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RISS 인기검색어
- 검색키워드
- 저자 : ( Hong-jun Mu ) (검색결과 71 건)
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홍진표,송해철,이무송,이창화,안준호,한오수,안태영,김성윤 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6
Objectives : The purpose of this study was to investigate the prevalence of erectile dysfunction (ED) in a rural area of Korea and to examine the relationship between the prevalence and correlates of subjects. Method : This study was done as a part of the chronic disease survey of rural area by the Asan Foundation. Among 30 years or older population from Jung Eup, a rural area of Korea, 711 male subjects were sampled using a cluster probability sampling method. Trained interviewers visited and interviewed subjects aged 30 years or older with a structured interview. ED was categorized as 'none', 'mild', 'moderate', or 'severe' according to the ability to 'attain and/or maintain an erection satisfactory for sexual intercourse'. Response rate was 54.3% (N=386). Results : The age weighted prevalence of ED was 27.2% (minimal 14.1%, moderate 7.6%, severe 5.5%). Prevalence and severity increased with age. Liver disease and underweight were significantly (p<0.05) associated with ED. Smoking seemed to be correlated with ED, but did not reach statistically significant level. Conclusion : ED was highly prevalent in the rural community of Korea. Medical, sociodemographic, and lifestyle variables associated with ED may alert physicians to patients at risk for ED and offer insight to its etiology.
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Application of Two Complementary Molecular Sexing Methods for East Asian Bird Species
Mu Yeong Lee,Yoon Jee Hong,Sun Kyung Park,Young Jun Kim,Tae Young Choi,Hang Lee,Mi Sook Min 한국유전학회 2008 Genes & Genomics Vol.30 No.4
Numerous avian species are sexually monomorphic, especially nestlings, posing difficulties in determining their sex by morphological traits alone. Despite the difficulties, sex identification of birds is an essential part of ex situ conservation breeding programs for endangered species, and the sex of individuals is an integral component of information required for research concerning ecology, behavior, genetics, and conservation biology. Therefore, molecular sexing methods are gaining increasing attention as an aid in study and conservation of many bird species. An amplification refractory mutation system (ARMS) method using the sequence differences between CHD1Z and CHD1W was applied for sex identification of 29 East Asian bird species to test the applicability of the method for a wide range of wild bird species. The sex of 25 bird species was successfully identified by the ARMS method using the P2/NP/MP primer set, and the sex of four additional species was identified by another primer set P2/P8. The methods were applied to sex 124 individual samples that were preliminarily sexed by only morphological characteristics of the birds. Of the specimens tested, 16 (12.9%) individuals showed different gender from the preliminary data. This showed that sex identification of monomorphic avian species by external morphology alone has a high risk of misidentification. Therefore, alternative molecular sexing methods are recommended in the sexing process where monomorphic individuals, damaged carcasses or parts of carcasses are involved.
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Lee, Mu-Yeong,Park, Sun-Kyung,Hong, Yoon-Jee,Kim, Young-Jun,Voloshina, Inna,Myslenkov, Alexander,Saveljev, Alexander P.,Choi, Tae-Young,Piao, Ren-Zhu,An, Jung-Hwa,Lee, Mun-Han,Lee, Hang,Min, Mi-Sook The Korean Society for Integrative Biology 2008 Animal cells and systems Vol.12 No.4
Siberian flying squirrel, an endangered species in South Korea, is distributed through major mountain regions of South Korea. The number of Siberian flying squirrel(Pteromys volans) in South Korea has decreased and their habitats are fragmented and isolated because of anthropogenic activities. So far no molecular genetic data has, however, been available for their conservation and management. To obtain better information concerning genetic diversity and phylogenetic relationships of the Siberian flying squirrel in South Korea, we examined 14 individuals from South Korea, 7 individuals from Russia, and 5 individuals from northeastern China along with previously published 29 haplotypes for 1,140 bp of the mtDNA cytochrome b gene. The 14 new individuals from South Korea had 7 haplotypes which were not observed in the regions of Russia and Hokkaido. The level of genetic diversity(0.616%) in the South Korean population was lower than that in eastern Russia(0.950%). The geographical distribution of mtDNA haplotypes and reduced median network confirmed that there are three major lineages of Siberian flying squirrel, occupying; Far Eastern, northern Eurasia, and the island of Hokkaido. The South Korean population only slightly distinct from the Eurasia, and eastern Russian population, and is part of the lineage Far Eastern. Based on these, we suggest that the South Korean population could be considered to belong to one partial ESU(Far Eastern) of three partial ESUs but a different management unit. However, the conservation priorities should be reconfirmed by nuclear genetic marker and ecological data.
