저산소 뇌허혈 백서에서 풍요한 환경이 운동과 인지 발달에 미치는 영향

양신승,김봉옥,최필순,김성겸,손민균 대한재활의학회 2010 Annals of Rehabilitation Medicine Vol.34 No.1

Objective: To investigate the effect of environmental enrichment on the cognitive and motor development in the experimental hypoxia-ischemic encephalopathy neonatal rat model. Method: Hypoxic-ischemic encephalopathy models were made in neonatal Sprague-Dawley rats at 3 days of age by ligating the unilateral carotid artery followed by inhalation of 8% oxygen and raised in the enriched environment (n=10), treadmill exercise (n=8) and non-stimulation (n=10) from the 3rd to 8th weeks of age. Neurobehavioral and histopathological changes were compared. Results: The neurobehavioral tests of the rats with hypoxic- ischemic encephalopathy showed prolonged latencies of achievement for cliff avoidance and negative geotaxis (p<0.05). Persisting abnormality into adult life of limb placing improved in exercise and enriched environment groups and spatial learning and memory in a water maze recovered in the rats with enriched environment (p<0.05). The density of dendritic spine increased in the hippocampus with enriched environment (p<0.05). Conclusion: The present study supports the possibilities of the positive effects after the enriched environment in the developing brain with hypoxic injury. (J Korean Acad Rehab Med 2010; 34: 1-9)

Shope Rabbit Papillomavirus DNA의 Cloning 및 특성 규명

신승식,양용태,정상인,최철순,구자현,고재경 중앙대학교 의과대학 의과학연구소 1989 中央醫大誌 Vol.14 No.2

Shope rabbit papillomavirus (SRPV), a member of Genus papillomavirus of Family Papovariridae, causes benign tumors (papillomas) of squamous epithelium both in its natural host, i.e.,, cottontail rabbits and in its artificial host, i.e., domestic rabbits. So far, SRPV has never been successfully cultivated in tissue culture cells, and the lack of reliable tissue culture system for transformation assay has seriously hindered the progress in the oncogenic study of this well-known DNA tumor virus. Therefore, the only possible way of obtaining SRPV in, the laboratory is to inoculate cottontail rabbits with SRPV and to harvest the virus-loaded papilloma tissues. This study was undertaken 1) to isolate SRPV DNA from SRPV-induced papillomas of either cottontail rabbits or domestic rabbits, 2) to determine the restriction endonuclease cleavage sites of such purified SRPV DNA, 3) to carry out cloning of SRPV DNA in E. coli with the use of pBR322 vector and 4) to test the oncogenicity of cloned SRPV DNA-pBR322 recombinants in the domestic rabbits through inoculation experiments. The results are summarized as follows. 1. Though repeated attempts failed to isolate purified Shope rabbit papillomavirus DNA from the domestic rabbit papillomas (DRP), a good yields of purified SRPV DNA were successfully isolated from the cottontial rabbit papillomas (GRP). 2. With the purified SRPV DNA from GRP, the presence of cleavage sites for a number of restriction endonucleases was confirmed and extended, and the approximate molecular length of isolated SRPV DNA was determined to be 8 kbp. 3. Molecular cloning of isolated SRPV DNA was completed in E. coli YMC-10, using pBR322 as the vector, at the Eco RI and Sal I cleavage site, respectively. The cloned products were either Eco RI-site cloned SRPV DNA-pBR322 recombinant or Sal I site-cloned SRPV DAN-pBR322 recombinant. 4. Inoculations of cloned SRPV DNA-pBR322 recombinants into the domestic rabbits' skin failed to establish the oncogenic potential of the cloned products.

10 대 여성의 임신에 관한 임상통계학적 고찰

신승권,윤광혁,양우열,고만석,정병욱,정진국,이호형 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.5

