Double Pylorus 治驗例

元致奎,金鍾信,朴景華,尹鏞圭,崔信恩 최신의학사 1977 最新醫學 Vol.20 No.5

There have been several case reports of the double pylorus in the English literature since Christien published the first case of congenital double pylorus in 1971. A 29-year-old male who had been suffered from epigastric discomfort for about eight years turned out to have congenital double pylorus. Here we report the congenital double pylorus which was treated successfully by subtotal gastrectomy, for the first time in Korea.

담도계 질환자의 담즙성분의 변동에 대한 연구 - 제1보 -

원치규,이광수,김진영 대한소화기학회 1984 대한소화기학회 추계학술대회 Vol.1984 No.-

骨折時 Corticosteroid 投與가 骨組織內 ^(32)p 沈着에 미치는 影響

元致奎 現代醫學社 1968 現代醫學 Vol.9 No.2

A series of experiment was conducted with male mice to observe the effect of corticosteroid n metabolism of fractured bone. One hundred and eighty mice were divided into two groups; one in vivo group and the other n vitro group. Each of these were further subdivided into control, cortisone and DOCA groups. (A) ln vivo experiment; Corticosteroid (cortisone acetate 0.5mg/day, DOCA 0. ling/day) were injected subcutaneously or three successive days and closed, complete fracture of left femur was induced manually imme-$iately following final administration of corticoid. Ten mice each were sacrificed at 2, 4 and 6 days fracture. All femurs, fracture and intact, were immersed for 24 hours in solution of the {rebs-Ringer phosphate containing two microcurie of radioactive phosphorus. (B)In vitro experiment: A complete simple fracture of left femur was incurred in each of 90 mice and these animals were sacrificed, at the various time intervals following fracture as in vivo' experiment. All femurs were incubated with the Krebs-Ringer phosphate solution (containing ZaC H332PO4) room temperature for 48 hours. The femurs of corticosteroid groups were treated with 1.5mg 'cortisone acetate and 0.3mg of DOCA. In all experiments, the colorimetric determination of phosphorus was made after the method ribed Fiske, Subbarrow and radioactivity measurement was obtained by Geiger counter. The wing results were obtained; (1) No significant changes in phosphorus level of bone were noted between fracture and acture, or between in vivo and in vitro. rvals after fracture likewise had no appreciable effect on the level of phosphorus. (2) Specific activities of the phosphorus were increased in fractured bones DOCA groups decreased in cortisone groups. It can be assumed that incorporation of bone salt is accelerated by fracture and administr) of DOCA while it is inhibited by cortisone. (3) The similar pattern was also found in specific activity of phosphorus in both vivo vitro, experiments. From the above experiment, it can be concluded that the effect of corticost on bone metabolism is direct.

Grynfeltt's Hernia 치험례

원치규 최신의학사 1995 最新醫學 Vol.38 No.1

1979년도 춘계 학술대회 : 59. 사체신장이식일예보고

원치규,김용일,이광수,이민혁,차희철 () 대한외과학회 1979 대한외과학회 학술대회자료집 Vol.- No.-

제30차 학술대회 : 132. 신장이식 - 10예 분석 -

원치규,김용일,이광수,정파완,김창호 () 대한외과학회 1978 대한외과학회 학술대회자료집 Vol.- No.-

肝腎症候群

元致奎,金鏞日 최신의학사 1978 最新醫學 Vol.21 No.5

膽囊 및 總輸膽管 膽石症患者의 膽囊 膽汁 脂質成分의 變動에 대한 硏究

金振瑛,元致奎 한양대학교 의과대학 1986 한양의대 학술지 Vol.6 No.1

Concentrations of bile lipids in gallbladder were analyzed and compared in 25 control subjects having no hepatobiliary and intestinal diseases, in 29 patients with gallbadder (GB) stones, and in 19 patients with common bile duct (CBD) stones. Bile samples were collected by aspirating the gallbladder with a syringe during laparotomy and analyzed for cholesterol, phospholipid, individual bile salts, bilirubin, proteins and total solids by microdetermination methods including thin layer chromatography and hydroxysteroid dehydrogenase assays. The results obtained were as follows: 1) Concentrations of cholesterol, phospholipid, total bile salts, bilirubin and proteins were decreased significantly in GB bile of patienst with GB and CBD stones, as compared with those of controls. The percent ratio of cholesterol to phospholipid or to bile salts (CROL/PL or CROL/BS) was significantly higher in both GB and CBD stones than in controls. The results suggested that decreases in bile lipid contents and increases in CROL/PL or CROL/BS were highly valuable to understand changes in bile compositions of GB bile in patients with gallstones. 2) GB bile was undersaturated with cholesterol in controls, but supersaturated in patients with gallstones especially in CBD stones. Plotting of bile lipid compositions on a triangular coordinate of cholesterol, phospholipids and bile salts revealed that bile samples located outside of the micellar zone were found to be 1 out of 25 cases of controls (4%), 10 out of 29 cases of GB stones (34%) and 13 out of 19 cases of CBD stones (68%), showing the highest supersaturability of GB bile with cholesterol in CBD stones. 3) All of the individual bile salts determined in the present study were significantly lower in GB bile of patients with gallstones than in that of controls (except for glycodeoxycholate and taurodeoxycholate in GB stone), and the results were marked in CBD stones than in GB stones. The degree of decrease in individual bile salts in GB bile of gallstones were observed to be greater in primary bile salts than secondary bile salts. 4) The ratio of glyco to tauro bile salts in GB bile was found to be lower significantly in patients with gallstones than in controls, suggesting that hepatic conjugation reaction of bile acids might be decreased more markedly with glycine than with taurine. 5) As compared with controls, concentrations of dihydroxy and trihydroxy bile salts in gallbladder bile were decreased in patients with gallstones, and the degree of decrease was observed to be marked in CBD stones than in GB stones. The ratio of dihydroxy to trihydroxy bile salts was significantly decreased in patients with gallstones than in controls.

