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약물로 유도된 망막변성 흰 쥐에서 발생한 망막전위도의 초기 가역적 변화
노규화,박태관,온영훈.Kyu Hwa Roh. M.D.. Tae Kwann Park. M.D.. Young Hoon Ohn. M.D.. Ph.D. 대한안과학회 2006 대한안과학회지 Vol.47 No.7
Purpose: To evaluate the early ERG (electroretinogram) changes in N-methyl-N-nitrosourea (MNU)-induced retinal degeneration in rats. Methods: Thirty-six 6-week-old male rats were injected intraperitoneally with 60mg/kg MNU and divided into 6 groups. Histology and ERG were recorded for the rats of each group before treatment and at 3, 6, 12, 18, and 24 hours after MNU injection. Promptly after the ERG recording, rats were sacrificed and the eyeballs prepared for histologic sectioning. The Tdt-mediated dUTP-digoxigenin nick end labeling (TUNEL) method was used to detect photoreceptor cell death. Results: The first decreases of ERG responses were noticed maximally at 3 hours after the treatment. Thereafter, the amplitude of the responses was partially recovered at 12 hours post-treatment. The second decrease of ERG amplitudes was observed in the 18-hour recordings, and those changes progressed to 24 hours after the treatment. In the histologic findings, TUNEL (+) cells in the Outer Nuclear Layer (ONL) were not detected at 3 hours after MNU injection, but were initially noticed at 6 hours post-injection. Conclusions: The first decreases of ERG amplitudes proceeded the appearance of TUNEL (+) cells in ONL, and these electrophysiological changes seemed to not be related to photoreceptor cell death. We propose that electrophysiological changes observed might be related to the MNU-induced activity enhancement of guanylate cyclase in the phototransduction pathway. We also show that photoreceptor cell death in the MNU-induced retinal degeneration model occurs at 6 hours after the treatment, which is earlier than the results of previous reports.
백순철,김동규,강승민,온영훈,Soon-Chul Baek,Dong-Kyu Kim,Seung-Min Kang,Young-Hoon Ohn 대한안과학회 2005 대한안과학회지 Vol.46 No.8
Purpose: To evaluate the results of amblyopia on multifocal electroretinogram (mfERG). Methods: The mfERG procedure was performed on nineteen monocular amblyopic patients (age ranged from 7 to 42 years) using the VERISTM (EDI, San Mateo, CA) system. The central 30 degrees of ocular fundus were stimulated by an array of 103 hexagonal elements for four minutes. The responses of six concentric rings (rings 1 to 6) radiating from the foveal center were averaged, and the latencies and amplitudes of N1, P1 and N2 were compared with the findings of the normal contralateral eyes. The mfERG procedure was recorded again after improvement of vision in one patient (No. 4) who underwent occlusion treatment for one month. Results: There were no significant differences of N1, P1 and N2 latencies between normal contralateral and amblyopic eyes (P>0.05). However, P1 amplitudes of the amblyopic eyes were reduced significantly compared with those of the normal contralateral eyes on rings 1 and 2 (P<0.05). N1 and N2 amplitudes of the amblyopic eyes were also reduced, but not significantly. After the successful occlusion treatment of patient No. 4, the responses of the amblyopic eye were improved but not the level of the contralateral normal eye. Conclusions: These results suggest that amblyopia may cause some changes in mfERG responses, especially in terms of amplitudes of the central retina. Further investigation is needed to determine whether these results are due to the physiologic change(s) of the amblyopia itself or to fixation instability during the test.