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RISS 인기검색어
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- 저자 : 최한설 (검색결과 3 건)
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Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease
최한설,이슬비,권정현,김혜순,손세정,홍영미 대한소아청소년과학회 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.10
Purpose: Incomplete Kawasaki disease (KD) is frequently associated with delayed diagnosis and treatment. Delayed diagnosis leads to increasing risk of coronary artery aneurysm. Anterior uveitis is an important ocular sign of KD. The purpose of this study was to assess differences in laboratory findings, including echocardiographic measurements, clinical characteristics such as fever duration and treatment responses between KD patients with and those without uveitis. Methods: We conducted a prospective study with 110 KD patients from January 2008 to June 2013. The study group (n=32, KD with uveitis) was compared with the control group (n=78, KD without uveitis). Laboratory data were obtained from each patient including complete blood count (CBC), erythrocyte sedimentation rate (ESR), platelet count, and level of alanine aminotransferase, aspartate aminotransferase, serum total protein, albumin, C-reactive protein (CRP), and N-terminal probrain natriuretic peptide (NT-pro BNP). Echocardiographic measurements and intravenous immunoglobulin responses were compared between the two groups. Results: The incidence of uveitis was 29.0%. Neutrophil counts and patient age were higher in the uveitis group than in the control group. ESR and CRP level were slightly increased in the uveitis group compared with the control group, but the difference between the two groups was not significant. No significant differences in coronary arterial complication and treatment responses were observed between the two groups. Conclusion: Uveitis is an important ocular sign in the diagnosis of incomplete KD. It is significantly associated with patient age and neutrophil count.
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Cardiac Function in Kawasaki Disease Patients with Respiratory Symptoms
이슬비,최한설,손세정,홍영미 대한심장학회 2015 Korean Circulation Journal Vol.45 No.4
Background and Objectives: Respiratory symptoms are often observed in children with Kawasaki disease (KD) during the acute phase. The association of respiratory viruses in children with KD was investigated using multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) and tissue Doppler echocardiography. Subjects and Methods: 138 KD patients were included from January 2010 to June 2013. We compared 3 groups (group 1: n=94, KD without respiratory symptoms; group 2: n=44, KD with respiratory symptoms; and group 3: n=50, febrile patients with respiratory symptoms). Laboratory data were obtained from each patient including N-terminal pro-brain natriuretic peptide (NT-proBNP). Echocardiographic measurements were compared between group 1 and group 2. RT-PCR was performed using nasopharyngeal secretion to screen for the presence of 14 viruses in groups 2 and 3. Results: The incidence of KD with respiratory symptoms was 31.8%. The duration of fever was significantly longer, and coronary artery diameter was larger in group 2 than in group 1. Tei index was significantly higher and coronary artery diameter larger in group 2 than group 1. Coronary artery diameter, C-reactive protein levels, platelet count, alanine aminotransferase levels, and NT-pro BNP levels were significantly higher and albumin levels lower in group 2 compared with group 3. Conclusion: NT-pro BNP was a valuable diagnostic tool in differentiating KD from other febrile viral respiratory infections. Some viruses were more frequently observed in KD patients than in febrile controls. Tei index using tissue Doppler imaging was increased in KD patients with respiratory symptoms.
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Cardiovascular Screening in Asymptomatic Adolescents with Metabolic Syndrome
배현경,최한설,손세정,신해정,남재환,홍영미 한국심초음파학회 2015 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.23 No.1
Background: In recent days, the prevalence of childhood metabolic syndrome (MS) has increased substantially due to theincreasing rate of childhood obesity on a global scale. The aims of this study were to detect the important parameters and providethe screening system to prevent cardiovascular disease in adolescents with MS. Methods: Ninety one male adolescents were divided into two groups based on the presence or absence of MS. Anthropometricmeasurement and laboratory study were studied. Intimal medial thickness and pulse wave velocity were estimated. Leftventricular mass index (LVMI), ejection fraction, myocardial velocity, strain and strain rate were measured by tissue Dopplerimaging and strain rate imaging. Results: The prevalence of MS was 7.7%. Weight, body mass index (BMI), waist circumference (WC), glucose, insulin,homeostasis model assessment of insulin resistance, triglyceride and LVMI were significantly increased in the MS group. Highdensity lipoprotein-cholesterol (HDL-C), peak early diastolic myocardial velocity (e’), systolic myocardial velocity (s’) and globallongitudinal strain were significantly lower in the MS group. In univariant analysis, LVMI was significantly correlated with BMI,WC, fat %, fat mass, systolic blood pressure, alanine aminotransferase, total cholesterol (TC) and low density lipoprotein-cholesterol. e’ was significantly correlated with BMI, fat %, fat mass, and HDL-C. Global circumferential strain had significant correlation withglucose and TC. Basal anterolateral strain rate was significantly correlated with weight, BMI, WC, fat %, and fat mass. Conclusion: LVMI, strain and strain rate are practical and accurate parameters for assessment of left ventricular function inadolescents with MS.
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