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김탁희,조경우,권삼현 전북대학교 의과학연구소 1986 全北醫大論文集 Vol.10 No.4
Biotin-containing decarboxylase, oxaloacetate decarboxylase, and methylmalonyl-CoA decarboxylase have been known that they can maintain a high gradient of Na+ across the bacterial cell membrane vesicles. Avidin, a substance which has avery high affinity for biotin prevented completely the sodium uptake and also decarboxylation reaction. It has been known that the evergy released by decarboxylation reaction could perform the high sodium gradient across the membrane vesicles. Neither hemodynamics nor urinary flow were changed by intravenous injection of avidin. Urinary excretion of sodium and chloride was significantly increased by intravenous injection of avidin. These results suggest that there might be a system sensitive to avidin which controls the sodium trasport in mammalian epithelial tissue of the kidney, and the system supposedly to be biotin-containing decarboxylases.
김탁희,이명선 韓國保健敎育.健康增進學會 2001 보건교육건강증진학회지 Vol.18 No.2
The objective of this study is to give basic materials for selection and improvement of contents of safety education, which is substantially helpful to elementary students, by analysis of contents of safety education in some subjects and assessment of the needs of elementary students for safety education. For this purpose, this study was analyzed the contents of safety education in five subjects for elementary school and conducted the survey of 883 students in some elementary schools in Seoul from April 7 to 22, 2000. The results were as follows; 1.As a result of analysis of the proportion of contents regarding safety-related education in some subjects, Physical Education occupied the highest proportion (14.09%), and that was followed by Practical Subject (9.55%) and Moral Education (9.34%). However, the proportions in Social Study and Natural Science were very low,1.85% and 1.31% each. In total lines of these five subjects, the numbers of line regarding safety education was contained by 5.78%. 2.Analyzing the proportion of domains of safety education in five textbooks, the Meaning of Safety and Basic Principles occupied the highest portion (29.5%), and that was followed by the Home Safety (24.0%), the Safety in School (17.1%), and the Play and leisure Safety (14.0%). The Coping with Accidents and First Aid, the Safety from Fire and Explosion, and the Traffic Safety occupied relatively low portion, 6.9%, 5.7%, and 2.8% each. 3.As a result of analysis of the proportion of the safety education domain in each subject, the Meaning of Safety and Basic Principles occupied the highest portion (23.6%) in Moral Education, the Home Safely (12.7%) in Practical Subject, and the Play and Leisure Safety (10.9%) in Physical Education. 4.Most of the participants in this survey experienced the Home Accidents (71.1%). And also, they experienced the Play and Leisure Accidents (57.9%), the Accidents in School (49.7%), the Traffic Accidents (45.3%), and the Fire and Explosion Accidents (24.7%) in order. 5.In the average proportion of the needs of participants for safety education in each domain, the Coping with Accidents and First Aid has the highest point (4.05). And, that was followed by the Home safety (3.79), the Safety from fire and Explosion (3.73), the Meaning of Safety and Basic Principles (3.65), the Play and Leisure Safety (3.50), the Safety in School (3.37), and the Traffic Safety (3.35). The average proportion of the needs for safety education of total domains was 3.66. 6.In the needs for safety education regarding the feature of participants, it showed higher scores in female students than male ones (p<0.001), in lower grader than higher grader (p<0.05), and in the students born to wealth than those born poor (p<0.05). Also, the children who recognize the necessity of safety education showed higher scores of the needs for safety education (p<0.001). And it also showed the same results of high score to the children whose parents did the safety education (p<0.001) and to the children and their parents who have the higher degree of practicing safety (p<0.001), and these differences were statistically significant. 7.In the extent of preference for methods of safety education, it showed high score to the Field learning, followed by the Audio-Visual Education, the Discussion, and the Instruction of teacher. In the extent of preference for subject regarding the contents of safety education by each domain, it showed high score to the subject of Safety for 4 domains - the Meaning of Safety and Basic Principles, the Traffic Safety, the Safety from Fire and Explosion, and the Coping with Accidents and First Aid. And also, they preferred Moral Education for 2 domains - the Home safety and the Safety in School, and Physical Education for a domain of the Play and Leisure Safety. 8.While 27 of 36 detail items was contained the content of safety education, the proportion of needs of participants for safety education showed more than average 3.00 score in 34 of 36 detail items. However, none of 9 detail items was included in five textbooks. Also, 2 detail items - the Coping with Disasters and the Safely from Poisoning - were included together 2 parts; One part had the higher ranked 7 items acquired by analysis of the needs, and the other had the higher ranked 7 items acquired by analysis of the contents. But, except those 2 items, none of items were matched with each part.
김용현,조경우,김탁희 대한신장학회 1987 Kidney Research and Clinical Practice Vol.6 No.2
The heart has been suggested as an endocrine gland secreting a new hormone affecting renal functions. Atrial cardiocytes are confirmed to secrete peptides possessing a rapid and potent natiriuretic and diuretic activity. In the present experiment, it was attempted to explore the possible alteration of the renal responsiveness to the atrial extract in spontaneously hypertensive rats as well as in normotensive Sprague-Dawley and Wistar rats as control. Intrarenal arterial infusion of atrial extract caused a decrease in blood pressure of spontaneously hypertensive rat as well as normotensive control rats. Plasma renin activity showed a decrease without significance in both spontaneously hypertensive and normotensive rats. Intrarenal arterial infusion of atrial extract caused increases of urinary volume and sodium excretion in normotensive rats, but did not affect in spontaneously hypertenssive rat. These date suggest that the natriuretic and diuretic effects by atrial extract are suppressed in spontaneously hypertensive rat compared to normotensive rats, and so that the renal responsiveness to the atrial natriuretic peptide may be altered in spontaneousely hypertensive rats.