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Lee, Sang-Yoon,Kim, Bo-Kyung,Yoon, Sa-Rah,Kim, Yeon-Joo,Liu, Tian,Woo, Joo-Hong,Chwae, Yong-Joon,Joe, Eun-Hye,Jou, Il-O Korean Society for Biochemistry and Molecular Bion 2010 Experimental and molecular medicine Vol.42 No.9
In brain tissue, astrocytes play defensive roles in central nervous system integrity by mediating immune responses against pathological conditions. Type I phosphatidylinositol 4-phosphate 5-kinase ${\alpha}$ ($PIP5K{\alpha}$) that is responsible for production of phosphatidylinositol 4,5-bisphosphate ($PI[4,5]P_2$) regulates many important cell functions at the cell surface. Here, we have examined whether $PIP5K{\alpha}$ is associated with astrocyte inflammatory responses. Gangliosides are releasable from damaged cell membranes of neurons and capable of inducing inflammatory responses. We found that treatment of primary cultured astrocytes with gangliosides significantly enhanced $PIP5K{\alpha}$ mRNA and protein expression levels. $PI(4,5)P_2$ imaging using a fluorescent tubby (R332H) expression as a $PI(4,5)P_2$-specific probe showed that ganglioside treatment increased $PI(4,5)P_2$ level. Interestingly, microRNA-based $PIP5K{\alpha}$ knockdown strongly reduced ganglioside-induced transcription of proinflammatory cytokines IL-$1{\beta}$ and $TNF{\alpha}$. $PIP5K{\alpha}$ knockdown also suppressed ganglioside-induced phosphorylation and nuclear translocation of NF-${\kappa}B$ and the degradation of $l{\kappa}B-{\alpha}$, indicating that $PIP5K{\alpha}$ knockdown interfered with the ganglioside-activated NF-${\kappa}B$ signaling. Together, these results suggest that $PIP5K{\alpha}$ is a novel inflammatory mediator that undergoes upregulation and contributes to immune responses by facilitating NF-${\kappa}B$ activation in ganglioside-stimulated astrocytes.
이주연(Jou Yeon Lee),김성일(Seong Il Kim) 한국농어촌관광학회 2006 농어촌관광연구 Vol.13 No.2
This study aimed to look at how a lifelong education program and learning groups related to the program in a rural community contributed to the rural tourism development. This study was also aiming at developing theoretical frameworks and research methods to investigate the effects of a lifelong education program and learning groups on the rural tourism development as well as the revitalization of a rural community. As a case study, this study chose the Green College that is a lifelong education program for community leaders and for (potential) rural tourism managers in Gangjin and it investigate the whole process from the development of the program until the end of the one-year program with surveys, participant observations, and interviews.
Young Il Kim,Jae-Seok Park,Jae Sung Choi,Sung-Shik Jou,길효욱,Sae-YongHong 대한중환자의학회 2012 Acute and Critical Care Vol.27 No.3
Although activated charcoal is an effective treatment for most toxic ingestions, aspiration of activated charcoal can be fatal. Here, we report that in 5 charcoal aspiration cases, bronchoscopy with suction and lavage was an effective way to remove charcoal from the lungs. Patients showed high APACHE II scores (range: 10-29), and either low PO2 levels, or low CO2 retention. After bronchoscopic removal of the aspirated charcoal, symptoms of hypoxia, CO2 retention, localized wheezing, and pneumonic infiltration as determined by chest radiography, improved in most patients. We report 5 cases of successful treatment of charcoal aspiration with bronchoscopic toilet.
고압산소요법이 생존이 위태로운 피판에 미치는 영향에 관한 임상적 연구
김동일,최준,송영주,백세민,백롱민,박성규 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.6
From August,;989 to February,1993,75 patients recieved adjuvant hyperbaric oxygen therapy after surgery. retrospective review of these 75 patients was undertaken to determine the effectiveness of hyperbaric oxygen therapy to improve survival of compromised flaps. The indications for postopeative hyperbaric oxygen therapy has been marked congestion and ischemic change of flaps. The regimen consisted of two 60-minute treatments of 100% oxygen at 2.5 ATA per day until flap survival or eschar formation. Hyperbaric oxygen was given to 75 patients having compromised flaps including 15 cervicofacial flaps, 4 cervicopectoral flaps, 11 groin distant flaps, 8 traumatic avulsion flaps, 4 superficial temporal fascia flaps, and 33 various local flaps. Complete survival was noted in 52 flaps(70%) after 5-14 days (mean 10 days) treatment of hyperbaric oxygen. 19 flaps(25%) showed partial improvement and 4 flaps(5%) ended in failure. Complication associated with hyperbaric oxygen was negligible except for ear pain during hyperbaric oxygen therapy in 15 patients. These data clearly indicate that hyperbaric oxygen has provided definite clinical benefit with minimal complication although a matched series comparing the results with and without hyperbaric oxygen therapy may be required to improve the efficacy of this treatment regimen.
