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Magnifying Endoscopy for Esophageal Ectopic Sebaceous Glands
Mu Song Jeon,김광하,Dong Young Jeong,Byeong Kyu Park,이문원,So-Jeong Lee,Do Youn Park 대한소화기내시경학회 2018 Clinical Endoscopy Vol.51 No.5
Ectopic sebaceous glands are found very rarely in the esophagus; heretofore, several cases have been reported. The sebaceous gland isoriginally a source of an endodermal origin; however, there have been controversies regarding whether the origin of the esophagealectopic sebaceous gland is ectodermal or endodermal. Ectopic sebaceous glands of the esophagus usually do not cause symptoms; thus,they are often found incidentally on endoscopy for routine health screening. Endoscopic findings are characterized by single or multipleyellow patches or nodular lesions of various sizes, sometimes with small central openings. We report two cases of esophageal ectopicsebaceous glands found incidentally during endoscopy with magnifying endoscopic findings. The lesions were in the mid-esophagusand lower esophagus, respectively, and both endoscopic findings were similar as multiple yellowish patches or plaques. Magnifyingendoscopy revealed the openings of the excretory ducts surrounded by circular microvessels in both cases.
( Mu Song Jeon ),( Hyun Young Woo ),( Jeong Heo ),( Ki Tae Yoon ),( Mong Cho ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background/Aims: The Budd-Chiari syndrome (BCS) is a rare condition defined as obstruction of hepatic venous outflow. It is a clinically challenging disorder, but recent development in treatment strategies makes it possible for clinicians to manage such patients successfully. We evaluated the clinical safety and feasibility of anticoagulation using oral warfarin for Budd-Chiari syndrome. Methods: Between February 1998 and March 2013, a total of 21 consecutive patients were diagnosed with BCS in Pusan national university hospital. Results: The average age of the cases was 54.9 years (ranging from 35 to 76 years). Of 21 patients, 10 were male, and other 11 were female. Etiologies were membranous obstruction in 13 cases, protein C/S deficiencies in 5 cases, antiphospholipid syndrome in 2 cases, and antithrombin III deficiency in 1 case. Major symptoms or signs were esophageal varices in 10 cases, gastric varices in 8 cases, ascites in 6 cases, lower extremity edema in 5 cases, collaterals of superficial veins in 5 cases, gastrointestinal bleeding in 4 cases, abdominal pain in 2 cases, and jaundice in 2 cases. Of 21 patients, 9 patients were treated with percutaneous transluminal angioplasty and oral anticoagulation with coumardin and 7 patients were treated with oral anticoagulation only. Coumadin was administered orally at 2.5mg/ d for approximately 39.7 months (ranging from 1 to 96 months). A median follow-up period was 48.8 months (ranging from 7 to 97 months). For 15 patients treated with warfarin, 13 (86.6%) experienced symptom improvement and 10 (71.4%) were identified as complete resolution, 1 (7.1%) as partial reso lution by follow-up radiography. There was no adverse event with warfarin treatment. Conclusions: The use of warfarin for anticoagulation proved to be simple, safe, and feasible for BCS patients.
이온 질화 처리에 의한 Ti-6Al-4V의 표면특성 개선
宋点植,金信起,全允祚,金慶勳,文武聖 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.3
This paper presents the results from the studies on the surface layers produced by ion nitriding at three different temperatures in order to improve wear resistance, hardness, and to modulate microstructure and chemical composition of surface layers. X-ray diffraction indicated the formation of two phases(TiN, Ti_2N) and the preferred orientations of TiN occured when nitrided at 810℃. Ion nitrided surface had the Vickers hardness of 860 Hv and greatly improved the wear resistance of Ti-6A1-4V. The cytotoxicity was measured with NIH 3T3 fibroblast by SRB method and was compared with that of the FDA approved Ti-6A1-4V. Corrosion resistance and cytotoxicity was similar to untreated Ti-6A1-4V alloy.
Genetic Variants in Interleukin-2 and Risk of Lymphoma among Children in Korea
Song, Nan,Han, So-Hee,Lee, Kyoung-Mu,Choi, Ji-Yeob,Park, Sue-K,Jeon, Su-Jee,Lee, Yun-Hee,Ahn, Hyo-Seop,Shin, Hee-Young,Kang, Hyoung-Jin,Koo, Hong-Hoe,Seo, Jong-Jin,Choi, Ji-Eun,Kang, Dae-Hee Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2
To estimate the genetic susceptibility for childhood lymphoma, we conducted an association study for 23 cases and 148 controls. Total 1536 tag single nucleotide polymorphisms (SNPs) were selected in 138 candidate gene regions related to immune responses, apoptosis, the cell cycle, and DNA repair. Twelve SNPs were significantly associated with the risk of lymphoma ($P_{trend}$ <0.05) in six genes ($IL1RN$, $IL2$, $IL12RB1$, $JAK3$, $TNFRSF13B$, and $XRCC3$). The most significant association was seen for $IL2$ variant rs2069762 ($OR_{TG+GG}$ vs. TT=3.43 (1.29-9.11), $P_{trend}$=0.002, min$P$=0.005). These findings suggest that common genetic variants in $IL2$ might play a role in the pathogenesis of childhood lymphoma.