본 병원 산부인과에서 1992년 1월 1일부터 1996년 12월 31일까지 만 5년 동안 경험하였던 10대 임산부 194명과 20∼29세까지의 대조군 200명을 대상으로 임신과 분만에 따른 각종 합병증과 위험인자를 비교 분석한 결과 다음과 같은 결과를 얻었다. 1. 연도별 분포는 1992년 1.08%, 1994년 1,32% 그 리고 1996년 2.11%로 점차 증가하는 경향을 보였다. 2. 연령 분포는 14세에서 19세 사이였으며, 19세 가 58.8%로 가장 많았다. 3. 과거 임신 경 력 첫 번째 임신인 경우가 56.7% 로 가장 많고 3회인 경우가 7예(3.6%), 4회인 경우도 1예(0.5%)이었다. 4. 산전관리의 빈도는 10대 임산부에서 대조군보 다 유의하게 낮았다(p<0.05). 5. 임신 주수의 분포는 10대 임산부는 평균 40+1주 로 대조군의 40+4주와 유의한 차이를 보이지 않았고, 37주 이하의 미숙아 분만과 42주 이상의 과숙아 분 만도 대조군과 유의한 차이는 없었다. 6. 임신중 산모 체중 증가는 10대 임산부에서 평 균 11.27 kg으로 대조군의 13.26 kg보다 유의하게 낮 았다(p<0.05). 10대 임산부에서는 5.0∼9.9 kg의 체중 증가가 유의하게 높은 빈도를 보였다. 7. 10대 임산부에서 신생아 평균 체중은 3.06 kg 로 대조군의 3.36 kg보다 의미있게 낮았다. 10대 임 산부에서 1,500∼2,499 gm인 경우가 6.2%로 대조군 의 2.0%보다 유의하게 높았고(p<0.05), 4,000 gm 이 상인 경우는 대조군과 유의한 차이는 없었다. 8. 제왕절개에 의한 복식 분만율은 5.7%로 대조군 의 20.5%와 유의한 차이를 보였다(p<0.05). 9. 제왕절개술의 적응증으로는 아두골반불균형, 협착 골반이 각각 36.3%, 27.3%로 대조군보다 많았 지만 통계학적으로 유의한 차이는 보이지 않았다. 10. 분만 전 합병증은 빈혈(16%), 방광염(4.1%), 임 신중독증(3.1%)이 대조군보다 높았지만 유의한 차이 는 없었다. 11. 분만 후 합병증은 빈혈(29.9%), 요로감염(13.9 %)이 대조군보다 높았지만 유의한 차이는 없었으며, 그 밖에 방광무력증, 산후출혈, 열상등도 대조군과 유의한 차이를 보이지 않았다. 12. 신생아 합병증에 있어서 주산기 사망률, 저 Apgar score, 자궁내 발육지연, 선천성 기형에서도 대 조군과 유의한 차이를 보이지 않았다. Social and Sexual mores have been changing rapidly and the problem of teenage pregnancy continues to grow in this country. Recently, industrialization and a complex urban society unduly prolong education and delay marriage and sexual gratification, and little attention has been given to the adolescent who are more susceptible and vulnerable than adults in physical, socioeconomical and psychological aspects. Several studies indicate that good prenatal care, meticulous medical care, intensive nutritional counselings and attention to the psychological, socioeconomic problems of pregnancy reduce the perinatal death and complication rate for pregnant teenagers. The objective of the study was to compare several obstetric characteristics and outcomes of one hundred ninety four pregnant under age 20 who were delivered at department of obstetrics and gynecology, Mokpo St. Columban Hospital from January 1992 to December 1996 to those of two hundred pregnant aged 20∼29 who were chosen at random during the same period as the control group. The results were as follows; 1. The proportion of birth to teenagers increased from 1.08% of all birth in 1992 to 2.11% in 1996. 2. Almost cases were in high teen group, age of 14∼19. The majority (58.8%) were in the age of 19. 3. 110 cases (56.7%) had no previous pregnancy history. Seven patients had three times, and one patient had four times of previous pregnancy history. 4. The frequency of prenatal care was significantly lower than the control group (p<0.05). 5. The mean gestational period was 40+1 weeks, and there was no significant difference between the study group and the control group. The incidence of preterm and postterm delivery was not significant difference between the two groups. 6. The mean weight gain of pregnant teenagers was 11.27 kg, significantly smaller than the control group. The maternal weight gain of 5.0∼9.9kg was significantly higher than the control group. 7. The mean birth weight (3.06kg) of infant was significantly smaller than the control group. The incidence of 1,500∼2,499 gm birth weight 6.2%) was significantly higher than the control group (2.0%). 8. The rate of abdominal delivery (5.7%) was significantly lower than the control group (20.5%). 9. The incidence of cephalopelvic disproportion and contracted pelvis for cesarean section was somewhat higher than the control group, but not significant statistically. 10. In the antepartum complication, anemia, cystitis, and pregnancy induced hypertension occurred more frequently in the teenage pregnancy than the control group, but not significant statistically. 11. In the postpartum complication, anemia (29.9%), urinary tract infection (13.9%) occurred more frequently than the control group, but not significant statistically. 12. The perinatal mortality, low Apgar score, intrauterine growth retardation, and congenital anomaly were not significant different between the two groups.

