효소법에 의한 혈청Ca측정의 실험적연구

이창규,이승관,유정록,김상섭,유병서,정운원,최명재,장철수,서장훈 高麗大學校 倂設 保健大學 保健科學硏究所 1996 保健科學論集 Vol.22 No.1

Major conventional method for assaying Ca are AAS and colorimetry of Ca complexes with ocpc. The former method is reliable and specific for Ca, but requires special and expensive equipment and is unsuitable for routine assay in clinical chemistry. The latter method, with ocpc, is widely available and has been improved by reaserchers so as to be more specific for Ca by the addition of 8-hydroxyquinoline to mask any Mg present. This modified method has been made more rapid and precise by adaptation to the Autoanalyzer and other random access analyzers. Tabata reported an enzymatic assay for calcium ion based on the activation of phospholipase D. Here we report a sensitive and specific enzymatic assay for total Ca in serum, based on the activation of porcine pancreatic α-amylase proposed by Kayamori. The results of correlation, and precision studies indicate an acceptable performance over a clinically relevant range but requires a new reference range for enzymatic method.

Lease-based consistency schemes in the web environment

Lee, Byoung-Hoon,Lim, Sung-Hwa,Kim, Jai-Hoon,Fox, Geoffrey C. Elsevier 2009 Future generation computer systems Vol.25 No.1

<P><B>Abstract</B></P><P>There are many methods to maintain consistency in the distributed computing environment. Ideally, efficient schemes for maintaining consistency should take into account the following factors: lease duration of replicated data, data access pattern and system parameters. One method used to supply strong consistency in the web environment is the lease method. During the proxy’s lease time from a web server, the web server can notify the modification to the proxy by invalidation or update. In this paper, we analyze lease protocol performance by the varying update/invalidation scheme, lease duration and read rates. By using these analyses, we can choose the adaptive lease time and proper protocol (invalidation or update scheme of the modification for each proxy in the web environment). As the number of proxies for web caching increases exponentially, a more efficient method for maintaining consistency needs to be designed. We also present three-tier hierarchies on which each group and node independently and adaptively choose the proper lease time and protocol for each proxy cache. These classifications of the scheme make proxy caching adaptive to client access pattern and system parameters.</P>

한국 주요 기업 ERP 패키지 도입의 재무성과: 탐험적인 비교 검증

이중정 ( Choong C. Lee ),홍성완 ( Sung Wan Hong ),박영훈 ( Young Hoon Park ),최희재 ( Hee Jai Choi ) LGCNS 엔트루정보기술연구소 2006 Entrue Journal of Information Technology Vol.5 No.2

본 연구는 ERP 시스템이 기업성과에 미치는 영향에 대하여 ERP 도입효과에 대한 분석 차원에서 이루어졌다. ERP 패키지를 도입한 국내 주요기업과 미도입 기업과의 재무적 성과를 도입시점을 전후로 나누어 비교분석하고 세부적으로는 도입기업을 대상으로 기존 연구들에서 공통적으로 언급된 ERP 도입의 핵심성공요인을 바탕으로 카테고리를 나누어 각각의 성공요인에 대한 성과 측정의 측면에서 객관적인 재무정보를 이용하여 ERP 구축에 따른 경영성과가 어떤 경우에 우월하게 발생하였는지를 탐험적으로 알아보았다. 그 결과 ERP 도입 시에 재무적으로 영향을 미치는 성공요인으로는 PI 시행 여부, Extended ERP 도입 여부, Task Force 팀 유지 여부, 변화관리 유무 등으로 나타났다. 장기적이고 지속적인 ERP 적응 노력이 이러한 주요 변수의 공통적인 성격임을 추론할 때 궁극적인 도입효과에 있어 기업의 장기적인 수행능력(capability) 향상 노력이 단기적인 IT 자원(resource)의 구축과 함께 강조되어야 함을 보여 주고 있다. This study is to investigate the impact of ERP package system on firm`s financial performance. Upon the conflicting results of previous a few studies on ERP impact on firm performance, this study tries to make the financial comparison between ERP-adopted and not-adopted firms among major Korean firms through a matched sample comparison group methodology and publicly available financial ratings. In addition, based on the key success factors for ERP adoption and implementation from previous studies, we test if these factors can make the difference in the financial performance among the ERP-adopted firms. Results indicate that firms with and without ERP do not show any statistically significant difference in financial performance over 3 years of time span before and after ERP adoption. However, among the ERP adopters, ones with successful PI implementation, Extended ERP implemantion, post-ERP Task Force Team, long term change management effort show the relatively strong financial performance than ones without these factors. This study findings overally indicate that while ERP system in major Korean firms may not produce the significant impacts on the firm`s financial performance yet, long term commitment and the development of IT capability to successfully use the ERP systems, as represented by the identified success factors above, would decide the winner of ERP venture in the long run.

