http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
주의력결핍 과잉행동장애 아동과 형제의 임상특징 및 신경심리학 소견
이현정(Hyun-Jeong Lee),박장호(Jangho Park),김효원(Hyo-Won Kim) 대한소아청소년정신의학회 2013 소아청소년정신의학 Vol.24 No.4
Objectives:This study aims to investigate the clinical characteristics and neuropsychological profiles of children with attention-deficit hyperactivity disorder (ADHD) and their siblings. Methods:Eighteen children (age 8.2±1.7 years, 12 boys) with ADHD and their 18 siblings (age 7.8±1.6 years, 8 boys) completed Continuous Performance (CPT), Stroop, Children’s Trail Making, Rey-Kim Memory, and Kim’s Frontal Executive Function tasks. The parents of these subjects underwent the Attention-Deficit/Hyperactivity Disorder Rating Scale (ARS), 10-item Parent General Behavior Inventory (P-GBI), and the Social Responsiveness Scale (SRS). Paired t-tests were used. Results:The inattention (p=.020), and hyperactivity-impulsivity (p=.001), scores of the ARS and the P-GBI score (p=.004) were significantly higher in children with ADHD than in their siblings. Deficits in social communication and motivation on SRS were higher in children with ADHD than in their siblings (p=.017 and p=.011, respectively). Z-scores of omission and commission errors as well as response time variability on visual CPT and omission errors on auditory CPT were in clinically significant range, and z-score of omission errors on auditory CPT was in borderline range in siblings. Omission (p=.018) and commission errors on Visual CPT (p=.007) were significantly higher in children with ADHD compared to their siblings. Recognition efficiency on Kim’s Frontal Executive Function Task was lower in children with ADHD compared to their siblings, but in normal range in both groups. Stroop interference and figure fluency on Kims Frontal Executive Function Task were in borderline range in ADHD group, and figure fluency was in borderline range in siblings. Conclusion:Our results support a preliminary evidence for mild degree of attention deficit in ADHD siblings. Further studies are needed to examine the cognitive functions of siblings with ADHD in larger samples.
Directional Matrix Nanotopography with Varied Sizes for Engineering Wound Healing
Kim, Jangho,Bae, Won-Gyu,Kim, Yeon Ju,Seonwoo, Hoon,Choung, Han-Wool,Jang, Kyoung-Je,Park, Sunho,Kim, Bog Hee,Kim, Hong-Nam,Choi, Kyoung Soon,Kim, Myung-Sun,Choung, Pill-Hoon,Choung, Yun-Hoon,Chung, J Wiley (John WileySons) 2017 Advanced healthcare materials Vol.6 No.19
Lee, Jangho,Ha, Su Jeong,Lee, Hye Jin,Kim, Min Jung,Kim, Jin Hee,Kim, Yun Tai,Song, Kyung-Mo,Kim, Young-Jun,Kim, Hyun Ku,Jung, Sung Keun The Royal Society of Chemistry 2016 Food & Function Vol.7 No.7
<▼1><▼1><P><I>Tremella fuciformis</I> Berk (TFB) prevent LPS-mediated inflammation by inhibition of NF-κB and MAPKs pathways.</P></▼1><▼2><P><I>Tremella fuciformis</I> Berk (TFB) has long been used as a traditional medicine in Asia. Although TFB exhibits antioxidant and anti-inflammatory effects, the mechanisms of action responsible have remained unknown. We confirmed the anti-inflammatory effects of <I>Tremella fuciformis</I> Berk extract (TFE) in RAW 264.7 cells and observed significantly suppressed LPS-induced iNOS/NO and COX-2/PGE2 production. TFE also suppressed LPS-induced IKK, IkB, and p65 phosphorylation, as well as LPS-induced translocation of p65 from the cytosol. Additionally, TFE inhibited LPS-induced phosphorylation of MAPKs. In an acute inflammation study, oral administration of TFE significantly inhibited LPS-induced IL-1β, IL-6 and TNF-α production and iNOS and COX-2 expression. The major bioactive compounds from TFB extract were identified as gentisic acid, protocatechuic acid, 4-hydroxybenzoic acid, and coumaric acid. Among these compounds, protocatechuic acid showed the strongest inhibitory effects on LPS-induced NO production in RAW 264.7 cells. Overall, these results suggest that TFE is a promising anti-inflammatory agent that suppresses iNOS/NO and COX-2/PGE2 expression, as well as the NF-κB and MAPK signaling pathways.</P></▼2></▼1>
( Sujin Kim ),( Sunho Park ),( Daun Kim ),( Woochan Kim ),( Dohyeon Lee ),( Sungmin Park ),( Jangho Kim ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Living cells are exposed to complex and functional microenvironment including soluble macromolecules, biophysical cues, and interactions between cell-cell and cell-extracellular matrix (ECM). This suggests that the design and manipulation of engineered cellular microenvironments is of great important in a wide variety of biological applications such as fundamental biology, therapeutic and diagnostic research, stem cells and regenerative medicine, and developing in vitro disease models. In this work, we described the development of nanoscale engineered biomimetic systems for animal tissue engineering. Specifically, we showed the nanoscale patterned scaffolds inspired by the unique architectures of native animal tissues and ECMs that can provide cells the in vivo-like topographical cell environment, and their applications for better understanding of the function of living animal cells and tissue regeneration without complex surgical treatments.