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정준래,홍성욱,한경희,최낙찬,고영무 朝鮮大學校 口腔生物學硏究所 2000 口腔生物學硏究 Vol.24 No.1
The high reactivity of fluoride agents used in topical fluoride treatments have raised important questions on their potential adverse effects on restorative materials. The purpose of this study was to evaluate the effect of various types of fluoride agents used for dental office and home treatments on the color change of some polyacid-modified resin composite(Compoglass and Dyract) and the resin-modified glass ionomer(Fuji Ⅱ LC). Each specimen was treated with 4 kinds of fluoride agents for 4 minutes every day until 8 weeks. The color change was measured using specimens aged up to two months with colorimeter. The resulted were as follows; 1. The color change of resin-modified glass ionomer cement Fuji Ⅱ LC was greater than any other material. 2. The color change of 3 kinds of materials were greatest in contact with 8% SnF_2 solutions. 3. It showed greater color change in case of materials immersed in fluoride agents than in water. In conclusion, Topically applied fluorides induced adverse effects on the color change characteristics of resin-modified glass ionomer cement and polyacid-modified composite resins suggesting that fluoride agents effective in limiting caries should be used with caution with patients who have aesthetic restoratives.
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Rhizopus oryzae를 이용한 바이오 디젤 생산
박상무,홍승준,이기영,김동운 全南大學校 觸媒硏究所 2002 觸媒硏究 論文集 Vol.23 No.-
Biodiesel was produced from soybean oil and methanol using fermentation broth or lipase. Production yield was 62% and 53.5% with purified Rhizopus oryzae lipase and Rhizopus oryzae broth respectively. This yield of biodiesel was highest in case of water content of 20%
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Clinical Value of Eukaryotic Elongation Factor 2 (eEF2) in Non-small Cell Lung Cancer Patients
Sun, Hong-Gang,Dong, Xue-Jun,Lu, Tao,Yang, Ming-Feng,Wang, Xing-Mu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: The purpose of this study was to evaluate a new type of tumor biomarker, eukaryotic elongation factor 2 (eEF2), in serum for the early diagnosis, confirmative diagnosis as well as assessment of treatment of non-small cell lung cancer (NSCLC). Methods: 130 patients with NSCLC and 50 healthy individuals undergoing physical examination in our hospital provided the observation and healthy control groups. An enzyme linked immune sorbent assay (ELISA) method was applied to determine serum eEF2 levels. Serum neuron specific enolase (NSE) and squamous cell carcinoma antigen (SCC) levels in the observation group were assessed with an automatic biochemical analyzer. Results: The median levels of eEF2 in the serum of NSCLC patients was found to be significantly higher than the healthy control group (p < 0.01) and it was markedly higher in stages III, IV than stages I, II (p < 0.05). eEF2 was higher with tumor size ${\geq}2$ cm than <2 cm (P< 0.01). Furthermore, two weeks after surgery patients showed a significant trend for eEF2 decrease (p < 0.05). Conclusions: The eukaryotic elongation factor 2 (eEF2) has certain clinical values for early diagnosis, verification, and prognosis as well as classification of lung cancer patients.