Pharmacological and Safety Profile of Dexlansoprazole: A New Proton Pump Inhibitor - Implications for Treatment of Gastroesophageal Reflux Disease in the Asia Pacific Region

( Khean Lee Goh ),( Myung Gyu Choi ),( Ping I Hsu ),( Hoon Jai Chun ),( Varocha Mahachai ),( Udom Kachintorn ),( Somchai Leelakusolvong ),( Nayoung Kim ),( Abdul Aziz Rani ),( Benjamin C Y Wong ),( Ju 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2016 Journal of Neurogastroenterology and Motility (JNM Vol.22 No.3

Although gastroesophageal reflux disease is not as common in Asia as in western countries, the prevalence has increased substantially during the past decade. Gastroesophageal reflux disease is associated with considerable reductions in subjective well-being and work productivity, as well as increased healthcare use. Proton pump inhibitors (PPIs) are currently the most effective treatment for gastroesophageal reflux disease. However, there are limitations associated with these drugs in terms of partial and non-response. Dexlansoprazole is the first PPI with a dual delayed release formulation designed to provide 2 separate releases of medication to extend the duration of effective plasma drug concentration. Dexlansoprazole has been shown to be effective for healing of erosive esophagitis, and to improve subjective well-being by controlling 24-hour symptoms. Dexlansoprazole has also been shown to achieve good plasma concentration regardless of administration with food, providing flexible dosing. Studies in healthy volunteers showed no clinically important effects on exposure to the active metabolite of clopidogrel or clopidogrel-induced platelet inhibition, with no dose adjustment of clopidogrel necessary when coprescribed. This review discusses the role of the new generation PPI, dexlansoprazole, in the treatment of gastroesophageal reflux disease in Asia. (J Neurogastroenterol Motil 2016;22:355-366)

한국인 안드로젠 저항성 증후군 환자의 안드로젠 수용체 유전자 변이 양상

박서영(Seo Yeong Park),최영민(Young Min Choi),박성효(Sung Hyo Park),양세원(Se Won Yang),구승엽(Seung Yup Ku),김석현(Seok Hyun Kim),김수응(Soo Woong Kim),백제승(Jai Seung Paik),양도훈(Do Hoon Yang),최두석(Doo Seok Choi),권혁찬(Hyuck C 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4

N/A Androgen insensitivity syndrome (AIS) is a X-linked disorder of sexual differentiation resulting from defective androgen receptor (AR) function. Androgens are secreted by the testes of 46,XY individuals, but there is loss of target organ response to the hormone. The abnormalities of AR are due to defects in the AR gene, and many mutations causing AIS have been reported since the cloning of AR gene. In this study, we analyzed the AR genes in twelve Korean patients with androgen insensitivity syndrome: 9 patients with complete AIS and 3 patients with partial AIS. DNAs were isolated from patients with AIS, and the coding region of AR gene was amplified by a polymerase chain reaction using 7 pairs of primers (exon B-H). Sequence analysis of the AR gene was performed using direct sequencing and single strand conformational polymorphism (SSCP). The AR gene mutations were identified in 7 out of 12 patients: 6 of 9 patients with complete AIS, and one of 3 patients with partial AIS. Mutations found were as follows: the point mutation (ATT→ACT) at position 680 of exon D, point mutation (TGG→TGC) at position 751 of exon E, point mutation (CAA→TAA) at position 792 of exon F, point mutations (CGC→TGC, GTG→ATG) at position 855 and 866 of exon G, and the deletion of 13 nucleotides (CGTATCATTGCAT) at position 840 of exon G, respectively. To the best of our knowledge, the point mutations found in exon D, exon E, and exon F, and the deletion in exon G have not been observed before. SSCP revealed bands with abnormal mobility in 10 out of 12 patients tested. Mutations were found 5 out of these 10 patients. The other two patients showed no abnormal band on SSCP, but showed mutations by direct sequencing. In conclusion, we have demonstrated the AR gene mutations, including three novel mutations, in Korean patients with AIS, and these abnormalities might be related to the pathogenesis of androgen insensitivity syndrome.

Slow-Pull Using a Fanning Technique Is More Useful Than the Standard Suction Technique in EUS-Guided Fine Needle Aspiration in Pancreatic Masses

( Jae Min Lee ),( Hong Sik Lee ),( Jong Jin Hyun ),( Jung Min Lee ),( In Kyung Yoo ),( Seung Han Kim ),( Hyuk Soon Choi ),( Eun Sun Kim ),( Bora Keum ),( Yeon Seok Seo ),( Yoon Tae Jeen ),( Hoon Jai C 대한간학회 2018 Gut and Liver Vol.12 No.3

Background/Aims: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is useful for obtaining pancreatic mass samples. The combination of modified techniques (i.e., slow-pull technique and fanning technique) may improve the quality of the sample obtained by EUS-FNA. We investigated the effectiveness of a combined slow-pull fanning technique in EUS-FNA for pancreatic mass. Methods: This prospective comparative study investigated EUS-FNA performed for pancreatic solid masses between August 2015 and July 2016. Pairwise specimens were alternately obtained using the following two techniques for targeted pancreatic lesions: standard suction or slow-pull with fanning. We compared the specimen quality, blood contamination, and diagnostic accuracy of these techniques. Results: Forty-eight consecutive patients were included (29 men; mean age, 68.1±11.9 years), and 96 pancreatic mass specimens were obtained. The slow-pull with fanning technique had a significantly superior diagnostic accuracy than the suction technique (88% vs 71%, p=0.044). Furthermore, blood contamination was significantly reduced using the slow-pull with fanning technique (ratio of no or slight contamination, 77% vs 56%, p=0.041). No difference was observed in the acquisition of adequate cellularity between the groups. In the subgroup analysis, the tumor size and sampling technique were related to the EUSFNA diagnostic accuracy. Conclusions: The slow-pull with needle fanning technique showed a good diagnostic yield for EUS-FNA for pancreatic mass. This technique can be useful for performing EUS-guided sampling for diagnosing pancreatic disease. (Gut Liver 2018;12:360-366)