Hydroxyapatite/Eggshell Membrane Composites for Healthcare Applications
( Sujin Kim ),( Sunho Park ),( Daun Kim ),( Woochan Kim ),( Sungmin Park ),( Jangho Kim ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.2
Eggshell membrane (ESM), one of the agricultural bioresources, is being recognized as emerging engineering platforms in various fields including healthcare applications. ESM is the protein-rich membrane between the eggshell and egg white, having interesting characteristics such as microfibrous structures and many functional chemical groups. However, the raw ESM has many limitations (e.g., limited scale-up platforms, low mechanical and bioactivity property), which raised some problems for its wide use as healthcare platforms. Here, we present new ESM-based engineering platforms based on nanotechnology for various healthcare applications, especially for bone tissue engineering (i.e., bone tissue repair and regeneration in animal and human systems). To enhance the mechanical and bioactivity property of law ESM, we used nanoscale hydroxyapatite powders (HAp) that can be incorporated into the ESM-based thin films. We demonstrated that the HAp/ESM composites provided unique properties of both HAp and ESM such as structural, chemical, and physical properties. Using the HAp/ESM composites, we showed that cell proliferation and differentiation of osteoblastic cells (MG-63) were enhanced on the HAp/ESM composites compared to those on the only ESM films. Our approach can enable the design and manipulation of ESM-based functional engineering platforms for healthcare applications including bone tissue engineering.
Designing Eggshell Membrane Proteins-based Nanotopographical Patches for Enhanced Bone Regeneration
( Daun Kim ),( Sunho Park ),( Sujin Kim ),( Yonghyun Gwon ),( Woochan Kim ),( Kwidug Yun ),( Jangho Kim ) 한국농업기계학회 2019 한국농업기계학회 학술발표논문집 Vol.24 No.2
Guided bone regeneration (GBR) membrane is considered as a platform that can heal bone defects (i.e., bone regeneration) while preventing gingiva infiltration into the bone regeneration area. Despite of the variety of current GBR membrane materials such as collagen, fast absorption and low tensile strength as well as high cost are still critical problems in bone regeneration. To overcome these limitations, synthetic polymers (e.g., polycaprolactone (PCL), one of FDA-approved materials) are used, which could be an alternative to current collage-based GBR membranes. However, the poor properties of PCL (e.g. low bioactivity and hydrophobic properties) are limited to use as a GBR membrane for bone regeneration. To address this issue, we proposed a rational design of PCL-based GBR membrane using eggshell membrane proteins (ESMP) and nanotechnology. We developed aligned nanotopography-based PCL patches using capillary force lithography. And then, the PCL nano-patches were coated with ESMP. We showed that the ESMP coated PCL nanotopography-based patches could enhance various characteristics (e.g., mechanical and adhesive properties) and bioactivity (e.g., bone regeneration in animal models) compared to other control groups such as PCL flat-patch, PCL nano-patch, and ESMP coated PCL flat-patch.
Experimental Study of Heating Surface Angle Effects on Single Bubble Growth
Jeongbae Kim,Hyung Dae Kim,Jangho Lee,Young Chul Kwon,Jeong Hoon Kim,Moo Hwan Kim 대한기계학회 2006 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.20 No.11
Nucleate pool boiling experiments were performed using pure R11 for various surface angles under constant heat flux conditions during saturated pool boiling. A 1-㎜-diameter circular heater with an artificial cavity in the center that was fabricated using a MEMS technique and a high-speed controller were used to maintain the constant heat flux. Bubble growth images were taken at 5000 frames per second using a high-speed CCD camera. The bubble geometry was obtained from the captured bubble images. The effects of the surface angle on the bubble growth behavior were analyzed for the initial and thermal growth regions using dimensional scales. The parameters that affected the bubble growth behavior were the bubble radius, bubble growth rate, sliding velocity, bubble shape, and advancing and receding contact angles. These phenomena require further analysis for various surface angles and the obtained constant heat flux data provide a good foundation for such future work.