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Pyronine-G의 水溶液中 Urea 및 Thiourea의 添加效果에 대한 Dimerization의 吸收分光學的 考察
崔虎燮 群山大學校 1984 論文集 Vol.9 No.-
The Dimerization of pyronine-G in aqueous solutions has been studied using spectroscopy in visible region (620 nm-440 nm), for the concentration from ?? to ??. This association can be described by a dimerization equilibrium constant ?? The decrease of the association of pyronine-G by adding urea and thiourea were explained, taking the effect of urea on the structure of water and hydrophobic bonding into account. In this studies want to discuss that the structure of Dimer by Fortran program.
Proflavine과 Coriphosphine(cp)의 誘導體들에 대한 光學的 吸收Spectra에 관한 硏究
崔虎燮 群山大學校 1984 論文集 Vol.7 No.-
The optical absorption spectra of several derivatives of proflavine(PF) and coriphosphine (CP) were measured in agueous solution at 25c. The effect of the perturbation of one both of the exonuclear amino groups on the spectral behavior was studied in order to explore the relationship between the spectra and the chemical structures of the symmetric 3.6-disubstituted acridine dyes which can bind to various polyelectrolytes, often showing metachromasy. The metachromatic spectra of the complexes between 3.6-diaminoacridine dyes and polyanions were reproduced reasonably well when one of the two groups of PF was converted to an acylamino group. A similar result was observed when the amino group of CP was acetylated. In these cases, the spectra show two absorption bands of nearly equal intensity on both sides of the single peak of PF and CP in the visible region. These results are indicative of the close similarity in chemical structures between the monoacylamino PF and the PF bound to the electron-rich sites of polyanions.
BCR-ABL 융합유전자를 동반한 급성 골수구성 백혈병 1예
최정민,송성은,이규진,이규원,이호섭 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1
BCR-ABL 융합 유전자를 동반한 급성골수구성백혈병은 그 빈도가 매우 낮고, 만성골수구성백혈병의 급성악화기와 임상적으로 유사한 특징을 가진다. 항암화학요법으로 관해유도가 되기 어렵거나, 관해유도 후 재발의 빈도가 높은 특징을 가지고 있어 예후가 나쁘다고 알려져있다. 저자들은 BCR-ABL 융합 유전자를 동반한 급성골 수구성백혈병1례를 경험하였기에 문헌고찰과 함께 보고 하는 바이다. BCR-ABL fusion gene is the hallmark of chronic myelogenous leukemia (CML), but it has been rarely reported in acute myeloid leukemia (AML). AML with BCR-ABL fusion gene has different features from blast crisis of CML. We experienced a rare case of AML with BCR-ABL fusion gene. Here we report this case with a brief review of literatures.
전류 모드 CMOS 다치 논리 회로를 이용한 8X8 병렬 승산기
이용섭,곽철호,김정범 강원대학교 정보통신연구소 2001 정보통신논문지 Vol.5 No.-
This paper presents new current-mode CMOS multiple-valued integrated circuits for high-density arithmetic systems. The validity and effectiveness of the proposed circuits are verified through the HSPICE simulation. A 8×8-bit parallel multiplier using the proposed circuits with 2V supply voltage is designed with a 0.25㎛ standard CMOS technology. The performance of the proposed multiplier is evaluated to be about 74% smaller than that of a corresponding binary implementation.
Antitumor Components Isolated from the Heartwood Extract of Dalbergia odorifera
Choi, Chun-Whan,Choi, Yeon-Hee,Cha, Mi-Ran,Kim, Young-Sup,Yon, Gyu-Hwan,Kim, Young-Kyoon,Choi, Sang-Un,Kim, Young-Ho,Ryu, Shi-Yong The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.4
Ongoing search for promising antitumor components from plant resources, we found that the methanol extract from the heartwood of Dalbergia odorifera (Leguminosae) demonstrated a significant inhibition on the proliferation of human tumor cell lines including multidrug resistant cells in vitro. Intensive bioassay-guided purification of the extract finally led to the isolation of seven flavonoids and two phenolic components as active constituents for antitumor property, in vitro, i.e., medicarpin (1), 2-hydroxy-3,4-dimethoxybenzaldehyde (2), formononetin (3), tectorigenin (4), mucronulatol (5), (3R)-5'-methoxyvestitol (6), hydroxyobtustyrene (7), liquiritigenin (8), and (3R)-calussequinone (9), respectively.
${\alpha}$-Glucosidase Inhibitiors from Seed Extract of Paeonia lactiflora
Choi, Chun-Whan,Choi, Yeon-Hee,Cha, Mi-Ran,Park, Jee-Hee,Kim, Young-Sup,Kim, Young-Kyoon,Choi, Sang-Un,Yon, Gyu-Hwan,Hong, Kyung-Sik,Kim, Young-Ho,Ryu, Shi-Yong The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.6
Alpha-glucosidase inhibitors are oral antihyperglycemic agents that act on alpha-glucosidase competitively, delaying intestinal carbohydrate absorption and lessening postprandial increases in glucose levels. In the search for new classes of ${\alpha}$-glucosidase inhibitors extracted from natural resources, 420 different plant extracts were evaluated for their inhibitory effect on ${\alpha}$-glucosidase, in vitro. Amongst the tested extracts, the seed extract of Paeonia lactiflora (Paeoniaceae) demonstrated a significant degree of inhibition on the enzyme, according to dose. Extensive bioassay-guided fractionation of the extract resulted in the isolation of six materials, luteolin (1), resveratrol (2), trans-${\varepsilon}$-viniferin (3), gnetin H (4), suffruticosol A (5) and suffruticosol B (6), that are active agents for ${\alpha}$-glucosidase inhibition. Resveratrol (2) is a well-known naturally occurring hydroxystilbene, particularly abundant in wine and some related stilbene oligomers. Materials (3-6) exhibited relatively strong inhibition of ${\alpha}$-glucosidase and their $IC_{50}$ values were calculated as: 0.92mM (2), 3.15mM (3), 1.15 mM (4), 2.53mM (5) and 3.15mM (6). In contrast, the ($IC_{50}$) value of the reference drug, acarbose, was estimated as 8.28mM in vitro.
Evolutionary conservation in multiple faces of protein interaction
Choi, Yoon Sup,Yang, Jae-Seong,Choi, Yonghwan,Ryu, Sung Ho,Kim, Sanguk Wiley Subscription Services, Inc., A Wiley Company 2009 Proteins Vol.77 No.1
<P>Protein interfaces are believed to be evolutionarily more conserved than the rest of the protein surface, but this has not been properly verified using a large protein structural set. Furthermore, recent systematic protein interaction analyses have proved that proteins interacting with many partners have multiple interfaces to connect protein interaction networks, which have never taken into account for conservation analysis of protein interface. Here, we studied the evolutionary conservation of protein interfaces using a large-scale dataset of 2646 protein interfaces with the classification of homodimeric/heterodimeric and obligatory/transient interactions, considering all their known multiple interfaces. We found that protein interfaces were indeed more conserved than noninterface surfaces, and the conservation level of protein interfaces increased when multiple interfaces were properly considered. These findings suggest that conservation analysis should be a good descriptor for protein interface identification and protein–protein interaction predictions. We applied this evolutionary feature to filter docking decoys and found that protein interface conservation worked remarkably well in selecting the near-native structures from the large number of generated docking complexes. Moreover, we discovered that a strong correlation exist between protein interface size and protein interface conservation, which could be a useful filter for the prediction of protein–protein interactions. Proteins 2009. © 2009 Wiley-Liss, Inc.</P>