자궁경부 세포검사에서 임신과 관련된 세포학적 변화

전이경,장회숙,김혜선,홍성란,최종순,박지영,조정숙,성석주,양재혁,김희숙,Chun, Yi-Kyeong,Jang, Hoi-Sook,Kim, Hye-Suu,Hong, Sung-Ran,Choi, Jong-Sun,Park, Ji-Young,Cho, Jung-Sook,Seong, Seok-Ju,Yang, Jae-Hyug,Kim, Hy-Sook 대한세포병리학회 2004 대한세포병리학회지 Vol.15 No.2

Due to insufficient clinical information, most cervicovaginal smears from pregnant or postpartum women have been screened without regard to pregnancy-related cytological changes. Here, we have reviewed 116 abnormal cervicovaginal smears from 103 pregnant and postpartum women. Initial cytological diagnoses revealed the following: 9 cases of high-grade squamous intraepithelial lesions (HSIL), 8 cases of low-grade squamous intraepithelial lesions (LSIL), 85 cases of atypical squamous cells of undetermined significance (ASCUS), and 14 cases involving atypical glandular cells of undetermined significance (AGUS). 31 cases upon review, involved pregnancy-related cytological changes, comprising 25 cases of decidua cells, 4 cases of Arias-Stella reaction, and 2 cases of cedidual cells coupled with Arias-Stella reaction. Interpretation errors were detected in 14 cases: 13 cases of decidual cells interpreted as either ASCUS favor reactive or ASCUS ruled out HSIL, and one case of Arias-Stella reaction was interpreted as ASCUS ruled out HSIL. Decidual cells and degenerated glandular cells with Arias-Stella reaction can result in diagnostic mistakes. In order to avoid misdiagnosis and unnecessary surgeries, both clinicians and pathologists must be aware of the pregnancy-related cytological changes. The clinician should also always inform the pathologist on the pregnancy status of the patient.

복막의 고분화성 유두상 중피종 -1예 보고-

전이경,김의정,홍성란 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.9

자궁경부 세포진에서 인유두종바이러스감염과 폐경후 편평세포 비정형성과의 연관성

전이경,문인걸,홍성란,김혜선,최종순,박지영,박종숙,김태진,김희숙,Chun, Yi-Kyeong,Moon, In-Gul,Hong, Sung-Ran,Kim, Hye-Sun,Choi, Jong-Sun,Park, Ji-Young,Park, Jong-Sook,Kim, Tae-Jin,Kim, Hy-Sook 대한세포병리학회 2004 대한세포병리학회지 Vol.15 No.2

Postmenopausal squamous atypia (PSA) is a phenomenon characterized by cellular alterations mimicking condyloma in the uterine cervix of postmenopausal women. It is not associated with human papillomavirus (HPV) infection. The aim of this study is to correlate findings with HPV infection and the cytohistologic findings of PSA. Eighty-three smears from postmenopausal women, initially interpreted as ASCUS and low-grade squamous intraepithelial lesions(LSIL), were reviewed according to the criteria of PSA. Fifty-eight cases were subsequently reclassified as PSA. Forty cases categorized as PSA were available for HPV-DNA detection by a nested polymerase chain reaction. Eight of these 40 cases(20%) showed biopsy-proven LSIL lesions. The HPV-DNA was detected in 42.5%(17/40), compared to 25%(5/20) of control cases. The HPV-DNA detection rate of biopsy-proven LSIL was 62.5%(5/8). It has been concluded that cytologic differential diagnosis of PSA from LSIL is difficult due to because of poor histologic and viral correlation.