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Identification of Driving <i>ALK</i> Fusion Genes and Genomic Landscape of Medullary Thyroid Cancer
Ji, Jun Ho,Oh, Young Lyun,Hong, Mineui,Yun, Jae Won,Lee, Hyun-Woo,Kim, DeokGeun,Ji, Yongick,Kim, Duk-Hwan,Park, Woong-Yang,Shin, Hyun-Tae,Kim, Kyoung-Mee,Ahn, Myung-Ju,Park, Keunchil,Sun, Jong-Mu Public Library of Science 2015 PLoS genetics Vol.11 No.8
<▼1><P>The genetic landscape of medullary thyroid cancer (MTC) is not yet fully understood, although some oncogenic mutations have been identified. To explore genetic profiles of MTCs, formalin-fixed, paraffin-embedded tumor tissues from MTC patients were assayed on the Ion AmpliSeq Cancer Panel v2. Eighty-four sporadic MTC samples and 36 paired normal thyroid tissues were successfully sequenced. We discovered 101 hotspot mutations in 18 genes in the 84 MTC tissue samples. The most common mutation was in the ret proto-oncogene, which occurred in 47 cases followed by mutations in genes encoding Harvey rat sarcoma viral oncogene homolog (N = 14), serine/threonine kinase 11 (N = 11), v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (N = 6), mutL homolog 1 (N = 4), Kiesten rat sarcoma viral oncogene homolog (N = 3) and MET proto-oncogene (N = 3). We also evaluated anaplastic lymphoma kinase (<I>ALK</I>) rearrangement by immunohistochemistry and break-apart fluorescence <I>in situ</I> hybridization (FISH). Two of 98 screened cases were positive for <I>ALK</I> FISH. To identify the genomic breakpoint and 5’ fusion partner of <I>ALK</I>, customized targeted cancer panel sequencing was performed using DNA from tumor samples of the two patients. Glutamine:fructose-6-phosphate transaminase 1 (<I>GFPT1)-ALK</I> and echinoderm microtubule-associated protein-like 4 (<I>EML4</I>)<I>-ALK</I> fusions were identified. Additional PCR analysis, followed by Sanger sequencing, confirmed the <I>GFPT1</I>-<I>ALK</I> fusion, indicating that the fusion is a result of intra-chromosomal translocation or deletion. Notably, a metastatic MTC case harboring the <I>EML4-ALK</I> fusion showed a dramatic response to an ALK inhibitor, crizotinib. In conclusion, we found several genetic mutations in MTC and are the first to identify <I>ALK</I> fusions in MTC. Our results suggest that the <I>EML4-ALK</I> fusion in MTC may be a potential driver mutation and a valid target of ALK inhibitors. Furthermore, the <I>GFPT1-ALK</I> fusion may be a potential candidate for molecular target therapy.</P></▼1><▼2><P><B>Author Summary</B></P><P>Little is known about the molecular biology of medullary thyroid cancer (MTC), which is a rare disease. Genomics are increasingly being used to improve our knowledge about disease biology and to identify therapeutic targets in many cancers. Here, we report the largest genomic results of MTC to date. MTC tissue frequently included several mutations. For the first time, anaplastic lymphoma kinase (<I>ALK</I>) rearrangements were detected in MTC: one case with a glutamine:fructose-6-phosphate transaminase 1 (<I>GFPT1</I>)<I>-ALK</I> fusion, and another case with an echinoderm microtubule-associated protein-like 4 (<I>EML4</I>)<I>-ALK</I> fusion. The fusion mechanism of the novel <I>GFPT1-ALK</I> fusion was successfully investigated using molecular biology techniques. In addition, an inhibitor of ALK (crizotinib) dramatically decreased the number of metastatic MTC lesions harboring the <I>EML4-ALK</I> fusion, thus verifying the fusion as a promising target in MTC. Our findings suggest that using rapidly improving sequencing techniques and accumulated genomic data to comprehensively perform genetic analyses on rare tumors, such as MTC, will help to improve the poor prognosis of orphan diseases.</P></▼2>
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