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흰쥐의 무기수은 투여시 Metallothionein 형성에 대한 셀레늄의 보상효과
양요환,이효민,신동천,정용 大韓産業醫學會 1989 대한직업환경의학회지 Vol.1 No.2
This study was conducted to investigate the metallothionein induction by sodium selenite in mercuric Chloride intoxication. Mercuric chloride of 3.0mg/kg of body weight was administered simultaneously with sodium selenite of either a high dosage of 2.5mg/kg via intraperitioneal injecion to rats. After the treatment, 6, 12, 24 and 72 hours later, mercury and selenium content in liver and kidney tissues, serum transaminase activities(SGOT, SGPT), metallothionein, glutathione, glutathione peroxidase activity and histological changes were determined. The results were summarized as follows on : 1. The combined administration of mercury and selenium significantly more decreased mercury concentrations in liver and kidney compared to the administration of mercury only. 2. The combined administration of mercury and selenium significantly more increased renal metallothionein compared to administration of mercury only. This phenomenon was more remarkable when a large dose(2.5mg/kg)of selenium was administered with mercuric chloride. 3. Glutathione concentration, glutathione peroxidase activity in liver and kidney and serum transaminase activity(SGOT, SGPT) were less suppressed in the combined administration group than the mercury only group.
연탄(煉炭)가스 중독자(中毒者)의 생활환경(生活環境)에 관(關)한 역학적(疫學的) 연구(硏究)
김인달,윤덕로,최용어,윤인재,이철구,양요환,Kim, In-Dal,Yun, Dork-Ro,Choi, Y.O.,Yun, I.C.,Lee, C.K.,Yang, Y.H. 대한예방의학회 1972 Journal of Preventive Medicine and Public Health Vol.5 No.1
Carbon monoxide poisoning is one of the most serious health problems in Korea, because we have been encountered with the highest incidence of CO poisoning in the world due to the unique heating system in home called 'ondal'. We opened Hyperbaric chamber unit in the Seoul National University Hospital last Jan, 1969. We have treated 848 patients as of Sept. 30., 1972, around 44 months period. We collected the informations on the environmental conditions of the place where CO intoxication actually occured by filling up the questionaire from 505 patients. The following findings were obtained. 1. Age distribution showed that the highest incidence was found in the younger age group between age of 10 to age of 29 in both sex. 2. Sex ratio of the patients was 1:1.14. 3. The socio-economic level of the patient was relatively low. 4. Housewife & housemaid were the major victims of the intoxication in the female patients & in the case of the male patient, occupational backgrounds were diverse. 5. Many patients from the middle class experienced the intoxication by sleeping at newly built room. 6. Many intoxication has been occured in the structure of houses where communicating doors are existing between living room & kitchen. 7. All findings obtained taught us again that CO poisoning is the serious by-product of the national fuel policy which put emphasis on the use of coal & socio-economic status is a very important parameter in this hazards.