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Rhee, Moo-Yong,Baek, Sang Hong,Kim, Weon,Park, Chang Gyu,Park, Seung Woo,Oh, Byung-Hee,Kim, Sang-Hyun,Kim, Jae-Joong,Shin, Joon-Han,Yoo, Byung-Su,Rim, Se-Joong,Ha, Jong-Won,Doh, Joon Hyung,Ahn, Youngk Dove Medical Press 2015 Drug design, development and therapy Vol.9 No.-
<P><B>Background</B></P><P>The study reported here compared the blood pressure (BP)-lowering efficacy of fimasartan alone with that of fimasartan/hydrochlorothiazide (HCTZ) combination in patients whose BP goal was not achieved after 4 weeks of treatment with once-daily fimasartan 60 mg.</P><P><B>Methods</B></P><P>Patients with sitting diastolic blood pressure (siDBP) ≥90 mmHg with 4 weeks of once-daily fimasartan 60 mg were randomly assigned to receive either once-daily fimasartan 60 mg/HCTZ 12.5 mg or fimasartan 60 mg for 4 weeks. After 4 weeks, the dose was increased from fimasartan 60 mg/HCTZ 12.5 mg to fimasartan 120 mg/HCTZ 12.5 mg or from fimasartan 60 mg to fimasartan 120 mg if siDBP was ≥90 mmHg.</P><P><B>Results</B></P><P>Of the 263 randomized patients, 256 patients who had available efficacy data were analyzed. The fimasartan/HCTZ treatment group showed a greater reduction of siDBP compared to the fimasartan treatment group at Week 4 (6.88±8.10 mmHg vs 3.38±7.33, <I>P</I>=0.0008), and the effect persisted at Week 8 (8.67±9.39 mmHg vs 5.02±8.27 mmHg, <I>P</I>=0.0023). Reduction of sitting systolic BP in the fimasartan/HCTZ treatment group was also greater than that in the fimasartan treatment group (at Week 4, 10.50±13.76 mmHg vs 5.75±12.18 mmHg, <I>P</I>=0.0069 and, at Week 8, 13.45±15.15 mmHg vs 6.84±13.57 mmHg, <I>P</I>=0.0007). The proportion of patients who achieved a reduction of siDBP ≥10 mmHg from baseline and/or a mean siDBP <90 mmHg after 4 weeks of treatment was higher in the fimasartan/HCTZ treatment group than in the fimasartan treatment group (53.6% vs 39.8%, <I>P</I>=0.0359). The overall incidence of adverse drug reaction was 11.79% with no significant difference between the treatment groups.</P><P><B>Conclusion</B></P><P>The combination treatment of fimasartan and HCTZ achieved better BP control than fimasartan monotherapy, and had comparable safety and tolerance to fimasartan monotherapy.</P>
( Woo Ho Ban ),( Jong Min Lee ),( Jick Hwan Ha ),( Chang Dong Yeo ),( Hyeon Hui Kang ),( Chinkook Rhee ),( Hwasik Moon ),( Sang Haak Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Non-small cell lung cancer (NSCLC) is one of the most fatal cancers worldwide. Age, performance status and stage are well-known prognostic factors for patients with NSCLC. Dyspnea is a common and distressing symptom in patients with NSCLC, however, the prognostic value of dyspnea remains uncertain. Methods: We retrospectively reviewed a prospective lung cancer database of St. Paul`s Hospital, The Catholic University of Korea, from 2001 to 2014. Dyspnea using mMRC scales and clinicopathologic parameters were analyzed to identity their prognostic roles. Results: Total 457 NSCLC patients were enrolled, 259 (56.7%) patients complained of dyspnea at initial presentation. Except 109 (42.1%) patients with unknown mMRC scales, there were 85 (32.8%) patients with mMRC grade 0 or 1, and 65 (25.1%) patients had mMRC grade 2 or higher. Pulmonary function parameters were signifi cantly decreased in patients with dyspnea, compared to those without dyspnea. The median survival for patients with dyspnea was shorter than those without dyspnea (7 vs. 15 months, p < .001). A signifi cant difference in median survival was also found between patients with mMRC grade 0 or 1 and those with mMRC grade 2 or higher (11 vs. 6 months, p < .001). In multivariate analysis, age (HR, 1.60; 95% CI: 1.20-2.14), poor performance status (HR, 3.67; 95% CI: 2.34-5.77), advanced stage (HR, 2.85; 95% CI: 1.93-4.22), FEV1 level (HR, 0.99; 95% CI: 0.99-1.00) and dyspnea of mMRC grade 2 or higher (HR, 1.89; 95% CI: 1.32-2.70) were associated with poor outcome. Conclusions: These results suggest dyspnea could be an independent prognostic factor for patients with NSCLC. Therefore, clinicians are required to pay more attention to NSCLC patients` complaining of dyspnea, individually.
