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오동도에서의 이용객에 의한 식생구조 (植生構造) 변화 및 이용자 심리분석에 관한 연구
박명규,이경재,박인협 ( Myong Kyu Park,Kyong Jae Lee,In Hyeop Park ) 한국산림과학회 1987 한국산림과학회지 Vol.76 No.4
This study was executed to analyze the user`s impact on vegetation structure changes and user`s psychology in Odongdo Island of Hallyo-Haesang National Park. Five sites were sampled for vegetation structure changes vi the study area according to the extent of impact observed. Also user`s psychology was studied through questionnaire with the visitors and 366 answers were collected at random sampling in May, 1986. Evergreen broad-leaved forest, i.e. Machilus thunbergii, Cinnamomum camphora, and Camellia japonica forest, took possession of 32.5% (3.91㏊) of total forest area when condisering the actual vegetation. Camellia japonica community covered 40.0% (4.72㏊) and Sasa coreana community took possession of 41.8% (5.02㏊). The area of environmental impact grade 3 and 4 area covered 44.3% of total forest area and it should be restored because self-repair seemed to be impossible. The evergreen broad-leaved forest was destoryed seriously with no younger trees in middle and lower layers by overuse impact and would be bared soon. So the preservation of autochthonous flora is required by the control of the number of users. It was shown that most of visitors come on holidays and Sunday and places which were favorably impressed were shown as the area of showing the sea and Camellia forest. Overall levels of satisfaction was comparatively low, consequently 55% of visitors were satisfied. This level of satisfaction was associated with number of users, landscape of forest and number of facilities.
Park, Min Hyeop,Choi, Miyeon,Kim, Yong-Seok,Son, Hyeon The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.2
3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), a competitive N-methyl-D-aspartate (NMDA) receptor antagonist, produces rapid antidepressant-like effects in animal models of depression. However, the molecular mechanisms underlying these behavioral actions remain unknown. Here, we demonstrate that CPP rapidly stimulates histone deacetylase (HDAC) 5 phosphorylation and nuclear export in rat hippocampal neurons. These effects are accompanied by calcium/calmodulin kinase II (CaMKII) and protein kinase D (PKD) phosphorylation. Behavioral experiments revealed that viral-mediated hippocampal knockdown of HDAC5 blocked the antidepressant effects of CPP in stressed animals. Taken together, our results imply that CPP acts via HDAC5 and suggest that HDAC5 is a common regulator contributing to the antidepressant actions of NMDA receptor antagonists such as CPP.
Min Hyeop Park,Miyeon Choi,Yong-Seok Kim,Hyeon Son 대한생리학회-대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.2
3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), a competitive N-methyl-D-aspartate (NMDA) receptor antagonist, produces rapid antidepressant-like effects in animal models of depression. However, the molecular mechanisms underlying these behavioral actions remain unknown. Here, we demonstrate that CPP rapidly stimulates histone deacetylase (HDAC) 5 phosphorylation and nuclear export in rat hippocampal neurons. These effects are accompanied by calcium/calmodulin kinase II (CaMKII) and protein kinase D (PKD) phosphorylation. Behavioral experiments revealed that viral-mediated hippocampal knockdown of HDAC5 blocked the antidepressant effects of CPP in stressed animals. Taken together, our results imply that CPP acts via HDAC5 and suggest that HDAC5 is a common regulator contributing to the antidepressant actions of NMDA receptor antagonists such as CPP.