전기방사 폴리이미드 나노섬유매트의 섬유배향이 이온전도도에 미치는 영향
허양일 ( Yang Il Huh ),김영희 ( Young Hee Kim ),안주현 ( Jou Hyeon Ahn ),이홍기 ( Hong Ki Lee ),나창운 ( Chang Woon Nah ) 한국고무학회 2010 엘라스토머 및 콤포지트 Vol.45 No.1
본 연구에서는 전기방사 장치의 드럼형태 컬렉터의 회전속도를 조절함으로써 제조된 섬유가 랜덤 또는 배향성(1축, 2축)을 갖는 폴리이미드(PI) 나노섬유 매트를 제조하였다. 제조된 PI 매트의 구조를 전자현미경(SEM)을 통해 관찰한 결과 전술한 배향성을 확인할 수 있었다. 1 M 리튬트리풀루오로-메탄-설포네이트와 테트라-에틸렌 글리콜디메틸 에테르의 혼합용액에 PI 매트를 침지시킨 후 이온전도기로 이온전도도를 측정하였다. 2축배향 매트가 가장 높은 이온전도도를 나타내었다. 1축 배향의 경우 이온의 이동방향과 수직방향이 평행방향보다 이온전도도가 낮게 나타났고, 아울러 일정한 주기성을 나타내었다. 주기성은 섬유간 거리와 이온 속도를 이용하여 설명할 수 있었다. In this study, polyimide(PI) nanofibers mats were prepared by electrospinning and three different fiber morphologies of random, uniaxial, and biaxial orientation were prepared by controlling the speed of drum-shaped collector and other parameters. The SEM studies reveal that the aforesaid morphologies were obtained on the nano-fibrous mats prepared. The ionic conductivity was measured using an in-plane type conductivity tester for the PI mats soaked in the mixture of 1M lithium trifluoro-methane-sulfonate and tetra-ethylene glycol dimethyl ether. The ionic conductivity was surprisingly higher for the biaxial PI mats. For the uniaxially-oriented mats, the ionic conductivity was found to be higher in the parallel direction compared to the perpendicular direction of the fiber orientation. A curious cyclic fluctuation was found in the ionic conductivity with time. The observed behavior was explained by considering the distance between fibers and transport speed of ions used in this study.
The Records of Origin and Transport of Sediments From the Past to the Present in the Yellow Sea
Yi, Hi-Il,Chun, Jong-Hwa,Shin, Im-C.,Shin, Dong-Hyeok,Jou, Hyeong-Tae The Korean Society of Oceanography 2004 Journal of the Korean Society of Oceanography Vol.39 No.1
A total of 116 surface sediment samples were obtained on the Yellow Sea and analyzed for grain size and geochemical elements in order to interpret the present sediment transportation. Thirty-nine cores and 3,070 line-km shallow seismic profiles are analyzed for sedimentary records of Yellow Sea in the past. Results show that the boundary of sediment transport between Korean side and Chinese side is about between $123^{\circ}E$ and $124^{\circ}E$. The similar result is produced from Shi et al. (in this publication). Two cyclonic patterns of surface sediments are recognized in the northeastern and southwestern Yellow Sea, while the strong front zone of the mud patch and sandy sediments are found in the southeastern Yellow Sea (the southwestern part of Korean coasts). The formation of fine-particle sediment packages, called for Northwest Mudbelt Deposit (NWMD), Hucksan Mudbelt Deposit (HSMD) and Jeju Mudbelt Deposit (JJMD), are resulted from eddies (gyres) of water circulations in the Yellow Sea. NWMD has been formed by cyclonic (anticlockwise) eddy. NWMD is composed of thick, homogeneous, relatively semi-consolidated gray clay-dominated deposit. On the other hand, HSMD and JJMD are formed by anticyclonic (clockwise) eddies. They are thick, homogeneous, organic-rich gray, silt-dominated deposit. Both core and surface sediments show that the middle zone across Chinese and Korean side contains bimodal frequency of grain-size distribution, indicating that two different transport mechanisms exist. These mud packages are surrounded by sand deposits from both Korea and China seas, indicating that Yellow Sea, which is the shallow sea and epicontinental shelf, is formed mostly by sand deposits including relict sands. The seismic profiles show such as small erosional/non-depositional channels, sand-ridges and sand-waves, Pleistocene-channelfilled deposits, a series of channels in the N-S major channel system, and thick Holocene sediment package, indicating that more complex sedimentary history exists in the Yellow Sea.
Jeong, Hey-Kyeong,Jou, Il-O,Joe, Eun-Hye Korean Society for Biochemistry and Molecular Bion 2010 Experimental and molecular medicine Vol.42 No.12
It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson's disease (PD). Recently, systemic inflammation has also emerged as a risk factor for PD. In the present study, we evaluated how systemic inflammation induced by intravenous (iv) lipopolysaccharides (LPS) injection affected brain inflammation and neuronal damage in the rat. Interestingly, almost all brain inflammatory responses, including morphological activation of microglia, neutrophil infiltration, and mRNA/protein expression of inflammatory mediators, appeared within 4-8 h, and subsided within 1-3 days, in the substantia nigra (SN), where dopaminergic neurons are located. More importantly, however, dopaminergic neuronal loss was not detectable for up to 8 d after iv LPS injection. Together, these results indicate that acute induction of systemic inflammation causes brain inflammation, but this is not sufficiently toxic to induce neuronal injury.