기형유발물질 상담을 위한 인간배아발생의 이해

전이경,이희철 한국모자보건학회 2016 한국모자보건학회지 Vol.20 No.2

발생 첫 주에는 수정란이 분할을 거듭하여 주머니 배 상태로 자궁내막에 착상하며, 발생 2주에는 장차 배아가 되는 납작한 원반모양의 2겹 배반이 만들어진다. 배아기는 발생 3주에서 발생 8주까지이며, 인체의 주요 기관이 형성되는 중요한 시기이자 중추신경계를 선두로 심장, 귀, 눈, 사지, 치아, 구개, 외부생식기 등 주요한 기형이 발생하는 시기이기도 하다. 창자배 형성은 발생 3주 초에 시작하여 4주 말까지 계속되며 배아덩이 위판 세포에서 장기형성에 관여하는 외배엽, 중배엽, 내배엽의 세 종자층이 생긴다. 기형유발인자에 민감한 시기이지만 임신부가 임신한 것을 모르고 주의를 소홀히 하기 쉽다. 발생 3주 말에 신경판의 양쪽 신경주름이 가운데에서 만나 합쳐져 신경관이 만들어지며 신경관은 장차 뇌와 척수가 된다. 발생 25일과 28일경에 머리 쪽과 꼬리 쪽 신경구멍이 막혀서 폐쇄된 관 모양이 되며 제대로 닫히지 않으면 신경관 결손을 초래한다. 신경능선세포는 양쪽 신경주름의 꼭대기에 위치한 신경외배엽에서 유래한 세포이며 다양한 조직과 기관을 만든다. 신경관을 떠나 이주한 신경능선세포는 여러 기형유발물질에 손상 받기 쉽다. 얼굴과 심장속막방석 발생에 관여하므로 손상되는 경우 얼굴과 심장기형의 동반이 드물지 않다. Human embryology is the study of development from a single cell to a baby in 9 months. Implantation occurs at the end of the first week of development. The second week of development is known as the week of 2’s. Gastrulation, the most characteristic event occurring in the third week, establishes three germ layers composed of ectoderm, mesoderm, and endoderm. The three germ layers and neural crest cells lead to the development of their own tissues and organs during the embryonic period, which extends from the third to the eighth week. Major congenital malformations occur in the embryonic period. The fetal period, from the third month to the day of birth, is the time for maturation of tissues and organs, and growth of the body. Because of the close relationship between embryology and congenital abnormalities, knowledge of human development is essential to assess the effects on the embryo when the mother has been exposed to teratogens. This paper briefly reviews the normal embryonic development and associated congenital malformation.

Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review

전이경 대한병리학회 2015 Journal of Pathology and Translational Medicine Vol.49 No.6

Neuroendocrine tumors of the female reproductive tract are a heterogeneous group of neoplasms that display various histologic findings and biologic behaviors. In this review, the classification and clinicopathologic characteristics of neuroendocrine tumors of the female reproductive tract are described. Differential diagnoses are discussed, especially for non-neuroendocrine tumors showing high-grade nuclei with neuroendocrine differentiation. This review also discusses recent advances in our pathogenetic understanding of these disorders.

유방의 수질암종의 세침흡인 세포학적 소견 - 1예 보고 -

전이경,고일향,Chun, Yi-Kyeong,Ko, Ill-Hyang 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.1

Medullary carcinoma (MC) of the breast is an uncommon histologic form of infiltrating ductal carcinoma and the cytologic features of MC are not well delineated. We recently experienced a case of fine needle aspiration cytology of MC of the breast. The characteristic cytopathologic features were cellular aspirate consisting of large, pleomorphic cells in background of many single to clusters of lymphocytes.

자궁경부와 질에 발생한 연화판증의 세포소견 -1예 보고-

전이경,홍성란,김혜선,김지영,김복만,김희숙,Chun, Yi-Kyeong,Hong, Sung-Ran,Kim, Hye-Sun,Kim, Ji-Young,Kim, Bok-Man,Kim, Hy-Sook 대한세포병리학회 2008 대한세포병리학회지 Vol.19 No.2

Malakoplakia is an uncommon chronic granulomatous inflammation that usually involves the urinary and gastrointestinal tracts, but rarely affects the female genital tract. We experienced a case of malakoplakia in a cervicovaginal smear in a 54-year-old woman. Colposcopic examination showed a friable, easily bleeding tissue in the uterine cervix and the vaginal fornix. The cervicovaginal smear consisted of numerous isolated histiocytes, polymorphonuclear leukocytes, lymphocytes, and plasma cells. The histiocytes had an abundant, granular, and degenerated cytoplasm with inflammatory cell debris. Michaelis-Gutmann bodies were readily identified.