Recurrent thymic carcinoid tumor in familial isolated primary hyperparathyroidism
Song, Jeong Eun,Shon, Mu Hyun,Kim, Ga Young,Lee, Da Young,Lee, Jung Hun,Kim, Jong Ho,Shon, Ho Sang,Lee, Ji Hyun,Jeon, Eon Ju,Jung, Eui Dal Yeungnam University College of Medicine 2014 Yeungnam University Journal of Medicine Vol.31 No.2
Familial isolated primary hyperparathyroidism(FIPH) is associated with multiple endocrine neoplasia type 1 (MEN1) syndrome, primary hyperparathyroidism accompanied by jaw-tumor syndrome, and familial hypocalciuric hypercalcemia. FIPH may be an early stage of MEN1 or an allelic variant of MEN1. Thymic carcinoid tumor is a rare tumor in MEN1 syndrome. Here, the authors report the case of a 40-year-old man diagnosed with recurrent thymic carcinoid tumor and FIPH. Both the patient and his elder sister had been previously diagnosed to have FIPH with a novel frameshift mutation in the MEN1 gene. Initially, the patient underwent thymectomy because of an incidental finding of a mediastinal mass in his chest X-ray, and had remained asymptomatic over the following 4 years. Pancreas computed tomography conducted to evaluate MEN1 syndrome revealed anterior and middle mediastinal masses, and resultantly, massive mass excision was performed. Histological findings disclosed atypical carcinoids with infiltrative margins. In view of the thymic carcinoid tumor relapse that occurred in this patient, the authors recommend that regular pancreas and pituitary imaging studies be conducted for FIPH associated with a MEN1 gene mutation.
Song, Nan,Sung, Hyuna,Choi, Ji-Yeob,Han, Sohee,Jeon, Sujee,Song, Minkyo,Lee, Yunhee,Park, Chulbum,Park, Sue K,Lee, Kyoung-Mu,Yoo, Keun-Young,Noh, Dong-Young,Ahn, Sei-Hyun,Lee, Sang-Ah,Kang, Daehee American Association for Cancer Research 2012 Cancer Epidemiology, Biomarkers & Prevention Vol.21 No.8
<P>Matrix metalloproteinase-2 (MMP-2) has been thought of as a predictor of recurrence or metastasis risk or prognostic markers in cancer. We evaluated whether preoperative serum levels of MMP-2 work as a prognostic biomarker in breast cancer prognosis.</P>
Recurrent thymic carcinoid tumor in familial isolated primary hyperparathyroidism
Jeong Eun Song,Mu Hyun Shon,Ga Young Kim,Da Young Lee,Jung Hun Lee,Jong Ho Kim,Ho Sang Shon,Ji Hyun Lee,Eon Ju Jeon,Eui Dal Jung 영남대학교 의과대학 2014 Yeungnam University Journal of Medicine Vol.31 No.2
Familial isolated primary hyperparathyroidism(FIPH) is associated with multiple endocrine neoplasia type 1 (MEN1) syndrome, primary hyperparathyroidism accompanied by jaw-tumor syndrome, and familial hypocalciuric hypercalcemia. FIPH may be an early stage of MEN1 or an allelic variant of MEN1. Thymic carcinoid tumor is a rare tumor in MEN1 syndrome. Here, the authors report the case of a 40-year-old man diagnosed with recurrent thymic carcinoid tumor and FIPH. Both the patient and his elder sister had been previously diagnosed to have FIPH with a novel frameshift mutation in the MEN1 gene. Initially, the patient underwent thymectomy because of an incidental finding of a mediastinal mass in his chest X-ray, and had remained asymptomatic over the following 4 years. Pancreas computed tomography conducted to evaluate MEN1 syndrome revealed anterior and middle mediastinal masses, and resultantly, massive mass excision was performed. Histological findings disclosed atypical carcinoids with infiltrative margins. In view of the thymic carcinoid tumor relapse that occurred in this patient, the authors recommend that regular pancreas and pituitary imaging studies be conducted for FIPH associated with a MEN1 gene mutation.