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뇌기능 장애 환자의 가상영상(Moving Sorround) 자극에 따른 자세 균형 제어
김연희 ( Yun Hee Kim ),최종덕 ( Jong Duk Choi ),이성범 ( Sung Bom Lee ),김종윤 ( Jong Yun Kim ),이석준 ( Suk Jun Lee ),박찬희 ( Chan Hee Park ),김남균 ( Nam Gyun Kim ) 한국감성과학회 2002 추계학술대회 Vol.2002 No.-
뇌기능 장애 환자에서 자세균형 제어능력의 저하는 보행 및 일상생활동작 수행 등에 어려움을 초래하며 이에 대한 정확한 평가 및 치료를 위하여 일상의 환경변화와 유사한 상황을 제공하고 이예 따른 자세제어력을 파악하는 것이 중요하다. 본 연구는 뇌기능 장애환자에서 움직이는 환경에 따른 자세균형제어기능을 정확히 평가하는 환경의 움직임이 자세균형제어에 미치는 영향을 분석하였다. 15명의 뇌기능 장애 환자들과 정상인 15명을 대상으로 실생활과 유사한 환경의 조성을 위하여 HMD를 이용한 가상영상 환경변화(Moving Surround)를 네가지 움직임 종류에 따라 제공하였다. 자세동요의 정도는 힘판을 이용하여 신체압력중심의 변화를 전체이동거리, 동요주파수, 최대 빈도 COP 위치 등으로 측정하였으며 환경의 차이에 따른 변화를 비교 분석하였다. 연구결과 검사 재검사 신뢰도 평가에서 일관된 분석결과를 나타냈고 뇌기능장애 환자와 정상인간의 분석에서는 두 그룹간의 차이를 확인할 수 있었다. 특히 전후로 빠르게 변하는 가상영상 환경에서 가장 큰 자세동요를 나타내었고 통계적으로 유의한 차이가 있었다. 본 연구를 통해 뇌기능 장애 환자에서 가상영성 환경변화가 자세균형제어에 미치는 영향을 확인할 수 있었으며 이러한 환자들을 위한 치료환경 조성 등에도 유용한 자료로 쓰일 수 있을 것으로 사료된다.
김연희 ( Yun Hee Kim ),김종민 ( Jong Min Kim ),송형명 ( Hyung Myung Song ),김승호 ( Seung Ho Kim ),안병용 ( Byeung Yong Ahn ),강영주 ( Yeong Ju Kang ),김은선 ( Eun Sun Kim ),김동수 ( Dong Soo Kim ) 한국환경분석학회 2013 환경분석과 독성보건 Vol.16 No.2
This study was performed to perceive environmental pollution in children`s playground in Gwangju metropolitan city. Two types of sand and synthetic rubber as flooring material were used in children`s playground. The sampling was collected from 20 sites in sand flooring material and 21 sites in synthetic rubber flooring material. They are measured to evaluate pH, heavy metals, and parasite eggs in sites of sand flooring material and also to heavy metals in sites of synthetic rubber floor material. In site of sand flooring material, pH range was from 5.8 to 8.8. The average concentration of Pb, As, Hg, Cd, and Cr6+ was 16.318, 0.343, 0.048, 0.258, and 0.000 in unit mg/kg, respectively. In site of synthetic rubber flooring material. The average value of the total sum concentration of heavy metals such as Pb, As, Hg, Cd, and Cr6+ was 70.427 mg/kg. This total concentration of heavy metals was even much lower than that of criteria (1,000 mg/kg). The parasite eggs were not found in sites of sand flooring material. Therefore, it showed that all sites in children`s playground was safe environmentally.
수두생바이러스백신 국가표준품 (2차) 제조 및 확립에 관한 연구
김연희(Yeon Hee Kim),김도근(Dokeun Kim),손여원(Yeo Won Sohn),한의리(Euiri Han),김석환(Seok Hwan Kim),임종미(Jong-Mi Lim),원윤정(Yun Jung Won),윤희성(Heui Seong Yoon),조문희(Moon Hee Jo),김관수(Kwan Soo Kim),김재욱(Jaeok Kim) 한국생물공학회 2010 KSBB Journal Vol.25 No.6
수두 생바이러스 백신과 같은 생물의약품은 다양한 물질이 복합적으로 구성되어 있어 단순한 물리·화학적 분석방법만으로는 그 특성을 규명할 수 없다. 따라서 이러한 생물의약품의 품질을 평가하기 위해서는 표준품이 필수적이다. 2002년과 2003년에 제조 및 확립한 1차 국가표준품의 재고량 소진 및 역가 감소에 따라 식품의약품안전평가원에서는 수두 생바이러스 백신의 2차 국가표준품을 확립하기 위하여 2008년 용역연구사업을 통해 국내의 수두 생바이러스 백신 제조회사에서 표준품 후보물질을 제조하였으며, 국가표준품후보물질의 역가산정을 위하여 국내 제조사 및 식품의약품안전평가원에서 공동연구를 수행하였다. 국내제조사를 포함한 3개의 공동연구 시험소에서 7회 이상의 반복시험을 수행하여 얻은 공동연구 결과를 통계학적으로 분석한 결과 3곳의 공동연구 시험소의 통합역가에 대한 변이계수 (coefficient variation, CV)는 1.24%로 각 시험소간의 기하평균 (GMT) 변동 수준이 매우 낮음을 확인할 수 있었다. 또한, 수두 생바이러스 백신의 2차 국가표준품의 표시역가는 4.26 log10 PFU/0.5 mL로 산정하였다. Biological products, such as live varicella vaccine, are composed of biological substances derived from biological organisms. It is very difficult to identify these biologics’ characteristics by analysis of simple physical and chemical methods alone. So the reference material is essential in order to evaluate the quality of bilogics. The 1’st national standard for varicella live vaccine was manufactured, established in 2002 and 2003, and have been used for the manufacturer’s quality control and national lot release since then. As the lack of its availability and the decrease of its stability, this study was initiated by National Institute of Food and Drug Safety Evaluation (NiFDS) in 2008 to manufacture and establish the 2nd national standard for varicella live vaccine. The candidate material was manufactured from one of domestic manufacterers and the joint research of the NiFDS and manufacturers of varicella live vaccine was conducted to estimate of the reliable virus content. In the collaborative study, 3 laboratories including NiFDS performed the virus content test more than 7 times and all assay results were statistically analyzed. The mean coefficient of variation (CV) was 1.24%, and the geometric mean titre (GMT) variation range of each laboratory was low. On the basis of the results of this study, the candidate material of 2nd national standard for varicella live vaccine was assigned a potency of 4.26 log10 pfu/0.5 mL, when reconstituted in 0.7 mL.