신세포암종의 요세포학적 소견 - 11예의 분석 -

전이경,조혜제,고일향,Chun, Yi-Kyeong,Cho, Hye-Jae,Ko, Ill-Hyang 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.2

Urine cytology is of limited value in the diagnosis of renal cell carcinoma with reported detection rates of $0\sim80%$. The aim of this study is to demonstrate the usefulness of urine cytology in renal cell carcinoma. In the eleven histologically proven cases of renal cell carcinoma, urinary smears were reevaluated. The cytologic results were as follows; positive for malignant cells in 3 cases(27%), suspicious in 2 cases(18%) and negative in 6 cases(55%). The average diameter of the tumor of the 5 cases reported as positive or suspicious for malignant cells was 9.7cm and 3 had invaded the renal pelvis. The other 6 tumors, reported as negative, were 5.7 cm in average diameter and one of them showed involvement of the renal pelvis. These results suggest that urine cytology is considered unsatisfactory in the early defection of renal cell carcinoma. However, careful examination of urinary smear could improve the detection rate especially in more advanced cases involving the renal pelvis as well as those of larger tumors.

자궁내 발달지연과 정상 말기임신 태반에서의 Telomerase 활성도와 MIB-1 및 Fas, Fas Ligand 발현차이에 관한 연구

전이경,홍성란,양문호 대한병리학회 2005 Journal of Pathology and Translational Medicine Vol.39 No.1

Background : The placenta from a pregnancy that is complicated by intrauterine growth retardation (IUGR) tends to be smaller than that from a normal pregnancy. To investigate this difference, we analyzed the telomerase activity, the proliferative activity and the mRNA levels of apoptosis mediators in placentas. Methods : In 20 placentas from normal third-trimester pregnancies and 22 placentas form pregnancies that were complicated by IUGR, the telomerase activity was detected by a telomeric repeat amplification protocol assay. The proliferative activity was assessed by immunohistochemical staining using the MIB-1 monoclonal antibody. The expression of the apoptosis mediator was evaluated by semi-quantitative reverse transcription-polymerase chain reactions for fas and fas ligand. Results : Telomerase activity was detected in 2 (10%) of 20 normal placentas, whereas it was not observed in all tested 13 placentas that were associated with IUGR. The proliferative activity was significantly low in the placentas that were associated with IUGR (7.44 2.96%), compared with the normal placentas (11.0 3.48%, p=0.002). There was no statistically significant difference in the mRNA levels of fas or fas ligand between two groups. Conclusions : Low telomerase and proliferative activities in the placenta may play a role in the pathogenesis of IUGR.

Absence of the Septum Pellucidum Associated with a Midline Fornical Nodule and Ventriculomegaly: A Report of Two Cases

전이경,김혜선,홍성란,지제근 대한의학회 2010 Journal of Korean medical science Vol.25 No.6

We report two autopsy cases that revealed the partial absence of the septum pellucidum with ventriculomegaly. In each case, the brain showed mild dilatation of both frontal horns of the lateral ventricles, normal third and fourth ventricles and no aqueductal stenosis. The posterior portion of the septum pellucidum was absent and the fornices were fused in a single midline nodule, abnormally displaced to a caudal position and lodged in the foramina of Monro. The brain base showed no apparent abnormalities;the optic nerves were well developed. We conclude that the caudally displaced fornix in the absence of the septum pellucidum may have intermittently obstructed the foramina of Monro and induced mild ventriculomegaly.