the NDV VLP vaccines. NDV VLP vaccines elicited anti-NDV antibodies and provided protection against a lethal challenge in a dose-dependent manner. Although the VLP vaccines containing 0.4 and 2 μg of VLPs failed to achieve high levels of protection, a single immunization with NDV VLP vaccine containing 10 or 50 μg could fully protect chickens from a lethal challenge and greatly reduced challenge virus shedding. Furthermore, we could easily differentiate infected from vaccinated animals (DIVA) using the hemagglutination inhibition (HI) test. These results strongly suggest that utilization of NDV VLP vaccine in poultry species may be a promising strategy for the better control of NDV.</P>

ORiginal Article : Clinical Outcomes of the Endoscopic Submucosal Dissection of Early Gastric Cancer Are Comparable between Absolute and New Expanded Criteria

( Keun Young Shin ),( Seong Woo Jeon ),( Kwang Bum Cho ),( Kyung Sik Park ),( Eun Soo Kim ),( Chang Keun Park ),( Yun Jin Chung ),( Joong Goo Kwon ),( Jin Tae Jung ),( Eun Young Kim ),( Kyeong Ok Kim The Editorial Office of Gut and Liver 2015 Gut and Liver Vol.9 No.2

Background/Aims: Advances in endoscopic submucosal dissection (ESD) techniques have led to the development of expanded criteria for endoscopic resection of early gastric cancer (EGC). The aim of this study was to evaluate the short- and long-term outcomes for ESD using indication criteria. Methods: A total of 1,105 patients underwent ESD for EGC at six medical centers. The patients were classified into the following two groups based on the lesion size, presence of ulceration and pathological review: an absolute criteria group (n=517) and an expanded criteria group (n=588). Results: The curative resection rates (91.1% vs 91.3%, p=0.896) were similar in the absolute criteria group and the expanded criteria group. The en bloc resection rates (93.4% and 92.3%, respectively; p=0.488) and complete resection rates (98.3% and 97.4%, respectively; p=0.357) did not differ between the groups. The cumulative disease-free survival rates and the overall survival rates were similar between the groups (p=0.778 and p=0.654, respectively). Independent factors for the curative resection of EGC included tumor location (upper vs middle and lower, 2.632 [1.128-6.144] vs 3.497 [1.560-7.842], respectively) and en bloc resection rate 12.576 [7.442-21.250]. Conclusions: The expanded criteria for ESD in cases of EGC is comparable with the widely accepted pre-existing criteria. (Gut Liver, 2015;9:181-187)