http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이제연,박미혜,김영주,전선희 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
Uric acid as a pathogenic factor was considered in preeclamptic pregnancies by recent epidemiological and experimental evidences, among which a similar vasoconstrictive effect of uric acid in placenta would inhibit fetal growth. We performed this study to determine the association of maternal uric acid levels with small-for-gestational-age (SGA) neonates in hypertensive women. We carried out a case-control study composed of 147 SGA group and 181 appropriate-for-gestational age (AGA) group, using retrospective analysis of electrical medical data bases from 328 hypertensive patients delivered at the Ewha Womans University MokDong Hospital from January 2000 to June 2013. We also divided the patients into early (n=85) and late onset of hyperension group (n=243) by gestational weeks at delivery (<34weeks Vs ≥34weeks). The mean maternal uric acid levels in total hypertensive patients and late onset of hypertensive patients were significantly higher in SGA group than AGA group (total patients; 6.48±1.48 vs 5.99±1.50 mg/dl, p=0.003, : late onset group; 6.41±1.55 vs 5.77±1.36 mg/dl, p=0.0006). However, in early onset group, there was no significant difference between SGA and AGA group ( 6.60±1.37 vs 6.94±1.75 mg/dl, p=0.17074) The sensitivity and specificity of uric acid at the cut off level 5.45 mg/dL for prediction of SGA in total hypertensive patients were 81.6% and 37 %, and those of uric acid at the cut off level 5.75 mg/dL in late onset hypertensive patients were 80.8% and 27.3%, showing low accuracy rate. Elevated maternal uric acid level was associated with development of SGA in hypertensive pregnant women. It needs further study that the uric acid as a pathogenic factor of SGA fetus might affect pregnant women differently according to the onset type of hypertension in pregnancy.
이제연,채령,홍석진,이상혁,진성민 대한이비인후과학회 2013 대한이비인후과학회지 두경부외과학 Vol.56 No.10
Background and Objectives High resolution manometry (HRM), a newly developed device that uses 36 channels to plot pressure topography of esophagus, has recently been applied to evaluate the esophageal and upper esophageal sphincter (UES) status; however, its definite role in laryngopharyngeal reflux disease (LPRD) is not well elucidated. The aim of this study was to evaluate clinical usefulness of HRM and to elucidate the association between HRM findings and dysphasia in LPRD patients. Subjects and Method A total of 56 patients who had been diagnosed LPRD from July 2010 to July 2011 were prospectively enrolled in this study. Patients consisted of 20 men and 36 women,with the mean age of 51.4 years. Every patient performed the questionnaire and HRM examination. A comparative analysis was performed to evaluate the correlation between the HRM results and LPRD. Results Of 30 patients (53.6%), there were 11 peristaltic dysfunction (19.7%), 6 relaxation impairment of lower esophageal sphincter (LES)(10.7%), 4 diffuse esophageal spasm (7.1%), 4 hypotensive LES (7.1%), 3 Nutcracker esophagus (5.4%), and 2 relaxation impairment of UES (3.6%). The mean distance of UES from the nostril was 17.88±2.17 cm and the mean UES basal pressure was 63.10±24.49 mm Hg. Differences between the prevalence of abnormal findings shown by HRM and dysphasia symptoms were not statistically significant. Conclusion In this study, a considerable amount of abnormalities in esophageal function were observed using HRM, and thus we think that HRM could provide useful information about esophagus dysfunction in LPRD patients.