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혈관질환 억제 효능이 있는 WK-38의 백서 신장 독성연구
김은주,이안숙,신선,김성연,장보윤,이호섭,강대길,Kim, Eun-Ju,Lee, An-Sook,Shin, Sun,Kim, Sung-Yeon,Chang, Bo-Yoon,Lee, Ho-Sub,Kang, Dae-Gill 대한한의학방제학회 2009 大韓韓醫學方劑學會誌 Vol.17 No.2
The kidney toxicities of WK-38 used for improvement of the vascular diseases, was examined using male and female Sprague-Dawley rats. The male and female rats were divided into 4 groups for intragastrical treatment with doses of 0, 5, 50, and 500 mg/kg/day for 13 weeks, respectively. In all male and female rats treated with WK-38, no mortality and gross pathological findings were shown for 13 weeks. There was substantially no change in body weight in all rats with treatment of WK-38. Urine osmolality as renal functional parameters were not exchanged in all rats treated with WK-38. The renal functional parameters including electrolytes excretory rate, creatinine clearance, and solute-free water reabsorption were significantly augmented on account of increase in urinary volume in female rats treated with WK-38, but not male. In summary, this study demonstrates that WK-38 exhibits no toxicity on kidney in all male and female rats.
혈관질환 억제 효능이 있는 BDR-29의 백서 신장 독성연구
김은주,강대길,이안숙,최덕호,조국현,김성연,이호섭,Kim, Eun-Ju,Kang, Dae-Gill,Lee, An-Sook,Choi, Deok-Ho,Cho, Kuk-Hyun,Kim, Sung-Yun,Lee, Ho-Sub 대한한의학방제학회 2008 大韓韓醫學方劑學會誌 Vol.16 No.2
The kidney toxicities of BDR-29 used for improvement of the vascular diseases, was examined using male and female Sprague-Dawley rats. The male and female rats were divided into 4 groups for intragastrical treatment with doses of 0, 5, 50, and 500 mg/kg/day for 13 weeks, respectively. In all male and female rats treated with BDR-29, no mortality and gross pathological findings were shown for 13 weeks. There substantially was no change in body weight in all rats with treatment of BDR-29. The renal functional parameters including urinary volume, urine osmolality, electrolytes excretory rate, creatinine clearance, and solute-free water reabsorption were not exchanged in all rats treated with BDR-29. Taken together, these results suggest that BDR-29 has no toxicity on kidney in all male and female rats.
쪽파 에탄올 추출물이 果糖 誘導 고혈압 백서의 腎臟 기능에 미치는 영향
강대길,이안숙,이윤미,손은진,염기복,이호섭 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.2
The present study was aimed to investigate whether ethanol-extract of Allium wageki has an ameliorative effect on the renal function in high fructose-diet induced hypertensive rats. The urine osmolality (Uosmol) was decreased in rats with high fructose-diet (60%) during the whole experiment period without change of the urine volume (UV). The urinary excretion of sodium (UNaV) and chloride (UCIV) were decrease significantly in rats with fructose-induced hypertensive rats, whereas urinary excretion of potassium (UKV) was increased. The creatinine clearance (Ccr) and solute-free water reabsorption were also decreased by treatment of fructose-rich diet. Among these renal functional parameters, Ccr was partially restored by the administration of ethanol-extract of Allium wageki. The Uosmol was also partially restored by the administration ethanol-extract of Allium wageki at the end of the experimental period. Taken together, ethanol-extract of Allium wageki has the ameliorative effect on glomerular filtration rate in rats with high fructose-diet induced hypertension.
Glycyrrhizin의 항산화 活性 및 Gentamicin 誘導 急性 腎不全 白鼠 腎臟의 Na,K-ATPase 발현에 미치는 영향
손은진,강대길,이안숙,이윤미,윤명호,염기복,노숙연,이호섭 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.2
The present study was aimed to investigate whether glycyrrhizin, which is the major component of Glycyrrhiza uralensis, has an antioxidant effect and regulatory effect on Na,K-ATPase in gentamicin-induced acute renal failure (ARF) rats . It is well known that reactive oxygen species (ROS), such as superoxide anion and hydroxyl radical, are main pathophysiological factor in gentamicin-induced ARF. Glycyrrhizin showed potent in vitro antioxidant activity, especially superoxide scavenging activity, in a dose-dependent manner. Plasma lipid peroxide level was restored to normal level by oral administration of glycyrrhizin (200 mg/kg) in the gentamicin-induced ARF rats. The expression of Na_(2)K-ATPase α 1 subunit was restored in the gentamicin-induced ARF rats by administration of glycyrrhizin, whereas β1 subunit was not restored. The renal functional parameters including urine volume, cleatinine clearance, urine osmolality, solute-free water reabroption were also partially restored in gentamidin-ARF rats by administration of glycyrrhizin. Taken together, the amelioration of renal functions and the expression of sodium pump by administration of glycyrrhizin in the gentamicin-induced ARF was appear to be mediated by the scavenging of ROS.