소아 비만의 역학적 특징 - 원인, 분류, 유병률, 증상 -

문경래 한국모자보건학회 1998 한국모자보건학회 학술대회 연제집 Vol.1998 No.2

유방암종에서 p53, cyclin D1 및 cathersin D 단백발현의 의의

문경래,김환정,이미자,기근홍,서재홍,양정원,조현진 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives: Breast carcinoma is a heterogenous disease. The prognosis of this carcinoma correlates with various prognostic factors. The aim of this study was to assess the prognostic significance of expression of p53, cyclin Dl and cathepsin D protiens in association with various prognostic factors in invasive breast carcinoma. Materials and Methods: The relationship is presented between expression of p53, cyclin D1 and cathepsin D by immunohistochemistry and various established prognostic factors such as tumor size, histologic grade, lymph node status and extensive intraductal component in 55 cases of invasive breast carcinoma. Results: No significant correlations were observed between expression of p53, cyclin Dl and cathepsin D and tumor size. The expression of p53 correlated with high histologic grade. The expression of p53 and cyclin Dl correlated with lymph node metastasis. Conclusion: These results indicate that expression of p53 and cyclin Dl in invasive ductal carcinoma may be an important prognostic factor, closely related to the high histologic grade and lymph node metastasis.

소아 비만의 진단과 치료

문경래,Moon, Kyung-Rye 대한소아소화기영양학회 1999 Pediatric gastroenterology, hepatology & nutrition Vol.2 No.1

영·유아의 영양평가

문경래 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S

Nutritional assessment therefore should be an integral part of the care in infant and and young child. Components of a complete nutritional assessment include a medical history, nutritional history including dietary intake, physical examination, anthropometrics (weight, length or stature, head circumference, midarm circumference, and triceps skinfold thickness), skeletal maturity staging, and biochemical tests of nutritional status. The use of age, gender, and disease-specific growth charts is essential in assessing nutritional status and monitoring nutrition interventions. The importance of accurate measurements using trained personnel and appropriate equipment cannot be overemphasized.

경구용 전해질 용액 치료의 최근진전

문경래 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

소루마사지요법이 중년여성의 하지통증, 피로, 우울에 미치는 영향

문경래,최보경 한국스포츠학회 2019 한국스포츠학회지 Vol.17 No.3

The purpose of this study was to investigate the effects of Soru-massage on lower extremity pain, fatigue, and depression in middle-aged women from 40 trainees who were trained at G Nursing Education in G Metropolitan City from August 18 to September 25, 2015. An experiment was conducted to see. The sample size was collected from 20 experimental groups and 20 control groups. The experimental group was subjected to twelve soru-massage treatments for a total of 6 weeks, and the control group did not undergo any experimental treatment. The blood pressure of each subject was measured before and after the massage therapy. Tests for pain, fatigue, and depression before and after the experiment were measured through a self-reported questionnaire. Finally, the control group consisted of 20 patients, and the experimental group dropped out of 2 due to personal circumstances. To evaluate the effect of lower limb fatigue and depression in middle-aged women, we applied the soru-massage therapy, one of the alternative therapies. In addition, the relationship between pain, fatigue and depression was related to their pain reduction, which lowered lower extremity pain in middle-aged women and had statistically significant results in pain-induced fatigue and depression. 본 연구는 2015년 8월 18일 ~ 9월 25일 까지 G광역시 V요양보호사 양성교육기관에서 교육중인 교육생 40명을대상으로 소루 마사지요법이 중년 여성의 하지통증, 피로, 우울에 미치는 영향을 알아보기 위해 실험을 실시하였다. 표본의 크기는 실험군 20명, 대조군 20명으로 표집 하였으며, 실험 군에는 총 6주간 12회의 소루 마사지요법을 적용하고대조군은 별다른 실험 처치를 하지 않았다. 마사지 요법 전과 후에 각 피험자의 혈압을 측정하였고, 실험 실시 전과 후에통증, 피로, 우울에 대한 검사를 자기기입식 설문지를 통하여 측정하였다. 최종적으로 대조군은 20명으로, 실험군은 개인사정으로 2명이 탈락하여 18명으로 총 38명이었다. 중년 여성의 하지 통증으로 인한 피로와 우울 감소에 영향을 미치는지를 알아보기 위해 대체요법의 하나인 소루 마사지요법을 적용하였다. 또한 통증과 피로, 우울간의 상관성을 조사하여그들의 통증 감소에 관련된 것으로 중년 여성의 하지 통증을 감소시키고, 통증으로 유발된 피로와 우울 감소에 통계학적으로 유의한 결과를 가져왔다.