광주지역 산업폐수 업종별 TOC 배출 특성에 관한 연구
김연희 ( Yun-hee Kim ),문경란 ( Kyoung-ran Moon ),윤상훈 ( Sang-hoon Yoon ),김지혜 ( Ji-hye Kim ),임민화 ( Min-hwa Lim ),진재성 ( Jae-sung Jin ),양명승 ( Myeong-sueng Yang ),정희윤 ( Hee-yun Jung ),배석진 ( Seok-jin Bae ),정재근 ( 한국수처리학회(구 한국수처리기술연구회) 2021 한국수처리학회지 Vol.29 No.2
In this study, 182 industrial wastewater samples obtained from Gwangju were assigned to 16 industries to investigate the characteristics of organic indexes(TOC, NPOC, COD<sub>Mn</sub>, and DOC). The average COD<sub>Mn</sub> and TOC concentrations by industrial wastewater classification in Gwangju in descending order were as follows : other machinery and equipment manufacturing > painting and other film treatment > textile dyeing, cleaning, and finishing processing. The correlations between TOC and COD<sub>Mn</sub>, NPOC, DOC showed high positive correlation coefficients which were more than 0.8. According to the revised Water Environment Conservation Act 2020 in which COD<sub>Mn</sub> from wastewater discharge facilities was replaced with TOC, a COD<sub>MN</sub> concentration of 130 mg/L in an “Na” region where the volume of wastewater discharge is lower than 2,000 m3/day, corresponds to 75 mg/L TOC, and the concentration ratio of COD<sub>MN</sub> to TOC is 1.73. The average ratio of COD<sub>Mn</sub> to TOC in five metropolitan cities (Gwang, Ulsan, Daejeon, Incheon, and Busan) was 1.55, and the converted TOC concentration corresponding to 130 mg/L COD<sub>Mn</sub> was 84 mg/L. The average measurement ratio of COD<sub>Mn</sub> to NPOC was 1.7, which was close to the COD<sub>Mn</sub> to TOC ratio of 1.73. These results propose that TOC concentration in wastewater discharge from “Na” regions should be changed to 84 mg/L from the current 75 mg/L or TOC concentrations might be applicable to NPOC concentrations in all wastewater discharge facilities.
중추 및 말초신경손상 환자에서 교감신경 피부반응의 특성
김연희 ( Yun Hee Kim ),양선호 ( Sun Ho Yang ),고명화 ( Myoung Hwan Ko ),서만욱 ( Man Wook Seo ),황평한 ( Pyoung Han Hwang ),서정환 ( Jun Hwan Seo ) 전북대학교 의과학연구소 2001 全北醫大論文集 Vol.25 No.2
Objective: To assess the changes of autonomic nervous system in the patients with central and peripheral nervous system lesions using sympathetic skin response(SSR). Method: 55 patient group consisted of 18 stroke, 20 radiculopathy, 10 spinal cord injury, 5 carpal tunnel syndrome and 2 traumatic brain injury. Control group consisted of 22 healthy subjects without neurologic disease. Electrical stimuli were applied over the median nerve at wrist and SSR were recorded simultaneously on bilateral palms and soles. SSR that was not evoked by 5 times of stimulation was considered as no response. Results: 1) 27.7 percent of the patients with stroke and 60 percent of the patients with spinal cord injury showed no response. 2) The amplitudes of SSRs recorded in the affected palms of stroke patients were significantly smaller than these of control group (P<0.05), regardless of stimulation side. 3) The amplitudes of SSRs recorded in the unaffected palm of stroke patients when stimulus was given to the affected side were smaller than these of control group (P<0.05). 4) In the patients with radiculopathy and carpal tunnel syndrome, the latency and amplitude of SSR showed no significant difference compared with these of control group (P>0.05). Conclusion: In central nervous system lesion, the abnormal findings of SSR reflected abnormal ascending and descending pathways of autonomic nervous system. In the patients with radiculopathy, the autonomic nervous system seemed to be maintained normally.
김연희(Kim, Yeon-Hee),김종훈(Kim, Jong-Hun),윤보성(Yun, Bo-Sung),김기수(Kim, Gi-Soo) 대한건축학회 2016 대한건축학회 학술발표대회 논문집 Vol.36 No.2
Modern cultural Assets are products of people in the modern society during their ordinary lives of political, economic, social and artistic behavior. They are omnifarious, a little different from the traditional cultural heritage and play an important role and function as a bridge between the old and the new. Studies on how to preserve and utilize the modern architectural heritages have been conducted ceaselessly but it seems that there are not many of them pinpointed on educational architectures. This Study reviewed theories and precedent case studies on architectural characteristics of registered modern cultural assets of domestic college buildings and put a small step to proceed further research on how to securely preserve and effectively utilize those assets in college according to the educational function and the ideology.