로드경비로봇 모델 연구

양경애,신승중 국제문화기술진흥원 2018 The Journal of the Convergence on Culture Technolo Vol.4 No.4

경찰청 생활안전국의 자료에 따르면 빈집 등에의 침입이 2013년부터 2016년까지 증가하였다. 이렇게 주거침입, 절도가 늘고 있다. 또한 검찰청 절도 통계자료에 따르면 2016년 총 203,573건의 절도범죄가 발생하였고 이중에 18.9% 가 침입절도로 침입한 뒤에 절도를 한 것으로 나타났다. 이렇게 침입을 하여 절도를 하는 형태의 절도가 가장 많기 때문에 우리는 관리할 것이 많은 공장에 보안을 강화하기 위해 로드경비로봇 모델을 연구하게 되었다. 높은 곳까지 보안에 신경쓰기위해 드론까지 사용하여 지상을 관리하는 로봇과 협동하여 제어하는 로드경비로봇 모델을제안하게 되었다. 로봇과 드론이 함께 움직이고 물체를 피해가는 자율주행 형태와 시간 간격을 체크하고 전력 부족 시에는 충전기에 다시 돌아와서 충전하는 형태의 모델이다. According to the National Security Service of the National Police Agency, intrusion into empty houses increased form 2013 to 2016. Consequentially this statistics seemed that house intrusion, burglary is increasing. Also according to the statistics of Public Prosecutors’Office, a total 203,573 theft crimes occurered in 2016, of which 18.9% were theft after intruding. By reson of this is most frequent case of intrusion and theft, we have been studing the RodSecurityRobot model to enhance security in many factories to manage. In order to care for security to the high place, we have propsed a road guard robot model which controls the ground in cooperation with the robot that manages the ground by using the drones. The robot and the drone move together to autonomy to avoid objects. And they check time interval. they also goes to the charger to charge when there is no battery.

주제 : 디지털 경영에서의 산업공학의 역할 ; HealthCare 기반의 CRM 발전방향

신승복,양현창,조문수 대한산업공학회 2001 대한산업공학회 추계학술대회논문집 Vol.2001 No.-

HealthCare 기반의 CRM 발전방향

신승복,양현창,조문수 대한산업공학회 2001 대한산업공학회 추계학술대회논문집 Vol.2001 No.11

자궁외임신에 관한 임상적 고찰

신승권,최호준,윤길팔,양영균,양우열,고만석 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.4

The study was undertaken for the clinical evaluation and statistical analysis on the 222 patients with ectopic pregnancy who had been adbitted and treated at the Mokpo St. Columban`s Hospital from Jan. 1, 1993 to Dec. 31, 1995. The results were obtained as follows. 1. Hospital incidence of ectopic pregnancy wasd 1 in 45 deliveries(222/10,078). 2. Ectopic pregnancy was found to occur most frequently in the age group, ranging from 31 to 35 years(36.9%). 3. Nullipara was 26.5% and woman who had experienced artificial abortion was 69.8%. 4. Hemoglobin value over 10.0 gm/dL was in 78.8% and below 8.9 gm/dL in 4.1%. 5. Initial systolic blood pressure rise above 100 mmHg was in 75.0%, the mean value was 104.5mmHg. 6. The clinical manifestations were appeared in 64.4% from the last menstrual peroid to the next 5~8 weeks. 7. Total amount of intraperitoneal hemorrhage between 100~1,000 ml was in 62.1%, above the 1,000 ml was in 29.3% and less than 100 ml was in 8.6%. 8. Ectopic pregnancy was implanted follopain tuve in 95.0% ovary in 4.5% and cervix in 0.5%. Among tubal pregnancies, ampulla portion was involved in 76.6%, interstitial portion in 3.1%, isthmic portion in 12.2% and fimbrial portion in 3.1%. 9. In the past history, the laparoscopic tubal ligation was in 18%, peritonitis was in 1.8%, appendectomy was in 7.2% and cesarean section was in 8.6%. 10. Culdocentesis was positive in 70.0% and urinary HCG test was positive in 90%. 11. 77.8% of total cases was treated by salpingectomy, 14.9% by salpingoophorectomy and 1.4% by hysterectomy. 12. Of 222 total cases, no death occurred.

오존을 이용한 전처리공정에서의 슬러지 ORP와 pH 변화

양세일,신승복,박주용,이승희 한국폐기물자원순환학회 2005 젊은 연구자 학술연구발표회 Vol.4 No.0

주제 : 디지털 경영에서의 산업공학의 역할 ; 인터넷을 기반으로 하는 학술회의 운영 방법과 향후 발전 방향

양현창,조문수,신승복 대한산업공학회 2001 대한산업공학회 추계학술대회논문집 Vol.2001 No.-

인터넷을 기반으로 하는 학술회의 운영 방법과 향후 발전 방향

양현창,조문수,신승복 대한산업공학회 2001 대한산업공학회 추계학술대회논문집 Vol.2001 No.11