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Endothelin Receptor Overexpression Alters Diastolic Function in Cultured Rat Ventricular Myocytes
( Misuk Kang1 ),( Jeffery W. Walker ),( Ka Young Chung ) 한국응용약물학회 2012 Biomolecules & Therapeutics(구 응용약물학회지) Vol.20 No.4
The endothelin (ET) signaling pathway controls many physiological processes in myocardium and often becomes upregulated in heart diseases. The aim of the present study was to investigate the effects of ET receptor upregulation on the contractile function of adult ventricular myocytes. Primary cultured adult rat ventricular myocytes were used as a model system of ET receptor overexpression in the heart. Endothelin receptor type A (ETA) or type B (ETB) was overexpressed by Adenoviral infection, and the twitch responses of infected ventricular myocytes were measured after ET-1 stimulation. Overexpression of ETA exaggerated positive inotropic effect (PIE) and diastolic shortening of ET-1, and induced a new twitch response including twitch broadening. On the contrary, overexpression of ETB increased PIE of ET-1, but did not affect other two twitch responses. Control myocytes expressing endogenous receptors showed a parallel increase in twitch amplitude and systolic Ca2+ in response to ET-1. However, intracellular Ca2+ did not change in proportion to the changes in contractility in myocytes overexpressing ETA. Overexpression of ETA enhanced both systolic and diastolic contractility without parallel changes in Ca2+. Differential regulation of this nature indicates that upregulation of ETA may contribute to diastolic myocardial dysfunction by selectively targeting myofi lament proteins that regulate resting cell length, twitch duration and responsiveness to prevailing Ca2+.
Perception of Child Abuse and Child Disciplinary Practice among Adults Abused as Children
Ka Young Moon,So Young Irene Lee,A Reum Lee,Ka Yeong An,Kyung Soo Jung,Kyoung-Il Paek,Hyun Ah Kang,Ji Young Kang,Shun Ah Chung 대한소아청소년정신의학회 2019 소아청소년정신의학 Vol.30 No.2
Objectives: The aim of this study was to compare differences in perception and knowledge of child abuse and child disciplinary practices according to the history of child abuse victimization. Methods: A questionnaire survey on child abuse was conducted with 491 adults raising children. We compared the perception and knowledge of child abuse and child disciplinary practices between two groups of adults with and without a history of childhood abuse victimization. Results: The group with a history of childhood abuse had lower levels of knowledge of child abuse (F=6.990, p<0.01) and engaged in more negative disciplinary practices (F=5.974, p<0.05) than those without. However, no differences in the perception of child abuse were observed between the two groups. Conclusion: The results suggest that adults with a history of childhood abuse have lower levels of knowledge of child abuse and use more negative disciplinary practices in raising their children. This highlights the need to administer not only educational but also more direct hands-on interventions to vulnerable parents in order to foster healthy parenting and disciplinary practices.
이소성 ACTH 생산에 의해 야기된 Cushing 증후군이 동반된 소세포 폐암
곽영임 ( Young Im Kwak ),임영혁 ( Young Hyuck Im ),천영국 ( Young Kug Cheon ),이가희 ( Ka Hee Yi ),남현석 ( Hyeon Seok Nam ),이춘택 ( Choon Taek Lee ),강윤구 ( Yoon Koo Kang ),이진오 ( Jhin Oh Lee ),강태웅 ( Tae Woong Kang ) 대한결핵 및 호흡기학회 1995 Tuberculosis and Respiratory Diseases Vol.42 No.6
Kang, Minju,Lim, Ka Ram,Won, Jong Woo,Na, Young Sang Elsevier 2018 JOURNAL OF ALLOYS AND COMPOUNDS Vol.769 No.-
<P><B>Abstract</B></P> <P>The effect of entropy on the strengths of the disordered and ordered phases was investigated. Cost effective AlCo<SUB>x</SUB>CrFeNi (x = 0, 0.25, 0.5, 0.75, and 1) high-entropy alloys were fabricated reducing Co content. The strength was considerably reduced when the Co content was zero. This was attributed to the low hardness of the A2 phase due to reduced configurational entropy compared with quinary system. On the other hand, the ordered B2 phase showed the opposite tendency. This result shows that the configurational entropy causes opposing effects on disordered and ordered phases, and the importance of considering the effect of entropy on each phase when the number of elements changed, and an alloy is composed of two or more phases, in particular, having BCC structure.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Effect of Entropy on the mechanical properties of each phase was studied. </LI> <LI> Considerably lower YS of the AlCrFeNi HEA is due to the low strength of the A2 matrix. </LI> <LI> Configurational entropy causes opposing effects on disordered and ordered phases. </LI> </UL> </P>