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김윤근,이상록,손지웅,김우경,박재경,지영구,송숙희,이명현,조상헌,민경업,고영률,김유영 대한천식알레르기학회 1996 천식 및 알레르기 Vol.16 No.3
Background: The bronchial hyperresponsiveness (BHR) may precede the development of asthma and constitutes a risk factor for the development of asthmatic symptoms, and may be developed by environmental factors in persons with genetic susceptibility. Controversy still exists whether atopy and airway responsiveness are factors determining the asthma diathesis or not. Qbjective: It was evaluated that airway responsiveness is related with the sensitization to common inhalant allergens, especially house dust mite. Methods: We performed the methacholine bronchial provocation test(MBPT) and skin prick test with 10 common inhalant allergens, including D. farinae and D. pteronyssinus in 502 nonasthmatic adults, which was composed of 223 atopics(Atopy) and 297 nonatopics (Normal), or 173 house dust mitesensitive atopics(HDM) and 347 house dust mite- insenstive persons(NHDM). Brindex(log[% fall of FEV, + 10]/log[last concentration of methacholine, mg/ml]) was used to quantify the degree of airway responsiveness, and we measured the Brindex of Atopy, Normal, HDM, and NHDM, respectively, and assessed correlations between atopy index(the sum of skin index by 10 allergens) and the skin index (mean wheal size by allergens per mean wheal size by histamine) of individual allergens, including D. farinae and D. pteronyssinus, and the Brindex. Results: The Brindex was significantly increased in Atopy(0.880+0.011) compared with Normal(0.840+0.003) (p=0.002), and in HDM(0.888+0.013) compared with NHDM (0842+0.007) (p=0.0008), respectively. The Brindex was significantly correlated with the atopy index(p<0.001) and the skin index of D.p, D.f, and cat(p<0.001), but not with other allergens(p > 0.05). Conclusion: The sensitization to common inhalant allergens, especially house dust mite and cat fur, was significantly correlated with the bronchial responsiveness to methacholine.
목련 (Magnolia kobus DC. var. borealis Sarg.) 추출성분의 항균성에 관한 연구
김윤근 한국목재공학회 1999 목재공학 Vol.27 No.1
Antimicrobial activities of the organosoluble extracts, seperated fractions and isolated lignans from the leaves tissue of Magnolia kobus DC. var. borealis Sang. were investigated. The results are summarized as follows : 1. The inhibitory components against the spore growing test were concentrated on light petroleum ether and diethyl ether soluble fractions. The light petroleum ether solubles of the leaves tissue had terpenes compound, so, that they caused growing inhibition. These appearance showed high values of Rf on TLC bioautography and GC analyses with monoterpenes. 2. In the lignans, syringaresinol(XIII), medioresinol(VI), phillygenin(VIII), kobusinol A(X) showed relatively high inhibitory effects in the spore growing test, and these are all showed structural characteristic of the phenolic hydroxyl group of guaiacyl and syringyl skelecton. 3. The light petroleum ether soluble fraction showed the strongest inhibitory effect against the antimicrobial activity in the seperated fractions. 4. The inhibitory effects of the lignans against the bacteria showed not so pronounced independantly, but the extracts and separated fractions contained with these lignans showed something synergism.