결장뉴 전기활동도에 대한 Ouabain의 영향

김홍용,원치규 한양대학교 의과대학 1986 한양의대 학술지 Vol.6 No.1

The actions of ouabain on the spontaneous activity and the contractions induced by electrical stimulation were studied over the wide range of ouabain concentration in the isolated guinea-pig taenia coli. Spontaneous contractions were recorded with force transducer, and spike action potentials were measured extracelluarly by the use of suction electrode. The contractions of isolated taenia coli were induced by the electrical stimulation for 5 seconds every 1 minute with alternating current (60Hz, 3.0 V/cm) through platinum plate electrodes located in parallel with the long axis of the preparation. Effects of vanadate on spontaneous activity and electrically induced contractions were compared with those of ouabain. All experiments were performed in tris-buffered tyrode solution which was aerated with 100% O₂ and kept at 35℃. The results obtained were as follows: 1) Responses of spontaneous contractions to ouabain were dependent on the concentrations of ouabain. Almost no effect was induced by 10(???)M ouabain, and 10(???)M ouabain caused a gradual increase and maintained a certain level of tension. However, above the conentration 10(???)M ouabain an initial increase followed by a decrease in tension was observed. 2) A continuous spike discharge without a silent period was induced by the administration of 10(???)M ouabain. Above 10(???)M ouabain, a transient initial increase in electrical activity was followed by a decrease in spike frequency and amplitude and finally membrane potential was sustained at a certain level without a fluctuation and spike discharge. 3) The characteristic response to 10(???)M ouabain was not blocked by the pretreatment with 10(???)M atropine. 4) The electrically stimulated contractions were partially inhibited from the concentration of 2 x 10(???)M ouabain. As the concentration of ouabain increased, the contractions were blocked more rapidly. 5) The effects of vanadate (10(???)⁴M) were different from those of ouabain (10(???)M). Ouabain caused an initial increase followed by a decrease in tension, whereas vanadate caused a gradual increase in tension initially and then maintained a relatively constant tension. As to the contractions induced by electrical stimulation, ouabain suppressed tension development and blocked completely, while vanadate caused an initial rapid inhibition of tension development and then gradual recovery. From the above results, the following conclusions could be drawn: 1) The constant tension development induced by 10(???)M ouabain was due to continuous spike discharge without a silent period. The continuous spike discharge might be associated with a slight membrane depolarization caused by mild blockage of Na pump. 2) The biphasic response induced by above 10(???)M ouabain seemed to occur by the different mechanisms. The initial increase in tension was associated with depolarization of membrane along with an increase in spike frequency, whereas the subsequent secondary relaxation occurred through a non-electricl mechanism. 3) The characteristic response to 10(???)M ouabain was resulted not from the ouabain action on nerve terminal, but from its direct action on the membrane of smooth muscle cells.

결장뉴 수축성에 대한 Calcium 및 Verapamil의 영향

김수길,원치규 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.2

The influences of extracellular ?? and verapamil on the spontaneous activity and contractions induced by electrical stimulation were studied in guinea-pig taenia coli. Spontaneous contractions were recorded with force transducer, and spike action potentials were measured extracellularly by use of suction electrode. Preparations of taenia coli were stimulated for 5 seconds every 1 minute with alternating current (60Hz, 3.0 V/cm) through plate electrodes located in parallel with the long asix of the preparation. All experiments were performed in Tris-buffered Tyrode solution which was aerated with 100% O₂ and kept at 35℃. The results obtained were as follows: 1) The amplitude of spontaneous contractions (isometric tension) was maximal at the concentration of 2 mM ??, and above or below 2 mM ?? that was reduced in a dose-dependent manner. The frequency of spontaneous contractions, however, was continuously accelerated as extracellular ?? increased. Verapamil suppressed both frequency and amplitude of spontaneous contractions dose-dependently, and blocked completely at the concentration of 1 mg/1. 2) The frequency between bursts of spike discharge (bursts frequency) increased in parallel with increases in extracellular ??, whereas the frequency of spikes in a burst (spikes frequency) was maximally accelerated at the concentration of 2mM ?? and above or below 2 mM ?? that was attenuated dose-dependently. 3) Effects of ?? on the amplitude of spontaneous contractions were closely related to those on the spikes frequency, while bursts frequency determined the contractions frequency. 4) The electrically stimulated contractions were abolished in ??-free solution, and then increased dose-dependently until 4 mM ??. Above 4 mM ??, isometric contractions decreased. Verapamil depressed the electrically dirven contractions dose-dependently. 5) The inhibitory actions of verapamil on spontaneity and on electrically induced contractions were antagonized by the aministration of extra ??. The above results suggested that external ?? are essential for both excitation and contraction in guinea-pig taenia coli, and also have a stabilizing effect on the membrane, and the effects of ?? on the amplitude of spontaneous contractions result from those on spikes frequency in a burst.