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수도권 일부 초등학교 고학년 학생의 구강보건에 관한 지식과 태도, 행동의 상관성 연구
김석환,김재홍,김지환,Kim, Seok-Hwan,Kim, Jae-Hong,Kim, Ji-Hwan 대한치과기공학회 2011 대한치과기공학회지 Vol.33 No.4
Purpose: The purpose of this study was to obtain data that can be utilized in the planning of oral health education plan, by surveying the correlation between oral health knowledge, attitude, and behavior among high grade students elementary school in some regions of the metropolitan. Methods: The subject of this study through the survey of the recognition of the oral health, a questionnaire survey was conducted for 548 male and female students who were in the 4th, 5th, 6th grade of elementary school in some regions of the metropolitan. Statistical analysis was conducted using the SPSS 12.0 with t-test, ANOVA, and correlation. Results: Knowledge of oral health was very high. Correct attitudes and positive behavior were indicated. There was a significant difference in oral health knowledge according to school year and parents' dental condition(P<.05). The student one recording oral health behavior degree where the oral health knowledge is high appears highly, considers statistically the difference which it was visible. Positive correlation was significantly observed among oral health knowledge, attitudes, and behavior. Especially, attitudes and toothbrush method were highly correlated(r=.853). Conclusion: Oral health program through the elementary school students and their parents for the development of proper oral health care education programs continue to be made should be considered.
탄력밴드 운동프로그램이 여성노인의 신체기능에 미치는 효과
김석환,노준희,Kim, Seok-Hwan,No, Jun-Hee 대한고유수용성신경근촉진법학회 2011 PNF and Movement Vol.9 No.4
Purpose : This study is to identify the effect of a thera-band exercise program on the physical function of elderly women. Methods : The subjects included 54 elderly women who participated in the program at J Senior Welfare Center in Jeollabuk-do. They were divided into two groups, 30 elderly women of control group and 24 of experimental group. A thera-band exercise program was conducted to both groups for total eight weeks-three times a week with a 50-minute period. After/before the experiment, the following seven categories were estimated for each subject: cardiopulmonary endurance, lower extremity power, upper extremity power, muscle endurance, flexibility, equilibrium, and agility. Results : There was a significant increase on the physical function of all the subjects in the experimental group and the control one after the experiment. Furthermore, the experimental group showed more meaningful improvement than the control one. Conclusion : On the basis of these findings, the thera-band exercise program contributes the enhancement of physical function of elderly women. Thus, more various physical exercise program should be developed for healthy aging.
Streptozotocin 유도 당뇨성 흰쥐에서 methotrexate의 신독성 생성기전에 관한 연구
김석환,김여정,이주연,강혜옥,이항우,최종원,Kim Seok-Hwan,Kim Yeo-Jeong,Lee Joo-Yeon,Kang Hye-Ok,Lee Hang-Woo,Choi Jong-Won 한국생명과학회 2006 생명과학회지 Vol.16 No.2
엽산과 유사한 구조를 가져 관절염 치료제로 쓰이는 methotrexate (MTX)의 당뇨병 쥐에서의 신독성 기전을 구명할 목적으로 실험동물 정상군과 STZ로 당뇨를 유발한군에 MTX률 투여하여 신장 독성을 유발하여 혈중 생화학적 변화를 관찰하고 free radical의 생성계와 해독계의 활성에 미치는 영향을 관찰하였다. 혈중 신장기능 지표 효소 및 신장조직의 지질과산화 함량이 정상군에 MTX를 투여한 군에 비해 당뇨쥐에 MTX를 투여한 군에서 현저히 증가하였다. 당뇨쥐에 MTX를 투여함으로써 활성산소 생성계인 phase I 단계 중 cytosol 효소계 활성이 정상쥐에 MTX를 투여한 군에 비하여 현저히 증가하였고, phase II 단계 중 glutathione S-transferase의 활성이 정상쥐에 MTX를 투여하였을때에 비하여 당뇨쥐에 MTX를 투여하였을때 현저히 감소하였다. 신조직 중 glutathione의 함량 또한 당뇨쥐에 MTX를 투여했을때 현저히 감소하였고 이러한 결과는 $\gamma$-glutamylcysteine synthetase와 glutathione reductase의 활성을 감소시킨 결과로 생각된다. 이상의 결과를 종합하여 볼때 당뇨쥐에 MTX를 투여하면 신독성이 증가함을 확인할 수 있었고, 그 기전은 cytosol계 효소 활성을 증가시켜 MTX의 대사계를 촉진시킴으로 독성물질의 생성을 증가시키고, 이로 인한 신조직중의 지질과산화 함량의 증가는 glutathione의 함량 감소에 의해 나타나는 결과로 사료되어진다. This study is investigated the effect on mechanism of nephrotoxicity formation of methotrexate(MTX) by hyperglycemic by streptozotocin(STZ). MTX was injected daily at two doses of 3, 6 mg/kg for 1 week in STZ-induced hyperglycemic rats. Activities of BUN, creatinine and LDH were significantly increased by treatment with MTX in STZ-induced diabetic group when compared to MTX treatment group in normal rats' Renal lipid peroxide content and activities of cytosolic enzyme were significantly increased in the treatment of MTX in diabetic group. The concentration of glutathione and glutathione biosynthesis enzymes were decreased by treatment with MTX in STZ-induced diabetic group. These results suggest that nephrotoxicity of MTX in STZ-induced hyperglycemic rat was caused by activation of renal metabolizing enzymes in cytosol and decrease of glutathione concentration.