Rhee, Jae-Sung,Raisuddin, Sheikh,Hwang, Dae-Sik,Lee, Kyun-Woo,Kim, Il-Chan,Lee, Jae-Seong Elsevier 2009 Ecotoxicology and environmental safety Vol.72 No.1
<P><B>Abstract</B></P> <P>Metallothionein (<I>MT</I>) gene expression was studied in different tissues, development stages and gender types of the mangrove killifish (<I>Kryptolebias marmoratus</I>). <I>MT</I> expression was also studied in a time-series experiment after exposure to trace metals and endocrine-disrupting chemicals (EDCs). The brain showed the highest level of <I>MT</I> transcripts. Although all the development stage showed some level of <I>MT</I> expression, the adult hermaphrodites showed the highest expression which was significantly higher than the secondary males. In the trace metal-exposed fish, cadmium caused the strongest induction of <I>MT</I>. However, other trace metals such as copper and zinc also caused <I>MT</I> gene induction. All the EDCs suppressed the expression of <I>MT</I> gene, and the effect of EDCs were not gender-specific. <I>K. marmoratus</I> has previously shown its suitability as a model species for toxicity studies and cancer research. This study demonstrated utility of <I>MT</I> as biomarker in <I>K. marmoratus</I>. However, confounding factors such as age, gender, and tissue types appear to influence the <I>MT</I> expression. Response of trace and organic pollutants such as EDCs also varied greatly. These observations suggest that <I>MT</I> would be a specific biomarker of trace metal exposure in <I>K. marmoratus</I> and expression would be influenced by intrinsic factors.</P>
Sung-Min Rhee,Gun Woo Nam,Joo Hyun Park,Hyeon Jang Jeong,Suk-Hee Park,Joo Han Oh 대한견주관절의학회 2021 대한견주관절학회 학술대회논문집 Vol.2021 No.3
Introduction and Background To compare the efficacy between the direct effect of nanofiber-based vitamin D sheet engineered with 3D printing(VTD sheet) and vitamin D supplementation(VTDS) as diet on tendon-to-bone healing and muscle regeneration after repair in a chronic rotator cuff tear model of rabbit Material and Method Sixty-four rabbits were randomly allocated into two groups(n=32), then each group was allocated into four small groups (Group A,A’:VTDS only,Group B,B’:Normal diet+sheet without vitamin D,Group C,C’:Normal diet+VTD sheet,Group D,D’:VTDS+VTD sheet,n=8 each). The supraspinatus tendons were repaired with the sheet only for groups B and B’, and VTD sheet for groups C,C’,D and D’ (Figure 1). Groups A,B,C, and D and groups A’,B’,C’, and D’ were extracted at 4 and 12 weeks after repair. respectively. Serum 25-OH VTD level was checked. The genes including COL1, COL3, BMP-2, SCX, SOX9, and ACAN was assessed at 4 and 12 weeks after repair. The histological and biomechanical evaluations of tendon-to-bone healing were done at 12 weeks after repair. Rotator cuff muscle cross-sectional areas were measured at 4 and 12 weeks after repair. ELISA was done to calculate vitamin D level in muscle at 12 weeks after repair. Results Serum VTD level of group D and D’ was highest among groups at the time of repair and extraction(p<0.001). At 4 weeks after repair, mRNA expression of COL1 in group D was highest among groups(p=0.046). At 12 weeks after repair, group D’ showed most dense collagen density(p=0.037), and had highest load to failure among groups(p=0.024). Regarding muscle regeneration, the cross-sectional area of muscle fiber was largest in group D and D’ at 4 and 12 weeks after repair(p<0.05) with highest VTD level of muscle by ELISA at 12 weeks after repair(p=0.003). Conclusions The use of nanofiber-based VTD sheet engineered with 3D printing may promote tendon-to-bone healing and regenerate rotator cuff muscle after repair in a chronic rabbit rotator cuff tear model.
Topical Oleo-Hydrogel Preparation of Ketoprofen with Enhanced Skin Permeability
Rhee, Gye Ju,Woo, Jong Soo,Hwang, Sung-Joo,Lee, Young Wook,Lee, Chang Hyun 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
In an attempt to improve the skin penetration of ketoprofen, various transdermal formulations were prepared, and their in vitro skin permeability and in vivo percutaneous absorption were evaluated. In vitro permeation studies were performed using a modified Franz cell diffusion system in which permeation parameters such as cumulative amount at 8 hr Q_8hr steady-state flux J_ss or lag time t_L were determined. In the in vivo percutaneous absorption study using the hairless mouse, maximum concentration C_max and area under the curve at 24 hr AIC_24hr were measured. The optimal transdermal formulation (oleo-hydorgel formulation) of ketoprofen showed a Q_8hr value of 227.20㎍/㎠, a J_ss value of 29.61㎍/㎠/hr, and a t_L value of 0.46 hr. The Q_8hr value of 227.20㎍/㎠. a J_ss value of were about 10-fold (p<.01) higher than those (Q_8hr = 19.61㎍/㎠; J_ss=7.99㎍/㎠/㎖) and AUC_24h (55.74㎍.hr/ml) values of the pitimal formulation were significantly (p<0.1) higher than those of K-gel and K-plaster. The relative bioavailability of the oleo-hydrogel following transdermal administration in reference to oral administration was about 37%, and the C_max value (4.73㎍/㎠) in the hypodermis following topical administration was much higher than those from the conventional products (C_max of K-gel and K-plaster were 0.92±-0.19㎍/㎠ and 1.27±0.37 ㎍/㎠, respectively). These data demonstrate that the oleo-hydrogel formulation of ketoprofen was more beneficial than conventional products (K-gel and K-plaster) in enhancing transdermal permeation and skin absorption of ketoprofen. Furthermore. there was a good correlation between in vitro permeation parameters and in vivo percutaneous absorption parameters.