면역결핍질환과 만성설사

文炅來 대한의학협회 1994 대한의학협회지 Vol.37 No.5

소아ㆍ청소년 비만의 예방대책

문경래 대한소아청소년과학회 2009 Clinical and Experimental Pediatrics (CEP) Vol.52 No.12

Prevalence of obesity in Korean children and adolescents has dramatically increased since the last 10–20 years. It is important to initiate prevention efforts early in childhood because prevalence of obesity in adolescence is the strongest predictor of its prevalence in adulthood. Intrauterine life, infancy, and preschool years may comprise the critical periods that are essential for the long-term regulation of energy balance therefore, obesity-prevention strategies should be initiated in utero and continued throughout childhood and adolescence. Families with high-risk children should be provided early education about maintaining normal weight. Encouraging physical activity and, especially, avoiding inactivity, are key challenges in the prevention of future obesity. Schools should be primarily involved in educating parents to discourage their children from excessively watching TV or playing computer games and eating unhealthy snacks and food. The involvement of medical practitioners is also important, especially, in the case of obese parents, obesity prevention strategies should be promoted from the first visit of pregnant women to the physicians. Health professionals can also be involved in obesity prevention because they are ideally equipped to identify young children at risk of obesity. Community and nation-wide efforts to increase awareness and promote environments that encourage physical activity and healthy nutrition are required.

소아청소년 비만의 포괄적인 예방 전략

문경래 대한소아소화기영양학회 2011 Pediatric gastroenterology, hepatology & nutrition Vol.14 No.4

With an uncontrollable amount of energy dense food engulfing children’s life today, no child is completely protected against being overweight or obese. An inordinate intake of energy dense food and lack of physical activity have resulted in a higher rate of obesity in children. In order to combat the seemingly intractable problem, various preventive measures against childhood obesity have been suggested and are currently in effect. It is imperative to evaluate the methodology and potential impact of published obesity-prevention programs, that focus primarily on home, school, and health care environments. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 325∼333)

백서의 총담관 결찰에 의한 간 섬유화의 초미세구조적 및 면역조직화학적 연구

문경래,노영일,서우철,박영봉,김만우,서재홍,박상기,Moon, Kyung-Rye,Rho, Young-Ill,Seo, Woo-Chul,Park, Yeong-Bong,Kim, Man-Woo,Seo, Jae-Hong,Park, Sang-Kee 대한소아소화기영양학회 1999 Pediatric gastroenterology, hepatology & nutrition Vol.2 No.2

Purpose: Proliferation of bile duct-like structures and fibrosis is a hepatic cellular reaction observed in most forms of human liver disease and in a variety of experimental conditions associated with liver injury. The aim of this study was to investigate the activation of Ito cells and bile duct proliferation in the rat after common bile duct ligation (CBDL). Methods: Hepatic morphological abnormalities were examined in rats whose bile ducts had been irreversibly ligated for 15, 21, 24 and 28 days. The liver was examined by immunohistochemical staining for ${\alpha}$-smooth muscle actin, the known marker of activated Ito cells, and light and electron microscopes. Results: After CBDL, the bile canalicular proliferation and interstitial fibrosis were gradually increased in the periportal areas extended to hepatic sinusoids. Ito cells positive for ${\alpha}$-smooth muscle actin were frequently observed in the periductular space and in perisinusoidal space of Disse. Ito cells and myofibroblasts were gradually increased in the interstitial fibrosis until the 28th day after CBDL. Ito cells and myofibroblasts had microfilaments with dense body at the periphery of the cell. Conclusions: Our results suggest that Ito cells may be fibroblastic or myogenic. It has also been postulated that during the development of hepatic fibrosis, Ito cells become myofibroblasts or fibroblast like cells. 목 적: 답즙 정체를 주 소견으로 하는 만성 간질환의 대부분에서 담소관의 증식과 간섬유화가 관찰된다. 특히 간외 담도 폐쇄증에서 가장 현저하다. 그러나 섬유화의 병인에 대해서는 아직까지 많은 논란이 제기되고 있다. 총담관 결찰 후 시간이 경과함에 따른 담소관의 증식과 간섬유화의 진행과정 및 간섬유화에 대한 Ito 세포의 역할을 형태학적으로 조사하고자 본 연구를 하였다. 방 법: 건강한 Sprague-Dawley계 수컷 흰쥐를 대상으로 총담관을 결찰한 후 15일, 21일, 24일, 28일째에 도살하여 담소관의 증식과 간 섬유화의 진행과정을 smooth muscle actin에 대한 면역조직화학적 염색과 전자현미경적 검사를 하였다. 결 과: 1) 총담관 결찰후 시간이 경과할수록 간문맥 중심으로 담소관의 증식과 결체조직의 증식이 증가하였다. 2) 면역조직화학적 검색에서 활성화된 Ito 세포는 smooth muscle actin에 양성반응을 보였고, 총담관 결찰후 시간이 경과할수록 담소관주위와 동모양혈관 주의에서 많이 관찰되었다. 3) 전자현미경적 관찰에서 총담관결찰 후 시간이 경과함에 따라 Ito 세포가 증가하였으며, 지방적의 수가 감소한 근섬유모 세포를 닮은 Ito 세포와 근섬유모 세포의 수가 증가하였다. 결 론: 총담관 결찰후에 볼 수있는 간 섬유화는 활성화된 Ito 세포의 증가와 Ito 세포가 교원질을 분비하는 근섬유 모세포로 변형되기 때문에 생긴 것으로 생각된다.