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Mutation and Expression of DNA2 Gene in Gastric and Colorectal Carcinomas
이석형,이성학,김유리,유남진 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.4
Background : Deregulation of DNA repair and replication are involved in cancer development. DNA2 is a nuclease/helicase that plays roles in DNA repair and replication. The aim of this study was to explore DNA2 mutation and DNA2 protein expression in gastric cancers (GCs) and colorectal cancers (CRCs). Methods : We analyzed two mononucleotide repeats in DNA2 in 27 GCs with high microsatellite instability (MSI-H), 34 GCs with stable MSI (MSS), 29 CRCs with MSI-H and 35 CRCs with MSS by single-strand conformation polymorphism. We also analyzed DNA2 expression in GCs and CRCs either with MSI-H or MSS. Results : We found DNA2 mutations in two GCs (7.1%) and two CRCs with MSI-H (6.9%), but not in cancers with MSS. The mutations consisted of three cases of a c.2593delT and one of a c.2592_2593delTT, which would result in premature stopping of amino acid synthesis (p.Ser-865Hisfsx6 and p.Ser865Thrfsx20, respectively). DNA2 expression was observed in 16 (80%) of the GCs and 15 (75%) of the CRCs with MSI-H, but all of the cancers with DNA2 frameshift mutations were weak or negative for DNA2. Conclusions : Our data indicate that DNA2 mutation and loss of DNA2 expression occur in GCs and CRCs, and suggest that these alterations may contribute to cancer pathogenesis by deregulating DNA repair and replication.
李奭炯 韓國中國語文學會 2000 中國文學 Vol.34 No.-
謝章鋌是淸末민詞壇的領油人物, 被評爲堅持比軟公正而客觀的論詞態度. 其<賭棋山莊飼話>所錄的論詞觀點是博看歷代詞籍而取捨選揮的結果. 他對詞的認識大體上以浙西詞派爲中心而折衷常州詞派的看法. 他親自體會淸末混亂的社會和失去方向的詞壇, 謨求詞學的未來發展方向. 本稿就是以謝章錠對未來詞學應該如何發展的深求爲重要問題來商討的. 詞本來是音樂的歌詞. 在淸末雖然詞樂佚傳已經?久了, 可是詞人仍然注意詞的音樂成分. 詞樂佚傳的情況, 詞的合律典否賞際上不可證賞, 因而對詞音樂性的論議흔可能流於空論. 謝章綎親眼看到浙西詞派末流和常州詞派末流所呈現的文學性破壞現狀的嚴重性, 看淸了重視音樂性的詞學態度是沒意義的, 主張要恢復詞的文學性. 其內容槪括了對性情的强調和題材範園的績大. 這些主張對於提高從來被認爲小道的詞文學地位和社會償値設服力復張. 可是這使詞失去其整體性, 反而加速詞的詩化.
선단 고정 지압구의 거동 메커니즘과 형상에 따른 지지력 증대효과 검증을 위한 3차원 수치해석
이석형,김석중,한진태,진현식,황규철,이정섭 한국지반공학회 2022 한국지반공학회논문집 Vol.38 No.9
Micropiles are cast-in-place-type piles with small diameters. They are widely used for the foundation reinforcement of existing buildings and structures because this technique is easy to construct and economic. A base expansion structure is developed following the mechanism of radial expansion at the pile tip under compression. Numerical analysis, durability tests, and centrifuge tests have been conducted using the base expansion structure. In this study, three-dimensional numerical modeling was performed to describe the behavioral mechanism of the base expansion structure using steel bar penetration under compressive loading, and numerical analyses using centrifuge test conditions were performed for the comparative studies. Additionally, the base structure was modified based on the results of lab-scale analyses, and the bearing capacities of micropiles were compared using field-scale numerical analyses under various ground conditions.
사장정(謝章鋌) 사론(詞論) 연구(硏究) - 사(詞)의 문학성 회복과 관련하여 -
이석형 한국중국어문학회 2000 中國文學 Vol.34 No.-
謝章鋌是淸末?詞壇的領油人物, 被評爲堅持比軟公正而客觀的論詞態度。 其<賭棋山莊詞話>所錄的論詞觀點是博看歷代詞籍而取捨選揮的結果。 他對詞的認識大體上以浙西詞派爲中心而折衷常州詞派的看法。 他親自體會淸末混亂的社會和失去方向的詞壇, 謀求詞學的未來發展方向。 本稿就是以謝章鋌對未來詞學應該如何發展的深求爲重要問題來商討的。 詞本來是音樂的歌詞。 在淸末雖然詞樂佚傳已經?久了, 可是詞人仍然注意詞的音樂成分。 詞樂佚傳的情況下, 詞的合律與否實際上不可證實, 因而對詞音樂性的論議?可能流於空論。 謝章鋌親眼看到浙西詞派末流和常州詞派末流所呈現的文學性破壞現狀的嚴重性, 看淸了重視音樂性的詞學態度是沒意義的, 主張要恢復詞的文學性。 其內容槪括了對性情的强調和題材範圍的擴大。 這些主張對於提高從來被認爲小道的詞文學地位和社會價値說服力?强。 可是這使詞失去其整體性, 反而加速詞的詩化。
Double crown retained RPD의 4년 임상 관찰
이석형,Lee Seok-Hyung 대한치과보철학회 2004 대한치과보철학회지 Vol.42 No.1
Statment of problem : Little in known about the importance of selection of various double crowns as retainer in determining the outcome of treatment with double crown retained removable partial denture. Purpose : To obtain information about the effects and the results of this treatment modality. Material and methods : This study describes 61 double crown retained removable partial dentures worn by 51 patients from Samsung Medical Center, Seoul a time ranging between 6 and 48 months and evaluate occlusal contacts on the denture teeth, denture movement, incidence of denture relining, denture retention, fracture of dentures and abutments, hygiene, residual ridge inflammatory changes, number of lost abutment,. interruption of denture use. Results : One tenth of all the restorations were relined. Restorations in 21 arches fractured repeatedly for various reasons . There was no apparent interrelationship between fractures and the five groups. Conclusion : Good prognoses of removable partial dentures were shown in all groups(Kennedy Classes I, II, III, combination and few remaining abutment).